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[190121_s_at] zinc metalloprotease

Description T25B6.2 /REP_DB=WormBase Gene ID /WP=CE14174 /TR=Q22763 /GB=AAC48223.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_highest_10_10 > 32      6grp_high1_10_10 > 13      4grp_highest_8_8 > 25      4grp_high_8_8 > 59      6grp_highest_nonorm > 12      6grp_total > 24      4grp_total > 60      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2876
1 2 3 4 range
A 3148.6
(2.8)
P 		3231.3
(2.9)
P 		3256
(3)
P 		443.1
(-3)
P 		2813
B 3073.7
(3)
P 		2394.8
(1.5)
P 		2939.1
(2.7)
P 		409.6
(-3)
P 		2664
C 3043.9
(2.9)
P 		2707.2
(2.2)
P 		3071.2
(3)
P 		379.7
(-3)
P 		2692
avr 3088.7
(3) 		2777.8
(2.3) 		3088.8
(3) 		410.8
(-3) 		2678

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1658
1 2 3 4 5 6 range
A 2451.4
(2)
P 		2718.8
(3)
P 		1752
(-0.6)
P 		1480.8
(-1.6)
P 		1164.9
(-2.7)
P 		1092.7
(-3)
P 		1626
B 2433.7
(2.8)
P 		2484.2
(3)
P 		2018.1
(0.9)
P 		1299.4
(-2.2)
P 		1255
(-2.4)
P 		1129
(-3)
P 		1355
C 2255.8
(1.6)
P 		2623
(3)
P 		2299.5
(1.8)
P 		1475.2
(-1.4)
P 		1067.3
(-3)
P 		1060.9
(-3)
P 		1562
avr 2380.3
(2.1) 		2608.7
(3) 		2023.2
(0.7) 		1418.5
(-1.7) 		1162.4
(-2.7) 		1094.2
(-3) 		1515
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1082
1 2 3 4 range
A 1146.4
(3)
P 		701.4
(0.5)
P 		851.2
(1.4)
P 		64.9
(-3)
P 		1082
B 980.2
(3)
P 		591.5
(0.4)
P 		681.1
(1)
P 		87.3
(-3)
P 		893
C 1007.6
(2.6)
P 		778.3
(1.3)
P 		1070.4
(3)
P 		64
(-3)
P 		1006
avr 1044.7
(3) 		690.4
(0.8) 		867.6
(1.9) 		72.1
(-3) 		973

