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[190536_s_at] Calpain thiol protease

Description T04A8.16 /REP_DB=WormBase Gene ID /WP=CE01070 /TR=Q22143 /GB=CAA84733.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Calpain thiol protease
Cluster 6grp_highest_10_10 > 65      6grp_high1_10_10 > 55      4grp_highest_8_8 > 51      4grp_high_8_8 > 24      6grp_highest_nonorm > 72      6grp_total > 56      4grp_total > 39      6grp_cgc > 36      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 228
1 2 3 4 range
A 439.4
(3)
P 		231.9
(-3)
P 		303.2
(-0.9)
P 		288.2
(-1.4)
P 		208
B 444
(3)
P 		262.2
(-3)
P 		262
(-3)
P 		323.3
(-1)
P 		182
C 460
(3)
P 		285.6
(-2.8)
P 		280.5
(-3)
P 		336.7
(-1.1)
P 		180
avr 447.8
(3) 		259.9
(-3) 		281.9
(-2.3) 		316.1
(-1.2) 		188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 185
1 2 3 4 5 6 range
A 377.8
(-1.1)
P 		417.2
(1.6)
P 		409
(1.1)
P 		413
(1.3)
P 		350.2
(-3)
P 		437.3
(3)
P 		87
B 523.9
(3)
P 		430.4
(-0.1)
P 		419.5
(-0.5)
P 		370.8
(-2.1)
P 		345.4
(-3)
P 		495.2
(2)
P 		179
C 430.9
(0.5)
P 		380.3
(-1.4)
P 		487.6
(2.7)
P 		456.8
(1.5)
P 		339.2
(-3)
P 		496.7
(3)
P 		158
avr 444.2
(1.5) 		409.3
(-0.1) 		438.7
(1.3) 		413.5
(0.1) 		344.9
(-3) 		476.4
(3) 		132
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 118
1 2 3 4 range
A 160
(3)
P 		50.3
(-2.6)
P 		79.3
(-1.1)
P 		42.2
(-3)
P 		118
B 141.6
(3)
P 		64.8
(-2.7)
P 		60.7
(-3)
P 		68.9
(-2.4)
P 		81
C 152.3
(3)
P 		82.1
(-1.4)
P 		97.8
(-0.4)
P 		56.8
(-3)
P 		96
avr 151.3
(3) 		65.7
(-2.4) 		79.3
(-1.5) 		56
(-3) 		95

