[Home] | [Total List]

[190547_at] thymidylate synthase

Description Y110A7A.4 /REP_DB=WormBase Gene ID /WP=CE24124 /TR=Q9N588 /GB=AAF60422.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=thymidylate synthase
Cluster 6grp_highest_10_10 > 77      6grp_high1_10_10 > 77      4grp_highest_8_8 > 16      4grp_high_8_8 > 52      6grp_highest_nonorm > 97      6grp_total > 68      4grp_total > 59      6grp_highest_sub > Da      6grp_high1_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 527
1 2 3 4 range
A 664
(0.3)
P 		820.2
(3)
P 		695.1
(0.8)
P 		477.2
(-3)
P 		343
B 773.5
(0.2)
P 		897.9
(1.9)
P 		977.8
(3)
P 		539.6
(-3)
P 		438
C 776.9
(1.4)
P 		896.3
(3)
P 		861.3
(2.5)
P 		450.9
(-3)
P 		445
avr 738.1
(0.9) 		871.5
(3) 		844.7
(2.6) 		489.2
(-3) 		382

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1219
1 2 3 4 5 6 range
A 792.8
(-3)
P 		871.5
(-2.4)
P 		837.9
(-2.6)
P 		833.7
(-2.7)
P 		1041.1
(-1)
P 		1552.8
(3)
P 		760
B 976.9
(-1.2)
P 		675
(-3)
P 		990.1
(-1.1)
P 		872.1
(-1.8)
P 		1093
(-0.5)
P 		1659.4
(3)
P 		984
C 915.9
(-2)
P 		857.9
(-2.3)
P 		721.3
(-3)
P 		833.5
(-2.4)
P 		829.3
(-2.4)
P 		1893.5
(3)
P 		1172
avr 895.2
(-2.4) 		801.5
(-3) 		849.8
(-2.7) 		846.4
(-2.7) 		987.8
(-1.8) 		1701.9
(3) 		900
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 230
1 2 3 4 range
A 241.8
(3)
P 		178
(0.8)
P 		181.7
(0.9)
P 		69.9
(-3)
P 		172
B 246.7
(3)
P 		221.8
(1.9)
P 		226.6
(2.1)
P 		115
(-3)
P 		132
C 257.2
(1.8)
P 		257.7
(1.9)
P 		300.2
(3)
P 		76
(-3)
P 		224
avr 248.6
(3) 		219.2
(1.9) 		236.2
(2.5) 		87
(-3) 		162

