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[189997_at] zinc metalloprotease

Description K03B8.5 /REP_DB=WormBase Gene ID /WP=CE06079 /TR=Q21181 /GB=CAA98504.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_total > 20      4grp_total > 10      6grp_cgc > 74      6grp_cgc_sub > 02_03_04_05      6grp_total_sub > Hat      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 126
1 2 3 4 range
A 71.5
(-3)
A 		76.4
(-2.3)
A 		76.6
(-2.3)
A 		112.5
(3)
A 		41
B 49.9
(-0.1)
A 		47.1
(-0.3)
A 		10.8
(-3)
A 		92.5
(3)
A 		82
C 28.6
(-3)
A 		55
(-1.5)
A 		55.9
(-1.5)
A 		136.5
(3)
P 		108
avr 50
(-2.8) 		59.5
(-1.9) 		47.8
(-3) 		113.8
(3) 		66

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 63
1 2 3 4 5 6 range
A 30.2
(-2.3)
A 		25.9
(-3)
A 		64.2
(3)
A 		48.5
(0.5)
A 		46.9
(0.3)
A 		31.4
(-2.1)
A 		38
B 6.8
(-3)
A 		41.9
(0.7)
A 		63.7
(3)
A 		19.7
(-1.6)
A 		44.2
(0.9)
A 		18.5
(-1.8)
A 		57
C 50.9
(1)
A 		69.4
(3)
M 		24.3
(-1.9)
A 		39.1
(-0.3)
A 		38.6
(-0.4)
A 		14.3
(-3)
A 		55
avr 29.3
(-1.4) 		45.7
(2) 		50.7
(3) 		35.8
(-0.1) 		43.2
(1.5) 		21.4
(-3) 		29
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 24
1 2 3 4 range
A 26
(3)
A 		16.6
(-2.9)
A 		20
(-0.8)
A 		16.5
(-3)
A 		10
B 15.9
(1.7)
A 		11.6
(0.2)
A 		2.5
(-3)
A 		19.7
(3)
A 		17
C 9.5
(-3)
A 		15.8
(-0.2)
A 		19.5
(1.4)
A 		23
(3)
P 		14
avr 17.1
(0.3) 		14.7
(-2.3) 		14
(-3) 		19.7
(3) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 19
1 2 3 4 5 6 range
A 5.6
(-3)
A 		9.2
(-0.5)
A 		14
(2.9)
A 		12.3
(1.7)
A 		14.2
(3)
A 		7.6
(-1.6)
A 		9
B 2.4
(-3)
A 		13.9
(1.5)
A 		15.5
(2.1)
A 		5.2
(-1.9)
A 		17.9
(3)
A 		6.9
(-1.3)
A 		16
C 18.9
(2.2)
A 		21.2
(3)
M 		6.2
(-2.5)
A 		7.9
(-1.9)
A 		12.5
(-0.2)
A 		4.8
(-3)
A 		16
avr 9
(-1.2) 		14.8
(2.9) 		11.9
(0.9) 		8.5
(-1.5) 		14.9
(3) 		6.4
(-3) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189997_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13746
Sequence Type Exemplar sequence
Representative Public ID K03B8.5 NCBI
Target Description K03B8.5 /REP_DB=WormBase Gene ID /WP=CE06079 /TR=Q21181 /GB=CAA98504.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073492(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073492 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-19) (nas-19) mRNA, complete cds. 11/11 None
SNAP00000002783 ENSEMBL cdna:SNAP chromosome:CEL140:V:11403783:11405277:-1 11/11 None
K03B8.5 ENSEMBL cdna:known chromosome:CEL140:V:11403783:11405698:-1 gene:K03B8.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000002799 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11403782-11405698(-) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol nas-19
Ensembl K03B8.5
Entrez Gene 186926 Entrez gene
SwissProt Q21181 EMBL-EBI
WormBase CE06079 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98504 Hypothetical protein K03B8.5 [Caenorhabditis elegans] ref|NP_505893.1| Nematode AStacin protease family member (nas-19) [Caenorhabditis elegans] sp|Q21181|NAS19_CAEEL Zinc metalloproteinase nas-19 precursor (Nematode astacin 19) 0.0
blast CAB02084 Hypothetical protein F20G2.4 [Caenorhabditis elegans] ref|NP_506409.2| Nematode AStacin protease family member (nas-24) [Caenorhabditis elegans] sp|Q93542|NAS24_CAEEL Zinc metalloproteinase nas-24 precursor (Nematode astacin 24) 1.0E-173
blast CAA98501 Hypothetical protein K03B8.2 [Caenorhabditis elegans] ref|NP_505892.1| Nematode AStacin protease family member (nas-17) [Caenorhabditis elegans] 8.0E-66
blast CAA98501 Hypothetical protein K03B8.2 [Caenorhabditis elegans] ref|NP_505892.1| Nematode AStacin protease family member (nas-17) [Caenorhabditis elegans] 1.0E-65
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.8E-21
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.3E-10
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.8E-21
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.3E-10
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_505893.1 1 20-42
K03B8.5 1 20-42
Sequence
Target Sequence 
>C. ELEGANS:189997_AT
gcagacacctatggtcctggaactatggatccattggatatggactacaaacaaacaatg
ggaaatagaagagtgactttttatgatatgtacaaaatcaatcaatactacggatgctgg
tgttccaaacagttggaatgcaaaaatggaggatatacttcaccgtcggattgctccaga
tgtaattgtccaaaaggattcttcggaaatctttgcgacgaaagacaacaagattcatac
gaattaatggctgtaaacaatttgtggcaatcaataacaattccatttgcttacaagcca
gagccaggatcggatggtttttattcaacatttgtgtacataactgggaaagctaactca
acaattgagattactctggaaggactccaggatgtaatatgcacggctggatgtactgtg
aacggtgttgaaattaagttcaaagaagattctaaaataaccagtccagtcgtctgctgt
actgataaaccaccatacaagaacgtgttcaaatcgtctcacaacccaacaatcattgaa
ttgtactcaaggacgactttaccatcagctgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCAGACACCTATGGTCCTGGAACTA 352 313 835 Antisense
TACTACGGATGCTGGTGTTCCAAAC 14 633 940 Antisense
ATGGAGGATATACTTCACCGTCGGA 598 51 980 Antisense
TCACCGTCGGATTGCTCCAGATGTA 107 625 994 Antisense
TACAAGCCAGAGCCAGGATCGGATG 649 641 1126 Antisense
GACTCCAGGATGTAATATGCACGGC 544 373 1217 Antisense
GCACGGCTGGATGTACTGTGAACGG 383 315 1235 Antisense
AAAATAACCAGTCCAGTCGTCTGCT 317 133 1288 Antisense
GTCGTCTGCTGTACTGATAAACCAC 355 473 1303 Antisense
GAACGTGTTCAAATCGTCTCACAAC 703 347 1335 Antisense
CAAGGACGACTTTACCATCAGCTGT 609 183 1382 Antisense
Sequence Source Affymetrix Proprietary Database