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[190472_s_at] Clathrin heavy chain

Description T20G5.1 /REP_DB=WormBase Gene ID /WP=CE00480 /TR=SW:P34574 /GB=CAA83003.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Clathrin heavy chain
Cluster 6grp_highest_10_10 > 60      6grp_high1_10_10 > 16      4grp_highest_8_8 > 35      4grp_high_8_8 > 56      6grp_highest_nonorm > 67      6grp_total > 06      4grp_total > 55      6grp_highest_sub > De      6grp_cgc > 13      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 736
1 2 3 4 range
A 2123.9
(3)
P 		1485
(-3)
P 		1764.3
(-0.4)
P 		1620.6
(-1.7)
P 		639
B 1868.4
(2.3)
P 		1615.3
(-2.3)
P 		1574.2
(-3)
P 		1908.1
(3)
P 		334
C 1756.7
(2)
P 		1489.9
(-1.6)
P 		1829.4
(3)
P 		1387.9
(-3)
P 		442
avr 1916.3
(3) 		1530.1
(-3) 		1722.6
(-0) 		1638.9
(-1.3) 		386

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1492
1 2 3 4 5 6 range
A 2106.8
(1.6)
P 		2387.4
(3)
P 		1201
(-3)
P 		1691.2
(-0.5)
P 		1677.6
(-0.6)
P 		1978.1
(0.9)
P 		1186
B 2598.2
(3)
P 		1995.8
(-0.2)
P 		1716.9
(-1.7)
P 		1879.8
(-0.8)
P 		1473.4
(-3)
P 		1564.3
(-2.5)
P 		1125
C 2693.1
(3)
P 		1907.9
(-0.8)
P 		2436.2
(1.7)
P 		1579.8
(-2.4)
P 		1899.1
(-0.9)
P 		1461.2
(-3)
P 		1232
avr 2466
(3) 		2097
(0.2) 		1784.7
(-2.1) 		1716.9
(-2.6) 		1683.4
(-2.9) 		1667.9
(-3) 		798
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 539
1 2 3 4 range
A 773.3
(3)
P 		322.3
(-2)
P 		461.2
(-0.5)
P 		237.2
(-3)
P 		536
B 595.8
(3)
P 		398.9
(-2.1)
P 		364.8
(-3)
P 		406.6
(-1.9)
P 		231
C 581.5
(2.2)
P 		428.3
(-0.1)
P 		637.6
(3)
P 		234
(-3)
P 		404
avr 650.2
(3) 		383.2
(-1.5) 		487.9
(0.3) 		292.6
(-3) 		358

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 737
1 2 3 4 5 6 range
A 388.4
(-1.7)
P 		849.1
(3)
P 		261.6
(-3)
P 		428.9
(-1.3)
P 		506.2
(-0.5)
P 		481.6
(-0.8)
P 		588
B 904
(3)
P 		664.3
(0)
P 		416.9
(-3)
P 		497.9
(-2)
P 		598.6
(-0.8)
P 		583.3
(-1)
P 		487
C 998.2
(3)
P 		582.2
(-0.7)
P 		620.1
(-0.3)
P 		317.7
(-3)
P 		614.5
(-0.4)
P 		489.2
(-1.5)
P 		681
avr 763.5
(3) 		698.5
(1.9) 		432.9
(-2.7) 		414.8
(-3) 		573.1
(-0.3) 		518
(-1.2) 		349
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190472_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6217
Sequence Type Exemplar sequence
Representative Public ID T20G5.1 NCBI
Target Description T20G5.1 /REP_DB=WormBase Gene ID /WP=CE00480 /TR=SW:P34574 /GB=CAA83003.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Clathrin heavy chain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066859(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066859 NCBI Caenorhabditis elegans Clathrin Heavy Chain family member (chc-1) (chc-1) mRNA, complete cds. 11/11 None
SNAP00000033303 ENSEMBL cdna:SNAP chromosome:CEL140:III:10203761:10209295:1 11/11 None
GENEFINDER00000033347 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:10203761:10209295:1 11/11 None
T20G5.1 ENSEMBL cdna:known chromosome:CEL140:III:10203761:10209586:1 gene:T20G5.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:10203756-10209291(+) 100.0 100.0
