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[190293_at] NA(+)/H(+) exchanger

Description B0495.4 /REP_DB=WormBase Gene ID /WP=CE01762 /TR=Q09432 /GB=AAA62524.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=NA(+)-H(+) exchanger
Cluster 6grp_highest_10_10 > 32      6grp_high1_10_10 > 13      4grp_highest_8_8 > 42      4grp_high_8_8 > 48      6grp_highest_nonorm > 41      6grp_total > 12      4grp_total > 55      6grp_highest_sub > De      6grp_cgc > 33      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Hat      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1023
1 2 3 4 range
A 1501.8
(3)
P 		801.7
(-1.4)
P 		932.6
(-0.6)
P 		546.8
(-3)
P 		955
B 1569.7
(3)
P 		813.5
(-2.6)
P 		956.1
(-1.6)
P 		766.2
(-3)
P 		804
C 1455.4
(3)
P 		786.5
(-2.4)
P 		1078.6
(-0)
P 		706.6
(-3)
P 		749
avr 1509
(3) 		800.6
(-2.1) 		989.1
(-0.7) 		673.2
(-3) 		836

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 793
1 2 3 4 5 6 range
A 864.4
(0.7)
P 		1161.8
(3)
P 		772.4
(0)
P 		680.1
(-0.7)
P 		379.9
(-3)
P 		428.4
(-2.6)
P 		782
B 877.8
(0.9)
P 		1104.3
(3)
P 		912.5
(1.2)
P 		511.9
(-2.5)
P 		465.2
(-2.9)
P 		454.3
(-3)
P 		650
C 1172.5
(3)
P 		1120.5
(2.6)
P 		848.1
(0.3)
P 		718.6
(-0.7)
P 		440.2
(-3)
P 		457.9
(-2.9)
P 		732
avr 971.6
(1.7) 		1128.9
(3) 		844.3
(0.6) 		636.9
(-1.2) 		428.4
(-3) 		446.9
(-2.8) 		701
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 467
1 2 3 4 range
A 546.8
(3)
P 		174
(-1.8)
P 		243.8
(-0.9)
P 		80
(-3)
P 		467
B 500.6
(3)
P 		200.9
(-2.3)
P 		221.6
(-2)
P 		163.3
(-3)
P 		337
C 481.8
(3)
P 		226.1
(-1.2)
P 		375.9
(1.2)
P 		119.1
(-3)
P 		363
avr 509.7
(3) 		200.3
(-1.8) 		280.4
(-0.5) 		120.8
(-3) 		389

