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[189973_at] zinc metalloprotease

Description T23H4.3 /REP_DB=WormBase Gene ID /WP=CE25126 /TR=P91828 /GB=CAB05814.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_high1_10_10 > 42      4grp_high_8_8 > 32      6grp_total > 31      4grp_total > 47      6grp_cgc > 72      6grp_high1_sub > 02_03      6grp_cgc_sub > 02      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 142
1 2 3 4 range
A 207.9
(3)
P 		86.4
(-2.6)
M 		84.5
(-2.7)
M 		77.7
(-3)
P 		130
B 190.1
(3)
P 		140.9
(0.1)
P 		89.5
(-3)
A 		104.4
(-2.1)
A 		101
C 219.2
(3)
P 		85.1
(-3)
P 		107.7
(-2)
P 		123.2
(-1.3)
P 		134
avr 205.7
(3) 		104.1
(-2.5) 		93.9
(-3) 		101.8
(-2.6) 		112

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 151
1 2 3 4 5 6 range
A 106.9
(-0.8)
A 		127.1
(0)
P 		198.6
(3)
P 		136.2
(0.4)
P 		84.1
(-1.8)
P 		54.7
(-3)
M 		144
B 114.8
(0.5)
P 		149.6
(3)
P 		111.9
(0.3)
P 		110.1
(0.1)
P 		114.1
(0.4)
P 		67
(-3)
P 		83
C 103.9
(0.1)
P 		155.9
(3)
P 		130.9
(1.6)
P 		136.6
(1.9)
P 		47.6
(-3)
M 		83.9
(-1)
P 		108
avr 108.5
(0.1) 		144.2
(2.8) 		147.1
(3) 		127.6
(1.5) 		81.9
(-2) 		68.5
(-3) 		79
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 64
1 2 3 4 range
A 75.7
(3)
P 		18.8
(-2.3)
M 		22.1
(-2)
M 		11.4
(-3)
P 		64
B 60.6
(3)
P 		34.8
(-0.9)
P 		20.7
(-3)
A 		22.2
(-2.8)
A 		40
C 72.6
(3)
P 		24.5
(-2.6)
P 		37.5
(-1.1)
P 		20.8
(-3)
P 		52
avr 69.6
(3) 		26
(-2.1) 		26.8
(-2) 		18.1
(-3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 37
1 2 3 4 5 6 range
A 19.7
(-1.8)
A 		45.2
(3)
P 		43.3
(2.6)
P 		34.6
(1)
P 		25.4
(-0.7)
P 		13.3
(-3)
M 		32
B 40
(0.6)
P 		49.8
(3)
P 		27.2
(-2.5)
P 		29.2
(-2)
P 		46.4
(2.2)
P 		25
(-3)
P 		25
C 38.5
(1.3)
P 		47.6
(3)
P 		33.3
(0.3)
P 		27.5
(-0.7)
P 		15.4
(-3)
M 		28.1
(-0.6)
P 		32
avr 32.7
(-0.5) 		47.5
(3) 		34.6
(-0) 		30.4
(-1) 		29.1
(-1.3) 		22.1
(-3) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189973_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1034
Sequence Type Exemplar sequence
Representative Public ID T23H4.3 NCBI
Target Description T23H4.3 /REP_DB=WormBase Gene ID /WP=CE25126 /TR=P91828 /GB=CAB05814.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060215(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060215 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-5) (nas-5) mRNA, complete cds. 11/11 None
GENEFINDER00000007948 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9894321:9896275:1 11/11 None
SNAP00000007945 ENSEMBL cdna:SNAP chromosome:CEL140:I:9894651:9896275:1 11/11 None
T23H4.3 ENSEMBL cdna:known chromosome:CEL140:I:9894321:9896275:1 gene:T23H4.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9894251-9896206(+) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol nas-5
Ensembl T23H4.3
Entrez Gene 188819 Entrez gene
SwissProt P91828 EMBL-EBI
WormBase CE25126 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB05814 Hypothetical protein T23H4.3 [Caenorhabditis elegans] ref|NP_492616.1| Nematode AStacin protease family member (nas-5) [Caenorhabditis elegans] sp|P91828|NAS5_CAEEL Zinc metalloproteinase nas-5 precursor (Nematode astacin 5) 0.0
blast CAE60270 Hypothetical protein CBG03849 [Caenorhabditis briggsae] 1.0E-162
blast CAB05814 Hypothetical protein T23H4.3 [Caenorhabditis elegans] ref|NP_492616.1| Nematode AStacin protease family member (nas-5) [Caenorhabditis elegans] sp|P91828|NAS5_CAEEL Zinc metalloproteinase nas-5 precursor (Nematode astacin 5) 1.0E-156
blast CAE60270 Hypothetical protein CBG03849 [Caenorhabditis briggsae] 1.0E-135
blast CAB63429 Hypothetical protein 4R79.1 [Caenorhabditis elegans] ref|NP_503121.2| Nematode AStacin protease family member (nas-6) [Caenorhabditis elegans] sp|Q9U3S9|NAS6_CAEEL Zinc metalloproteinase nas-6 precursor (Nematode astacin 6) 9.0E-35
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.5E-63
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.5E-63
Sequence
Target Sequence 
>C. ELEGANS:189973_AT
gagttatttcacgttattggcctgtggcatgaacatatgagagctgatagagatgctttt
attaatgttctctataaaaatattgagcctgcacaatatcctcaatttgagaagttgtca
tctcgtgatgcaactacttacagtgttccatatgattataattctgtaatgcattatgat
gagaatgcttttgcaaaaccaggaaagattagtatgatgacaaaggattcaaaatttcag
aaagttattggtcaccccaaagatgcttctagcaatgactataagaaagtgtgtgcaatc
tatcattgttccaaatgtatgcatcaagatttccaacaaattgttgagcaagaacatatt
gagttgaataatccaattattacaaatgcacctgtacaacaaggagattcgtgtacagat
cggttaggaatatgtccaatgttgaaatcaagagaaatgcttaattgtaaagtaatggct
acattttgttgttcttcatgttctgcaccaacatctacaacaactacaacatctggaact
ccatccgatggatcactt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGTTATTTCACGTTATTGGCCTGT 497 397 508 Antisense
GATGCTTTTATTAATGTTCTCTATA 578 413 559 Antisense
GAGCCTGCACAATATCCTCAATTTG 675 385 592 Antisense
AGAAGTTGTCATCTCGTGATGCAAC 351 75 617 Antisense
GATGCAACTACTTACAGTGTTCCAT 36 413 634 Antisense
TTTCAGAAAGTTATTGGTCACCCCA 643 555 742 Antisense
GTCACCCCAAAGATGCTTCTAGCAA 362 465 758 Antisense
GTGTGTGCAATCTATCATTGTTCCA 187 489 796 Antisense
GGAGATTCGTGTACAGATCGGTTAG 186 519 910 Antisense
GTTGTTCTTCATGTTCTGCACCAAC 578 437 995 Antisense
TGGAACTCCATCCGATGGATCACTT 432 547 1041 Antisense
Sequence Source Affymetrix Proprietary Database