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[190038_at] zinc metalloprotease

Description K03B8.1 /REP_DB=WormBase Gene ID /WP=CE06075 /TR=Q21180 /GB=CAA98503.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_total > 66      4grp_total > 0      6grp_cgc > 55      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 76
1 2 3 4 range
A 6.3
(-2.8)
A 		6.7
(-2.8)
A 		35.9
(3)
A 		5.5
(-3)
A 		30
B 19.5
(3)
A 		7
(-2.4)
A 		5.5
(-3)
A 		10.2
(-1)
A 		14
C 8.3
(-2.8)
A 		5.5
(-3)
A 		14
(-2.3)
A 		81
(3)
A 		76
avr 11.4
(-1.8) 		6.4
(-3) 		18.5
(-0.2) 		32.2
(3) 		26

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 49
1 2 3 4 5 6 range
A 7.5
(-2.7)
A 		38.4
(1.3)
A 		13.9
(-1.9)
A 		5.1
(-3)
A 		5.7
(-2.9)
A 		51.3
(3)
A 		46
B 2.2
(-2.9)
A 		5.5
(-2)
A 		1.9
(-3)
A 		22.9
(3)
A 		8.8
(-1)
A 		2
(-3)
A 		21
C 6.9
(-2.7)
A 		6.4
(-2.9)
A 		24.9
(3)
A 		9.5
(-1.9)
A 		18.9
(1.1)
A 		6.1
(-3)
A 		19
avr 5.5
(-3) 		16.8
(1.7) 		13.6
(0.4) 		12.5
(-0.1) 		11.1
(-0.7) 		19.8
(3) 		14
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 13
1 2 3 4 range
A 2.3
(-2)
A 		1.4
(-2.6)
A 		9.4
(3)
A 		0.8
(-3)
A 		9
B 6.2
(3)
A 		1.7
(-2.5)
A 		1.3
(-3)
A 		2.2
(-1.9)
A 		5
C 2.8
(-2.4)
A 		1.6
(-3)
A 		4.9
(-1.4)
A 		13.7
(3)
A 		12
avr 3.8
(0.3) 		1.6
(-3) 		5.2
(2.4) 		5.6
(3) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 13
1 2 3 4 5 6 range
A 1.4
(-3)
A 		13.6
(3)
A 		3
(-2.2)
A 		1.3
(-3)
A 		1.7
(-2.8)
A 		12.5
(2.5)
A 		12
B 0.8
(-2.7)
A 		1.8
(-1.6)
A 		0.5
(-3)
A 		6.1
(3)
A 		3.6
(0.3)
A 		0.7
(-2.8)
A 		6
C 2.5
(-2.2)
A 		2
(-2.9)
A 		6.3
(3)
A 		1.9
(-3)
A 		6.1
(2.7)
A 		2
(-2.9)
A 		4
avr 1.6
(-3) 		5.8
(3) 		3.3
(-0.6) 		3.1
(-0.9) 		3.8
(0.1) 		5.1
(2) 		4
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190038_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13319
Sequence Type Exemplar sequence
Representative Public ID K03B8.1 NCBI
Target Description K03B8.1 /REP_DB=WormBase Gene ID /WP=CE06075 /TR=Q21180 /GB=CAA98503.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073488(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073488 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-16) (nas-16) mRNA, complete cds. 11/11 None
SNAP00000002774 ENSEMBL cdna:SNAP chromosome:CEL140:V:11394810:11396096:1 11/11 None
GENEFINDER00000002794 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11394520:11396096:1 11/11 None
K03B8.1 ENSEMBL cdna:known chromosome:CEL140:V:11394520:11396096:1 gene:K03B8.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11394519-11396096(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol nas-16
Ensembl K03B8.1
Entrez Gene 186922 Entrez gene
SwissProt Q21180 EMBL-EBI
WormBase CE06075 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98503 Hypothetical protein K03B8.1 [Caenorhabditis elegans] ref|NP_505889.1| Nematode AStacin protease family member (nas-16) [Caenorhabditis elegans] sp|Q21180|NAS16_CAEEL Zinc metalloproteinase nas-16 precursor (Nematode astacin 16) 0.0
blast CAA98503 Hypothetical protein K03B8.1 [Caenorhabditis elegans] ref|NP_505889.1| Nematode AStacin protease family member (nas-16) [Caenorhabditis elegans] sp|Q21180|NAS16_CAEEL Zinc metalloproteinase nas-16 precursor (Nematode astacin 16) 1.0E-157
blast CAA98502 Hypothetical protein K03B8.3 [Caenorhabditis elegans] ref|NP_505891.1| Nematode AStacin protease family member (nas-18) [Caenorhabditis elegans] sp|Q21179|NAS18_CAEEL Zinc metalloproteinase nas-18 precursor (Nematode astacin 18) 1.0E-105
blast CAA98502 Hypothetical protein K03B8.3 [Caenorhabditis elegans] ref|NP_505891.1| Nematode AStacin protease family member (nas-18) [Caenorhabditis elegans] sp|Q21179|NAS18_CAEEL Zinc metalloproteinase nas-18 precursor (Nematode astacin 18) 1.0E-104
blast CAE75238 Hypothetical protein CBG23190 [Caenorhabditis briggsae] 1.0E-100
blast CAE75238 Hypothetical protein CBG23190 [Caenorhabditis briggsae] 1.0E-95
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.5E-44
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 4.0E-26
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.5E-44
Sequence
Target Sequence 
>C. ELEGANS:190038_AT
tatacaaatccgtccaattgtttggaatgtatttgtccattgggatatggaggagtgtta
tgtgatcgagtagttgcttgtagtgtccagttaagtgcagattcgtattggaaaggatcc
tggatttctgttggaagtagtgttttgagagatactacagaccccgttaaagcgtttatc
tcaataaatgctccgaaagataaaattattgaagttaaaattgtgaaaatagaaaatttc
tcgtgtgactctggttgcaataataatggagtggagattaaatacatgggggatccaaga
atcactaatccaattatttgctgtgagaatcaagtggacccatccaacaagggatacaaa
gccaagctgaatccacttttgat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TATACAAATCCGTCCAATTGTTTGG 189 659 865 Antisense
GAGTGTTATGTGATCGAGTAGTTGC 226 401 917 Antisense
GAGTAGTTGCTTGTAGTGTCCAGTT 387 399 932 Antisense
GTGTCCAGTTAAGTGCAGATTCGTA 396 487 947 Antisense
AAGGATCCTGGATTTCTGTTGGAAG 279 161 977 Antisense
AGATACTACAGACCCCGTTAAAGCG 159 1 1014 Antisense
AAATTTCTCGTGTGACTCTGGTTGC 121 117 1098 Antisense
ATGGGGGATCCAAGAATCACTAATC 364 49 1150 Antisense
TGTGAGAATCAAGTGGACCCATCCA 389 555 1186 Antisense
GTGGACCCATCCAACAAGGGATACA 572 489 1198 Antisense
AAGCCAAGCTGAATCCACTTTTGAT 355 149 1223 Antisense
Sequence Source Affymetrix Proprietary Database