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[189612_at] guanylate cyclase

Description H27A22.1 /REP_DB=WormBase Gene ID /WP=CE17979 /TR=O17912 /GB=CAA19471.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_highest_10_10 > 54      6grp_high1_10_10 > 34      4grp_highest_8_8 > 17      4grp_high_8_8 > 60      6grp_highest_nonorm > 75      6grp_total > 80      4grp_total > 59      6grp_high1_sub > 02      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 537
1 2 3 4 range
A 916.5
(0.8)
P 		851.9
(-0)
P 		1087.7
(3)
P 		617.1
(-3)
P 		471
B 843.9
(1.2)
P 		907.3
(2)
P 		974.5
(3)
P 		550.8
(-3)
P 		424
C 830.7
(-0.1)
P 		1034.6
(3)
P 		986.1
(2.3)
P 		637.9
(-3)
P 		397
avr 863.7
(0.8) 		931.3
(1.8) 		1016.1
(3) 		601.9
(-3) 		414

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 319
1 2 3 4 5 6 range
A 905.7
(1.6)
P 		893.5
(1.2)
P 		767.5
(-3)
P 		849.3
(-0.3)
P 		898.5
(1.4)
P 		947
(3)
P 		180
B 852.5
(-1)
P 		882.1
(-0.3)
P 		768.5
(-2.9)
P 		1026.5
(3)
P 		765
(-3)
P 		940.6
(1)
P 		262
C 843.1
(-0.3)
P 		935.8
(1.5)
P 		1012.2
(3)
P 		825.2
(-0.7)
P 		876.1
(0.3)
P 		707.3
(-3)
P 		305
avr 867.1
(-0.8) 		903.8
(3) 		849.4
(-2.7) 		900.3
(2.6) 		846.5
(-3) 		865
(-1.1) 		57
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 253
1 2 3 4 range
A 333.7
(3)
P 		184.9
(-0.7)
P 		284.3
(1.8)
P 		90.3
(-3)
P 		243
B 269.1
(3)
P 		224.1
(1.2)
P 		225.8
(1.3)
P 		117.4
(-3)
P 		152
C 275
(1.3)
P 		297.5
(1.8)
P 		343.7
(3)
P 		107.6
(-3)
P 		236
avr 292.6
(3) 		235.5
(1.2) 		284.6
(2.7) 		105.1
(-3) 		188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 185
1 2 3 4 5 6 range
A 167
(-3)
P 		317.8
(3)
P 		167.1
(-3)
P 		215.4
(-1.1)
P 		271.1
(1.1)
P 		230.6
(-0.5)
P 		151
B 296.6
(1)
P 		293.6
(0.9)
P 		186.6
(-3)
P 		271.9
(0.1)
P 		310.8
(1.5)
P 		350.7
(3)
P 		164
C 312.5
(3)
P 		285.5
(1.9)
P 		257.6
(0.8)
P 		165.9
(-3)
P 		283.5
(1.8)
P 		236.8
(-0.1)
P 		147
avr 258.7
(0.5) 		299
(3) 		203.8
(-3) 		217.7
(-2.1) 		288.5
(2.3) 		272.7
(1.3) 		95
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189612_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11371
Sequence Type Exemplar sequence
Representative Public ID H27A22.1 NCBI
Target Description H27A22.1 /REP_DB=WormBase Gene ID /WP=CE17979 /TR=O17912 /GB=CAA19471.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073322(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073322 NCBI Caenorhabditis elegans H27A22.1 (H27A22.1) mRNA, complete cds. 11/11 None
H27A22.1 ENSEMBL cdna:known chromosome:CEL140:V:10605042:10608165:1 gene:H27A22.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000002417 4/11 Cross Hyb Matching Probes None
SNAP00000018631 7/11 Cross Hyb Matching Probes None
GENEFINDER00000018633 5/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10606712-10607976(+) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Ensembl H27A22.1
Entrez Gene 179482 Entrez gene
SwissProt O17912 EMBL-EBI
WormBase CE17979 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1582803_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) cfa
CANINE_2:CFA.3719.1.S1_S_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) cfa
CANINE_2:CFAAFFX.10213.1.S1_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) cfa
DROSOPHILA_2:1631426_AT dm
