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[190048_s_at] cysteine proteinase

Description F32B5.8 /REP_DB=WormBase Gene ID /WP=CE09855 /TR=O01850 /GB=AAB54210.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=cysteine proteinase
Cluster 6grp_highest_10_10 > 29      6grp_high1_10_10 > 82      4grp_highest_8_8 > 05      4grp_high_8_8 > 30      6grp_highest_nonorm > 39      6grp_total > 83      4grp_total > 24      6grp_highest_sub > 04_05      6grp_cgc > 86      6grp_high1_sub > 04      6grp_cgc_sub > 04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 6113
1 2 3 4 range
A 3007.3
(-3)
P 		5094.2
(-0.2)
P 		6718.7
(1.9)
P 		7535.6
(3)
P 		4528
B 2982.3
(-3)
P 		6362.6
(0.3)
P 		6593.7
(0.5)
P 		9095.7
(3)
P 		6113
C 3083.4
(-3)
P 		5678.1
(1.2)
P 		6304.7
(2.3)
P 		6762.2
(3)
P 		3679
avr 3024.3
(-3) 		5711.6
(0.4) 		6539
(1.4) 		7797.8
(3) 		4774

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 9637
1 2 3 4 5 6 range
A 1865.4
(-3)
P 		3809.1
(-1.6)
P 		5110.7
(-0.7)
P 		10160.4
(3)
P 		9609.5
(2.6)
P 		4120.7
(-1.4)
P 		8295
B 1902.3
(-3)
P 		3864.8
(-1.7)
P 		6306.1
(-0.1)
P 		10859.2
(3)
P 		9396.2
(2)
P 		4193.9
(-1.5)
P 		8957
C 2262.5
(-3)
P 		3939.5
(-1.9)
P 		5266.6
(-1)
P 		11502.5
(3)
P 		9291.7
(1.6)
P 		4537.8
(-1.5)
P 		9240
avr 2010.1
(-3) 		3871.1
(-1.7) 		5561.1
(-0.6) 		10840.7
(3) 		9432.5
(2) 		4284.1
(-1.5) 		8831
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1246
1 2 3 4 range
A 1094.9
(-3)
P 		1105.8
(-2.9)
P 		1756.4
(3)
P 		1103.1
(-2.9)
P 		662
B 951
(-3)
P 		1571.4
(0.8)
P 		1527.9
(0.5)
P 		1938.3
(3)
P 		987
C 1020.7
(-3)
P 		1632.5
(0.1)
P 		2197.4
(3)
P 		1140.2
(-2.4)
P 		1177
avr 1022.2
(-3) 		1436.6
(0.1) 		1827.2
(3) 		1393.9
(-0.2) 		805