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 701
1 2 3 4 5 6 range
A 451.9
(-1.4)
P 		966.9
(3)
P 		381.5
(-2)
P 		375.6
(-2.1)
P 		351.5
(-2.3)
P 		266
(-3)
P 		701
B 846.8
(3)
P 		826.9
(2.8)
P 		490.1
(-1.3)
P 		344.2
(-3)
P 		509.9
(-1)
P 		421
(-2.1)
P 		503
C 836.1
(3)
P 		800.4
(2.6)
P 		585.3
(0.2)
P 		296.7
(-3)
P 		345.4
(-2.5)
P 		355.1
(-2.4)
P 		539
avr 711.6
(1.3) 		864.7
(3) 		485.6
(-1.3) 		338.8
(-3) 		402.3
(-2.3) 		347.4
(-2.9) 		526
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190121_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16084
Sequence Type Exemplar sequence
Representative Public ID T25B6.2 NCBI
Target Description T25B6.2 /REP_DB=WormBase Gene ID /WP=CE14174 /TR=Q22763 /GB=AAC48223.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077127(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077127 NCBI Caenorhabditis elegans T25B6.2 (T25B6.2) mRNA, complete cds. 11/11 None
SNAP00000006430 ENSEMBL cdna:SNAP chromosome:CEL140:X:9034518:9038311:1 11/11 None
GENEFINDER00000006437 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:9034518:9038311:1 11/11 None
T25B6.2a ENSEMBL cdna:known chromosome:CEL140:X:9034489:9038462:1 gene:T25B6.2 11/11 None
T25B6.2b.4 ENSEMBL cdna:known chromosome:CEL140:X:9034492:9038311:1 gene:T25B6.2 11/11 None
T25B6.2b.1 ENSEMBL cdna:known chromosome:CEL140:X:9034493:9038311:1 gene:T25B6.2 11/11 None
T25B6.2b.3 ENSEMBL cdna:known chromosome:CEL140:X:9034598:9038311:1 gene:T25B6.2 11/11 None
T25B6.2b.2 ENSEMBL cdna:known chromosome:CEL140:X:9035406:9038311:1 gene:T25B6.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:9034516-9038310(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Ensembl T25B6.2
Entrez Gene 181144 Entrez gene
SwissProt Q22763 EMBL-EBI
WormBase CE14174 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6306 DNA methylation inferred from electronic annotation QuickGO AmiGO
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
4245 neprilysin activity inferred from electronic annotation QuickGO AmiGO
8170 N-methyltransferase activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_509528 T25B6.2 [Caenorhabditis elegans] gb|AAC48223.1| Hypothetical protein T25B6.2 [Caenorhabditis elegans] 0.0
blast CAE57291 Hypothetical protein CBG00200 [Caenorhabditis briggsae] 0.0
blast AAQ75756 zinc metallopeptidase 6 [Ancylostoma ceylanicum] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR008753 EMBL-EBI Peptidase M13 7.9E-5
Pfam IPR008753 EMBL-EBI Peptidase M13 1.6E-14
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 8.1E-125
Pfam IPR008753 EMBL-EBI Peptidase M13 1.6E-14
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 8.1E-125
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509528.1 1 7-29
T25B6.2a 1 7-29
SNAP00000006430 1 7-29
GENEFINDER00000006437 1 7-29
Sequence
Target Sequence 
>C. ELEGANS:190121_S_AT
gaacccaccatactacaacttgaactatccacaagcgtacaattttgctggacaaggagg
tactggaggacacgaattgactcacggatatgatgacgaaggagtgcaattcggtttcaa
tggagagctgactgattgttcgtggaacaagtgtggatggatggacacgaactcttcctc
tggattcatcgacatggctcaatgtgttgtcactcaatttagtacacaatgttgcccaga
aaagacaggaaatattcattgtgcaaatggagctacgactcaaggagaaaacattgctga
tttgggaggacaacaggctgcatacagatcatacagacaatatgttgcaaccactagaaa
aggtgttgaagaagatagacttccaggattggagaattacactcctaatcaaatcttctg
gatcacatatggttactcatggtgtatgaagcaatccgacgccaatttagttcaccagct
tcttaccaaccctcactcaccggctcaatgcagaaccaaccaggttatgcaagatattcc
agagttcggaaaagactttggatgtgttcgtggtagcccaatgtacccagaacc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAACCCACCATACTACAACTTGAAC 454 347 1782 Antisense
GAACTATCCACAAGCGTACAATTTT 17 351 1803 Antisense
GGAGTGCAATTCGGTTTCAATGGAG 8 517 1882 Antisense
GGAGAGCTGACTGATTGTTCGTGGA 337 519 1903 Antisense
ATGGATGGACACGAACTCTTCCTCT 695 51 1938 Antisense
TCCTCTGGATTCATCGACATGGCTC 443 593 1957 Antisense
TTACACTCCTAATCAAATCTTCTGG 17 683 2178 Antisense
GCAATCCGACGCCAATTTAGTTCAC 489 321 2232 Antisense
CTCACCGGCTCAATGCAGAACCAAC 157 229 2277 Antisense
ACTTTGGATGTGTTCGTGGTAGCCC 144 101 2336 Antisense
GTGGTAGCCCAATGTACCCAGAACC 477 485 2351 Antisense
Sequence Source Affymetrix Proprietary Database