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[190051_at] guanine nucleotide-binding protein

Description F38E1.5 /REP_DB=WormBase Gene ID /WP=CE04523 /GEN=gpa-2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=guanine nucleotide-binding protein
Cluster 6grp_total > 16      4grp_total > 22      6grp_cgc > 21      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 165
1 2 3 4 range
A 137.1
(3)
P 		18
(-2.5)
A 		7.9
(-3)
A 		98.6
(1.2)
A 		129
B 96.9
(0)
P 		70
(-1)
A 		20.3
(-3)
A 		172.7
(3)
P 		152
C 147.7
(3)
P 		17.2
(-3)
A 		44.5
(-1.7)
A 		146.1
(2.9)
A 		131
avr 127.2
(2.4) 		35.1
(-2.4) 		24.2
(-3) 		139.1
(3) 		115

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 159
1 2 3 4 5 6 range
A 84.5
(1.6)
A 		109.6
(3)
P 		80.3
(1.3)
P 		43.1
(-0.7)
A 		3.1
(-3)
A 		26.2
(-1.7)
A 		107
B 153.9
(3)
P 		81.2
(-0.4)
A 		86.3
(-0.2)
P 		25.9
(-3)
A 		28.9
(-2.9)
A 		48.6
(-1.9)
A 		128
C 162.3
(3)
P 		68.7
(-0.9)
A 		27.2
(-2.6)
A 		17.5
(-3)
A 		33.9
(-2.3)
A 		17.3
(-3)
A 		145
avr 133.6
(3) 		86.5
(0.5) 		64.6
(-0.7) 		28.8
(-2.6) 		22
(-3) 		30.7
(-2.5) 		112
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 48
1 2 3 4 range
A 49.9
(3)
P 		3.9
(-2.8)
A 		2.1
(-3)
A 		14.4
(-1.5)
A 		48
B 30.9
(1.9)
P 		17.3
(-0.6)
A 		4.7
(-3)
A 		36.8
(3)
P 		32
C 48.9
(3)
P 		5
(-3)
A 		15.5
(-1.6)
A 		24.6
(-0.3)
A 		44
avr 43.2
(3) 		8.7
(-2.8) 		7.4
(-3) 		25.3
(-0) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 59
1 2 3 4 5 6 range
A 15.6
(-0.7)
A 		39
(3)
P 		17.5
(-0.4)
P 		10.9
(-1.4)
A 		0.9
(-3)
A 		6.4
(-2.1)
A 		38
B 53.6
(3)
P 		27
(-0.4)
A 		21
(-1.2)
P 		6.9
(-3)
A 		11.7
(-2.4)
A 		18.1
(-1.6)
A 		47
C 60.2
(3)
P 		21
(-1.1)
A 		6.9
(-2.6)
A 		3.5
(-3)
A 		11
(-2.2)
A 		5.8
(-2.8)
A 		57
avr 43.1
(3) 		29
(0.7) 		15.1
(-1.7) 		7.1
(-3) 		7.9
(-2.9) 		10.1
(-2.5) 		36
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190051_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11661
Sequence Type Exemplar sequence
Representative Public ID F38E1.5 NCBI
Target Description F38E1.5 /REP_DB=WormBase Gene ID /WP=CE04523 /GEN=gpa-2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=guanine nucleotide-binding protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_072756(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_072756 NCBI Caenorhabditis elegans G Protein, Alpha subunit family member (gpa-2) (gpa-2) mRNA, complete cds. 11/11 None
SNAP00000006028 ENSEMBL cdna:SNAP chromosome:CEL140:V:8374780:8376276:1 11/11 None
GENEFINDER00000006039 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:8373604:8376276:1 11/11 None
F38E1.5 ENSEMBL cdna:known chromosome:CEL140:V:8373604:8376276:1 gene:F38E1.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:8373604-8376277(+) 100.0 100.0
Public Domain and Genome References
Gene Title guanine nucleotide-binding protein
Gene Symbol gpa-2
Ensembl F38E1.5
Entrez Gene 179219 Entrez gene
SwissProt P22454 EMBL-EBI
WormBase CE04523 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7186 G-protein coupled receptor protein signaling pathway inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4871 signal transducer activity inferred from electronic annotation QuickGO AmiGO
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA37312 G-protein a-2 [Caenorhabditis elegans] gb|AAA83475.1| G protein, alpha subunit protein 2 [Caenorhabditis elegans] ref|NP_505157.1| G Protein, Alpha subunit family member (gpa-2) [Caenorhabditis elegans] gb|AAG32078.1| heterotrimeric G protein alpha subunit [Caenorhabditis elegans] sp|P22454|GPA2_CAEEL Guanine nucleotide-binding protein alpha-2 subunit 0.0
blast AAW02901 gpa-2 [Caenorhabditis briggsae] sp|Q4VT35|GPA2_CAEBR Guanine nucleotide-binding protein alpha-2 subunit 0.0
blast CAA37312 G-protein a-2 [Caenorhabditis elegans] gb|AAA83475.1| G protein, alpha subunit protein 2 [Caenorhabditis elegans] ref|NP_505157.1| G Protein, Alpha subunit family member (gpa-2) [Caenorhabditis elegans] gb|AAG32078.1| heterotrimeric G protein alpha subunit [Caenorhabditis elegans] sp|P22454|GPA2_CAEEL Guanine nucleotide-binding protein alpha-2 subunit 1.0E-175
blast CAE66064 Hypothetical protein CBG11277 [Caenorhabditis briggsae] 1.0E-164
Protein Domains
Database ID Description E-Value
Pfam IPR001019 EMBL-EBI Guanine nucleotide binding protein (G-protein), alpha subunit 1.0E-126
Pfam IPR001019 EMBL-EBI Guanine nucleotide binding protein (G-protein), alpha subunit 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:190051_AT
tatcacccaaatgcgacagacacccttcttttgcggacaaagacaactggaattgtagaa
gttggatttgaaattaaaaaagtcaagtttagagtatttgacgtaggaggtcaacggtcg
gagagaaagaaatggattcattgttttgaagatgtcaatgcaattattttcattgcagcg
ctttccgagtataacgaagttttgtttgaagatgagacaacgaaccgaatgatcgaatcc
atgcgacttttcgaatcaatttgtaattctcgatggttccataatactaatattatcctt
ttcttgaacaaaaaggatttgttcgaggagaaaatcaagaaggagaatattcataaggcg
tttccggaatatcgaggagagcaaaattacgctgaaacagtcgcatttatcaagacgaaa
ttcgaggcgctttccaataacccgaagaagacattctacgtgcacgaaacatgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATCACCCAAATGCGACAGACACCC 339 659 520 Antisense
CACCCTTCTTTTGCGGACAAAGACA 667 199 540 Antisense
GACGTAGGAGGTCAACGGTCGGAGA 661 377 619 Antisense
TTATTTTCATTGCAGCGCTTTCCGA 415 679 683 Antisense
GCAGCGCTTTCCGAGTATAACGAAG 629 313 694 Antisense
GAATCCATGCGACTTTTCGAATCAA 591 329 754 Antisense
ATAAGGCGTTTCCGGAATATCGAGG 597 23 872 Antisense
ACGCTGAAACAGTCGCATTTATCAA 461 91 908 Antisense
GACGAAATTCGAGGCGCTTTCCAAT 351 377 933 Antisense
GCGCTTTCCAATAACCCGAAGAAGA 388 287 946 Antisense
GACATTCTACGTGCACGAAACATGC 116 371 969 Antisense
Sequence Source Affymetrix Proprietary Database