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3474
1 2 3 4 5 6 range
A 343.9
(-3)
P 		1354.7
(-0.6)
P 		1113
(-1.2)
P 		2576.9
(2.2)
P 		2899.7
(3)
P 		1003.3
(-1.5)
P 		2556
B 661.9
(-3)
P 		1286.4
(-1.8)
P 		1531.3
(-1.3)
P 		2876.2
(1.2)
P 		3817.6
(3)
P 		1563.9
(-1.3)
P 		3156
C 838.6
(-3)
P 		1202.1
(-2)
P 		1340.5
(-1.6)
P 		2313.2
(1.1)
P 		3006.7
(3)
P 		1519.1
(-1.1)
P 		2168
avr 614.8
(-3) 		1281.1
(-1.5) 		1328.3
(-1.4) 		2588.8
(1.5) 		3241.3
(3) 		1362.1
(-1.3) 		2627
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190048_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.245
Sequence Type Exemplar sequence
Representative Public ID F32B5.8 NCBI
Target Description F32B5.8 /REP_DB=WormBase Gene ID /WP=CE09855 /TR=O01850 /GB=AAB54210.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=cysteine proteinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058622(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058622 NCBI Caenorhabditis elegans CathePsin Z family member (cpz-1) (cpz-1) mRNA, complete cds. 11/11 None
SNAP00000012559 ENSEMBL cdna:SNAP chromosome:CEL140:I:2686699:2689416:-1 11/11 None
GENEFINDER00000012566 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:2686699:2688068:-1 11/11 None
F32B5.8 ENSEMBL cdna:known chromosome:CEL140:I:2686656:2689468:-1 gene:F32B5.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:2686698-2691806(-) 100.0 100.0
Public Domain and Genome References
Gene Title cysteine proteinase
Gene Symbol cpz-1
Ensembl F32B5.8
Entrez Gene 171829 Entrez gene
SwissProt O01850 EMBL-EBI
WormBase CE36646 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1599209_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE:1595015_S_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE:1595014_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE:1589646_S_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE:1583406_S_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE_2:CFA.12490.1.A1_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CANINE_2:CFAAFFX.18934.1.S1_AT similar to Cathepsin Z precursor (Cathepsin X) (Cathepsin P) cfa
CHICKEN:GGAAFFX.22250.1.S1_AT similar to cathepsin Y gga
HG-U95AV2:32514_S_AT cathepsin Z hs
HG-U133A:210042_S_AT cathepsin Z hs
HG-U133_PLUS_2:210042_S_AT cathepsin Z hs
HG-U133A_2:210042_S_AT cathepsin Z hs
HG-FOCUS:210042_S_AT cathepsin Z hs
HU35KSUBA:AA131127_AT cathepsin Z hs
U133_X3P:G3650497_3P_AT cathepsin Z hs
HG-U133A_2:212562_S_AT Cathepsin Z hs
HG-U133_PLUS_2:212562_S_AT Cathepsin Z hs
HG-U133A:212562_S_AT Cathepsin Z hs
HG-U95AV2:32515_S_AT Cathepsin Z hs
HG-U95C:55330_AT Cathepsin Z hs
HU35KSUBA:AA481918_AT Cathepsin Z hs
HU35KSUBC:RC_AA421515_AT Cathepsin Z hs
U133_X3P:HS.252549.1.A1_3P_A_AT Cathepsin Z hs
MU11KSUBB:MSA.3665.0_S_AT cathepsin Z mm
MG-U74AV2:92633_AT cathepsin Z mm
MOE430A:1417869_S_AT cathepsin Z mm
MOUSE430A_2:1417869_S_AT cathepsin Z mm
MOUSE430_2:1417869_S_AT cathepsin Z mm
MOE430A:1417868_A_AT cathepsin Z mm
MOUSE430A_2:1417868_A_AT cathepsin Z mm
MOUSE430_2:1417868_A_AT cathepsin Z mm
MOE430A:1417870_X_AT cathepsin Z mm
MOUSE430A_2:1417870_X_AT cathepsin Z mm
MOUSE430_2:1417870_X_AT cathepsin Z mm
MU19KSUBC:TC39624_S_AT Cathepsin Z, mRNA (cDNA clone MGC:5694 IMAGE:3588457) mm
MU19KSUBC:TC39625_S_AT Cathepsin Z, mRNA (cDNA clone MGC:5694 IMAGE:3588457) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
8234 cysteine-type peptidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast tpg|DAA01510.1 TPA: cathepsin Z-like enzyme; CPZ-1 [Caenorhabditis elegans] gb|AAB54210.2| Cathepsin z protein 1 [Caenorhabditis elegans] ref|NP_491023.2| CathePsin Z family member (cpz-1) [Caenorhabditis elegans] 0.0
blast CAE60490 Hypothetical protein CBG04105 [Caenorhabditis briggsae] 1.0E-177
blast AAC47348 cysteine protease precursor [Onchocerca volvulus] 1.0E-139
blast tpg|DAA01510.1 TPA: cathepsin Z-like enzyme; CPZ-1 [Caenorhabditis elegans] gb|AAB54210.2| Cathepsin z protein 1 [Caenorhabditis elegans] ref|NP_491023.2| CathePsin Z family member (cpz-1) [Caenorhabditis elegans] 1.0E-136
Protein Domains
Database ID Description E-Value
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 5.4E-67
Pfam IPR000668 EMBL-EBI Peptidase C1A, papain 4.6E-58
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_491023.2 1 4-22
F32B5.8 1 4-22
SNAP00000012559 1 4-22
Sequence
Target Sequence 
>C. ELEGANS:190048_S_AT
ccaccagcgcactagctgatcgtatcaatatcaagcgaaagaacgcgtggccacaagcct
atctgtcagttcaagaagttatcgattgctccggtgcgggaacttgtgtgatgggcggag
agccgggcggtgtctacaagtatgctcacgagcacggaattccacacgagacatgcaata
actaccaggcgagagacggaaaatgcgacccctacaaccgttgtggctcctgctggcccg
gcgagtgcttctccatcaaaaactacaccctctacaaggtctccgagtacggaaccgtcc
atggctacgagaagatgaaggccgagatctaccacaagggaccaattgcctgcggaatcg
ctgccaccaaagccttcgagacctatgcag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCACCAGCGCACTAGCTGATCGTAT 678 273 674 Antisense
CGTGGCCACAAGCCTATCTGTCAGT 91 245 719 Antisense
AGAAGTTATCGATTGCTCCGGTGCG 387 75 747 Antisense
GCTCCGGTGCGGGAACTTGTGTGAT 163 299 761 Antisense
GAGAGCCGGGCGGTGTCTACAAGTA 99 393 791 Antisense
GCGAGTGCTTCTCCATCAAAAACTA 584 289 914 Antisense
CCTCTACAAGGTCTCCGAGTACGGA 259 265 942 Antisense
GAGTACGGAACCGTCCATGGCTACG 524 391 958 Antisense
AGGCCGAGATCTACCACAAGGGACC 22 53 992 Antisense
GACCAATTGCCTGCGGAATCGCTGC 654 383 1013 Antisense
ACCAAAGCCTTCGAGACCTATGCAG 54 85 1039 Antisense
Sequence Source Affymetrix Proprietary Database