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[190144_at] p-glycoprotein (MDR)

Description F22E10.1 /REP_DB=WormBase Gene ID /WP=CE03260 /TR=Q19733 /GB=CAA91799.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster 6grp_total > 09      4grp_total > 47      6grp_cgc > 0      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 209
1 2 3 4 range
A 349
(3)
A 		139.9
(-3)
A 		181.2
(-1.8)
A 		200.7
(-1.3)
A 		209
B 313.9
(3)
A 		210.2
(-0.6)
A 		140.5
(-3)
A 		194
(-1.1)
A 		173
C 300.1
(3)
A 		170.7
(-2.6)
A 		199.7
(-1.4)
A 		162.2
(-3)
A 		138
avr 321
(3) 		173.6
(-3) 		173.8
(-3) 		185.6
(-2.5) 		147

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 277
1 2 3 4 5 6 range
A 433.6
(3)
P 		205.2
(-2.7)
A 		191.4
(-3)
A 		215.6
(-2.4)
A 		217.1
(-2.4)
A 		223.7
(-2.2)
A 		242
B 310.5
(3)
A 		256.9
(0.5)
A 		198.2
(-2.2)
A 		234.2
(-0.5)
A 		223.3
(-1)
A 		181.1
(-3)
A 		129
C 228.9
(-1.2)
A 		233.4
(-1.1)
A 		201.5
(-1.9)
A 		394.2
(3)
A 		156.3
(-3)
A 		172
(-2.6)
A 		238
avr 324.3
(3) 		231.8
(-1.2) 		197
(-2.8) 		281.3
(1) 		198.9
(-2.7) 		192.3
(-3) 		132
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 100
1 2 3 4 range
A 127.1
(3)
A 		30.4
(-2.9)
A 		47.4
(-1.9)
A 		29.4
(-3)
A 		98
B 100.1
(3)
A 		51.9
(-1.3)
A 		32.6
(-3)
A 		41.4
(-2.2)
A 		68
C 99.4
(3)
A 		49.1
(-1.2)
A 		69.6
(0.5)
A 		27.4
(-3)
A 		72
avr 108.9
(3) 		43.8
(-2.1) 		49.9
(-1.6) 		32.7
(-3) 		76

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 66
1 2 3 4 5 6 range
A 79.9
(3)
P 		73
(1.9)
A 		41.7
(-3)
A 		54.7
(-1)
A 		65.5
(0.7)
A 		54.5
(-1)
A 		38
B 108.1
(3)
A 		85.5
(0.7)
A 		48.1
(-3)
A 		62
(-1.6)
A 		90.7
(1.3)
A 		67.5
(-1.1)
A 		60
C 84.8
(3)
A 		71.2
(0.6)
A 		51.3
(-2.9)
A 		79.3
(2)
A 		50.6
(-3)
A 		57.6
(-1.8)
A 		34
avr 90.9
(3) 		76.6
(1) 		47
(-3) 		65.3
(-0.5) 		68.9
(-0) 		59.9
(-1.2) 		44
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190144_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17384
Sequence Type Exemplar sequence
Representative Public ID F22E10.1 NCBI
Target Description F22E10.1 /REP_DB=WormBase Gene ID /WP=CE03260 /TR=Q19733 /GB=CAA91799.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein (MDR)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077725(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077725 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-12) (pgp-12) mRNA, complete cds. 11/11 None
SNAP00000002360 ENSEMBL cdna:SNAP chromosome:CEL140:X:12731769:12737223:1 11/11 None
GENEFINDER00000002368 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:12731769:12737223:1 11/11 None
F22E10.1 ENSEMBL cdna:known chromosome:CEL140:X:12731769:12737343:1 gene:F22E10.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:12731768-12737223(+) 100.0 100.0
Public Domain and Genome References
Gene Title p-glycoprotein (MDR)
Gene Symbol pgp-12
Ensembl F22E10.1
Entrez Gene 181415 Entrez gene
SwissProt Q19733 EMBL-EBI
WormBase CE03260 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91799 Hypothetical protein F22E10.1 [Caenorhabditis elegans] ref|NP_510126.1| P-GlycoProtein related family member (pgp-12) [Caenorhabditis elegans] 0.0
blast CAE57223 Hypothetical protein CBG00086 [Caenorhabditis briggsae] 0.0
blast CAE57219 Hypothetical protein CBG00079 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.5E-47
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 3.5E-24
Pfam IPR003439 EMBL-EBI ABC transporter 7.2E-64
Pfam IPR003439 EMBL-EBI ABC transporter 2.8E-63
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510126.1 11 92-114,134-156,215-234,238-257,317-339,359-381,764-786,796-818,881-898,902-924,991-1013
F22E10.1 11 92-114,134-156,215-234,238-257,317-339,359-381,764-786,796-818,881-898,902-924,991-1013
SNAP00000002360 11 92-114,134-156,215-234,238-257,317-339,359-381,764-786,796-818,881-898,902-924,991-1013
GENEFINDER00000002368 11 92-114,134-156,215-234,238-257,317-339,359-381,764-786,796-818,881-898,902-924,991-1013
Sequence
Target Sequence 
>C. ELEGANS:190144_AT
ttagttggcccatcaggcactggaaaaagtacttgtattgccatgcttgaacgattttat
gatgtttccggtggagcactgagaatcgatggacagaatatcaaatcactctcccttcac
catcttcgaacacaaatggcattagttggccaggagccccgtttgtttgcaggaactatt
aaagaaaacgtgtgttttgggctaaaagatgtctctgttgaaaaagtccatcaagctttg
gaactcgcaaatgcttcccggttccttgcaaacttgccagcaggcattgatacagaagtt
ggagagaaaggaggacaattgtcgggaggacaaaagcagagaatcgcaattgccagagca
ttggtcagagatcctaagattttgctgctagatgaagccacttccgcattggattcggaa
tctgaaagggccgtacaagaagcgctggatcgtgctcgtgaaggtcgtacttgcatcaca
attgcccatcgcttgtcgtctattcagaactccgacctcattgtttacattgatcatggc
atggtacaagaagctggaaaccatgctcaccttatgtca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTAGTTGGCCCATCAGGCACTGGAA 454 673 3340 Antisense
GTACTTGTATTGCCATGCTTGAACG 401 459 3368 Antisense
TGGCATTAGTTGGCCAGGAGCCCCG 666 545 3476 Antisense
GCCCCGTTTGTTTGCAGGAACTATT 681 283 3495 Antisense
TTGGAACTCGCAAATGCTTCCCGGT 286 709 3577 Antisense
TGAAGCCACTTCCGCATTGGATTCG 100 575 3732 Antisense
AAGGGCCGTACAAGAAGCGCTGGAT 12 159 3765 Antisense
GGATCGTGCTCGTGAAGGTCGTACT 287 511 3786 Antisense
CGCTTGTCGTCTATTCAGAACTCCG 86 255 3829 Antisense
AGAACTCCGACCTCATTGTTTACAT 237 71 3845 Antisense
TGGAAACCATGCTCACCTTATGTCA 590 547 3894 Antisense
Sequence Source Affymetrix Proprietary Database