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[189604_s_at] alpha-mannosidase

Description C47E12.3 /REP_DB=WormBase Gene ID /WP=CE05447 /TR=Q18679 /GB=CAA93106.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=alpha-mannosidase
Cluster 6grp_highest_10_10 > 37      6grp_high1_10_10 > 73      4grp_highest_8_8 > 34      4grp_high_8_8 > 58      6grp_highest_nonorm > 74      6grp_total > 73      4grp_total > 61      6grp_highest_sub > 03_04      6grp_high1_sub > 03_04      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 526
1 2 3 4 range
A 750.5
(0.6)
P 		636.4
(-0.9)
P 		933.5
(3)
P 		481.6
(-3)
P 		452
B 913.7
(3)
P 		752.4
(0.6)
P 		780.4
(1)
P 		513.7
(-3)
P 		400
C 988.7
(3)
P 		725.2
(-0)
P 		796.6
(0.8)
P 		462.8
(-3)
P 		526
avr 884.3
(3) 		704.7
(0.3) 		836.8
(2.3) 		486
(-3) 		398

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 283
1 2 3 4 5 6 range
A 608
(-3)
P 		796.1
(2.4)
P 		818.4
(3)
P 		690
(-0.7)
P 		683.8
(-0.8)
P 		662.1
(-1.5)
P 		210
B 535.1
(-3)
P 		698.8
(1.9)
P 		735.6
(3)
P 		726.2
(2.7)
P 		692.4
(1.7)
P 		693.5
(1.7)
P 		201
C 635.8
(-0.5)
P 		548.9
(-3)
P 		752.7
(3)
P 		754.4
(3)
P 		738.4
(2.5)
P 		752.4
(2.9)
P 		206
avr 593
(-3) 		681.3
(0) 		768.9
(3) 		723.5
(1.5) 		704.9
(0.8) 		702.7
(0.7) 		176
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 257
1 2 3 4 range
A 273.2
(3)
P 		138.1
(-1)
P 		244
(2.1)
P 		70.5
(-3)
P 		203
B 291.4
(3)
P 		185.8
(-0.5)
P 		180.8
(-0.6)
P 		109.5
(-3)
P 		182
C 327.3
(3)
P 		208.5
(0.1)
P 		277.7
(1.8)
P 		78
(-3)
P 		249
avr 297.3
(3) 		177.5
(-0.4) 		234.2
(1.2) 		86
(-3) 		211

