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[190248_s_at] p-glycoprotein (MDR)

Description F22E10.3 /REP_DB=WormBase Gene ID /WP=CE03262 /TR=Q19735 /GB=CAA91801.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster 6grp_highest_10_10 > 42      6grp_high1_10_10 > 13      4grp_highest_8_8 > 57      4grp_high_8_8 > 34      6grp_highest_nonorm > 30      6grp_total > 12      4grp_total > 46      6grp_highest_sub > 02      6grp_cgc > 33      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Hat      6grp_rule_based > S2      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1968
1 2 3 4 range
A 2769.3
(3)
P 		1811.3
(0)
P 		838.2
(-3)
P 		915
(-2.8)
P 		1931
B 2609.2
(3)
P 		1301.5
(-1.4)
P 		835.5
(-3)
P 		926.4
(-2.7)
P 		1774
C 2395.6
(3)
P 		1271.6
(-1.2)
P 		801.8
(-3)
P 		841
(-2.9)
P 		1594
avr 2591.4
(3) 		1461.5
(-0.8) 		825.2
(-3) 		894.1
(-2.8) 		1766

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1404
1 2 3 4 5 6 range
A 1028
(0.4)
P 		1599.3
(3)
P 		658.9
(-1.2)
P 		535.5
(-1.8)
P 		363.6
(-2.6)
P 		263.8
(-3)
P 		1336
B 1050.3
(0.8)
P 		1545.9
(3)
P 		877.7
(0)
P 		521.3
(-1.6)
P 		308.4
(-2.5)
P 		195.7
(-3)
P 		1350
C 1415.1
(3)
P 		1249.8
(2.2)
P 		889.7
(0.3)
P 		517.7
(-1.5)
P 		373.2
(-2.3)
P 		229.3
(-3)
P 		1186
avr 1164.5
(1.5) 		1465
(3) 		808.8
(-0.2) 		524.8
(-1.6) 		348.4
(-2.4) 		229.6
(-3) 		1235
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 874
1 2 3 4 range
A 1008.3
(3)
P 		393.2
(-1.2)
P 		219.1
(-2.4)
P 		133.9
(-3)
P 		874
B 832
(3)
P 		321.4
(-1.8)
P 		193.6
(-3)
P 		197.4
(-3)
P 		638
C 793
(3)
P 		365.6
(-0.9)
P 		279.4
(-1.7)
P 		141.8
(-3)
P 		651
avr 877.8
(3) 		360.1
(-1.3) 		230.7
(-2.4) 		157.7
(-3) 		720

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 505
1 2 3 4 5 6 range
A 189.5
(-1.5)
P 		568.8
(3)
P 		143.5
(-2.1)
P 		135.8
(-2.1)
P 		109.7
(-2.5)
P 		64.2
(-3)
P 		505
B 365.4
(1)
P 		514.6
(3)
P 		213.1
(-1.1)
P 		138.1
(-2.1)
P 		125.3
(-2.3)
P 		73
(-3)
P 		442
C 524.5
(3)
P 		381.4
(1.1)
P 		226.4
(-1)
P 		104.1
(-2.6)
P 		120.8
(-2.4)
P 		76.8
(-3)
P 		448
avr 359.8
(1.2) 		488.3
(3) 		194.3
(-1.2) 		126
(-2.2) 		118.6
(-2.3) 		71.3
(-3) 		417
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190248_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17669
Sequence Type Exemplar sequence
Representative Public ID F22E10.3 NCBI
Target Description F22E10.3 /REP_DB=WormBase Gene ID /WP=CE03262 /TR=Q19735 /GB=CAA91801.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077727(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077727 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-14) (pgp-14) mRNA, complete cds. 11/11 None
SNAP00000002362 ENSEMBL cdna:SNAP chromosome:CEL140:X:12744926:12749474:-1 11/11 None
GENEFINDER00000002365 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12744926:12749474:-1 11/11 None
F22E10.3.1 ENSEMBL cdna:known chromosome:CEL140:X:12744168:12749499:-1 gene:F22E10.3 11/11 A 
F22E10.3.3 ENSEMBL cdna:known chromosome:CEL140:X:12744169:12749474:-1 gene:F22E10.3 11/11 A 
F22E10.3.2 ENSEMBL cdna:known chromosome:CEL140:X:12744629:12749499:-1 gene:F22E10.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12744925-12749474(-) 100.0 100.0
Public Domain and Genome References
Gene Title p-glycoprotein (MDR)
Gene Symbol pgp-14
Ensembl F22E10.3
Entrez Gene 181416 Entrez gene
SwissProt Q19735 EMBL-EBI
WormBase CE03262 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91801 Hypothetical protein F22E10.3 [Caenorhabditis elegans] ref|NP_510128.1| P-GlycoProtein related family member (pgp-14) [Caenorhabditis elegans] gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14) [Caenorhabditis elegans] 0.0
blast CAE57219 Hypothetical protein CBG00079 [Caenorhabditis briggsae] 0.0
blast CAE57218 Hypothetical protein CBG00078 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.9E-51
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.3E-26
Pfam IPR003439 EMBL-EBI ABC transporter 4.4E-65
Pfam IPR003439 EMBL-EBI ABC transporter 1.5E-65
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510128.1 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
F22E10.3.1 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
F22E10.3.3 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
F22E10.3.2 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
SNAP00000002362 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
GENEFINDER00000002365 11 102-124,150-172,227-246,250-269,329-351,361-383,767-789,809-831,890-909,913-935,992-1014
Sequence
Target Sequence 
>C. ELEGANS:190248_S_AT
gatgttactggcggagcacttcgaattgatggacaagacattcgaaaattgtcactgttc
catctcagaacacaaatggcgctggtcggccaagagcctcgtcttttcgcaggaaccatc
cgcgagaacgtgtgccttgggttgaaggatgtgccacttgaaaagatcaatcaagcctta
gaacttgccaatgctaacagattccttgccaacttgccagccggaattgacacagatgta
ggagaaaaaggaggacaattgtcgggaggtcagaaacagagaattgcaattgccagagct
ttggtccgagaccccaaaattctgcttctggatgaagccacgtcagctttggattcggaa
tccgaaagggctgtacaagaggcattagatcgtgcccgagaaggtcgtacgtgtatcaca
attgcccatcgtttgtcgtccattcagaactctgaccttattgtgtacatcgataagggc
aaggtgcaggaagctggcaaccacacgcagttgatgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATGTTACTGGCGGAGCACTTCGAA 508 409 3427 Antisense
AAATTGTCACTGTTCCATCTCAGAA 353 115 3472 Antisense
AAATGGCGCTGGTCGGCCAAGAGCC 417 119 3500 Antisense
ATGCTAACAGATTCCTTGCCAACTT 246 43 3617 Antisense
AACTTGCCAGCCGGAATTGACACAG 291 139 3637 Antisense
ATTGCCAGAGCTTTGGTCCGAGACC 447 5 3715 Antisense
GAGACCCCAAAATTCTGCTTCTGGA 228 395 3734 Antisense
GAAGCCACGTCAGCTTTGGATTCGG 168 345 3760 Antisense
GTTTGTCGTCCATTCAGAACTCTGA 377 451 3857 Antisense
GAACTCTGACCTTATTGTGTACATC 459 349 3873 Antisense
GCTGGCAACCACACGCAGTTGATGC 60 295 3919 Antisense
Sequence Source Affymetrix Proprietary Database