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[190066_at] zinc metalloprotease

Description K03B8.3 /REP_DB=WormBase Gene ID /WP=CE06077 /TR=Q21179 /GB=CAA98502.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_total > 93      4grp_total > 19      6grp_cgc > 88      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 43
1 2 3 4 range
A 54.5
(1.9)
M 		28.9
(-3)
A 		60.2
(3)
A 		48.1
(0.7)
A 		31
B 50.3
(-0.3)
A 		54.2
(0.4)
A 		35.1
(-3)
A 		69.3
(3)
A 		34
C 38.7
(-3)
A 		72.2
(3)
A 		45
(-1.9)
P 		53.9
(-0.3)
A 		34
avr 47.8
(-2.4) 		51.8
(-0.1) 		46.8
(-3) 		57.1
(3) 		10

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 54
1 2 3 4 5 6 range
A 55.6
(1.9)
A 		28.3
(-2.2)
A 		52.9
(1.5)
P 		22.8
(-3)
A 		62.7
(3)
P 		45.2
(0.4)
A 		40
B 36.4
(-0.2)
A 		21.6
(-3)
A 		41.8
(0.8)
A 		53.2
(3)
A 		49
(2.2)
A 		27.5
(-1.9)
P 		32
C 55.4
(1.6)
A 		67.8
(3)
A 		13.9
(-3)
A 		61
(2.2)
A 		53.2
(1.4)
A 		55
(1.6)
A 		54
avr 49.1
(1.1) 		39.2
(-2) 		36.2
(-3) 		45.7
(0) 		55
(3) 		42.6
(-1) 		19
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 15
1 2 3 4 range
A 19.9
(3)
M 		6.3
(-3)
A 		15.7
(1.1)
A 		7
(-2.7)
A 		14
B 16
(3)
A 		13.4
(1)
A 		8.1
(-3)
A 		14.8
(2.1)
A 		8
C 12.8
(-1.1)
A 		20.8
(3)
A 		15.7
(0.4)
P 		9.1
(-3)
A 		12
avr 16.2
(3) 		13.5
(0.3) 		13.2
(-0.1) 		10.3
(-3) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 17
1 2 3 4 5 6 range
A 10.2
(-1)
A 		10.1
(-1)
A 		11.5
(-0.4)
P 		5.8
(-3)
A 		18.9
(3)
P 		11
(-0.6)
A 		13
B 12.7
(-0.4)
A 		7.2
(-3)
A 		10.1
(-1.6)
A 		14.1
(0.3)
A 		19.9
(3)
A 		10.3
(-1.5)
P 		13
C 20.5
(2.9)
A 		20.7
(3)
A 		3.5
(-3)
A 		12.3
(0.1)
A 		17.2
(1.8)
A 		18.4
(2.2)
A 		17
avr 14.5
(0.6) 		12.7
(-0.5) 		8.4
(-3) 		10.7
(-1.7) 		18.7
(3) 		13.2
(-0.2) 		10
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190066_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13531
Sequence Type Exemplar sequence
Representative Public ID K03B8.3 NCBI
Target Description K03B8.3 /REP_DB=WormBase Gene ID /WP=CE06077 /TR=Q21179 /GB=CAA98502.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073490(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073490 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-18) (nas-18) mRNA, complete cds. 11/11 None
SNAP00000002778 ENSEMBL cdna:SNAP chromosome:CEL140:V:11399609:11400469:1 11/11 None
GENEFINDER00000002802 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11398399:11400469:1 11/11 None
K03B8.3 ENSEMBL cdna:known chromosome:CEL140:V:11398399:11400469:1 gene:K03B8.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11398398-11400469(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol nas-18
Ensembl K03B8.3
Entrez Gene 186924 Entrez gene
SwissProt Q21179 EMBL-EBI
WormBase CE06077 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98502 Hypothetical protein K03B8.3 [Caenorhabditis elegans] ref|NP_505891.1| Nematode AStacin protease family member (nas-18) [Caenorhabditis elegans] sp|Q21179|NAS18_CAEEL Zinc metalloproteinase nas-18 precursor (Nematode astacin 18) 0.0
blast CAA98502 Hypothetical protein K03B8.3 [Caenorhabditis elegans] ref|NP_505891.1| Nematode AStacin protease family member (nas-18) [Caenorhabditis elegans] sp|Q21179|NAS18_CAEEL Zinc metalloproteinase nas-18 precursor (Nematode astacin 18) 1.0E-133
blast CAA98503 Hypothetical protein K03B8.1 [Caenorhabditis elegans] ref|NP_505889.1| Nematode AStacin protease family member (nas-16) [Caenorhabditis elegans] sp|Q21180|NAS16_CAEEL Zinc metalloproteinase nas-16 precursor (Nematode astacin 16) 1.0E-104
blast CAE75238 Hypothetical protein CBG23190 [Caenorhabditis briggsae] 3.0E-80
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.6E-48
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 4.3E-23
Sequence
Target Sequence 
>C. ELEGANS:190066_AT
tatgcaattttcaaccaatctacaaacgttgtaccttatgaatacggaagcactatgcat
tactatgcgaatatatcgacaatgtttcccaagaagtcagaatactctgccacacttgga
ataggaagagtcacgttttatgatatggtaattttaaatactgcatacaactgcaaatgt
ccaaatgaattattgtgtggaaatggaggatacacaaatccgtcgaaatgctcggaatgc
atttgtccgttgggatatggtggagtcttgtgtgatcgtccaagtcttattggaaaggat
actggattgccattggaagtaaaagataaaattattgaagtgaaagttgtgggaatagat
aatttctttagttaccctacctgtcttattaatggattggagatcaaatatatgggggat
cccagaatcacaaatccaatttattgttcggctgatttaatcaatgggaaatcgttcaga
tcaaaattgaatccgcttcttatgaatattcacacactttttgggaaaaacaaagtgact
ttccattacagatatgtgactgaacgcttgagtggctaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATGCAATTTTCAACCAATCTACAA 195 657 622 Antisense
ATATCGACAATGTTTCCCAAGAAGT 90 19 694 Antisense
GTCAGAATACTCTGCCACACTTGGA 643 465 717 Antisense
GATACACAAATCCGTCGAAATGCTC 522 423 830 Antisense
TATGGTGGAGTCTTGTGTGATCGTC 529 655 877 Antisense
TTGTGTGATCGTCCAAGTCTTATTG 502 699 889 Antisense
TAGTTACCCTACCTGTCTTATTAAT 124 649 990 Antisense
ATGGGGGATCCCAGAATCACAAATC 244 49 1033 Antisense
GATCAAAATTGAATCCGCTTCTTAT 52 423 1100 Antisense
ATGAATATTCACACACTTTTTGGGA 310 43 1123 Antisense
GTGACTGAACGCTTGAGTGGCTACA 417 483 1177 Antisense
Sequence Source Affymetrix Proprietary Database