DROSGENOME1:152356_AT dm
CHICKEN:GGA.12082.1.S1_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) gga
HG-U133_PLUS_2:205174_S_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HG-U133A:205174_S_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HG-FOCUS:205174_S_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HG-U133A_2:205174_S_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HUGENEFL:X71125_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
U133_X3P:G9257235_3P_X_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
U133_X3P:G9257235_3P_A_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HG-U95AV2:35966_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
HG-U95E:91301_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) hs
MG-U74BV2:106869_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) mm
MOE430A:1426622_A_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) mm
MOUSE430A_2:1426622_A_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) mm
MOUSE430_2:1426622_A_AT glutaminyl-peptide cyclotransferase (glutaminyl cyclase) mm
RG-U34A:RC_AA859661_AT similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) rn
RAE230A:1377867_AT similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) rn
RAT230_2:1377867_AT similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) rn
Protein Similarities
Method ID Description E-Value
blast CAB08740 Hypothetical protein H27A22.1 [Caenorhabditis elegans] emb|CAA19471.1| Hypothetical protein H27A22.1 [Caenorhabditis elegans] ref|NP_505723.1| H27A22.1 [Caenorhabditis elegans] 0.0
blast CAE64859 Hypothetical protein CBG09655 [Caenorhabditis briggsae] 0.0
blast AAF50733 CG32412-PA [Drosophila melanogaster] gb|AAM50154.1| GH11174p [Drosophila melanogaster] ref|NP_729109.1| CG32412-PA [Drosophila melanogaster] 5.0E-63
Protein Domains
Database ID Description E-Value
Pfam IPR005191 EMBL-EBI Peptidase M28, glutaminyl cyclase 6.5E-62
Pfam IPR005191 EMBL-EBI Peptidase M28, glutaminyl cyclase 5.4E-29
Sequence
Target Sequence 
>C. ELEGANS:189612_AT
agctgtaccctgtgctatgatgcttgatattgctcaaacacttgctccatatatgtacaa
acgagttgctcagcagattggacttcaattgattttctttgatggtgaagaagcattccg
tgattggactgctactgattcactttatggatcaaggcacttggcacagaaatgggagca
aaagtggtatccatcttcaagtagtctcaacaattttgaactcagcaaagaacttgatag
gattgacgttctcatgctattggatctactcggagctgccaatccatcaattggaaatac
gataggaatgggtgcaaacgatcttttcagccagttagctgatgtggaatcgaatctccg
aacttcgggatgtcttagttctttgagaaggaatgtctttaataagcaattatcgtacaa
tcaagttgaagatgatcacattccatttttgaaaagaggagttccaattcttcatctgat
cacagttccattcccatccgtctggcatcgatcttccgataatgcaaatgctcttcatta
tccaacaatcgatcatatgactgcagttattcgtgtcttcgtg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGCTGTACCCTGTGCTATGATGCTT 502 79 429 Antisense
TTGCTCAAACACTTGCTCCATATAT 459 701 458 Antisense
GATTGGACTGCTACTGATTCACTTT 388 435 550 Antisense
GTGGTATCCATCTTCAAGTAGTCTC 380 489 612 Antisense
GTTCTCATGCTATTGGATCTACTCG 402 443 676 Antisense
TACTCGGAGCTGCCAATCCATCAAT 677 645 695 Antisense
ATGGGTGCAAACGATCTTTTCAGCC 326 49 736 Antisense
GGAATCGAATCTCCGAACTTCGGGA 263 529 774 Antisense
GAGTTCCAATTCTTCATCTGATCAC 89 399 887 Antisense
TCATCTGATCACAGTTCCATTCCCA 55 621 900 Antisense
GACTGCAGTTATTCGTGTCTTCGTG 507 375 987 Antisense
Sequence Source Affymetrix Proprietary Database