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[190219_at] Src homology domain 3

Description K11E4.4 /REP_DB=WormBase Gene ID /WP=CE18886 /TR=Q21430 /GB=CAA94159.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Src homology domain 3
Cluster 6grp_total > 16      4grp_total > 13      6grp_cgc > 13      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 177
1 2 3 4 range
A 120.4
(1.5)
A 		96.9
(0.4)
A 		21
(-3)
A 		153.7
(3)
A 		133
B 73.8
(-1.1)
A 		18.5
(-3)
A 		60
(-1.6)
A 		195.9
(3)
A 		177
C 130.8
(0.6)
A 		69.9
(-1.8)
A 		41.1
(-3)
A 		188.9
(3)
A 		148
avr 108.3
(-0.1) 		61.8
(-2.1) 		40.7
(-3) 		179.5
(3) 		139

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 155
1 2 3 4 5 6 range
A 169.1
(3)
A 		68.5
(-2.4)
A 		106.6
(-0.3)
A 		58.2
(-2.9)
A 		117.9
(0.3)
A 		56.3
(-3)
A 		113
B 92.4
(0.8)
A 		137.2
(3)
A 		14
(-3)
A 		76.6
(0)
A 		48.5
(-1.3)
A 		86.3
(0.5)
A 		123
C 112.4
(3)
A 		105.6
(2.6)
A 		16.2
(-3)
A 		79.4
(0.9)
A 		32.6
(-2)
A 		38.8
(-1.6)
A 		96
avr 124.6
(3) 		103.8
(1.4) 		45.6
(-3) 		71.4
(-1) 		66.3
(-1.4) 		60.5
(-1.9) 		79
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 39
1 2 3 4 range
A 43.8
(3)
A 		21
(-0.6)
A 		5.5
(-3)
A 		22.5
(-0.3)
A 		38
B 23.5
(0)
A 		4.6
(-3)
A 		13.9
(-1.5)
A 		41.8
(3)
A 		37
C 43.3
(3)
A 		20.1
(-1.8)
A 		14.3
(-3)
A 		31.9
(0.6)
A 		29
avr 36.9
(3) 		15.2
(-2.1) 		11.2
(-3) 		32.1
(1.9) 		26

