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[189811_s_at] CDC46

Description R10E4.4 /REP_DB=WormBase Gene ID /WP=CE03558 /GEN=mcm-5 /TR=SW:Q21902 /GB=CAA90765.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=CDC46
Cluster 6grp_highest_10_10 > 96      6grp_high1_10_10 > 58      4grp_highest_8_8 > 33      4grp_high_8_8 > 59      6grp_highest_nonorm > 98      6grp_total > 59      4grp_total > 61      6grp_highest_sub > Cu      6grp_cgc > 28      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 676
1 2 3 4 range
A 1104.8
(3)
P 		869.9
(0.9)
P 		1060.3
(2.6)
P 		428.5
(-3)
P 		676
B 1016.2
(3)
P 		981.7
(2.6)
P 		991.1
(2.7)
P 		472.4
(-3)
P 		544
C 962
(2.5)
P 		939.3
(2.3)
P 		1004.2
(3)
P 		473.5
(-3)
P 		531
avr 1027.7
(3) 		930.3
(2) 		1018.5
(2.9) 		458.1
(-3) 		570

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1450
1 2 3 4 5 6 range
A 1491.3
(1.4)
P 		736.7
(-1.7)
P 		429
(-3)
P 		673.5
(-2)
P 		905.1
(-1)
P 		1878.8
(3)
P 		1450
B 1295.7
(0.8)
P 		761.1
(-1.7)
P 		470.3
(-3)
P 		627.1
(-2.3)
P 		969.6
(-0.7)
P 		1763
(3)
P 		1293
C 1063.5
(-0.9)
P 		742.5
(-2.5)
P 		633
(-3)
P 		727.5
(-2.5)
P 		852.9
(-1.9)
P 		1849.5
(3)
P 		1217
avr 1283.5
(0.5) 		746.8
(-1.9) 		510.8
(-3) 		676
(-2.2) 		909.2
(-1.2) 		1830.4
(3) 		1320
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 340
1 2 3 4 range
A 402.3
(3)
P 		188.8
(-0.8)
P 		277.2
(0.8)
P 		62.7
(-3)
P 		340
B 324
(3)
P 		242.5
(0.8)
P 		229.7
(0.5)
P 		100.7
(-3)
P 		223
C 318.5
(2.3)
P 		270
(1.2)
P 		350
(3)
P 		79.8
(-3)
P 		270
avr 348.3
(3) 		233.8
(0.4) 		285.6
(1.6) 		81.1
(-3) 		267