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 115
1 2 3 4 5 6 range
A 69.7
(-3)
P 		148.4
(3)
P 		89.1
(-1.5)
P 		104.7
(-0.3)
P 		105.7
(-0.3)
P 		106.5
(-0.2)
P 		79
B 182.3
(2.8)
P 		143.3
(0.1)
P 		101.9
(-2.7)
P 		98.2
(-3)
P 		140.3
(-0.1)
P 		184.7
(3)
P 		87
C 159.7
(2.5)
P 		116
(-1.1)
P 		124.1
(-0.4)
P 		91.9
(-3)
P 		109.8
(-1.6)
P 		166.3
(3)
P 		74
avr 137.2
(1.3) 		135.9
(1.2) 		105
(-2.3) 		98.3
(-3) 		118.6
(-0.8) 		152.5
(3) 		54
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190536_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7109
Sequence Type Exemplar sequence
Representative Public ID T04A8.16 NCBI
Target Description T04A8.16 /REP_DB=WormBase Gene ID /WP=CE01070 /TR=Q22143 /GB=CAA84733.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Calpain thiol protease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065563(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065563 NCBI Caenorhabditis elegans CaLPain family member (clp-2) (clp-2) mRNA, complete cds. 11/11 None
SNAP00000041098 ENSEMBL cdna:SNAP chromosome:CEL140:III:4700411:4703978:-1 11/11 None
GENEFINDER00000041120 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:4700411:4703978:-1 11/11 None
T04A8.16 ENSEMBL cdna:known chromosome:CEL140:III:4700297:4704016:-1 gene:T04A8.16 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:4700410-4703978(-) 100.0 100.0
Public Domain and Genome References
Gene Title Calpain thiol protease
Gene Symbol clp-2
Ensembl T04A8.16
Entrez Gene 175618 Entrez gene
SwissProt Q22143 EMBL-EBI
WormBase CE01070 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.10010.1.S1_AT similar to calpain 7 cfa
CHICKEN:GGAAFFX.23584.1.S1_AT similar to PalBH gga
CHICKEN:GGAAFFX.7320.1.S1_AT similar to PalBH gga
CHICKEN:GGAAFFX.7320.1.S1_S_AT similar to PalBH gga
HG-U95AV2:32517_AT calpain 7 hs
HG-U133_PLUS_2:203357_S_AT calpain 7 hs
HG-U133A_2:203357_S_AT calpain 7 hs
HG-U133A:203357_S_AT calpain 7 hs
HU35KSUBA:AA449863_AT calpain 7 hs
HU35KSUBC:RC_N46420_AT calpain 7 hs
HU35KSUBD:RC_AA283709_AT calpain 7 hs
U133_X3P:G7656958_3P_A_AT calpain 7 hs
U133_X3P:HS.7145.0.A2_3P_AT calpain 7 hs
HG-U133A_2:203356_AT calpain 7 hs
HG-FOCUS:203356_AT calpain 7 hs
HG-U133_PLUS_2:203356_AT calpain 7 hs
HG-U133A:203356_AT calpain 7 hs
HG-U95C:60562_I_AT calpain 7 hs
HG-U95C:60563_R_AT calpain 7 hs
HG-U133_PLUS_2:239778_X_AT Calpain 7 hs
HG-U133B:239778_X_AT Calpain 7 hs
HG-U95AV2:32516_AT Calpain 7 hs
HG-U95E:69140_AT Calpain 7 hs
HG-U95D:70850_AT Calpain 7 hs
U133_X3P:HS.194626.0.A1_3P_AT Calpain 7 hs
MG-U74AV2:160718_AT calpain 7 mm
MOE430A:1423098_AT calpain 7 mm
MOUSE430A_2:1423098_AT calpain 7 mm
MOUSE430_2:1423098_AT calpain 7 mm
MOE430A:1423097_S_AT calpain 7 mm
MOUSE430A_2:1423097_S_AT calpain 7 mm
MOUSE430_2:1423097_S_AT calpain 7 mm
MOE430A:1423096_AT calpain 7 mm
MOUSE430A_2:1423096_AT calpain 7 mm
MOUSE430_2:1423096_AT calpain 7 mm
MG-U74BV2:116359_AT Calpain 7 (Capn7), mRNA mm
MG-U74BV2:116496_AT Calpain 7 (Capn7), mRNA mm
MOUSE430_2:1444346_AT Calpain 7 (Capn7), mRNA mm
MOE430B:1444346_AT Calpain 7 (Capn7), mRNA mm
MU19KSUBB:TC32749_AT Calpain 7 (Capn7), mRNA mm
RG-U34C:RC_AI169441_AT calpain 7 (predicted) rn
RAE230A:1373111_AT calpain 7 (predicted) rn
RAT230_2:1373111_AT calpain 7 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4198 calpain activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA84733 Hypothetical protein T04A8.16 [Caenorhabditis elegans] ref|NP_497964.1| CaLPain family member (clp-2) [Caenorhabditis elegans] 0.0
blast CAE71151 Hypothetical protein CBG18007 [Caenorhabditis briggsae] 0.0
blast XP_418783 PREDICTED: similar to PalBH [Gallus gallus] 1.0E-173
Protein Domains
Database ID Description E-Value
Pfam IPR001300 EMBL-EBI Peptidase C2, calpain 7.9E-9
Pfam IPR001300 EMBL-EBI Peptidase C2, calpain 2.1E-6
Pfam IPR007330 EMBL-EBI MIT 1.4E-13
Pfam IPR001300 EMBL-EBI Peptidase C2, calpain 7.9E-9
Pfam IPR001300 EMBL-EBI Peptidase C2, calpain 2.1E-6
Pfam IPR007330 EMBL-EBI MIT 3.0E-21
Sequence
Target Sequence 
>C. ELEGANS:190536_S_AT
gcgatcgacgattttgctgtgaacaaagagtttatcactcttattgtgtatgaaactggg
caaaagatctatataccaagcaacccgcaaccaatatccgacggtgttcgtatcaatagt
ccattgtatttatgtcaactctcgaataaaaaaccaggaattaccaaatacacgttggtt
gttgctcagtatgagaaaaccaatacaatcaactattctcttcgtgtattttcaacaact
gatgttaaattagaacctgtacagcttccctattcaatttccaaaactactcgtggaaac
tgggatggctctgataaataccctatcatgaaactcacacttcactcaaagtcagatgaa
atcgctttatttatggaattaaaagctccaaaacagttttgtgtcgctttggaaatgaaa
caaaactcatcagatcgaactgttttcttggaaacgaaaagttcgggagcatatcgacct
ggatacactgttctcacactggaaaaagttccagcaggaaagtattacgtgaaaatttca
acttatacggcaggcgacaaaggccccttcatcctccgaatcgattctact

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCGATCGACGATTTTGCTGTGAACA 627 289 1807 Antisense
CAACCCGCAACCAATATCCGACGGT 228 187 1887 Antisense
AATACACGTTGGTTGTTGCTCAGTA 562 171 1973 Antisense
ACTATTCTCTTCGTGTATTTTCAAC 176 103 2018 Antisense
TTAGAACCTGTACAGCTTCCCTATT 92 681 2056 Antisense
ACTCGTGGAAACTGGGATGGCTCTG 59 99 2095 Antisense
GAAACTCACACTTCACTCAAAGTCA 94 357 2136 Antisense
AAGTTCGGGAGCATATCGACCTGGA 296 135 2265 Antisense
TCGACCTGGATACACTGTTCTCACA 189 603 2280 Antisense
ATACGGCAGGCGACAAAGGCCCCTT 589 21 2351 Antisense
CTTCATCCTCCGAATCGATTCTACT 267 221 2373 Antisense
Sequence Source Affymetrix Proprietary Database