Public Domain and Genome References
Gene Title Clathrin heavy chain
Gene Symbol chc-1
Ensembl T20G5.1
Entrez Gene 176434 Entrez gene
SwissProt P34574 EMBL-EBI
WormBase CE00480 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:256437_S_AT clathrin heavy chain, putative at
CANINE:1605541_AT similar to Clathrin heavy chain 1 (CLH-17) cfa
CANINE:1596046_AT similar to Clathrin heavy chain 1 (CLH-17) cfa
CANINE:1593830_S_AT similar to Clathrin heavy chain 1 (CLH-17) cfa
CANINE:1586197_AT similar to Clathrin heavy chain 1 (CLH-17) cfa
CANINE_2:CFAAFFX.27024.1.S1_S_AT similar to Clathrin heavy chain 1 (CLH-17) cfa
DROSOPHILA_2:1639985_S_AT Clathrin heavy chain dm
DROSGENOME1:155008_AT Clathrin heavy chain dm
CHICKEN:GGA.2120.1.S1_AT clathrin, heavy polypeptide (Hc) gga
HG-U95AV2:41159_AT clathrin, heavy polypeptide (Hc) hs
HG-U133_PLUS_2:210498_AT clathrin, heavy polypeptide (Hc) hs
HG-U133A_2:210498_AT clathrin, heavy polypeptide (Hc) hs
HG-U133A:210498_AT clathrin, heavy polypeptide (Hc) hs
HG-U133_PLUS_2:200614_AT clathrin, heavy polypeptide (Hc) hs
HG-U133A:200614_AT clathrin, heavy polypeptide (Hc) hs
HG-FOCUS:200614_AT clathrin, heavy polypeptide (Hc) hs
HG-U133A_2:200614_AT clathrin, heavy polypeptide (Hc) hs
HU35KSUBC:RC_N30042_S_AT clathrin, heavy polypeptide (Hc) hs
HUGENEFL:D21260_AT clathrin, heavy polypeptide (Hc) hs
U133_X3P:G4758011_3P_AT clathrin, heavy polypeptide (Hc) hs
U133_X3P:G11493430_RC_3P_AT clathrin, heavy polypeptide (Hc) hs
HG-U95E:84461_AT clathrin, heavy polypeptide (Hc) hs
HG-U95E:91168_AT clathrin, heavy polypeptide (Hc) hs
HG-U133_PLUS_2:220855_AT Clathrin, heavy polypeptide (Hc) hs
HG-U133A:220855_AT Clathrin, heavy polypeptide (Hc) hs
HG-U133A_2:220855_AT Clathrin, heavy polypeptide (Hc) hs
HU35KSUBC:RC_W90627_AT Clathrin, heavy polypeptide (Hc) hs
U133_X3P:G7662551_3P_X_AT Clathrin, heavy polypeptide (Hc) hs
HG-U95B:55312_AT Clathrin, heavy polypeptide (Hc) hs
HG-U133_PLUS_2:238646_AT Clathrin, heavy polypeptide (Hc) hs
HG-U133B:238646_AT Clathrin, heavy polypeptide (Hc) hs
HG-U95B:59481_AT Clathrin, heavy polypeptide (Hc) hs
HG-U95D:79996_AT Clathrin, heavy polypeptide (Hc) hs
HU35KSUBC:RC_N74958_AT Clathrin, heavy polypeptide (Hc) hs
U133_X3P:HS.169755.0.A1_3P_AT Clathrin, heavy polypeptide (Hc) hs
MOE430A:1454626_AT clathrin, heavy polypeptide (Hc) mm
MOUSE430_2:1454626_AT clathrin, heavy polypeptide (Hc) mm
MOUSE430A_2:1454626_AT clathrin, heavy polypeptide (Hc) mm
MU11KSUBA:AA139495_F_AT clathrin, heavy polypeptide (Hc) mm
MG-U74CV2:134316_AT clathrin, heavy polypeptide (Hc) mm
MG-U74AV2:160252_AT clathrin, heavy polypeptide (Hc) mm
MG-U74CV2:171610_AT clathrin, heavy polypeptide (Hc) mm
MOE430B:1439094_AT clathrin, heavy polypeptide (Hc) mm
MOUSE430_2:1439094_AT clathrin, heavy polypeptide (Hc) mm
MOE430B:1440457_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
MOUSE430_2:1440457_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
MU19KSUBA:TC20517_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
MU19KSUBA:TC20517_G_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
