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[190573_at] serine/threonine kinase

Description F19H6.1 /REP_DB=WormBase Gene ID /WP=CE03232 /TR=Q19530 /GB=CAA92169.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 06      6grp_high1_10_10 > 10      4grp_highest_8_8 > 19      4grp_high_8_8 > 63      6grp_highest_nonorm > 52      6grp_total > 22      4grp_total > 56      6grp_highest_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 284
1 2 3 4 range
A 732
(-1)
P 		639.2
(-3)
P 		923.3
(3)
P 		686.7
(-2)
P 		284
B 668.8
(-3)
P 		805.5
(2.1)
P 		829.5
(3)
P 		762.7
(0.5)
P 		161
C 742.7
(-1.8)
P 		729.7
(-2.4)
P 		849.9
(3)
P 		717.2
(-3)
P 		133
avr 714.5
(-3) 		724.8
(-2.6) 		867.6
(3) 		722.2
(-2.7) 		153

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 415
1 2 3 4 5 6 range
A 760.9
(3)
P 		655.2
(1.3)
P 		491.9
(-1.2)
P 		678.8
(1.7)
P 		564.9
(-0.1)
P 		380.6
(-3)
P 		380
B 630.9
(1.6)
P 		640.6
(1.8)
P 		593.4
(0.9)
P 		700.8
(3)
P 		531.8
(-0.3)
P 		394.3
(-3)
P 		307
C 570.5
(-0.5)
P 		578.9
(-0.4)
P 		725.9
(1.9)
P 		795.7
(3)
P 		461
(-2.2)
P 		410.3
(-3)
P 		385
avr 654.1
(1.7) 		624.9
(1.2) 		603.7
(0.8) 		725.1
(3) 		519.2
(-0.7) 		395.1
(-3) 		330
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 196
1 2 3 4 range
A 266.5
(3)
P 		138.8
(-1.6)
P 		241.4
(2.1)
P 		100.5
(-3)
P 		166
B 213.3
(3)
P 		198.9
(1.3)
P 		192.2
(0.5)
P 		162.5
(-3)
P 		51
C 245.9
(1.3)
P 		209.8
(0)
P 		296.2
(3)
P 		120.9
(-3)
P 		175
avr 241.9
(2.9) 		182.5
(-0.2) 		243.3
(3) 		128
(-3) 		115

