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[189739_at] Tyrosine kinase

Description B0523.1 /REP_DB=WormBase Gene ID /WP=CE02438 /TR=SW:P34265 /GB=AAB37087.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=Tyrosine kinase
Cluster 6grp_total > 66      4grp_total > 47      6grp_cgc > 47      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 25
1 2 3 4 range
A 6.2
(-3)
A 		9.1
(-1.1)
A 		8.8
(-1.3)
A 		15.2
(3)
A 		9
B 30.5
(3)
A 		8.9
(-2.1)
A 		14.7
(-0.7)
A 		5.1
(-3)
A 		25
C 5.9
(-3)
A 		6.7
(-2)
A 		7.3
(-1.2)
A 		10.5
(3)
A 		5
avr 14.2
(3) 		8.2
(-3) 		10.3
(-0.9) 		10.3
(-0.9) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 53
1 2 3 4 5 6 range
A 6.6
(-2.9)
A 		5.8
(-3)
A 		47.9
(3)
A 		7.1
(-2.8)
A 		11.2
(-2.2)
A 		30.3
(0.5)
A 		42
B 6.6
(-2.7)
A 		8.8
(-2.2)
A 		10.2
(-1.9)
A 		30
(2.5)
A 		5.4
(-3)
A 		32.1
(3)
A 		27
C 6.7
(-2.9)
A 		20.5
(-1.3)
A 		5.4
(-3)
A 		7.9
(-2.7)
A 		6.5
(-2.9)
A 		58.3
(3)
A 		53
avr 6.6
(-3) 		11.7
(-2.1) 		21.2
(-0.4) 		15
(-1.5) 		7.7
(-2.8) 		40.2
(3) 		34
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 9
1 2 3 4 range
A 2.3
(3)
A 		2
(-3)
A 		2.3
(3)
A 		2.2
(1)
A 		0
B 9.7
(3)
A 		2.2
(-2.2)
A 		3.4
(-1.4)
A 		1.1
(-3)
A 		9
C 1.9
(-2.1)
A 		1.9
(-2.1)
A 		2.5
(3)
A 		1.8
(-3)
A 		1
avr 4.6
(3) 		2
(-2.4) 		2.7
(-0.9) 		1.7
(-3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 18
1 2 3 4 5 6 range
A 1.2
(-3)
A 		2.1
(-2.4)
A 		10.4
(3)
A 		1.8
(-2.6)
A 		3.4
(-1.6)
A 		7.4
(1)
A 		9
B 2.3
(-2.9)
A 		2.9
(-2.6)
A 		2.5
(-2.8)
A 		7.9
(0.5)
A 		2.2
(-3)
A 		12
(3)
A 		10
C 2.5
(-2.6)
A 		6.2
(-1.4)
A 		1.4
(-3)
A 		1.6
(-2.9)
A 		2.1
(-2.8)
A 		19.5
(3)
A 		18
avr 2
(-3) 		3.7
(-2.1) 		4.8
(-1.5) 		3.8
(-2) 		2.6
(-2.7) 		13
(3) 		11
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189739_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7358
Sequence Type Exemplar sequence
Representative Public ID B0523.1 NCBI
Target Description B0523.1 /REP_DB=WormBase Gene ID /WP=CE02438 /TR=SW:P34265 /GB=AAB37087.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=Tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066511(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066511 NCBI Caenorhabditis elegans protein KINase family member (kin-31) (kin-31) mRNA, complete cds. 11/11 None
SNAP00000022049 ENSEMBL cdna:SNAP chromosome:CEL140:III:8671674:8673528:1 11/11 None
GENEFINDER00000022051 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:8671875:8673528:1 11/11 None
B0523.1 ENSEMBL cdna:known chromosome:CEL140:III:8671606:8673528:1 gene:B0523.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:8671668-8673523(+) 100.0 100.0
Public Domain and Genome References
Gene Title Tyrosine kinase
Gene Symbol kin-31
Ensembl B0523.1
Entrez Gene 176214 Entrez gene
SwissProt P34265 EMBL-EBI
WormBase CE33023 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB37087 Protein kinase protein 31 [Caenorhabditis elegans] ref|NP_498912.3| protein KINase family member (kin-31) [Caenorhabditis elegans] sp|P34265|KIN31_CAEEL Probable tyrosine-protein kinase kin-31 0.0
blast G88535 protein B0523.1 [imported] - Caenorhabditis elegans 0.0
blast S44734 probable protein-tyrosine kinase (EC 2.7.1.112) - Caenorhabditis elegans 0.0
Protein Families
Method ID Description E-Value
hanks 1.9.5 AGC group; AGC Other; DdK2 3.0E-65
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 2.6E-32
Pfam IPR000719 EMBL-EBI Protein kinase 5.4E-55
Pfam IPR000980 EMBL-EBI SH2 motif 2.6E-32
Pfam IPR000719 EMBL-EBI Protein kinase 2.0E-30
Pfam IPR000719 EMBL-EBI Protein kinase 4.0E-16
Sequence
Target Sequence 
>C. ELEGANS:189739_AT
tgttcctggtgatggagctcgcgacgggcggcgctttggatagctacttgaagcataatg
agttgctgccgattgacaagagacacgagatgcttcttcaagcagcatggggtctcgagt
acatccatggaaaacccatgctgcatagggacatcgccgcgcgaaattgcctttatggag
atgggaaggtttgctctcagaagactgacgtctgggcttacgggattctctgctgggaga
tcttcaacaacggagccgagccgtatccgggactgactgccaatgaggttgctaagcagg
tgactgatggataccgtatgccaccacaccagttggctgcgccagaggttcaagcgttga
tgacgagatgctgcgcggagaaccccaacgatcgtccaacaatgtcggatgtcgctcaga
tcttgcaacgcgtcactggtcaaggacgtcccaactttgca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTTCCTGGTGATGGAGCTCGCGAC 202 563 629 Antisense
AGCAGCATGGGGTCTCGAGTACATC 626 77 729 Antisense
ACATCGCCGCGCGAAATTGCCTTTA 95 107 779 Antisense
TGACGTCTGGGCTTACGGGATTCTC 585 569 834 Antisense
AGATCTTCAACAACGGAGCCGAGCC 346 61 866 Antisense
TATCCGGGACTGACTGCCAATGAGG 449 657 892 Antisense
GTTGGCTGCGCCAGAGGTTCAAGCG 8 437 960 Antisense
TGACGAGATGCTGCGCGGAGAACCC 327 571 989 Antisense
ACCCCAACGATCGTCCAACAATGTC 482 87 1010 Antisense
GTCGCTCAGATCTTGCAACGCGTCA 389 475 1039 Antisense
TGGTCAAGGACGTCCCAACTTTGCA 403 547 1065 Antisense
Sequence Source Affymetrix Proprietary Database