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[190391_s_at] sorbitol dehydrogenase

Description R04B5.6 /REP_DB=WormBase Gene ID /WP=CE06216 /TR=Q21703 /GB=CAA94842.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=sorbitol dehydrogenase
Cluster 6grp_total > 91      4grp_total > 45      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 78
1 2 3 4 range
A 87.4
(3)
P 		55
(-0.9)
A 		53.8
(-1.1)
A 		37.9
(-3)
A 		50
B 62.1
(3)
A 		43.5
(0.9)
A 		46.4
(1.2)
P 		9.5
(-3)
A 		53
C 86.3
(3)
P 		75.6
(2)
A 		24.5
(-3)
A 		65
(0.9)
A 		62
avr 78.6
(3) 		58
(-0) 		41.6
(-2.4) 		37.5
(-3) 		41

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 190
1 2 3 4 5 6 range
A 107.7
(-0.5)
P 		54.2
(-3)
A 		72.2
(-2.2)
M 		179.8
(2.8)
P 		183.6
(3)
P 		57.9
(-2.8)
M 		129
B 116.5
(-0.5)
P 		101.7
(-1)
P 		66.8
(-2.1)
P 		182.3
(1.6)
P 		227.6
(3)
P 		38.1
(-3)
A 		190
C 89
(-1.9)
P 		65.2
(-2.9)
P 		66.2
(-2.9)
P 		171.7
(1.8)
P 		197.9
(3)
P 		63.2
(-3)
A 		135
avr 104.4
(-0.9) 		73.7
(-2.2) 		68.4
(-2.4) 		177.9
(2) 		203
(3) 		53.1
(-3) 		150
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 30
1 2 3 4 range
A 31.8
(3)
P 		11.9
(-1.6)
A 		14.1
(-1.1)
A 		5.6
(-3)
A 		26
B 19.8
(3)
A 		10.7
(-0.1)
A 		10.8
(-0)
P 		2
(-3)
A 		18
C 28.6
(3)
P 		21.7
(0.9)
A 		8.5
(-3)
A 		11
(-2.3)
A 		20
avr 26.7
(3) 		14.8
(-0.5) 		11.1
(-1.6) 		6.2
(-3) 		21

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 78
1 2 3 4 5 6 range
A 19.9
(-2.2)
P 		19.3
(-2.2)
A 		15.7
(-2.8)
M 		45.6
(1.6)
P 		55.4
(3)
P 		14.1
(-3)
M 		41
B 40.5
(-1)
P 		33.9
(-1.5)
P 		16.2
(-2.8)
P 		48.3
(-0.4)
P 		92.5
(3)
P 		14.2
(-3)
A 		78
C 33
(-0.9)
P 		19.9
(-2.6)
P 		16.8
(-3)
P 		34.5
(-0.8)
P 		64
(3)
P 		21.2
(-2.4)
A 		47
avr 31.1
(-1.4) 		24.4
(-2.1) 		16.2
(-3) 		42.8
(-0.1) 		70.6
(3) 		16.5
(-3) 		54
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190391_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11288
Sequence Type Exemplar sequence
Representative Public ID R04B5.6 NCBI
Target Description R04B5.6 /REP_DB=WormBase Gene ID /WP=CE06216 /TR=Q21703 /GB=CAA94842.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=sorbitol dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073189(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073189 NCBI Caenorhabditis elegans R04B5.6 (R04B5.6) mRNA, complete cds. 11/11 None
SNAP00000020536 ENSEMBL cdna:SNAP chromosome:CEL140:V:10087862:10089618:1 11/11 None
GENEFINDER00000020549 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:10087862:10089155:1 11/11 None
R04B5.6 ENSEMBL cdna:known chromosome:CEL140:V:10087862:10089894:1 gene:R04B5.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10087861-10089618(+) 100.0 100.0
Public Domain and Genome References
Gene Title sorbitol dehydrogenase
Ensembl R04B5.6
Entrez Gene 179404 Entrez gene
SwissProt Q21703 EMBL-EBI
WormBase CE06216 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248398_AT sorbitol dehydrogenase, putative / L-iditol 2-dehydrogenase, putative at
DROSOPHILA_2:1634742_AT Sorbitol dehydrogenase-2 dm
DROSGENOME1:141276_AT Sorbitol dehydrogenase-2 dm
YEAST_2:1777143_S_AT Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism Sc
YEAST_2:1777143_S_AT Sorbitol dehydrogenase; expression is induced in the presence of sorbitol Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
4024 alcohol dehydrogenase activity, zinc-dependent inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94842 Hypothetical protein R04B5.6 [Caenorhabditis elegans] ref|NP_505590.1| R04B5.6 [Caenorhabditis elegans] 1.0E-173
blast CAA94842 Hypothetical protein R04B5.6 [Caenorhabditis elegans] ref|NP_505590.1| R04B5.6 [Caenorhabditis elegans] 1.0E-145
blast CAA94841 Hypothetical protein R04B5.5 [Caenorhabditis elegans] ref|NP_505591.1| R04B5.5 [Caenorhabditis elegans] 1.0E-142
blast CAE64010 Hypothetical protein CBG08605 [Caenorhabditis briggsae] 1.0E-140
Protein Domains
Database ID Description E-Value
Pfam IPR002085 EMBL-EBI Zinc-containing alcohol dehydrogenase superfamily 8.0E-101
Pfam IPR002085 EMBL-EBI Zinc-containing alcohol dehydrogenase superfamily 9.8E-93
Sequence
Target Sequence 
>C. ELEGANS:190391_S_AT
cacttcttgagccattgtctgttgcaattcaagcatgccgccgtggaactgttcaaatgg
gacaaaaaatacttgttctcggagcaggaccaattggagtcttgaatcttcttactgcta
aagcgataggtgcatcaaaagtagtaatcactgatttgaacgacgagagacttgctcttg
cacgcctattaggagctgatgctacaatcaatgttatgggaaaacgttcggatgaagtaa
gatcagagatcatcaaggcatttggcgatcaacaacctcatgtttcaattgagtgcacag
gggtccagccgtgtgtcgagacagctatcatgacaacaagatccggaggagttgttgttc
tagttggattgggtgcagagagagttgagattccattgattcaatcaccgaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CACTTCTTGAGCCATTGTCTGTTGC 164 197 458 Antisense
TGTTGCAATTCAAGCATGCCGCCGT 232 563 477 Antisense
ATGCCGCCGTGGAACTGTTCAAATG 123 41 492 Antisense
GGAGTCTTGAATCTTCTTACTGCTA 676 515 553 Antisense
GAACGACGAGAGACTTGCTCTTGCA 478 347 615 Antisense
CTTGCTCTTGCACGCCTATTAGGAG 585 217 628 Antisense
GCATTTGGCGATCAACAACCTCATG 135 309 715 Antisense
CAATTGAGTGCACAGGGGTCCAGCC 431 113 743 Antisense
TCCAGCCGTGTGTCGAGACAGCTAT 449 589 761 Antisense
GATCCGGAGGAGTTGTTGTTCTAGT 662 415 797 Antisense
GATTCCATTGATTCAATCACCGACA 677 433 846 Antisense
Sequence Source Affymetrix Proprietary Database