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[189657_s_at] thymidine kinases

Description Y43C5A.5 /REP_DB=WormBase Gene ID /WP=CE19154 /TR=Q9XXF3 /GB=CAA19501.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Thymidine kinases
Cluster 6grp_highest_10_10 > 29      6grp_high1_10_10 > 92      4grp_highest_8_8 > 11      4grp_high_8_8 > 47      6grp_highest_nonorm > 54      6grp_total > 81      4grp_total > 49      6grp_highest_sub > 04_05      6grp_cgc > 86      6grp_high1_sub > 04_05      6grp_cgc_sub > 04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 376
1 2 3 4 range
A 206.1
(-3)
P 		391.8
(2.5)
P 		410.5
(3)
P 		262.2
(-1.4)
P 		204
B 198.1
(-3)
P 		439.8
(1.3)
P 		536.5
(3)
P 		286.1
(-1.4)
P 		338
C 255.1
(-3)
P 		515.2
(1.9)
P 		574.2
(3)
P 		257
(-3)
P 		319
avr 219.8
(-3) 		448.9
(1.8) 		507.1
(3) 		268.4
(-2) 		287

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2432
1 2 3 4 5 6 range
A 354.1
(-3)
P 		473.2
(-2.6)
P 		662.3
(-2.1)
P 		2339.4
(3)
P 		1808.4
(1.4)
P 		911.4
(-1.3)
P 		1985
B 295.9
(-3)
P 		541.9
(-2.2)
P 		611.6
(-1.9)
P 		2064
(3)
P 		1855.9
(2.3)
P 		831.3
(-1.2)
P 		1768
C 261.4
(-3)
P 		506.4
(-2.4)
P 		634.8
(-2.1)
P 		2693.5
(3)
P 		1556
(0.2)
P 		996.4
(-1.2)
P 		2432
avr 303.8
(-3) 		507.2
(-2.4) 		636.2
(-2) 		2365.6
(3) 		1740.1
(1.2) 		913
(-1.2) 		2062
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 162
1 2 3 4 range
A 75.1
(0.2)
P 		85
(1.1)
P 		107.3
(3)
P 		38.4
(-3)
P 		69
B 63.2
(-2.8)
P 		108.6
(1.5)
P 		124.3
(3)
P 		61
(-3)
P 		63
C 84.5
(-1.4)
P 		148.1
(1)
P 		200.1
(3)
P 		43.3
(-3)
P 		157
avr 74.3
(-1.3) 		113.9
(1.1) 		143.9
(3) 		47.6
(-3) 		96

