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[190263_at] CLPP-like protease

Description ZK970.2 /REP_DB=WormBase Gene ID /WP=CE02402 /TR=SW:Q27539 /GB=CAA88886.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=CLPP-like protease
Cluster 6grp_highest_10_10 > 25      6grp_high1_10_10 > 41      4grp_highest_8_8 > 22      4grp_high_8_8 > 06      6grp_highest_nonorm > 52      6grp_total > 52      4grp_total > 01      6grp_highest_sub > 03      6grp_cgc > 91      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 291
1 2 3 4 range
A 471.6
(-3)
P 		514.6
(-2)
P 		471.1
(-3)
P 		722.5
(3)
P 		251
B 518
(3)
P 		431.5
(-3)
P 		482.9
(0.6)
P 		434.4
(-2.8)
P 		87
C 440.6
(-3)
P 		476.8
(-1.8)
P 		504.7
(-1)
P 		629.3
(3)
P 		189
avr 476.7
(-2.9) 		474.3
(-3) 		486.2
(-2.4) 		595.4
(3) 		121

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 500
1 2 3 4 5 6 range
A 551.1
(-0.7)
P 		546.3
(-0.8)
P 		817.2
(3)
P 		703.4
(1.4)
P 		478.5
(-1.8)
P 		389.7
(-3)
P 		428
B 602.4
(-1.5)
P 		605.3
(-1.5)
P 		889.8
(3)
P 		656.5
(-0.7)
P 		552.6
(-2.3)
P 		507.9
(-3)
P 		382
C 536.3
(-1)
P 		633.8
(0.8)
P 		755.2
(3)
P 		428.4
(-3)
P 		576.4
(-0.3)
P 		526.8
(-1.2)
P 		327
avr 563.3
(-1.5) 		595.1
(-0.9) 		820.7
(3) 		596.1
(-0.9) 		535.8
(-1.9) 		474.8
(-3) 		346
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 83
1 2 3 4 range
A 171.7
(3)
P 		111.7
(-2.5)
P 		123.2
(-1.4)
P 		105.8
(-3)
P 		66
B 165.2
(3)
P 		106.6
(-1.8)
P 		111.9
(-1.4)
P 		92.6
(-3)
P 		73
C 145.9
(0.4)
P 		137.1
(-0.3)
P 		175.9
(3)
P 		106.1
(-3)
P 		70
avr 160.9
(3) 		118.5
(-1.3) 		137
(0.6) 		101.5
(-3) 		59