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 171
1 2 3 4 5 6 range
A 112.1
(-3)
P 		283.1
(3)
P 		178.2
(-0.7)
P 		175
(-0.8)
P 		206.4
(0.3)
P 		161.2
(-1.3)
P 		171
B 186.2
(-2.6)
P 		232.6
(0.2)
P 		178.6
(-3)
P 		192.4
(-2.2)
P 		281.3
(3)
P 		258.6
(1.7)
P 		103
C 235.7
(2)
P 		167.5
(-2.1)
P 		191.6
(-0.6)
P 		151.7
(-3)
P 		238.9
(2.2)
P 		251.9
(3)
P 		100
avr 178
(-2.6) 		227.7
(1.7) 		182.8
(-2.2) 		173
(-3) 		242.2
(3) 		223.9
(1.4) 		69
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189604_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10256
Sequence Type Exemplar sequence
Representative Public ID C47E12.3 NCBI
Target Description C47E12.3 /REP_DB=WormBase Gene ID /WP=CE05447 /TR=Q18679 /GB=CAA93106.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=alpha-mannosidase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069401(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069401 NCBI Caenorhabditis elegans C47E12.3 (alpha-mannosidase) mRNA, complete cds. 11/11 A 
SNAP00000021571 ENSEMBL cdna:SNAP chromosome:CEL140:IV:9999279:10001537:-1 11/11 None
GENEFINDER00000021590 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:9995696:10001537:-1 11/11 None
C47E12.3 ENSEMBL cdna:known chromosome:CEL140:IV:9999086:10001818:-1 gene:C47E12.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:9998699-10001543(-) 100.0 100.0
Public Domain and Genome References
Gene Title alpha-mannosidase
Ensembl C47E12.3
Entrez Gene 177857 Entrez gene
SwissProt Q18679 EMBL-EBI
WormBase CE33766 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262299_AT glycoside hydrolase family 47 protein at
ATGENOME1:14510_AT glycoside hydrolase family 47 protein at
CANINE_2:CFAAFFX.9356.1.S1_AT similar to ER degradation-enhancing alpha-mannosidase-like cfa
CHICKEN:GGAAFFX.12311.1.S1_AT ER degradation enhancer, mannosidase alpha-like 1 gga
HU35KSUBD:RC_N23299_S_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HUGENEFL:D86967_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133A:203279_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133_PLUS_2:203279_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133A_2:203279_AT ER degradation enhancer, mannosidase alpha-like 1 hs
U133_X3P:G7662001_3P_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U95AV2:31898_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133_PLUS_2:230659_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133B:230659_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133_PLUS_2:231450_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U133B:231450_AT ER degradation enhancer, mannosidase alpha-like 1 hs
HG-U95D:73042_AT ER degradation enhancer, mannosidase alpha-like 1 hs
U133_X3P:HS.154332.1.S1_3P_AT ER degradation enhancer, mannosidase alpha-like 1 hs
U133_X3P:HS.224616.0.A1_3P_AT ER degradation enhancer, mannosidase alpha-like 1 hs
MG-U74AV2:104065_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MG-U74BV2:112453_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MG-U74CV2:134076_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MG-U74CV2:170707_I_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOE430A:1451218_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOUSE430A_2:1451218_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOUSE430_2:1451218_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOE430A:1424065_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOUSE430A_2:1424065_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MOUSE430_2:1424065_AT ER degradation enhancer, mannosidase alpha-like 1 mm
MG-U74CV2:168810_R_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
MG-U74CV2:169357_R_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
MU19KSUBB:TC34897_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
MU19KSUBC:TC41035_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
MU19KSUBC:TC41113_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
MU19KSUBC:TC41113_G_AT ER degradation enhancer, mannosidase alpha-like 1, mRNA (cDNA clone MGC:25513 IMAGE:2654113) mm
RG-U34B:RC_AI010461_AT similar to mKIAA0212 protein rn
RAE230B:1395248_AT similar to mKIAA0212 protein rn
RAT230_2:1395248_AT similar to mKIAA0212 protein rn
RAE230B:1384186_AT similar to mKIAA0212 protein rn
RAT230_2:1384186_AT similar to mKIAA0212 protein rn
RAE230A:1372533_AT Similar to mKIAA0212 protein rn
RAT230_2:1372533_AT Similar to mKIAA0212 protein rn
RAE230A:1390328_AT Similar to mKIAA0212 protein rn
RAT230_2:1390328_AT Similar to mKIAA0212 protein rn
RG-U34B:RC_AI012228_AT Similar to mKIAA0212 protein rn
RG-U34C:RC_AI175790_AT Similar to mKIAA0212 protein rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6487 protein amino acid N-linked glycosylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity inferred from electronic annotation QuickGO AmiGO
5509 calcium ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93106 Hypothetical protein C47E12.3 [Caenorhabditis elegans] ref|NP_501802.2| C47E12.3 [Caenorhabditis elegans] 0.0
blast CAE59950 Hypothetical protein CBG03437 [Caenorhabditis briggsae] 0.0
blast CAD89728 Hypothetical protein C47E12.4a [Caenorhabditis elegans] ref|NP_001023073.1| C47E12.4a [Caenorhabditis elegans] 0.0
blast NP_055489 ER degradation enhancer, mannosidase alpha-like 1 [Homo sapiens] gb|AAH19088.1| ER degradation enhancer, mannosidase alpha-like 1 [Homo sapiens] sp|Q92611|EDEM1_HUMAN ER degradation-enhancing alpha-mannosidase-like 1.0E-175
Protein Domains
Database ID Description E-Value
Pfam IPR001382 EMBL-EBI Glycoside hydrolase, family 47 1.0E-126
Pfam IPR001382 EMBL-EBI Glycoside hydrolase, family 47 1.0E-126
Pfam IPR008162 EMBL-EBI Inorganic pyrophosphatase 1.2E-102
Sequence
Target Sequence 
>C. ELEGANS:189604_S_AT
tactccgccatctcaatatgatccacctctcaaaccattgccacgtaccaactcatcatt
ttgcgaaactgccacagacttcacttttggaaccccaccacttcgtcattctcaaatgcg
tgaattgttcaaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACTCCGCCATCTCAATATGATCCA 306 647 1389 Antisense
TCAATATGATCCACCTCTCAAACCA 665 633 1401 Antisense
GTACCAACTCATCATTTTGCGAAAC 533 455 1433 Antisense
AACTCATCATTTTGCGAAACTGCCA 266 141 1438 Antisense
ATCATTTTGCGAAACTGCCACAGAC 244 31 1443 Antisense
GCGAAACTGCCACAGACTTCACTTT 223 289 1451 Antisense
AACTGCCACAGACTTCACTTTTGGA 151 143 1455 Antisense
GCCACAGACTTCACTTTTGGAACCC 410 277 1459 Antisense
CACCACTTCGTCATTCTCAAATGCG 58 203 1484 Antisense
CCACTTCGTCATTCTCAAATGCGTG 149 273 1486 Antisense
TTCTCAAATGCGTGAATTGTTCAAA 184 689 1497 Antisense
Sequence Source Affymetrix Proprietary Database