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[189562_at] beta-arrestin

Description F53H8.2 /REP_DB=WormBase Gene ID /WP=CE04655 /TR=SW:P51485 /GB=AAA82342.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta-arrestin
Cluster 6grp_highest_10_10 > 72      6grp_high1_10_10 > 28      4grp_highest_8_8 > 53      4grp_high_8_8 > 17      6grp_highest_nonorm > 70      6grp_total > 27      4grp_total > 23      6grp_highest_sub > Cu      6grp_cgc > 06      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 203
1 2 3 4 range
A 424.7
(3)
P 		305
(-1.4)
P 		260
(-3)
P 		337.9
(-0.2)
P 		165
B 462.6
(3)
P 		275.7
(-3)
P 		301.2
(-2.2)
P 		409.5
(1.3)
P 		187
C 383.5
(3)
P 		326.4
(-1.4)
P 		306.2
(-3)
P 		381
(2.8)
P 		77
avr 423.6
(3) 		302.4
(-2.4) 		289.1
(-3) 		376.1
(0.9) 		135

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 215
1 2 3 4 5 6 range
A 354.1
(3)
P 		269.7
(-0.9)
P 		224
(-3)
P 		252.3
(-1.7)
P 		261.5
(-1.3)
P 		297.4
(0.4)
P 		130
B 420.4
(3)
P 		291.5
(-0.6)
P 		255.7
(-1.6)
P 		205.1
(-3)
P 		249
(-1.8)
P 		287.1
(-0.7)
P 		215
C 403.9
(3)
P 		307.6
(-0.8)
P 		262.2
(-2.6)
P 		252.4
(-3)
P 		258.2
(-2.8)
P 		295.3
(-1.3)
P 		152
avr 392.8
(3) 		289.6
(-1) 		247.3
(-2.6) 		236.6
(-3) 		256.2
(-2.2) 		293.3
(-0.8) 		156
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 105
1 2 3 4 range
A 154.6
(3)
P 		66.2
(-2)
P 		68
(-1.9)
P 		49.5
(-3)
P 		105
B 147.5
(3)
P 		68.1
(-3)
P 		69.8
(-2.9)
P 		87.3
(-1.5)
P 		79
C 126.9
(3)
P 		93.8
(-0.2)
P 		106.7
(1.1)
P 		64.2
(-3)
P 		63
avr 143
(3) 		76
(-2.3) 		81.5
(-1.9) 		67
(-3) 		76