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 564
1 2 3 4 5 6 range
A 274.9
(-0)
P 		262
(-0.2)
P 		93.4
(-3)
P 		170.8
(-1.7)
P 		273.1
(-0)
P 		457.4
(3)
P 		364
B 450.8
(0.7)
P 		253.3
(-1.5)
P 		114.2
(-3)
P 		166.1
(-2.4)
P 		393.9
(0.1)
P 		657.4
(3)
P 		543
C 394.2
(0.1)
P 		226.6
(-2)
P 		161.1
(-2.8)
P 		146.3
(-3)
P 		276
(-1.4)
P 		619.1
(3)
P 		473
avr 373.3
(0.3) 		247.3
(-1.4) 		122.9
(-3) 		161.1
(-2.5) 		314.3
(-0.5) 		578
(3) 		455
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189811_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6961
Sequence Type Exemplar sequence
Representative Public ID R10E4.4 NCBI
Target Description R10E4.4 /REP_DB=WormBase Gene ID /WP=CE03558 /GEN=mcm-5 /TR=SW:Q21902 /GB=CAA90765.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=CDC46
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065457(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065457 NCBI Caenorhabditis elegans R10E4.4 (CDC46) mRNA, complete cds. 11/11 None
SNAP00000016397 ENSEMBL cdna:SNAP chromosome:CEL140:III:4288354:4291218:-1 11/11 None
GENEFINDER00000016404 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:4288354:4291218:-1 11/11 None
R10E4.4.2 ENSEMBL cdna:known chromosome:CEL140:III:4288245:4291253:-1 gene:R10E4.4 11/11 None
R10E4.4.1 ENSEMBL cdna:known chromosome:CEL140:III:4288245:4291236:-1 gene:R10E4.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:4288353-4291218(-) 100.0 100.0
Public Domain and Genome References
Gene Title CDC46
Gene Symbol mcm-5
Ensembl R10E4.4
Entrez Gene 175552 Entrez gene
SwissProt Q21902 EMBL-EBI
WormBase CE03558 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:266959_AT minichromosome maintenance family protein / MCM family protein at
ATGENOME1:16887_AT minichromosome maintenance family protein / MCM family protein at
CANINE_2:CFA.4343.1.S1_AT similar to DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46) cfa
CANINE_2:CFA.4343.1.S1_S_AT similar to DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46) cfa
CANINE_2:CFAAFFX.3459.1.S1_AT similar to DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46) cfa
DROSOPHILA_2:1626647_AT Minichromosome maintenance 5 dm
DROSGENOME1:143897_AT Minichromosome maintenance 5 dm
CHICKEN:GGAAFFX.12177.1.S1_S_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) gga
HG-U133_PLUS_2:201755_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U133A:201755_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U133A_2:201755_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U95AV2:982_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HC-G110:982_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HUGENEFL:X74795_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
U133_X3P:G6981191_3P_A_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
U133_X3P:HS.77171.1.A1_3P_A_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U133A_2:216237_S_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-FOCUS:216237_S_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U133_PLUS_2:216237_S_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HG-U133A:216237_S_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
HU35KSUBD:RC_N70873_AT MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) hs
MOE430A:1415945_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MOUSE430A_2:1415945_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MOUSE430_2:1415945_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MU11KSUBA:D26090_S_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MG-U74AV2:100156_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MG-U74AV2:162102_R_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MOE430B:1436808_X_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MOUSE430_2:1436808_X_AT minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) mm
MG-U74CV2:167677_R_AT Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA mm
MU19KSUBA:TC14662_S_AT Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA mm
MU19KSUBC:TC41972_S_AT Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA mm
YEAST_2:1771390_AT Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6270 DNA replication initiation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
8094 DNA-dependent ATPase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90765 Hypothetical protein R10E4.4 [Caenorhabditis elegans] ref|NP_497858.1| R10E4.4 [Caenorhabditis elegans] sp|Q21902|MCM5_CAEEL DNA replication licensing factor mcm-5 0.0
blast CAE66915 Hypothetical protein CBG12303 [Caenorhabditis briggsae] 0.0
blast AAH47250 Mcm5-prov protein [Xenopus laevis] sp|P55862|MCM5_XENLA DNA replication licensing factor MCM5 (CDC46 homolog) (x.CDC46) gb|AAC60224.1| MCM5/CDC46p [Xenopus laevis] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001208 EMBL-EBI MCM 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:189811_S_AT
tggtttcttgactatcgagttcctcaagaaattcgtcacatatgctcgtttgaactgtgg
accacgtcttactccgcaagcttctgagaagctcgttaatcactacgttaagatgagaaa
tccagttgtcaatgctgatgcttttaaatcaggaaagaaggctcataattcggcaattcc
gattaccgttcgtcaactcgaagccattgttcgtattgctgaaagtattgcaaagatgga
gcttcagcagtttgccactgacaagcacgtcgaggaagcgctccgtctgttccgtgtttc
aacaattgaagcggcggcaactggaaatttggcaggagtcgaaggatttacttcaacagc
tgatcaagaagcattgaatcgtatcgaagtgcaaatgaagaagagattcgcaatcggtac
acacgtttctgagcatttgattgttcaagactttgttgctcgtcaacattatagagagtc
tcttgtcaagaaggttatcgataatttggtccgtcgtggagacttgcaaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGGTTTCTTGACTATCGAGTTCCTC 407 551 1725 Antisense
GAAATTCGTCACATATGCTCGTTTG 597 363 1752 Antisense
TGAACTGTGGACCACGTCTTACTCC 460 573 1775 Antisense
GTCTTACTCCGCAAGCTTCTGAGAA 594 467 1790 Antisense
TTCCGATTACCGTTCGTCAACTCGA 12 699 1901 Antisense
AGCTTCAGCAGTTTGCCACTGACAA 327 79 1964 Antisense
GACAAGCACGTCGAGGAAGCGCTCC 489 365 1984 Antisense
CCGTCTGTTCCGTGTTTCAACAATT 354 263 2007 Antisense
GCAATCGGTACACACGTTTCTGAGC 388 321 2134 Antisense
GTTCAAGACTTTGTTGCTCGTCAAC 249 445 2167 Antisense
TGGTCCGTCGTGGAGACTTGCAACA 582 549 2231 Antisense
Sequence Source Affymetrix Proprietary Database