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[190182_at] p-glycoprotein (MDR)

Description F22E10.4 /REP_DB=WormBase Gene ID /WP=CE03263 /TR=Q19736 /GB=CAA91802.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster 6grp_high1_10_10 > 24      4grp_high_8_8 > 30      6grp_total > 15      4grp_total > 33      6grp_cgc > 14      6grp_high1_sub > 02      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 120
1 2 3 4 range
A 71
(-0.1)
P 		88.5
(2.1)
P 		95.6
(3)
A 		48.4
(-3)
A 		47
B 67
(1)
P 		49.4
(-3)
P 		75.9
(3)
P 		66.6
(0.9)
P 		27
C 36.2
(-3)
P 		133
(1.8)
P 		81
(-0.8)
P 		156.1
(3)
P 		120
avr 58.1
(-3) 		90.3
(3) 		84.2
(1.8) 		90.4
(3) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 62
1 2 3 4 5 6 range
A 102.2
(3)
P 		93.7
(1.8)
P 		73.9
(-1)
P 		59.4
(-3)
P 		84.2
(0.5)
P 		64.3
(-2.3)
A 		43
B 82.2
(0.5)
P 		73.9
(-0.7)
P 		61.4
(-2.5)
A 		98.9
(3)
P 		58.1
(-3)
P 		65
(-2)
P 		41
C 68.9
(0)
P 		96.3
(3)
P 		46.3
(-2.4)
A 		40.7
(-3)
P 		50.6
(-1.9)
M 		58.4
(-1.1)
P 		56
avr 84.4
(2.2) 		88
(3) 		60.5
(-3) 		66.3
(-1.7) 		64.3
(-2.2) 		62.6
(-2.5) 		28
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 31
1 2 3 4 range
A 25.8
(3)
P 		19.2
(0.9)
P 		25
(2.7)
A 		7.1
(-3)
A 		19
B 21.4
(3)
P 		12.2
(-3)
P 		17.6
(0.5)
P 		14.2
(-1.7)
P 		9
C 12
(-3)
P 		38.2
(3)
P 		28.2
(0.7)
P 		26.3
(0.3)
P 		26
avr 19.7
(-0) 		23.2
(2.7) 		23.6
(3) 		15.9
(-3) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 25
1 2 3 4 5 6 range
A 18.8
(-1.8)
P 		33.3
(3)
P 		16.1
(-2.7)
P 		15.1
(-3)
P 		25.4
(0.4)
P 		15.7
(-2.8)
A 		18
B 28.6
(3)
P 		24.6
(1.2)
P 		14.9
(-3)
A 		26.2
(1.9)
P 		23.6
(0.8)
P 		24.2
(1.1)
P 		14
C 25.6
(1.9)
P 		29.4
(3)
P 		11.8
(-2)
A 		8.2
(-3)
P 		16.4
(-0.7)
M 		19.6
(0.2)
P 		21
avr 24.3
(1.1) 		29.1
(3) 		14.3
(-3) 		16.5
(-2.1) 		21.8
(0) 		19.8
(-0.8) 		15
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190182_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17816
Sequence Type Exemplar sequence
Representative Public ID F22E10.4 NCBI
Target Description F22E10.4 /REP_DB=WormBase Gene ID /WP=CE03263 /TR=Q19736 /GB=CAA91802.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077728(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077728 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-15) (pgp-15) mRNA, complete cds. 11/11 None
SNAP00000002363 ENSEMBL cdna:SNAP chromosome:CEL140:X:12751296:12755881:-1 11/11 None
GENEFINDER00000002366 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12751296:12755881:-1 11/11 None
F22E10.4 ENSEMBL cdna:known chromosome:CEL140:X:12751296:12755881:-1 gene:F22E10.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12751295-12755881(-) 100.0 100.0
Public Domain and Genome References
Gene Title p-glycoprotein (MDR)
Gene Symbol pgp-15
Ensembl F22E10.4
Entrez Gene 184846 Entrez gene
SwissProt Q19736 EMBL-EBI
WormBase CE03263 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:257873_AT P-glycoprotein, putative at
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91802 Hypothetical protein F22E10.4 [Caenorhabditis elegans] ref|NP_510129.1| P-GlycoProtein related family member (pgp-15) [Caenorhabditis elegans] 0.0
blast CAE57218 Hypothetical protein CBG00078 [Caenorhabditis briggsae] 0.0
blast CAA91801 Hypothetical protein F22E10.3 [Caenorhabditis elegans] ref|NP_510128.1| P-GlycoProtein related family member (pgp-14) [Caenorhabditis elegans] gb|AAR89639.1| P-glycoprotein related (146.8 kD) (pgp-14) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.0E-53
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.0E-11
Pfam IPR003439 EMBL-EBI ABC transporter 1.4E-65
Pfam IPR003439 EMBL-EBI ABC transporter 9.1E-66
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 6.4E-47
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.8E-9
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.1E-14
Pfam IPR003439 EMBL-EBI ABC transporter 1.4E-65
Pfam IPR003439 EMBL-EBI ABC transporter 9.1E-66
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510129.1 9 97-119,144-166,221-240,333-355,362-384,768-790,811-833,892-914,935-957
F22E10.4 9 97-119,144-166,221-240,333-355,362-384,768-790,811-833,892-914,935-957
SNAP00000002363 8 93-115,170-189,282-304,311-333,717-739,760-782,843-865,926-948
GENEFINDER00000002366 9 97-119,144-166,221-240,333-355,362-384,768-790,811-833,892-914,935-957
Sequence
Target Sequence 
>C. ELEGANS:190182_AT
tcgtaggcccatctggttcaggaaagagtacatgcattggaatgcttgaaagattctatg
atgtcactgggggaacacttcgaatcgatggacaagacatcagaggtctctccttgtttc
acctcagaactcagatggcactggtcggtcaggagcccagattgtttgccggcacgataa
aggagaacatttgcttgggcttggaaaacgtgccaatggagaagatcaatcacgcgttag
aactagcaaatgcaaatcggttcctggctaatcttccggcaggtattgagactgacgtcg
gagagaagggatcaaaactttctgggggacagaaacagagaatagcaattgcgagagcgt
tggttcgagatccaaagattttactgctagatgaagccacttcagcattagattcggaat
cagaaagggctgtacaagaagctttggatcgagcacgagaagggcgtacttgtattacaa
ttgctcatcggttgtcttcaattca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCGTAGGCCCATCTGGTTCAGGAAA 110 605 3197 Antisense
GTCACTGGGGGAACACTTCGAATCG 521 465 3259 Antisense
GACATCAGAGGTCTCTCCTTGTTTC 21 371 3292 Antisense
TCCTTGTTTCACCTCAGAACTCAGA 464 591 3307 Antisense
GAACTCAGATGGCACTGGTCGGTCA 401 347 3323 Antisense
CGGTCAGGAGCCCAGATTGTTTGCC 563 241 3342 Antisense
GGAGAACATTTGCTTGGGCTTGGAA 526 509 3378 Antisense
AATGCAAATCGGTTCCTGGCTAATC 595 165 3445 Antisense
TTCCTGGCTAATCTTCCGGCAGGTA 632 699 3457 Antisense
AAGCCACTTCAGCATTAGATTCGGA 486 147 3590 Antisense
TTGCTCATCGGTTGTCTTCAATTCA 565 703 3677 Antisense
Sequence Source Affymetrix Proprietary Database