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 330
1 2 3 4 5 6 range
A 159.3
(-1.9)
P 		413.2
(3)
P 		168.2
(-1.8)
P 		172.5
(-1.7)
P 		114.6
(-2.8)
P 		104.3
(-3)
P 		309
B 305.4
(1.4)
P 		367.6
(3)
P 		221.6
(-0.8)
P 		135.6
(-3)
P 		189
(-1.6)
P 		169.4
(-2.1)
P 		232
C 434.6
(3)
P 		341.9
(1.1)
P 		215.9
(-1.5)
P 		144.5
(-3)
P 		142.5
(-3)
P 		153.3
(-2.8)
P 		292
avr 299.8
(1.1) 		374.2
(3) 		201.9
(-1.5) 		150.9
(-2.8) 		148.7
(-2.8) 		142.3
(-3) 		232
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190293_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4061
Sequence Type Exemplar sequence
Representative Public ID B0495.4 NCBI
Target Description B0495.4 /REP_DB=WormBase Gene ID /WP=CE01762 /TR=Q09432 /GB=AAA62524.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=NA(+)-H(+) exchanger
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063213(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063213 NCBI Caenorhabditis elegans Na/H eXchanger family member (nhx-2) (nhx-2) mRNA, complete cds. 10/11 None
SNAP00000031529 ENSEMBL cdna:SNAP chromosome:CEL140:II:7690743:7693864:-1 9/11 None
GENEFINDER00000031537 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7690737:7693864:-1 9/11 None
B0495.4 ENSEMBL cdna:known chromosome:CEL140:II:7690632:7693874:-1 gene:B0495.4 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7690733-7693810(-) 100.0 100.0
Public Domain and Genome References
Gene Title NA(+)/H(+) exchanger
Gene Symbol nhx-2
Ensembl B0495.4
Entrez Gene 174242 Entrez gene
SwissProt Q09432 EMBL-EBI
WormBase CE29549 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1635858_S_AT dm
DROSGENOME1:151002_AT dm
DROSGENOME1:146572_AT dm
CHICKEN:GGAAFFX.7939.1.S1_AT similar to Na+/H+ antiporter gga
CHICKEN:GGAAFFX.7939.2.S1_AT similar to Na+/H+ antiporter gga
CHICKEN:GGAAFFX.7939.2.S1_S_AT similar to Na+/H+ antiporter gga
HG-U95AV2:32981_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U133_PLUS_2:207212_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U133A:207212_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-FOCUS:207212_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U133A_2:207212_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HUGENEFL:U28043_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
U133_X3P:G6806920_3P_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HU35KSUBB:RC_N95578_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
U133_X3P:HS.5855.0.S1_3P_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U133_PLUS_2:226125_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U133B:226125_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U95B:48826_S_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HG-U95C:64465_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
HU35KSUBD:RC_D20954_AT Solute carrier family 9 (sodium/hydrogen exchanger), member 3 hs
MG-U74BV2:106486_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 mm
MOE430B:1441236_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 mm
MOUSE430_2:1441236_AT solute carrier family 9 (sodium/hydrogen exchanger), member 3 mm
RG-U34A:M85300_AT solute carrier family 9, member 3 rn
RAE230A:1387542_AT solute carrier family 9, member 3 rn
RAT230_2:1387542_AT solute carrier family 9, member 3 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6814 sodium ion transport inferred from electronic annotation QuickGO AmiGO
6885 regulation of pH inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
16324 apical plasma membrane inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
15299 solute:hydrogen antiporter activity inferred from electronic annotation QuickGO AmiGO
15385 sodium:hydrogen antiporter activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA62524 Na/h exchanger protein 2 [Caenorhabditis elegans] ref|NP_495614.3| Na/H eXchanger family member (nhx-2) [Caenorhabditis elegans] 0.0
blast AAM18102 putative Na-H exchanger isoform 2 [Caenorhabditis elegans] 0.0
blast CAE67516 Hypothetical protein CBG13035 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006153 EMBL-EBI Sodium/hydrogen exchanger 1.0E-126
Pfam IPR006153 EMBL-EBI Sodium/hydrogen exchanger 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495614.3 11 31-53,63-80,92-111,121-143,155-177,187-209,230-252,267-296,317-339,349-371,414-433
B0495.4 11 31-53,63-80,92-111,121-143,155-177,187-209,230-252,267-296,317-339,349-371,414-433
SNAP00000031529 11 48-70,80-97,109-128,138-160,172-194,204-226,247-269,284-313,334-356,366-388,431-450
GENEFINDER00000031537 11 48-70,80-97,109-128,138-160,172-194,204-226,247-269,284-313,334-356,366-388,431-450
Sequence
Target Sequence 
>C. ELEGANS:190293_AT
gcaattccagattttatacccggaaagaatatgtttgtcaccagttgtatcattgtcatc
tacttcactgtattcctccagggaattacactgaaaccaattgccgaattcctacaagtt
gagaaaaagaatgttcactcaaagaacatgattgagcatatttacagcgaagggcatcat
tggattcgtgattcgtggaatgcactcaacaataattatttgagaccaattttagttaat
aagaacaatatgaaggagatggataagactaaattggtcagaaagtacaagcatttggtt
gatgaagatgcaaagaagattgcacgtggagatttaaatagtaatatggtatttacaaaa
gctcttattgaacatacaagaagtcgaacaaatacaatgatcgatggagtaagttcgact
agtaaaatagatttcaccaaacacatgaaagagaattttggagtaacagtctatgatgat
catagtactgtacctatgacaccaactcatttattccaagaaacaactgaagttgaatat
tcggttcggagcgaaatcaacgacaat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCAATTCCAGATTTTATACCCGGAA 283 323 1192 Antisense
TATCATTGTCATCTACTTCACTGTA 57 659 1239 Antisense
CTTCACTGTATTCCTCCAGGGAATT 518 221 1254 Antisense
ATTACACTGAAACCAATTGCCGAAT 423 11 1276 Antisense
AATTGCCGAATTCCTACAAGTTGAG 51 177 1290 Antisense
TGAGCATATTTACAGCGAAGGGCAT 291 569 1344 Antisense
GAAGGGCATCATTGGATTCGTGATT 467 335 1360 Antisense
GTGATTCGTGGAATGCACTCAACAA 501 483 1379 Antisense
GTACTGTACCTATGACACCAACTCA 367 459 1676 Antisense
GACACCAACTCATTTATTCCAAGAA 371 367 1689 Antisense
GGTTCGGAGCGAAATCAACGACAAT 566 505 1734 Antisense
Sequence Source Affymetrix Proprietary Database