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 488
1 2 3 4 5 6 range
A 146.1
(-3)
P 		310
(1.2)
P 		182.5
(-2.1)
P 		211.5
(-1.3)
P 		314.2
(1.3)
P 		378.1
(3)
P 		232
B 339.9
(-1.2)
P 		224.7
(-3)
P 		240.4
(-2.8)
P 		231
(-2.9)
P 		444.1
(0.3)
P 		618.8
(3)
P 		394
C 339.5
(-0.8)
P 		261.8
(-1.8)
P 		183.6
(-2.8)
P 		167.6
(-3)
P 		268.3
(-1.7)
P 		633.9
(3)
P 		466
avr 275.2
(-1.7) 		265.5
(-1.9) 		202.2
(-3) 		203.4
(-3) 		342.2
(-0.5) 		543.6
(3) 		341
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190547_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.409
Sequence Type Exemplar sequence
Representative Public ID Y110A7A.4 NCBI
Target Description Y110A7A.4 /REP_DB=WormBase Gene ID /WP=CE24124 /TR=Q9N588 /GB=AAF60422.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=thymidylate synthase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059131(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059131 NCBI Caenorhabditis elegans Y110A7A.4 (Y110A7A.4) mRNA, complete cds. 11/11 None
SNAP00000029214 ENSEMBL cdna:SNAP chromosome:CEL140:I:5138264:5139311:1 11/11 None
GENEFINDER00000029235 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:5138264:5140660:1 11/11 None
Y110A7A.4 ENSEMBL cdna:known chromosome:CEL140:I:5138207:5139366:1 gene:Y110A7A.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:5138272-5139311(+) 100.0 100.0
Public Domain and Genome References
Gene Title thymidylate synthase
Ensembl Y110A7A.4
Entrez Gene 172149 Entrez gene
SwissProt Q9N588 EMBL-EBI
WormBase CE24124 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:12919_S_AT bifunctional dihydrofolate reductase-thymidylate synthase 2 / DHFR-TS (THY-2) at
ATH1-121501:263601_S_AT bifunctional dihydrofolate reductase-thymidylate synthase 1 / DHFR-TS (THY-1) at
CANINE:1590937_AT similar to Thymidylate synthase (TS) (TSase) cfa
CANINE:1585547_AT similar to Thymidylate synthase (TS) (TSase) cfa
CANINE_2:CFA.5556.1.A1_S_AT similar to Thymidylate synthase (TS) (TSase) cfa
CANINE_2:CFA.9380.1.A1_AT similar to Thymidylate synthase (TS) (TSase) cfa
CANINE_2:CFAAFFX.28075.1.S1_AT similar to Thymidylate synthase (TS) (TSase) cfa
DROSOPHILA_2:1624747_AT dm
DROSGENOME1:144031_AT dm
CHICKEN:GGA.12234.1.S1_AT thymidylate synthetase gga
CHICKEN:GGAAFFX.9462.1.S1_AT thymidylate synthetase gga
HG-U95AV2:1505_AT thymidylate synthetase hs
HC-G110:1505_AT thymidylate synthetase hs
HG-U133A:202589_AT thymidylate synthetase hs
HG-U133_PLUS_2:202589_AT thymidylate synthetase hs
HG-FOCUS:202589_AT thymidylate synthetase hs
HG-U133A_2:202589_AT thymidylate synthetase hs
HG-U133_PLUS_2:217684_AT thymidylate synthetase hs
HG-U133A_2:217684_AT thymidylate synthetase hs
HG-U133A:217684_AT thymidylate synthetase hs
HUGENEFL:D00596_AT thymidylate synthetase hs
U133_X3P:G4507750_3P_AT thymidylate synthetase hs
U133_X3P:HS2.432651.1.S1_3P_S_AT thymidylate synthetase hs
U133_X3P:HS.141307.0.S1_3P_AT thymidylate synthetase hs
HG-U133_PLUS_2:1554696_S_AT thymidylate synthetase hs
HG-U95AV2:37899_AT thymidylate synthetase hs
HG-U133_PLUS_2:217690_AT Thymidylate synthetase hs
HG-U133A_2:217690_AT Thymidylate synthetase hs
HG-U133A:217690_AT Thymidylate synthetase hs
HG-U133_PLUS_2:243016_AT Thymidylate synthetase hs
HG-U133B:243016_AT Thymidylate synthetase hs
HG-U95B:48296_AT Thymidylate synthetase hs
HU35KSUBC:RC_AA236888_AT Thymidylate synthetase hs
U133_X3P:HS.141307.0.A1_3P_AT Thymidylate synthetase hs
U133_X3P:HS.87491.0.A1_3P_AT Thymidylate synthetase hs
MOUSE430_2:1442192_AT thymidylate synthase mm
MOE430B:1442192_AT thymidylate synthase mm
MOUSE430A_2:1424991_S_AT thymidylate synthase mm
MOE430A:1424991_S_AT thymidylate synthase mm
MOUSE430_2:1424991_S_AT thymidylate synthase mm
MOUSE430A_2:1438690_AT thymidylate synthase mm
MOUSE430_2:1438690_AT thymidylate synthase mm
MOE430A:1438690_AT thymidylate synthase mm
MU11KSUBA:M13352_S_AT thymidylate synthase mm
MU11KSUBB:MSA.2511.0_AT thymidylate synthase mm
MG-U74AV2:93236_S_AT thymidylate synthase mm
MOE430A:1427811_AT thymidylate synthase mm
MOUSE430A_2:1427811_AT thymidylate synthase mm
MOUSE430_2:1427811_AT thymidylate synthase mm
MOE430A:1427810_AT thymidylate synthase mm
MOUSE430A_2:1427810_AT thymidylate synthase mm
MOUSE430_2:1427810_AT thymidylate synthase mm
RG-U34A:L12138_AT thymidylate synthase rn
RAE230A:1369499_AT thymidylate synthase rn
RAT230_2:1369499_AT thymidylate synthase rn
YEAST_2:1770448_AT Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6231 dTMP biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4799 thymidylate synthase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAC97508 thymidylate synthase; TS [Caenorhabditis elegans] 1.0E-178
blast AAC97508 thymidylate synthase; TS [Caenorhabditis elegans] 1.0E-177
blast AAF60422 Hypothetical protein Y110A7A.4 [Caenorhabditis elegans] ref|NP_491532.3| Y110A7A.4 [Caenorhabditis elegans] 1.0E-176
blast AAC97508 thymidylate synthase; TS [Caenorhabditis elegans] 1.0E-176
blast AAF60422 Hypothetical protein Y110A7A.4 [Caenorhabditis elegans] ref|NP_491532.3| Y110A7A.4 [Caenorhabditis elegans] 1.0E-175
blast CAE72941 Hypothetical protein CBG20269 [Caenorhabditis briggsae] 1.0E-155
Protein Domains
Database ID Description E-Value
Pfam IPR000398 EMBL-EBI Thymidylate synthase 1.0E-126
Pfam IPR000398 EMBL-EBI Thymidylate synthase 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000029235 1 458-480
Sequence
Target Sequence 
>C. ELEGANS:190547_AT
agaaaaacggcgatcgcgcgttccttgacaatctcggatttacgtctcgtgaagaaggag
atcttggaccagtttatggatttcaatggagacactttggggcgaaatatgtggattgtc
atacagattactctggacaaggtgttgatcagttggctgaagttatccgacagattaagg
agcaaccggatagtcgaagaatcattatgtccgcgtggaatccgtcggatcttggacaaa
tggttctgccaccgtgtcacacaatgtgtcagttctatgtggacaatggagagctctcgt
gtcagctttaccaacgaagtggagatatgggtctcggagttccattcaaccttgccagct
acggccttctcacccacatgattgcaaaagtgtgtggattgaaaccaggaacccttgttc
atactctcggagatgctcatgtctactcaaatcatgtggatgctctcaaaattcaactgg
accgtgagccatacgctttccccaaaattcgattcacgcgagacgtggcctcaatcgatg
atttcacttctgatatgattgccctggatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGAAAAACGGCGATCGCGCGTTCCT 240 73 338 Antisense
CAATCTCGGATTTACGTCTCGTGAA 633 179 366 Antisense
CATTATGTCCGCGTGGAATCCGTCG 557 215 540 Antisense
AATGGAGAGCTCTCGTGTCAGCTTT 368 163 622 Antisense
CCTTCTCACCCACATGATTGCAAAA 603 269 702 Antisense
ACCAGGAACCCTTGTTCATACTCTC 153 87 741 Antisense
TCTCGGAGATGCTCATGTCTACTCA 493 609 762 Antisense
CAACTGGACCGTGAGCCATACGCTT 204 185 811 Antisense
TACGCTTTCCCCAAAATTCGATTCA 400 641 829 Antisense
GATTCACGCGAGACGTGGCCTCAAT 70 431 848 Antisense
ACTTCTGATATGATTGCCCTGGATG 464 101 883 Antisense
Sequence Source Affymetrix Proprietary Database