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 689
1 2 3 4 5 6 range
A 65.3
(-3)
P 		168.3
(-1.8)
P 		144.2
(-2.1)
P 		593.3
(3)
P 		545.7
(2.5)
P 		221.9
(-1.2)
P 		528
B 102.9
(-3)
P 		180.4
(-2.3)
P 		148.5
(-2.6)
P 		546.7
(1.1)
P 		754
(3)
P 		310
(-1.1)
P 		651
C 96.9
(-3)
P 		154.5
(-2.2)
P 		161.6
(-2.1)
P 		541.7
(3)
P 		503.5
(2.5)
P 		333.5
(0.2)
P 		445
avr 88.4
(-3) 		167.7
(-2.1) 		151.4
(-2.3) 		560.6
(2.5) 		601.1
(3) 		288.5
(-0.7) 		513
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189657_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8875
Sequence Type Exemplar sequence
Representative Public ID Y43C5A.5 NCBI
Target Description Y43C5A.5 /REP_DB=WormBase Gene ID /WP=CE19154 /TR=Q9XXF3 /GB=CAA19501.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Thymidine kinases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069485(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069485 NCBI Caenorhabditis elegans THymidine Kinase family member (thk-1) (thk-1) mRNA, complete cds. 11/11 None
SNAP00000044404 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10279636:10280560:-1 11/11 None
GENEFINDER00000044410 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10279636:10280560:-1 11/11 None
Y43C5A.5 ENSEMBL cdna:known chromosome:CEL140:IV:10279435:10281553:-1 gene:Y43C5A.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10279641-10280568(-) 96.91 96.91
Public Domain and Genome References
Gene Title thymidine kinases
Gene Symbol thk-1
Ensembl Y43C5A.5
Entrez Gene 177913 Entrez gene
SwissProt Q9XXF3 EMBL-EBI
WormBase CE19154 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:249874_AT thymidine kinase, putative at
CANINE_2:CFAAFFX.8890.1.S1_AT similar to Thymidine kinase, cytosolic cfa
CHICKEN:GGA.421.2.S1_A_AT thymidine kinase 1, soluble gga
HG-U95AV2:910_AT thymidine kinase 1, soluble hs
HC-G110:910_AT thymidine kinase 1, soluble hs
HG-U133_PLUS_2:202338_AT thymidine kinase 1, soluble hs
HG-U133A:202338_AT thymidine kinase 1, soluble hs
HG-FOCUS:202338_AT thymidine kinase 1, soluble hs
HG-U133A_2:202338_AT thymidine kinase 1, soluble hs
HU35KSUBD:RC_AA287022_S_AT thymidine kinase 1, soluble hs
HUGENEFL:M15205_AT thymidine kinase 1, soluble hs
U133_X3P:G4507518_3P_X_AT thymidine kinase 1, soluble hs
U133_X3P:G4507518_3P_AT thymidine kinase 1, soluble hs
U133_X3P:HS2.105097.2.S1_3P_S_AT thymidine kinase 1, soluble hs
HG-U133_PLUS_2:1554408_A_AT thymidine kinase 1, soluble hs
HG-U95AV2:41400_AT thymidine kinase 1, soluble hs
HG-U133_PLUS_2:243103_AT Thymidine kinase 1, soluble hs
HG-U133B:243103_AT Thymidine kinase 1, soluble hs
HG-U95E:69924_AT Thymidine kinase 1, soluble hs
U133_X3P:HS.202129.0.A1_3P_AT Thymidine kinase 1, soluble hs
MU11KSUBA:M19438_S_AT thymidine kinase 1 mm
MG-U74AV2:96081_AT thymidine kinase 1 mm
MG-U74CV2:139602_AT thymidine kinase 1 mm
MG-U74AV2:161150_AT thymidine kinase 1 mm
MG-U74CV2:171561_AT thymidine kinase 1 mm
MG-U74CV2:171407_I_AT thymidine kinase 1 mm
MOE430A:1416258_AT thymidine kinase 1 mm
MOUSE430A_2:1416258_AT thymidine kinase 1 mm
MOUSE430_2:1416258_AT thymidine kinase 1 mm
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
4797 thymidine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA19501 Hypothetical protein Y43C5A.5 [Caenorhabditis elegans] ref|NP_501886.1| THymidine Kinase family member (thk-1) [Caenorhabditis elegans] gb|AAR98639.1| thyymidine kinase (29.6 kD) (thk-1) [Caenorhabditis elegans] 1.0E-151
blast CAA19501 Hypothetical protein Y43C5A.5 [Caenorhabditis elegans] ref|NP_501886.1| THymidine Kinase family member (thk-1) [Caenorhabditis elegans] gb|AAR98639.1| thyymidine kinase (29.6 kD) (thk-1) [Caenorhabditis elegans] 1.0E-146
blast CAE60728 Hypothetical protein CBG04406 [Caenorhabditis briggsae] 1.0E-136
blast AAH07872 Thymidine kinase 1, soluble [Homo sapiens] gb|AAH07986.1| TK1 protein [Homo sapiens] gb|AAP35587.1| thymidine kinase 1, soluble [Homo sapiens] gb|AAX32749.1| thymidine kinase 1 [synthetic construct] gb|AAX32748.1| thymidine kinase 1 [synthetic construct] gb|AAH06484.1| Thymidine kinase 1, soluble [Homo sapiens] sp|P04183|KITH_HUMAN Thymidine kinase, cytosolic 9.0E-40
Protein Domains
Database ID Description E-Value
Pfam IPR001267 EMBL-EBI Thymidine kinase 4.4E-72
Pfam IPR001267 EMBL-EBI Thymidine kinase 4.4E-72
Sequence
Target Sequence 
>C. ELEGANS:189657_S_AT
ttacgatgccgatctcgtggctactcatagcaagatgactggccagggacggactgtcaa
ggctcatcgtctctctgaagttcaatctcagatcttcaacgatgaggttcaagtcgtttc
gattgacgagggacagttctttgaagatctcgccgaaacttgcgaagaacttgctcaaag
agggaaagttgtttgtgtcgctgcactcaatggaacattcgagagaaagccgttcccaca
aatttctttgctacttccgtacgcgaatgaaatcaagcaagttaccgctgtatgtgtcga
atgcggatcgcaagcaaacttctcattccgcagcacattggacaaaaaggttgaggtgat
cggaggttcggacacttatacagctctctgcagagaatgttatgttcaaaagagcgaaga
aaaagatgctgaagaacagatgaaaactggttgtgataagaacgaaaacgatattactgg
gattttcttggcgaaaaaagagcaaagatctgatggatccgtgtctcctccacgaaagaa
a

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTACGATGCCGATCTCGTGGCTACT 488 681 234 Antisense
GACGGACTGTCAAGGCTCATCGTCT 347 377 281 Antisense
CTCATCGTCTCTCTGAAGTTCAATC 531 227 296 Antisense
AGTTCTTTGAAGATCTCGCCGAAAC 19 65 368 Antisense
AGTTGTTTGTGTCGCTGCACTCAAT 549 63 420 Antisense
ATTCGAGAGAAAGCCGTTCCCACAA 172 9 450 Antisense
TTTGCTACTTCCGTACGCGAATGAA 308 667 480 Antisense
GATCGCAAGCAAACTTCTCATTCCG 598 417 539 Antisense
TTCTCATTCCGCAGCACATTGGACA 686 689 553 Antisense
CGGACACTTATACAGCTCTCTGCAG 641 241 602 Antisense
ATCCGTGTCTCCTCCACGAAAGAAA 274 39 750 Antisense
Sequence Source Affymetrix Proprietary Database