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[190531_at] Human AF-9 protein like

Description M04B2.3 /REP_DB=WormBase Gene ID /WP=CE12388 /TR=Q21501 /GB=CAB01234.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Human AF-9 protein like
Cluster 6grp_highest_10_10 > 65      6grp_high1_10_10 > 55      4grp_highest_8_8 > 62      4grp_high_8_8 > 18      6grp_highest_nonorm > 74      6grp_total > 56      4grp_total > 29      6grp_cgc > 36      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 206
1 2 3 4 range
A 602
(2.8)
P 		608.9
(3)
P 		434
(-3)
P 		576.8
(1.9)
P 		175
B 628.5
(2.5)
P 		527.9
(-2.2)
P 		510.5
(-3)
P 		639.6
(3)
P 		129
C 627.8
(3)
P 		552.8
(-0.8)
P 		510.5
(-3)
P 		576.6
(0.4)
P 		117
avr 619.4
(3) 		563.2
(0.5) 		485
(-3) 		597.7
(2) 		134

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 295
1 2 3 4 5 6 range
A 659
(1.4)
P 		659.6
(1.4)
P 		715.1
(3)
P 		701.9
(2.6)
P 		501.8
(-3)
P 		707.4
(2.8)
P 		213
B 638.8
(0.9)
P 		634.4
(0.8)
P 		608.6
(0.3)
P 		560.5
(-0.7)
P 		445.9
(-3)
P 		741.2
(3)
P 		295
C 597.3
(-0.4)
P 		627.3
(0.4)
P 		628
(0.4)
P 		502.2
(-3)
P 		543.8
(-1.9)
P 		724
(3)
P 		222
avr 631.7
(0.6) 		640.4
(0.8) 		650.6
(1.1) 		588.2
(-0.6) 		497.2
(-3) 		724.2
(3) 		227
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 135
1 2 3 4 range
A 219.2
(3)
P 		132.2
(-0.9)
P 		113.5
(-1.7)
P 		84.4
(-3)
P 		135
B 200.4
(3)
P 		130.4
(-2.1)
P 		118.3
(-3)
P 		136.3
(-1.7)
P 		82
C 207.8
(3)
P 		158.9
(0.3)
P 		177.9
(1.4)
P 		97.2
(-3)
P 		111
avr 209.1
(3) 		140.5
(-1) 		136.6
(-1.2) 		106
(-3) 		103