MU19KSUBC:TC37752_F_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
MU19KSUBC:TC39506_AT Clathrin, heavy polypeptide (Hc), mRNA (cDNA clone IMAGE:4949242) mm
RG-U34A:J03583_AT clathrin, heavy polypeptide (Hc) rn
RAE230A:1398842_AT clathrin, heavy polypeptide (Hc) rn
RAT230_2:1398842_AT clathrin, heavy polypeptide (Hc) rn
RG-U34B:RC_AA964536_AT Clathrin, heavy polypeptide (Hc) rn
YEAST_2:1774993_AT Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function Sc
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
30125 clathrin vesicle coat inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA83003 Hypothetical protein T20G5.1 [Caenorhabditis elegans] ref|NP_499260.1| Clathrin Heavy Chain family member (chc-1) [Caenorhabditis elegans] sp|P34574|CLH_CAEEL Probable clathrin heavy chain 0.0
blast CAE64972 Hypothetical protein CBG09806 [Caenorhabditis briggsae] 0.0
blast XP_623111 PREDICTED: similar to ENSANGP00000018215 [Apis mellifera] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001473 EMBL-EBI Clathrin propeller repeat, N-terminal 1.0E-4
Pfam IPR001473 EMBL-EBI Clathrin propeller repeat, N-terminal 1.2E-4
Pfam IPR001473 EMBL-EBI Clathrin propeller repeat, N-terminal 1.5E-8
Pfam IPR001473 EMBL-EBI Clathrin propeller repeat, N-terminal 1.5E-4
Pfam IPR001473 EMBL-EBI Clathrin propeller repeat, N-terminal 3.9E-9
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 6.1E-28
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 9.7E-46
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 7.6E-45
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 1.3E-49
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 3.0E-42
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 4.8E-51
Pfam IPR000547 EMBL-EBI 7-Fold repeat in clathrin and VPS proteins 3.9E-39
Sequence
Target Sequence 
>C. ELEGANS:190472_S_AT
cttcgttcttctattgaggctcaagacaactttgacaatatcactttggcccaacaactt
gagaagcacccacttgtggaattcagaagaatttccgcatacttgttcaagggaaacaac
agatggaagcaatcgatcgagctttgcaaaaaagacaagctgtacaaggatgccatggaa
tacgctgcagaatcgagaaacggagaactcgccgaagagctcttgtcattcttcctggat
gagaaactttatgattgttttgccgcctccctttaccattgttatgatctccttcacccc
gatgtcatcatggagctcgcttggaagcataagattatggattacgccatgccttacatg
atccaagttatgagagattatcagacgagacttgagaagttggagcgttctgagcatgag
aggaaagaggagaaggctgagcagcaacaaaacaatggaatgaccatggaaccacaactt
atgcttacctatggtgcccctgccccacaaatgacttatccaggaacaactggtggctat
ggcggacagcctgcttac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTTCGTTCTTCTATTGAGGCTCAAG 503 219 4456 Antisense
GACAATATCACTTTGGCCCAACAAC 675 363 4489 Antisense
GAATTTCCGCATACTTGTTCAAGGG 279 325 4544 Antisense
GAGAACTCGCCGAAGAGCTCTTGTC 568 391 4658 Antisense
AACTTTATGATTGTTTTGCCGCCTC 431 139 4700 Antisense
GCCTCCCTTTACCATTGTTATGATC 115 283 4720 Antisense
CCTTCACCCCGATGTCATCATGGAG 634 267 4746 Antisense
GATTACGCCATGCCTTACATGATCC 112 431 4795 Antisense
GAACCACAACTTATGCTTACCTATG 690 343 4924 Antisense
TGCCCCACAAATGACTTATCCAGGA 124 585 4956 Antisense
TGGCTATGGCGGACAGCCTGCTTAC 420 543 4989 Antisense
Sequence Source Affymetrix Proprietary Database