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[189468_s_at] Protein kinase C

Description F09E5.1 /REP_DB=WormBase Gene ID /WP=CE02604 /TR=Q19266 /GB=AAA79341.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Protein kinase C
Cluster 6grp_highest_10_10 > 82      6grp_high1_10_10 > 39      4grp_highest_8_8 > 40      4grp_high_8_8 > 43      6grp_highest_nonorm > 71      6grp_total > 39      4grp_total > 53      6grp_highest_sub > Cu      6grp_cgc > 07      6grp_high1_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 174
1 2 3 4 range
A 252.9
(-2)
P 		361.4
(3)
P 		277.8
(-0.9)
P 		231.9
(-3)
P 		130
B 405.4
(3)
P 		258.3
(-3)
P 		284.6
(-1.9)
P 		281.8
(-2)
P 		147
C 296.4
(1.1)
P 		314.1
(3)
P 		299.4
(1.4)
P 		257.4
(-3)
P 		57
avr 318.2
(3) 		311.3
(2.3) 		287.3
(-0) 		257
(-3) 		61

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 140
1 2 3 4 5 6 range
A 291.7
(-0.2)
P 		325
(1.6)
P 		239.8
(-3)
P 		319
(1.3)
P 		350.5
(3)
P 		318.1
(1.2)
P 		111
B 350.3
(3)
P 		294.5
(-3)
P 		336.9
(1.6)
P 		319.1
(-0.4)
P 		301.6
(-2.2)
P 		319.1
(-0.4)
P 		56
C 379.4
(3)
P 		321.3
(0.5)
P 		358.6
(2.1)
P 		239.3
(-3)
P 		303.8
(-0.2)
P 		346.5
(1.6)
P 		140
avr 340.5
(3) 		313.6
(-0.4) 		311.8
(-0.6) 		292.5
(-3) 		318.6
(0.3) 		327.9
(1.4) 		48
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 95
1 2 3 4 range
A 92.1
(3)
P 		78.5
(1.6)
P 		72.6
(1)
P 		34
(-3)
P 		58
B 129.3
(3)
P 		63.8
(-2.7)
P 		65.9
(-2.5)
P 		60.1
(-3)
P 		69
C 98.1
(2.4)
P 		90.3
(1.6)
P 		104.4
(3)
P 		43.4
(-3)
P 		61
avr 106.5
(3) 		77.5
(0.1) 		81
(0.5) 		45.8
(-3) 		61

