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[189332_s_at] metalloprotease /// ---

Description F56A4.1 /REP_DB=WormBase Gene ID /WP=CE23772 /TR=Q9N5R0 /GB=AAF39841.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=metalloprotease
Cluster 6grp_total > 91      4grp_total > 24      6grp_cgc > 97      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 19
1 2 3 4 range
A 6.3
(-3)
A 		11.1
(-1.1)
A 		15
(0.4)
A 		21.5
(3)
A 		15
B 2.7
(-2.8)
A 		4.8
(2.1)
A 		2.6
(-3)
A 		5.2
(3)
A 		3
C 6.9
(-1.4)
A 		8.6
(0.7)
A 		10.4
(3)
A 		5.6
(-3)
A 		5
avr 5.3
(-3) 		8.2
(0.2) 		9.3
(1.4) 		10.8
(3) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 14
1 2 3 4 5 6 range
A 9.1
(0.6)
A 		6.4
(-0.7)
A 		2
(-3)
A 		11.7
(2)
A 		13.7
(3)
A 		5.3
(-1.3)
A 		12
B 7.3
(2.6)
A 		6.5
(1.4)
A 		7.6
(3)
A 		4.5
(-1.7)
A 		6.3
(1.1)
A 		3.6
(-3)
A 		4
C 8
(-1.9)
A 		13.2
(1.4)
A 		6.3
(-3)
A 		15.8
(3)
A 		10.3
(-0.5)
A 		9.7
(-0.9)
A 		10
avr 8.1
(0.1) 		8.7
(0.8) 		5.3
(-3) 		10.7
(3) 		10.1
(2.3) 		6.2
(-2) 		5
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3
1 2 3 4 range
A 2.3
(-3)
A 		2.4
(-2.6)
A 		3.9
(3)
A 		3.2
(0.4)
A 		2
B 0.9
(0)
A 		1.2
(3)
A 		0.6
(-3)
A 		1.1
(2)
A 		1
C 2.3
(0.1)
A 		2.5
(0.6)
A 		3.6
(3)
A 		0.9
(-3)
A 		3
avr 1.8
(-2.4) 		2
(-1.2) 		2.7
(3) 		1.7
(-3) 		1

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4
1 2 3 4 5 6 range
A 1.7
(-0.9)
A 		2.3
(0.1)
A 		0.4
(-3)
A 		3
(1.2)
A 		4.1
(3)
A 		1.3
(-1.5)
A 		4
B 2.6
(3)
A 		2.2
(1.3)
A 		1.8
(-0.4)
A 		1.2
(-3)
A 		2.6
(3)
A 		1.3
(-2.6)
A 		1
C 3
(0.5)
A 		4
(3)
A 		1.6
(-3)
A 		3.2
(1)
A 		3.3
(1.3)
A 		3.3
(1.3)
A 		2
avr 2.4
(0.3) 		2.8
(1.5) 		1.3
(-3) 		2.5
(0.6) 		3.3
(3) 		2
(-0.9) 		2
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189332_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.15488
Sequence Type Exemplar sequence
Representative Public ID F56A4.1 NCBI
Target Description F56A4.1 /REP_DB=WormBase Gene ID /WP=CE23772 /TR=Q9N5R0 /GB=AAF39841.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_071251(11), NM_071277(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_071251 NCBI Caenorhabditis elegans Y19D10A.6 (Y19D10A.6) mRNA, complete cds. 11/11 None
NM_071277 NCBI Caenorhabditis elegans F56A4.1 (metalloprotease) mRNA, complete cds. 11/11 None
SNAP00000029967 ENSEMBL cdna:SNAP chromosome:CEL140:V:2354931:2365157:1 11/11 None
GENEFINDER00000029982 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:2358741:2360371:1 11/11 None
SNAP00000032948 ENSEMBL cdna:SNAP chromosome:CEL140:V:2462892:2473118:1 11/11 None
GENEFINDER00000032954 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:2466702:2468332:1 11/11 None
Y19D10A.6 ENSEMBL cdna:known chromosome:CEL140:V:2359805:2360371:1 gene:Y19D10A.6 11/11 None
F56A4.1 ENSEMBL cdna:known chromosome:CEL140:V:2467664:2468332:1 gene:F56A4.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:2467663-2468332(+) 100.0 100.0
chrV:2359702-2360371(+) 100.0 100.0
Public Domain and Genome References
Gene Title metalloprotease

Gene Symbol nas-2
Ensembl Y19D10A.6
F56A4.1
Entrez Gene 186345 Entrez gene
189484 Entrez gene
SwissProt Q9N5R0 EMBL-EBI
Q966D9 EMBL-EBI
WormBase CE38964 Wormbase
CE20885 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF39841 Nematode astacin protease protein 2 [Caenorhabditis elegans] 1.0E-149
blast Q9N5R0 Zinc metalloproteinase nas-2 precursor (Nematode astacin 2) 1.0E-144
blast NP_503678 F56A4.1 [Caenorhabditis elegans] 1.0E-117
blast AAF39841 Nematode astacin protease protein 2 [Caenorhabditis elegans] 1.0E-115
blast NP_503678 F56A4.1 [Caenorhabditis elegans] 1.0E-115
blast Q9N5R0 Zinc metalloproteinase nas-2 precursor (Nematode astacin 2) 1.0E-115
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.1E-15
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.2E-5
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 7.7E-30
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.2E-5
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.7E-29
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.2E-5
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.1E-30
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.2E-5
Sequence
Target Sequence 
>C. ELEGANS:189332_S_AT
aatgtcacctgtgtcaggttccgtccccgtgctgcaactgacaagcattatcttcaaatt
aataagtactttaacgtagaacgctgcttttcctatataggccgtcaaagcagccgcacg
ctttttggaactcctgaaggaaacgtcgagacccgaatgagactcgatcccgcatgcctt
cgcggcaatggacgtggaattgtgatgcatgagttgatgcacatcctaggattctaccac
gagcatcagagagacgatcgggaccgtcgcatcgttggatcagctgtgcattataatttc
aagatctatcgccgtgccaagacattatatatgggcgcttacgatgccaattcaattatg
cactacaacttccaaaatcttccttggcagaggagagatcatttttcgacgtcggatatt
attaacataaatactttttacaagtgcaagaacctattgagcagtaaacttgctccgaaa
gtccctattagtcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATGTCACCTGTGTCAGGTTCCGTC 435 159 130 Antisense
TCCCCGTGCTGCAACTGACAAGCAT 699 595 153 Antisense
GAACGCTGCTTTTCCTATATAGGCC 93 347 208 Antisense
AAAGCAGCCGCACGCTTTTTGGAAC 145 123 236 Antisense
GAGACCCGAATGAGACTCGATCCCG 4 387 277 Antisense
GCATGCCTTCGCGGCAATGGACGTG 583 307 301 Antisense
GAGAGACGATCGGGACCGTCGCATC 137 395 378 Antisense
ATCTATCGCCGTGCCAAGACATTAT 488 31 433 Antisense
ATGGGCGCTTACGATGCCAATTCAA 55 51 460 Antisense
GGAGAGATCATTTTTCGACGTCGGA 217 519 521 Antisense
TTGCTCCGAAAGTCCCTATTAGTCC 132 683 599 Antisense
Sequence Source Affymetrix Proprietary Database