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 175
1 2 3 4 5 6 range
A 121.5
(-3)
P 		234.6
(3)
P 		155.7
(-1.2)
P 		178
(-0)
P 		151.4
(-1.4)
P 		172.2
(-0.3)
P 		113
B 222.3
(0.5)
P 		211.2
(-0)
P 		147.8
(-3)
P 		148.5
(-3)
P 		181.2
(-1.4)
P 		276.4
(3)
P 		129
C 221.4
(2.1)
P 		191.4
(0.8)
P 		159.8
(-0.5)
P 		101
(-3)
P 		176
(0.2)
P 		242.4
(3)
P 		141
avr 188.4
(0.1) 		212.4
(1.8) 		154.4
(-2.2) 		142.5
(-3) 		169.5
(-1.2) 		230.3
(3) 		88
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190531_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8556
Sequence Type Exemplar sequence
Representative Public ID M04B2.3 NCBI
Target Description M04B2.3 /REP_DB=WormBase Gene ID /WP=CE12388 /TR=Q21501 /GB=CAB01234.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Human AF-9 protein like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069771(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069771 NCBI Caenorhabditis elegans human GAS41-Like family member (gfl-1) (gfl-1) mRNA, complete cds. 11/11 None
SNAP00000026176 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11516639:11522099:1 11/11 None
GENEFINDER00000026182 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11521272:11522099:1 11/11 None
M04B2.3 ENSEMBL cdna:known chromosome:CEL140:IV:11521272:11522099:1 gene:M04B2.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11521277-11522105(+) 100.0 100.0
Public Domain and Genome References
Gene Title Human AF-9 protein like
Gene Symbol gfl-1
Ensembl M04B2.3
Entrez Gene 187434 Entrez gene
SwissProt Q21501 EMBL-EBI
WormBase CE12388 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248955_AT YEATS family protein at
CANINE:1587940_AT similar to YEATS domain containing 4 cfa
CANINE_2:CFA.10196.1.A1_AT similar to YEATS domain containing 4 cfa
CANINE_2:CFAAFFX.1601.1.S1_AT similar to YEATS domain containing 4 cfa
CANINE_2:CFAAFFX.1601.1.S1_S_AT similar to YEATS domain containing 4 cfa
DROSOPHILA_2:1633609_AT dm
DROSGENOME1:153869_AT dm
HU35KSUBA:RC_AA449741_AT YEATS domain containing 4 hs
HG-U133A:218911_AT YEATS domain containing 4 hs
HG-U133_PLUS_2:218911_AT YEATS domain containing 4 hs
HG-FOCUS:218911_AT YEATS domain containing 4 hs
HG-U133A_2:218911_AT YEATS domain containing 4 hs
U133_X3P:G5729837_3P_AT YEATS domain containing 4 hs
HG-U95C:64121_AT YEATS domain containing 4 hs
MG-U74CV2:169003_F_AT YEATS domain containing 4 mm
MG-U74BV2:113151_AT YEATS domain containing 4 mm
MG-U74CV2:166169_F_AT YEATS domain containing 4 mm
MG-U74CV2:171096_I_AT YEATS domain containing 4 mm
MG-U74CV2:169882_R_AT YEATS domain containing 4 mm
MOE430A:1423105_A_AT YEATS domain containing 4 mm
MOUSE430A_2:1423105_A_AT YEATS domain containing 4 mm
MOUSE430_2:1423105_A_AT YEATS domain containing 4 mm
MU19KSUBA:TC16205_AT YEATS domain containing 4, mRNA (cDNA clone MGC:28311 IMAGE:4013548) mm
RG-U34C:RC_AI072812_AT similar to glioma-amplified sequence-41 (predicted) rn
RAE230A:1378100_AT similar to glioma-amplified sequence-41 (predicted) rn
RAT230_2:1378100_AT similar to glioma-amplified sequence-41 (predicted) rn
RAE230B:1395782_AT similar to glioma-amplified sequence-41 (predicted) rn
RAT230_2:1395782_AT similar to glioma-amplified sequence-41 (predicted) rn
RG-U34B:RC_AA997428_AT Similar to glioma-amplified sequence-41 (predicted) rn
YEAST_2:1770150_AT Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3682 chromatin binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01234 Hypothetical protein M04B2.3 [Caenorhabditis elegans] ref|NP_502172.1| human GAS41-Like family member (gfl-1) [Caenorhabditis elegans] 1.0E-120
blast CAE62105 Hypothetical protein CBG06140 [Caenorhabditis briggsae] 1.0E-100
blast XP_792019 PREDICTED: similar to YEATS domain containing 4 [Strongylocentrotus purpuratus] 1.0E-53
Protein Domains
Database ID Description E-Value
Pfam IPR005033 EMBL-EBI YEATS family 3.7E-61
Pfam IPR005033 EMBL-EBI YEATS family 3.7E-61
Sequence
Target Sequence 
>C. ELEGANS:190531_AT
taacacagcgactccgttcggatacaaacgggattctgatcaacacacacatcaatggac
agttttcctaaagccataccttatagaagatccgaccaagtggatccgaaaagtgcaatt
caaactgcacgagagttacgcagttccgtacagagttgtcgaaaaaccaccatatgaagt
aactgaaactgggtggggagagttcgaaattcagattagaatctatttcgtggatccaaa
tgaaaagccaataacagctttccattatttacggcttttccagccgaccattgaactgcc
atcaggaaatcaaattgtttgcatggagttttatgatgaaattattttccaagagccgac
tgtccaaatgtacaaggcactgcaggcaagcgatggaaaacggcctgataaacaggcatt
tttgaatgatattgaacaagtgaaaactaggactcgtgaattgggggaggtggctcagaa
agaaatcgccgccgaaatagaagacctccgtgaatcactga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TAACACAGCGACTCCGTTCGGATAC 446 635 72 Antisense
ACGGGATTCTGATCAACACACACAT 618 95 99 Antisense
GACAGTTTTCCTAAAGCCATACCTT 32 369 129 Antisense
ACGCAGTTCCGTACAGAGTTGTCGA 576 91 209 Antisense
AACAGCTTTCCATTATTTACGGCTT 609 135 324 Antisense
TTTACGGCTTTTCCAGCCGACCATT 545 671 339 Antisense
CCGACCATTGAACTGCCATCAGGAA 19 265 355 Antisense
TTATTTTCCAAGAGCCGACTGTCCA 603 675 413 Antisense
GTACAAGGCACTGCAGGCAAGCGAT 19 461 441 Antisense
ATCGCCGCCGAAATAGAAGACCTCC 518 37 556 Antisense
ATAGAAGACCTCCGTGAATCACTGA 23 23 568 Antisense
Sequence Source Affymetrix Proprietary Database