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 93
1 2 3 4 5 6 range
A 53.8
(-2.8)
P 		115.6
(3)
P 		52.2
(-3)
P 		80.9
(-0.3)
P 		105.8
(2.1)
P 		77.4
(-0.6)
P 		63
B 121.9
(2.9)
P 		98
(-0.6)
P 		81.8
(-3)
P 		84.5
(-2.6)
P 		122.5
(3)
P 		119
(2.5)
P 		41
C 140.6
(3)
P 		98
(0.2)
P 		91.3
(-0.2)
P 		48.1
(-3)
P 		98.3
(0.3)
P 		116
(1.4)
P 		93
avr 105.4
(2.4) 		103.9
(2.2) 		75.1
(-2.4) 		71.2
(-3) 		108.9
(3) 		104.1
(2.2) 		38
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189468_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5930
Sequence Type Exemplar sequence
Representative Public ID F09E5.1 NCBI
Target Description F09E5.1 /REP_DB=WormBase Gene ID /WP=CE02604 /TR=Q19266 /GB=AAA79341.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Protein kinase C
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062610(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062610 NCBI Caenorhabditis elegans Protein Kinase C family member (pkc-3) (pkc-3) mRNA, complete cds. 11/11 A 
F09E5.1.2 ENSEMBL cdna:known chromosome:CEL140:II:5379995:5384139:1 gene:F09E5.1 11/11 None
F09E5.1.1 ENSEMBL cdna:known chromosome:CEL140:II:5379997:5384139:1 gene:F09E5.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000023191 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5379995-5383600(+) 100.0 100.0
Public Domain and Genome References
Gene Title Protein kinase C
Gene Symbol pkc-3
Ensembl F09E5.1
Entrez Gene 173914 Entrez gene
SwissProt Q19266 EMBL-EBI
WormBase CE02604 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.22822.1.S1_S_AT similar to Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) cfa
DROSOPHILA_2:1627948_AT atypical protein kinase C dm
DROSGENOME1:147229_AT atypical protein kinase C dm
CHICKEN:GGAAFFX.5908.1.S1_S_AT protein kinase C, iota gga
HG-U95AV2:1603_G_AT protein kinase C, iota hs
HC-G110:1603_G_AT protein kinase C, iota hs
HG-U95AV2:1602_AT protein kinase C, iota hs
HC-G110:1602_AT protein kinase C, iota hs
HG-U133A:209678_S_AT protein kinase C, iota hs
HG-U133_PLUS_2:209678_S_AT protein kinase C, iota hs
HG-FOCUS:209678_S_AT protein kinase C, iota hs
HG-U133A_2:209678_S_AT protein kinase C, iota hs
HG-U133_PLUS_2:209677_AT protein kinase C, iota hs
HG-U133A_2:209677_AT protein kinase C, iota hs
HG-U133A:209677_AT protein kinase C, iota hs
HU35KSUBC:RC_AA479362_AT protein kinase C, iota hs
HUGENEFL:L33881_AT protein kinase C, iota hs
HG-U133_PLUS_2:213518_AT protein kinase C, iota hs
HG-U133A_2:213518_AT protein kinase C, iota hs
HG-U133A:213518_AT protein kinase C, iota hs
U133_X3P:G432273_3P_A_AT protein kinase C, iota hs
U133_X3P:HS.47144.1.A1_3P_AT protein kinase C, iota hs
U133_X3P:HS.1904.0.S2_3P_AT protein kinase C, iota hs
HG-U95AV2:41579_S_AT protein kinase C, iota hs
HG-U95B:46745_F_AT protein kinase C, iota hs
HG-U95C:57381_R_AT protein kinase C, iota hs
MU11KSUBA:D28577_S_AT protein kinase C, iota mm
MG-U74AV2:101148_AT protein kinase C, iota mm
MG-U74BV2:162598_AT protein kinase C, iota mm
MOE430A:1448695_AT protein kinase C, iota mm
MOUSE430A_2:1448695_AT protein kinase C, iota mm
MOUSE430_2:1448695_AT protein kinase C, iota mm
MOE430A:1417410_S_AT protein kinase C, iota mm
MOUSE430A_2:1417410_S_AT protein kinase C, iota mm
MOUSE430_2:1417410_S_AT protein kinase C, iota mm
MU19KSUBA:TC14905_AT Protein kinase C, iota, mRNA (cDNA clone MGC:13807 IMAGE:3980628) mm
MU19KSUBA:TC14905_G_AT Protein kinase C, iota, mRNA (cDNA clone MGC:13807 IMAGE:3980628) mm
MU19KSUBB:TC28259_AT Protein kinase C, iota, mRNA (cDNA clone MGC:13807 IMAGE:3980628) mm
MU19KSUBB:TC32419_AT Protein kinase C, iota, mRNA (cDNA clone MGC:13807 IMAGE:3980628) mm
MU19KSUBC:TC41385_AT Protein kinase C, iota, mRNA (cDNA clone MGC:13807 IMAGE:3980628) mm
RAE230A:1388251_AT protein kinase C, lambda rn
RAT230_2:1388251_AT protein kinase C, lambda rn
RAT230_2:1371203_AT protein kinase C, lambda rn
RAE230A:1371203_AT protein kinase C, lambda rn
RAE230A:1373047_AT Protein kinase C, lambda rn
RAT230_2:1373047_AT Protein kinase C, lambda rn
RAE230B:1398468_AT Protein kinase C, lambda rn
RAT230_2:1398468_AT Protein kinase C, lambda rn
RG-U34B:RC_AI007955_AT Protein kinase C, lambda rn
RG-U34C:RC_AI072240_AT Protein kinase C, lambda rn
RG-U34C:RC_AI179206_AT Protein kinase C, lambda rn
RG-U34A:RC_AI639360_AT Protein kinase C, lambda rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA79341 Protein kinase c protein 3 [Caenorhabditis elegans] ref|NP_495011.1| Protein Kinase C family member (pkc-3) [Caenorhabditis elegans] gb|AAB88885.1| protein kinase C3 [Caenorhabditis elegans] sp|Q19266|KPC3_CAEEL Protein kinase C-like 3 (Atypical protein kinase C-3) (aPKC3) 0.0
blast CAE59089 Hypothetical protein CBG02381 [Caenorhabditis briggsae] 0.0
blast NP_001012707 protein kinase C, lambda [Xenopus tropicalis] gb|AAW77999.1| protein kinase C lambda [Xenopus tropicalis] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-61
hanks 1.2.17 AGC group; AGC I Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family; PKCi 1.0E-121
Protein Domains
Database ID Description E-Value
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 6.9E-11
Pfam IPR000270 EMBL-EBI Octicosapeptide/Phox/Bem1p 9.9E-23
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-75
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 1.1E-28
Sequence
Target Sequence 
>C. ELEGANS:189468_S_AT
gatttaacttcaactttctgtggaacacccaattatattgcaccagaaatattgagaggt
gatgaatatggattcagtgttgattggtgggcattgggagtgttaatgtttgaaatgatg
gctggtcgatctccattcgatattgttggaatgcagaattccgaggaaaatacagaagat
tatcttttccaaatcattcttgaacgacagattcgaatccctagatcactttctgtacgg
gcttctggtattctaaagggattcctgaacaaggatccaacagaacgtctgggatgtaag
cttgacattaatgaaggtcttcgtgatatgaaagaacatcaattcttccgtggattcatt
gattgggaagctttggaacagaaggctgtcgcacctccatatcatccagctgtggaaagt
gatcgcgatttgacacactttgatcatcagttcaccgacgaacttccacaattatcacct
gaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATTTAACTTCAACTTTCTGTGGAA 129 429 1231 Antisense
GGAACACCCAATTATATTGCACCAG 435 529 1252 Antisense
AATGATGGCTGGTCGATCTCCATTC 178 165 1344 Antisense
GAATCCCTAGATCACTTTCTGTACG 637 329 1445 Antisense
TTCTGTACGGGCTTCTGGTATTCTA 656 693 1461 Antisense
GAACAAGGATCCAACAGAACGTCTG 62 353 1497 Antisense
GAACATCAATTCTTCCGTGGATTCA 253 351 1564 Antisense
ACCTCCATATCATCCAGCTGTGGAA 506 87 1623 Antisense
GTGATCGCGATTTGACACACTTTGA 596 483 1649 Antisense
ATCAGTTCACCGACGAACTTCCACA 598 27 1676 Antisense
GAACTTCCACAATTATCACCTGACA 217 351 1690 Antisense
Sequence Source Affymetrix Proprietary Database