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 140
1 2 3 4 5 6 range
A 140.3
(-1)
P 		233
(3)
P 		107.1
(-2.4)
P 		172.2
(0.4)
P 		170.5
(0.3)
P 		92.7
(-3)
P 		140
B 219.5
(3)
P 		213.2
(2.5)
P 		144.1
(-3)
P 		185.6
(0.3)
P 		216.1
(2.7)
P 		147
(-2.8)
P 		75
C 211.5
(3)
P 		176.6
(0.2)
P 		184.8
(0.8)
P 		160
(-1.2)
P 		149.2
(-2)
P 		137.4
(-3)
P 		74
avr 190.4
(1.7) 		207.6
(3) 		145.3
(-1.6) 		172.6
(0.4) 		178.6
(0.9) 		125.7
(-3) 		82
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190573_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16547
Sequence Type Exemplar sequence
Representative Public ID F19H6.1 NCBI
Target Description F19H6.1 /REP_DB=WormBase Gene ID /WP=CE03232 /TR=Q19530 /GB=CAA92169.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077679(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077679 NCBI Caenorhabditis elegans F19H6.1 (F19H6.1) mRNA, complete cds. 11/11 None
GENEFINDER00000003020 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12389716:12391047:-1 11/11 None
F19H6.1 ENSEMBL cdna:known chromosome:CEL140:X:12389716:12391393:-1 gene:F19H6.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12389824-12391393(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Ensembl F19H6.1
Entrez Gene 181398 Entrez gene
SwissProt Q19530 EMBL-EBI
WormBase CE31484 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.19686.1.S1_AT similar to NIMA (never in mitosis gene a)-related kinase 7 cfa
CANINE_2:CFA.21354.1.S1_AT similar to NIMA (never in mitosis gene a)-related kinase 7 cfa
CANINE_2:CFA.21354.1.S1_S_AT similar to NIMA (never in mitosis gene a)-related kinase 7 cfa
CANINE_2:CFAAFFX.17658.1.S1_AT similar to NIMA (never in mitosis gene a)-related kinase 7 cfa
CHICKEN:GGA.17537.1.S1_AT NIMA (never in mitosis gene a)-related kinase 7 gga
CHICKEN:GGAAFFX.1475.1.S1_AT NIMA (never in mitosis gene a)-related kinase 7 gga
HG-U95D:91600_AT NIMA (never in mitosis gene a)-related kinase 7 hs
U133_X3P:HS.24119.0.S1_3P_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U133A_2:212530_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U133_PLUS_2:212530_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U133A:212530_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U95AV2:34752_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U95D:68625_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U95D:72641_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U95D:83210_I_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HG-U95D:83212_R_AT NIMA (never in mitosis gene a)-related kinase 7 hs
HU35KSUBA:AA095022_AT NIMA (never in mitosis gene a)-related kinase 7 hs
MOE430A:1416816_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOUSE430A_2:1416816_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOUSE430_2:1416816_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MG-U74AV2:102827_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOE430A:1448474_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOUSE430A_2:1448474_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOUSE430_2:1448474_AT NIMA (never in mitosis gene a)-related expressed kinase 7 mm
MOUSE430_2:1444753_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MOE430B:1444753_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MOE430A:1416817_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MOUSE430A_2:1416817_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MOUSE430_2:1416817_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MU19KSUBB:TC30016_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MU19KSUBB:TC33041_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MU19KSUBB:TC33041_G_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
MU19KSUBB:TC34371_AT NIMA (never in mitosis gene a)-related expressed kinase 7, mRNA (cDNA clone MGC:46827 IMAGE:3994871) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92169 Hypothetical protein F19H6.1 [Caenorhabditis elegans] emb|CAA90762.2| Hypothetical protein F19H6.1 [Caenorhabditis elegans] ref|NP_510080.2| F19H6.1 [Caenorhabditis elegans] 1.0E-175
blast CAE57256 Hypothetical protein CBG00136 [Caenorhabditis briggsae] 1.0E-147
blast CAA92169 Hypothetical protein F19H6.1 [Caenorhabditis elegans] emb|CAA90762.2| Hypothetical protein F19H6.1 [Caenorhabditis elegans] ref|NP_510080.2| F19H6.1 [Caenorhabditis elegans] 1.0E-124
blast NP_001026435 NIMA (never in mitosis gene a)-related kinase 7 [Gallus gallus] emb|CAH65243.1| hypothetical protein [Gallus gallus] 1.0E-117
blast CAE57256 Hypothetical protein CBG00136 [Caenorhabditis briggsae] 1.0E-109
blast AAT45117 NIMA-family kinase Nek7 [Xenopus laevis] gb|AAH74381.1| Nek7 protein [Xenopus laevis] 3.0E-91
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-16
hanks 1.4.3 AGC group; AGC IV GPCR kinases; RhoK 3.0E-67
hanks 1.1.12 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); TPK1 5.0E-22
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.2E-70
Pfam IPR000719 EMBL-EBI Protein kinase 5.1E-52
Sequence
Target Sequence 
>C. ELEGANS:190573_AT
aattagcgagagccttagcccacatgcattccaaacgtataatgcatagagatatcaaac
ccgccaatgttttcataacgggaaacggaatcgtaaagttgggtgatttggggctaggcc
gattcttttcctcgaaaacaactgctgctcattcactcgtgggaactccttattacatgt
cacctgaaagaattcaagaatccgggtataatttcaaatccgatttatggtcgactggat
gtctgttatacgaaatggcagctcttcagtcaccattctacggtgacaagatgaacctgt
actcactttgcaagaaaatcgaaaactgcgaatatccacctctgcctgctgatatttatt
caacgcaagtaagtgcaaacctgtgttttgttcaacttagctccgcgacttggtatcccg
ttgtatacttccagaagct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATTAGCGAGAGCCTTAGCCCACAT 581 173 410 Antisense
GCCCACATGCATTCCAAACGTATAA 561 285 427 Antisense
GATATCAAACCCGCCAATGTTTTCA 549 423 460 Antisense
GTTGGGTGATTTGGGGCTAGGCCGA 148 437 507 Antisense
GAAAACAACTGCTGCTCATTCACTC 478 355 543 Antisense
CTCATTCACTCGTGGGAACTCCTTA 580 227 557 Antisense
GGAACTCCTTATTACATGTCACCTG 639 529 571 Antisense
CGAAATGGCAGCTCTTCAGTCACCA 116 253 660 Antisense
GATGAACCTGTACTCACTTTGCAAG 263 413 699 Antisense
GAAAACTGCGAATATCCACCTCTGC 587 353 730 Antisense
ATCCCGTTGTATACTTCCAGAAGCT 451 37 824 Antisense
Sequence Source Affymetrix Proprietary Database