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 138
1 2 3 4 5 6 range
A 101.6
(-2.6)
P 		194.3
(3)
P 		178
(2)
P 		178.4
(2)
P 		144.4
(-0)
P 		94.9
(-3)
P 		99
B 209.6
(1.2)
P 		201.5
(0.3)
P 		216.1
(2)
P 		173.9
(-3)
P 		224.5
(3)
P 		189.4
(-1.2)
P 		51
C 198.8
(3)
P 		193.4
(2.7)
P 		192.2
(2.6)
P 		86.1
(-3)
P 		186.5
(2.3)
P 		176.3
(1.8)
P 		113
avr 170
(-0.1) 		196.4
(3) 		195.4
(2.9) 		146.1
(-3) 		185.1
(1.7) 		153.5
(-2.1) 		50
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190263_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2608
Sequence Type Exemplar sequence
Representative Public ID ZK970.2 NCBI
Target Description ZK970.2 /REP_DB=WormBase Gene ID /WP=CE02402 /TR=SW:Q27539 /GB=CAA88886.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=CLPP-like protease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063814(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063814 NCBI Caenorhabditis elegans ZK970.2 (ZK970.2) mRNA, complete cds. 11/11 A 
SNAP00000004309 ENSEMBL cdna:SNAP chromosome:CEL140:II:10300734:10302737:-1 11/11 None
GENEFINDER00000004328 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:10301829:10302692:-1 11/11 None
ZK970.2 ENSEMBL cdna:known chromosome:CEL140:II:10300699:10302769:-1 gene:ZK970.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:10300730-10302689(-) 100.0 100.0
Public Domain and Genome References
Gene Title CLPP-like protease
Ensembl ZK970.2
Entrez Gene 174594 Entrez gene
SwissProt Q27539 EMBL-EBI
WormBase CE02402 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:249873_AT ATP-dependent Clp protease proteolytic subunit, putative at
CANINE_2:CFA.16056.1.S1_AT similar to Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor (Endopeptidase Clp) cfa
CANINE_2:CFAAFFX.28567.1.S1_AT similar to Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor (Endopeptidase Clp) cfa
CANINE_2:CFAAFFX.28567.1.S1_S_AT similar to Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor (Endopeptidase Clp) cfa
DROSOPHILA_2:1633579_AT dm
DROSGENOME1:152331_AT dm
HG-U133_PLUS_2:202799_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
HG-U133A:202799_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
HG-FOCUS:202799_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
HG-U133A_2:202799_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
HUGENEFL:Z50853_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
U133_X3P:G5174418_3P_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
HG-U95AV2:32528_AT ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) hs
MU11KSUBA:AA274721_S_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MU11KSUBB:MSA.3830.0_S_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MG-U74AV2:93048_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOE430A:1416615_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOUSE430A_2:1416615_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOUSE430_2:1416615_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOE430A:1416616_S_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOUSE430A_2:1416616_S_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MOUSE430_2:1416616_S_AT caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) mm
MU19KSUBA:TC18675_AT Caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli), mRNA (cDNA clone MGC:5755 IMAGE:3487489) mm
RG-U34B:RC_AI031012_AT similar to ClpP protease rn
RAE230A:1371789_AT similar to ClpP protease rn
RAT230_2:1371789_AT similar to ClpP protease rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8462 endopeptidase Clp activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88886 Hypothetical protein ZK970.2 [Caenorhabditis elegans] ref|NP_496215.1| ZK970.2 [Caenorhabditis elegans] sp|Q27539|CLPP_CAEEL Probable ClpP-like protease (Endopeptidase Clp) 1.0E-113
blast CAA88886 Hypothetical protein ZK970.2 [Caenorhabditis elegans] ref|NP_496215.1| ZK970.2 [Caenorhabditis elegans] sp|Q27539|CLPP_CAEEL Probable ClpP-like protease (Endopeptidase Clp) 1.0E-108
blast CAE57828 Hypothetical protein CBG00853 [Caenorhabditis briggsae] 1.0E-104
blast CAE57828 Hypothetical protein CBG00853 [Caenorhabditis briggsae] 1.0E-101
blast CAG05962 unnamed protein product [Tetraodon nigroviridis] 3.0E-68
blast CAA88886 Hypothetical protein ZK970.2 [Caenorhabditis elegans] ref|NP_496215.1| ZK970.2 [Caenorhabditis elegans] sp|Q27539|CLPP_CAEEL Probable ClpP-like protease (Endopeptidase Clp) 7.0E-35
Protein Domains
Database ID Description E-Value
Pfam IPR001907 EMBL-EBI Peptidase S14, ClpP 5.2E-119
Pfam IPR001907 EMBL-EBI Peptidase S14, ClpP 5.5E-31
Pfam IPR001907 EMBL-EBI Peptidase S14, ClpP 3.9E-39
Pfam IPR001907 EMBL-EBI Peptidase S14, ClpP 5.2E-119
Sequence
Target Sequence 
>C. ELEGANS:190263_AT
gttcaatcacgcgttggaattccatttgtaatcgataatgaaggaaaaggagaacgtaca
tatgatatttactcgagacttcttcgcgatcgaatcgtttgtcttatgacaccggtagat
gatttcattgcttctgcacttatcgcacaactcttgtttcttcaaagcgaaagtggcaaa
aaaccaattcacatgtatattaacagtccaggcggcagtgtaacagcaggacttgctatt
tatgacacaatacaaatgataagtgcaccagtgtccacatgggtgatcggacaagcatca
tcaatgggatcactgctgctttgtgccggtgaaaaaggaatgcgaagtgctctcccga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTCAATCACGCGTTGGAATTCCAT 437 445 25 Antisense
TTTACTCGAGACTTCTTCGCGATCG 591 673 92 Antisense
GCGATCGAATCGTTTGTCTTATGAC 135 291 110 Antisense
GATTTCATTGCTTCTGCACTTATCG 136 429 145 Antisense
GCACTTATCGCACAACTCTTGTTTC 611 315 160 Antisense
GTATATTAACAGTCCAGGCGGCAGT 46 453 219 Antisense
GCGGCAGTGTAACAGCAGGACTTGC 153 293 236 Antisense
TAAGTGCACCAGTGTCCACATGGGT 241 637 284 Antisense
GCATCATCAATGGGATCACTGCTGC 348 309 319 Antisense
TCACTGCTGCTTTGTGCCGGTGAAA 79 621 334 Antisense
AAAGGAATGCGAAGTGCTCTCCCGA 364 121 358 Antisense
Sequence Source Affymetrix Proprietary Database