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[189752_s_at] thymidylate kinase

Description R53.2 /REP_DB=WormBase Gene ID /WP=CE03571 /TR=SW:Q22018 /GB=CAA91347.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=thymidylate kinase
Cluster 6grp_highest_10_10 > 26      6grp_high1_10_10 > 52      4grp_high_8_8 > 45      6grp_highest_nonorm > 62      6grp_total > 62      4grp_total > 50      6grp_highest_sub > 03      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 653
1 2 3 4 range
A 142.8
(-2.3)
P 		639.3
(3)
P 		486.9
(1.4)
P 		74.2
(-3)
A 		565
B 152.4
(-2.8)
P 		727.2
(3)
P 		547
(1.2)
P 		128.2
(-3)
P 		599
C 162.9
(-2.8)
P 		597.9
(2.3)
P 		656
(3)
P 		143.1
(-3)
P 		513
avr 152.7
(-2.6) 		654.8
(3) 		563.3
(2) 		115.2
(-3) 		540

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 499
1 2 3 4 5 6 range
A 330.9
(-3)
P 		588.2
(0.6)
P 		680.4
(1.9)
P 		757.8
(3)
P 		467.7
(-1.1)
P 		330.3
(-3)
P 		428
B 297.1
(-3)
P 		576
(0.4)
P 		796
(3)
P 		544
(-0)
P 		402.5
(-1.7)
P 		374.5
(-2.1)
P 		499
C 303
(-3)
P 		621
(3)
P 		438.1
(-0.5)
P 		520.5
(1.1)
P 		472.9
(0.2)
P 		429.1
(-0.6)
P 		318
avr 310.3
(-3) 		595.1
(2.2) 		638.2
(3) 		607.4
(2.4) 		447.7
(-0.5) 		378
(-1.8) 		328
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 218
1 2 3 4 range
A 52
(-1.1)
P 		138.8
(3)
P 		127.3
(2.5)
P 		10.9
(-3)
A 		128
B 48.6
(-2.2)
P 		179.6
(3)
P 		126.8
(0.9)
P 		27.3
(-3)
P 		152
C 53.9
(-2.1)
P 		171.9
(1.3)
P 		228.6
(3)
P 		24.1
(-3)
P 		205
avr 51.5
(-1.7) 		163.4
(3) 		160.9
(2.9) 		20.8
(-3) 		143