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 42
1 2 3 4 5 6 range
A 31.2
(1.8)
A 		24.4
(-0.1)
A 		23.2
(-0.4)
A 		14.8
(-2.7)
A 		35.6
(3)
A 		13.7
(-3)
A 		22
B 32.2
(1.1)
A 		45.7
(3)
A 		3.4
(-3)
A 		20.3
(-0.6)
A 		19.7
(-0.7)
A 		32.2
(1.1)
A 		42
C 41.7
(3)
A 		32.2
(1.5)
A 		4.1
(-3)
A 		16
(-1.1)
A 		10.5
(-2)
A 		13
(-1.6)
A 		38
avr 35
(3) 		34.1
(2.8) 		10.2
(-3) 		17
(-1.4) 		21.9
(-0.2) 		19.6
(-0.7) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190219_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17371
Sequence Type Exemplar sequence
Representative Public ID K11E4.4 NCBI
Target Description K11E4.4 /REP_DB=WormBase Gene ID /WP=CE18886 /TR=Q21430 /GB=CAA94159.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Src homology domain 3
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077896(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077896 NCBI Caenorhabditis elegans Temporarily Assigned Gene name family member (tag-207) (tag-207) mRNA, complete cds. 11/11 None
GENEFINDER00000028499 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:13727222:13733328:1 11/11 None
K11E4.4 ENSEMBL cdna:known chromosome:CEL140:X:13724584:13734269:1 gene:K11E4.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000028497 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:13724583-13733341(+) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 3
Gene Symbol tag-207
Ensembl K11E4.4
Entrez Gene 181490 Entrez gene
SwissProt Q21430 EMBL-EBI
WormBase CE18886 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1639115_S_AT rho-type guanine exchange factor dm
HG-U133A:202547_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133A_2:202547_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:202547_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:229642_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133B:229642_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:202548_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-FOCUS:202548_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133A:202548_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133A_2:202548_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HU35KSUBD:RC_N39578_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HU35KSUBD:RC_AA452871_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HUGENEFL:D63476_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:G4505572_3P_A_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS2.377064.1.S1_3P_X_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.201919.0.A1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.172813.0.A1_3P_A_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.13625.0.A1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.117494.0.S1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:1562270_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:1562271_X_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:236416_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133B:236416_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:239397_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133B:239397_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:242999_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133B:242999_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95AV2:40828_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95B:42569_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95D:69169_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95E:81222_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS2.435797.1.S1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS2.280149.1.S1_3P_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.202402.0.A1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:1557439_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:1561075_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95E:69979_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133_PLUS_2:235412_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U133B:235412_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HG-U95E:74610_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HU35KSUBB:RC_T69754_S_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
HU35KSUBD:RC_AA302772_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
U133_X3P:HS.130839.0.A1_3P_AT Rho guanine nucleotide exchange factor (GEF) 7 hs
MOE430A:1449066_A_AT Rho guanine nucleotide exchange factor (GEF7) mm
MOUSE430A_2:1449066_A_AT Rho guanine nucleotide exchange factor (GEF7) mm
MOUSE430_2:1449066_A_AT Rho guanine nucleotide exchange factor (GEF7) mm
MOE430A:1424482_AT Rho guanine nucleotide exchange factor (GEF7) mm
MOUSE430A_2:1424482_AT Rho guanine nucleotide exchange factor (GEF7) mm
MOUSE430_2:1424482_AT Rho guanine nucleotide exchange factor (GEF7) mm
MU11KSUBB:U96634_S_AT Rho guanine nucleotide exchange factor (GEF7) mm
MG-U74AV2:98434_AT Rho guanine nucleotide exchange factor (GEF7) mm
MG-U74BV2:106830_AT Rho guanine nucleotide exchange factor (GEF7) mm
MU19KSUBA:TC23197_S_AT Rho guanine nucleotide exchange factor (GEF7) (Arhgef7), mRNA mm
RG-U34A:RC_AA874918_AT Rho guanine nucleotide exchange factor 7 rn
RAE230A:1368925_A_AT Rho guanine nucleotide exchange factor 7 rn
RAT230_2:1368925_A_AT Rho guanine nucleotide exchange factor 7 rn
RAT230_2:1375702_AT Rho guanine nucleotide exchange factor 7 rn
RAE230A:1375702_AT Rho guanine nucleotide exchange factor 7 rn
RAE230B:1384647_AT Rho guanine nucleotide exchange factor 7 rn
RAT230_2:1384647_AT Rho guanine nucleotide exchange factor 7 rn
RG-U34C:RC_AI071719_AT Rho guanine nucleotide exchange factor 7 rn
Protein Similarities
Method ID Description E-Value
blast CAA94159 Hypothetical protein K11E4.4 [Caenorhabditis elegans] ref|NP_510297.1| Temporarily Assigned Gene name family member (tag-207) [Caenorhabditis elegans] 0.0
blast CAE63090 Hypothetical protein CBG07380 [Caenorhabditis briggsae] 0.0
blast NP_059098 Rho guanine nucleotide exchange factor (GEF7) [Mus musculus] gb|AAH44838.1| Rho guanine nucleotide exchange factor (GEF7) [Mus musculus] dbj|BAC35033.1| unnamed protein product [Mus musculus] 4.0E-56
blast NP_059098 Rho guanine nucleotide exchange factor (GEF7) [Mus musculus] gb|AAH44838.1| Rho guanine nucleotide exchange factor (GEF7) [Mus musculus] dbj|BAC35033.1| unnamed protein product [Mus musculus] 7.0E-56
Protein Domains
Database ID Description E-Value
Pfam IPR001452 EMBL-EBI SH3 1.5E-15
Pfam IPR001452 EMBL-EBI SH3 1.5E-15
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510297.1 3 21-43,58-80,144-166
K11E4.4 3 21-43,58-80,144-166
Sequence
Target Sequence 
>C. ELEGANS:190219_AT
tgaactcggaatggtgctccctgaaggatttgagctgccaacaagcagtcgcaattcaag
gaatactgcagataacctgcaattctcccagttcccatcgtttttcctaagcgggaacgc
cggcaaacgaggtgatcgtaacattcgacttcgaaaagacgcggctcgtgatgaggagat
tgagtttgagacacttcgaattttggaaggatactgtgtggaaactggtggcggacagtc
ggacttccatgcaaatgaaagttatcaacaaccacatttgattgttgcagaagatgagaa
gattctgatggaggagatgattggagatgaagttgttttgcaagagaaaagtattgtgga
tgctgtgtacgccatcaaagatcaactttcgttccttcagaccgaatttcaaaaactagc
aaaagttgttgaatccgaacaaaaagcacgccgtcgtctggagcacaatttgccaaaaat
gtctggggtgatctcgccagatgggagttccagt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGAACTCGGAATGGTGCTCCCTGAA 584 573 1941 Antisense
AGATAACCTGCAATTCTCCCAGTTC 250 65 2010 Antisense
GGGAACGCCGGCAAACGAGGTGATC 584 493 2053 Antisense
GAGGTGATCGTAACATTCGACTTCG 32 403 2069 Antisense
GACTTCGAAAAGACGCGGCTCGTGA 500 371 2087 Antisense
GGACAGTCGGACTTCCATGCAAATG 352 525 2173 Antisense
GTGGATGCTGTGTACGCCATCAAAG 43 491 2296 Antisense
TCAACTTTCGTTCCTTCAGACCGAA 280 629 2322 Antisense
GAACAAAAAGCACGCCGTCGTCTGG 588 351 2377 Antisense
CCGTCGTCTGGAGCACAATTTGCCA 91 263 2391 Antisense
GATCTCGCCAGATGGGAGTTCCAGT 454 419 2430 Antisense
Sequence Source Affymetrix Proprietary Database