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 101
1 2 3 4 5 6 range
A 65.3
(-0.9)
P 		95.9
(3)
P 		48.8
(-3)
P 		64
(-1.1)
P 		78.9
(0.8)
P 		72.4
(0)
P 		47
B 146.3
(3)
P 		97
(-0.2)
P 		62.1
(-2.5)
P 		54.3
(-3)
P 		101.2
(0.1)
P 		107.1
(0.4)
P 		92
C 149.7
(3)
P 		93.9
(-0.4)
P 		66.7
(-2)
P 		50.7
(-3)
P 		83.5
(-1)
P 		98.9
(-0.1)
P 		99
avr 120.4
(3) 		95.6
(0.7) 		59.2
(-2.7) 		56.3
(-3) 		87.9
(-0) 		92.8
(0.4) 		64
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189562_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.18101
Sequence Type Exemplar sequence
Representative Public ID F53H8.2 NCBI
Target Description F53H8.2 /REP_DB=WormBase Gene ID /WP=CE04655 /TR=SW:P51485 /GB=AAA82342.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta-arrestin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075782(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075782 NCBI Caenorhabditis elegans F53H8.2 (beta-arrestin) mRNA, complete cds. 11/11 None
GENEFINDER00000026706 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:950805:954034:1 11/11 None
F53H8.2.2 ENSEMBL cdna:known chromosome:CEL140:X:950682:954160:1 gene:F53H8.2 11/11 None
F53H8.2.1 ENSEMBL cdna:known chromosome:CEL140:X:950779:954230:1 gene:F53H8.2 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000026701 5/11 Cross Hyb Matching Probes None
SNAP00000026702 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:950804-954034(+) 100.0 100.0
Public Domain and Genome References
Gene Title beta-arrestin
Gene Symbol arr-1
Ensembl F53H8.2
Entrez Gene 180446 Entrez gene
SwissProt P51485 EMBL-EBI
WormBase CE28831 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.9060.1.S1_S_AT similar to arrestin beta 1 isoform A cfa
DROSOPHILA_2:1623793_AT kurtz dm
DROSGENOME1:150964_AT kurtz dm
HG-U133B:222756_S_AT arrestin, beta 1 hs
HG-U133_PLUS_2:222756_S_AT arrestin, beta 1 hs
HG-U133_PLUS_2:218832_X_AT arrestin, beta 1 hs
HG-U133A:218832_X_AT arrestin, beta 1 hs
HG-FOCUS:218832_X_AT arrestin, beta 1 hs
HG-U133A_2:218832_X_AT arrestin, beta 1 hs
HU35KSUBD:RC_R06413_AT arrestin, beta 1 hs
U133_X3P:G10880135_3P_A_AT arrestin, beta 1 hs
U133_X3P:HS.112278.0.S2_3P_X_AT arrestin, beta 1 hs
U133_X3P:HS.112278.0.S2_3P_AT arrestin, beta 1 hs
HG-U133_PLUS_2:222912_AT arrestin, beta 1 hs
HG-U133B:222912_AT arrestin, beta 1 hs
HG-U95C:59336_AT arrestin, beta 1 hs
HG-U133_PLUS_2:228444_AT Arrestin, beta 1 hs
HG-U133B:228444_AT Arrestin, beta 1 hs
U133_X3P:HS.112278.2.A1_3P_AT Arrestin, beta 1 hs
MU11KSUBA:AA038975_AT arrestin, beta 1 mm
MG-U74AV2:100473_AT arrestin, beta 1 mm
MG-U74AV2:162481_F_AT arrestin, beta 1 mm
MOE430A:1460444_AT arrestin, beta 1 mm
MOUSE430A_2:1460444_AT arrestin, beta 1 mm
MOUSE430_2:1460444_AT arrestin, beta 1 mm
RN-U34:M91589_AT arrestin, beta 1 rn
RT-U34:M91589_AT arrestin, beta 1 rn
RG-U34A:M91589_AT arrestin, beta 1 rn
RAE230A:1368968_AT arrestin, beta 1 rn
RAT230_2:1368968_AT arrestin, beta 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
7600 sensory perception inferred from electronic annotation QuickGO AmiGO
45744 negative regulation of G-protein coupled receptor protein signaling pathway inferred from sequence similarity QuickGO AmiGO
30512 negative regulation of transforming growth factor beta receptor signaling pathway inferred from sequence similarity QuickGO AmiGO
45810 negative regulation of frizzled signaling pathway inferred from sequence similarity QuickGO AmiGO
48260 positive regulation of receptor mediated endocytosis inferred from sequence similarity QuickGO AmiGO
45860 positive regulation of protein kinase activity inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5829 cytosol inferred from sequence similarity QuickGO AmiGO
9898 internal side of plasma membrane inferred from sequence similarity QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
1664 G-protein-coupled receptor binding inferred from sequence similarity QuickGO AmiGO
50750 low-density lipoprotein receptor binding inferred from sequence similarity QuickGO AmiGO
5160 transforming growth factor beta receptor binding inferred from sequence similarity QuickGO AmiGO
19901 protein kinase binding inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA82342 Arrestin family protein 1 [Caenorhabditis elegans] ref|NP_508183.1| F53H8.2 [Caenorhabditis elegans] sp|P51485|ARRB_CAEEL Probable beta-arrestin 0.0
blast T34297 hypothetical protein F53H8.2 - Caenorhabditis elegans 0.0
blast CAE63594 Hypothetical protein CBG08085 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000698 EMBL-EBI Arrestin 1.1E-62
Pfam IPR000698 EMBL-EBI Arrestin 1.8E-42
Pfam IPR000698 EMBL-EBI Arrestin 1.1E-62
Pfam IPR000698 EMBL-EBI Arrestin 2.4E-38
Sequence
Target Sequence 
>C. ELEGANS:189562_AT
atatttgtctcttcacaactgcttcgtattcctgcgaggttgccaggattgagagcaacg
aaggatttccagtcggaccaggcggcactctttcaaaggtcttcgcagtgtgtcctctat
tgagcaacaacaaggacaagcgagggctcgcattggatggacaactcaagcatgaggaca
ctaatttagcttcaagcacaatattggactctaaaacatcaaaggaaagtcttggaattg
tagttcaatacagagtgaaagttcgcgcagttcttggaccactaaacggagaactgttcg
ccgagctgccgttcacattaacacactcgaagcctccagagagccccgagagaacggatc
gtggccttccatcaatcgaagcaacaaatggctccgaaccagtcgatattgatctcatcc
aactacacgaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATATTTGTCTCTTCACAACTGCTTC 560 19 824 Antisense
CGAAGGATTTCCAGTCGGACCAGGC 394 249 882 Antisense
GCGGCACTCTTTCAAAGGTCTTCGC 22 293 905 Antisense
CGCAGTGTGTCCTCTATTGAGCAAC 149 255 927 Antisense
GAGGGCTCGCATTGGATGGACAACT 199 395 965 Antisense
TGAAAGTTCGCGCAGTTCTTGGACC 564 571 1079 Antisense
AAACGGAGAACTGTTCGCCGAGCTG 413 125 1107 Antisense
TCACATTAACACACTCGAAGCCTCC 40 627 1136 Antisense
GAGCCCCGAGAGAACGGATCGTGGC 117 387 1164 Antisense
GCAACAAATGGCTCCGAACCAGTCG 358 317 1204 Antisense
ATTGATCTCATCCAACTACACGAAG 697 3 1231 Antisense
Sequence Source Affymetrix Proprietary Database