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 148
1 2 3 4 5 6 range
A 61
(-3)
P 		209.2
(3)
P 		148.2
(0.5)
P 		192.2
(2.3)
P 		141.1
(0.2)
P 		80.4
(-2.2)
P 		148
B 103.4
(-3)
P 		191.7
(2.9)
P 		193.3
(3)
P 		144.1
(-0.3)
P 		163.5
(1)
P 		139.7
(-0.6)
P 		90
C 112.3
(-2.5)
P 		189.5
(3)
P 		111.5
(-2.5)
P 		104.7
(-3)
P 		153
(0.4)
P 		143.7
(-0.2)
P 		85
avr 92.2
(-3) 		196.8
(3) 		151
(0.4) 		147
(0.1) 		152.5
(0.5) 		121.3
(-1.3) 		105
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189752_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2752
Sequence Type Exemplar sequence
Representative Public ID R53.2 NCBI
Target Description R53.2 /REP_DB=WormBase Gene ID /WP=CE03571 /TR=SW:Q22018 /GB=CAA91347.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=thymidylate kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063750(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063750 NCBI Caenorhabditis elegans R53.2 (R53.2) mRNA, complete cds. 11/11 None
GENEFINDER00000040708 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9963074:9967958:-1 11/11 None
R53.2 ENSEMBL cdna:known chromosome:CEL140:II:9962878:9967043:-1 gene:R53.2 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000040700 4/11 Cross Hyb Matching Probes None
SNAP00000040701 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9963070-9966989(-) 100.0 100.0
Public Domain and Genome References
Gene Title thymidylate kinase
Ensembl R53.2
Entrez Gene 174553 Entrez gene
SwissProt Q22018 EMBL-EBI
WormBase CE03571 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:13347_AT thymidylate kinase family protein at
ATH1-121501:247735_AT thymidylate kinase family protein at
CANINE_2:CFA.20180.1.S1_S_AT similar to deoxythymidylate kinase (thymidylate kinase) cfa
DROSOPHILA_2:1640118_AT dm
DROSGENOME1:153185_AT dm
HG-U95AV2:1136_AT deoxythymidylate kinase (thymidylate kinase) hs
HC-G110:1136_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-U133A:203270_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-U133_PLUS_2:203270_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-U133A_2:203270_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-FOCUS:203270_AT deoxythymidylate kinase (thymidylate kinase) hs
HU35KSUBA:L16991_AT deoxythymidylate kinase (thymidylate kinase) hs
HUGENEFL:L16991_AT deoxythymidylate kinase (thymidylate kinase) hs
U133_X3P:G6912339_3P_S_AT deoxythymidylate kinase (thymidylate kinase) hs
U133_X3P:HS2.367821.1.S1_3P_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-U133_PLUS_2:1553984_S_AT deoxythymidylate kinase (thymidylate kinase) hs
HG-U133_PLUS_2:1565694_AT deoxythymidylate kinase (thymidylate kinase) hs
U133_X3P:HS2.367821.1.A1_3P_AT Deoxythymidylate kinase (thymidylate kinase) hs
U133_X3P:HS2.352231.1.A1_3P_X_AT Deoxythymidylate kinase (thymidylate kinase) hs
U133_X3P:HS2.352231.1.A1_3P_AT Deoxythymidylate kinase (thymidylate kinase) hs
HG-U133_PLUS_2:1553983_AT Deoxythymidylate kinase (thymidylate kinase) hs
HG-U133_PLUS_2:1565693_AT Deoxythymidylate kinase (thymidylate kinase) hs
HG-U95D:84135_AT Deoxythymidylate kinase (thymidylate kinase) hs
MOUSE430_2:1438096_A_AT deoxythymidylate kinase mm
MOUSE430A_2:1438096_A_AT deoxythymidylate kinase mm
MOE430A:1438096_A_AT deoxythymidylate kinase mm
MOUSE430_2:1449116_A_AT deoxythymidylate kinase mm
MOE430A:1449116_A_AT deoxythymidylate kinase mm
MOUSE430A_2:1449116_A_AT deoxythymidylate kinase mm
MU11KSUBA:AA259483_AT deoxythymidylate kinase mm
MU11KSUBB:MSA.9773.0_S_AT deoxythymidylate kinase mm
MG-U74AV2:98619_AT deoxythymidylate kinase mm
MG-U74AV2:98618_AT deoxythymidylate kinase mm
MG-U74CV2:168667_I_AT deoxythymidylate kinase mm
MOE430A:1452681_AT deoxythymidylate kinase mm
MOUSE430A_2:1452681_AT deoxythymidylate kinase mm
MOUSE430_2:1452681_AT deoxythymidylate kinase mm
MU19KSUBB:TC26591_AT Deoxythymidylate kinase, mRNA (cDNA clone MGC:29227 IMAGE:5039765) mm
MU19KSUBB:TC33759_AT Deoxythymidylate kinase, mRNA (cDNA clone MGC:29227 IMAGE:5039765) mm
RG-U34B:RC_AA943116_AT deoxythymidylate kinase (predicted) rn
RAE230B:1383068_AT deoxythymidylate kinase (predicted) rn
RAT230_2:1383068_AT deoxythymidylate kinase (predicted) rn
RAE230B:1383067_A_AT deoxythymidylate kinase (predicted) rn
RAT230_2:1383067_A_AT deoxythymidylate kinase (predicted) rn
YEAST_2:1770221_AT Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6233 dTDP biosynthesis inferred from electronic annotation QuickGO AmiGO
6235 dTTP biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4798 thymidylate kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91347 Hypothetical protein R53.2 [Caenorhabditis elegans] ref|NP_496151.1| R53.2 [Caenorhabditis elegans] sp|Q22018|DTYMK_CAEEL Probable thymidylate kinase (dTMP kinase) 1.0E-119
blast CAA91347 Hypothetical protein R53.2 [Caenorhabditis elegans] ref|NP_496151.1| R53.2 [Caenorhabditis elegans] sp|Q22018|DTYMK_CAEEL Probable thymidylate kinase (dTMP kinase) 1.0E-116
blast CAE57949 Hypothetical protein CBG01006 [Caenorhabditis briggsae] 3.0E-81
blast CAE57949 Hypothetical protein CBG01006 [Caenorhabditis briggsae] 2.0E-77
blast CAA91350 Hypothetical protein R53.4 [Caenorhabditis elegans] ref|NP_496152.1| R53.4 [Caenorhabditis elegans] sp|Q22021|ATPK_CAEEL Putative ATP synthase f chain, mitochondrial 2.0E-71
blast AAM62744 thymidylate kinase-like protein [Arabidopsis thaliana] 4.0E-42
Protein Domains
Database ID Description E-Value
Pfam IPR000062 EMBL-EBI Thymidylate kinase 4.2E-87
Pfam IPR000062 EMBL-EBI Thymidylate kinase 5.2E-79
Sequence
Target Sequence 
>C. ELEGANS:189752_S_AT
gtattcgaagggctcgatcggtccggcaagtcgacacaagccaagcgactcgttgagtcc
atcaacaaaaaatccacagaatccggagatgcttcatcttccccatcagccgttcttcaa
gcttttccagatcgttcctcttcaattggaaagctaattgatcaatatctcagaaaagaa
attgatatggatgagcacgcacttcatttactcttctctgctgatcgattttcaaagaat
caaatgatccgtgacaacattgctaaaggaatcgatgtgatctgcgatcggtattgctat
agcggagttgcatattcattggctaaaggtcttcccgagcaatgggtccgctcttccgac
gttggacttccaaaacccgacgcagttctcttttttgacgtttccccggaagttgcagct
caacgtggtggattcggagaggaacgcctcg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTATTCGAAGGGCTCGATCGGTCCG 366 439 46 Antisense
TCGGTCCGGCAAGTCGACACAAGCC 605 603 63 Antisense
CGACACAAGCCAAGCGACTCGTTGA 484 251 77 Antisense
GAATCCGGAGATGCTTCATCTTCCC 696 329 124 Antisense
TGAGCACGCACTTCATTTACTCTTC 359 569 237 Antisense
GATCTGCGATCGGTATTGCTATAGC 439 419 324 Antisense
ATTGGCTAAAGGTCTTCCCGAGCAA 152 3 363 Antisense
CCGACGCAGTTCTCTTTTTTGACGT 338 263 422 Antisense
TGACGTTTCCCCGGAAGTTGCAGCT 668 403 441 Antisense
GTTGCAGCTCAACGTGGTGGATTCG 286 439 457 Antisense
GGTGGATTCGGAGAGGAACGCCTCG 584 491 472 Antisense
Sequence Source Affymetrix Proprietary Database