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[189215_at] protein kinase

Description F23C8.7 /REP_DB=WormBase Gene ID /WP=CE20716 /TR=Q9TXI2 /GB=AAD03135.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein kinase
Cluster 6grp_total > 85      4grp_total > 0      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 81
1 2 3 4 range
A 8.5
(-3)
A 		18.6
(-2.2)
A 		89
(3)
A 		86
(2.8)
A 		81
B 12.4
(-2.8)
A 		11.1
(-3)
A 		53.8
(2.6)
A 		56.6
(3)
A 		46
C 33.6
(-1.2)
A 		14
(-3)
A 		32.2
(-1.3)
A 		78.1
(3)
A 		64
avr 18.2
(-2.6) 		14.6
(-3) 		58.3
(1.4) 		73.6
(3) 		59

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 110
1 2 3 4 5 6 range
A 10.4
(-3)
A 		67.8
(0.3)
A 		43.9
(-1.1)
A 		76.6
(0.8)
A 		57.5
(-0.3)
A 		115
(3)
P 		105
B 7.2
(-3)
A 		15.2
(-2.3)
A 		31.9
(-0.8)
A 		71.5
(2.6)
A 		75.9
(3)
A 		47.4
(0.5)
P 		69
C 4.9
(-3)
A 		12.1
(-2.4)
A 		17.7
(-2)
A 		9.7
(-2.6)
A 		82.7
(3)
P 		57
(1)
P 		78
avr 7.5
(-3) 		31.7
(-0.8) 		31.2
(-0.8) 		52.6
(1.1) 		72
(2.9) 		73.1
(3) 		66
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 21
1 2 3 4 range
A 3.1
(-3)
A 		4
(-2.7)
A 		23.3
(3)
A 		12.6
(-0.2)
A 		20
B 4
(-2.2)
A 		2.7
(-3)
A 		12.5
(3)
A 		12.1
(2.8)
A 		10
C 11.1
(1.6)
A 		4
(-3)
A 		11.2
(1.7)
A 		13.2
(3)
A 		9
avr 6.1
(-1.8) 		3.6
(-3) 		15.7
(3) 		12.6
(1.5) 		12

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 29
1 2 3 4 5 6 range
A 1.9
(-3)
A 		24.1
(2.1)
A 		9.6
(-1.2)
A 		19.4
(1)
A 		17.4
(0.6)
A 		28
(3)
P 		26
B 2.5
(-3)
A 		5.1
(-2.4)
A 		7.8
(-1.9)
A 		18.9
(0.5)
A 		30.8
(3)
A 		17.7
(0.2)
P 		28
C 1.8
(-3)
A 		3.7
(-2.5)
A 		4.5
(-2.4)
A 		1.9
(-3)
A 		26.8
(3)
P 		19.1
(1.2)
P 		25
avr 2.1
(-3) 		11
(-0.7) 		7.3
(-1.6) 		13.4
(-0) 		25
(3) 		21.6
(2.1) 		23
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189215_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.273
Sequence Type Exemplar sequence
Representative Public ID F23C8.7 NCBI
Target Description F23C8.7 /REP_DB=WormBase Gene ID /WP=CE20716 /TR=Q9TXI2 /GB=AAD03135.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_058574(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_058574 NCBI Caenorhabditis elegans F23C8.7 (F23C8.7) mRNA, complete cds. 11/11 None
SNAP00000018135 ENSEMBL cdna:SNAP chromosome:CEL140:I:2422406:2425074:-1 11/11 None
GENEFINDER00000018155 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:2422406:2424929:-1 11/11 None
F23C8.7 ENSEMBL cdna:known chromosome:CEL140:I:2422406:2425074:-1 gene:F23C8.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:2422405-2425074(-) 100.0 100.0
Public Domain and Genome References
Gene Title protein kinase
Ensembl F23C8.7
Entrez Gene 184892 Entrez gene
SwissProt Q9TXI2 EMBL-EBI
WormBase CE20716 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAD03135 Hypothetical protein F23C8.7 [Caenorhabditis elegans] ref|NP_490975.1| F23C8.7 [Caenorhabditis elegans] 0.0
blast AAB03183 Hypothetical protein C25A8.5 [Caenorhabditis elegans] ref|NP_501081.1| C25A8.5 [Caenorhabditis elegans] 0.0
blast CAE67394 Hypothetical protein CBG12879 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-14
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-14
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 3.0E-66
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 1.0E-66
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 7.2E-17
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-65
Pfam IPR000980 EMBL-EBI SH2 motif 1.1E-9
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-65
Sequence
Target Sequence 
>C. ELEGANS:189215_AT
gaagaatccgaatttggtgcccgacaagaagatggagatgatctaccaagcagcgtgtgg
aatctcgtatatgcacgagaagaaacttctacatcgagacattgcggcgagaaattgcct
gtatggaggtggtcaggtcaagattgcggattttgggttatcccgtgagggaatctcgta
tgtcatggacctgacgaagaaggttccgattcgttggttggctccggagacgttgaaagc
ggggatttatagtccgaagactgatgtgtttgcgttcggaataatggcttgggagatcac
tgagaatgggaaggagccgtacccagacatgagagttgctgacgtcgtcggaaaggtccg
taatggataccgcatgcggtttgatccggtctttgtggacttcagattcggcgactatgt
cacgaagcactgctgggctgaaaatccggcggatcgtgtgagcatggcggatgttctgcg
ctatcttcagacaacttttgggatgaagccagtggttctatcgattctatcgagcaatcg
ctcgaccgaggaggagatgaagacgatgaagccgccaatgttctcggtg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAGAATCCGAATTTGGTGCCCGAC 31 341 648 Antisense
GGAGATGATCTACCAAGCAGCGTGT 48 519 681 Antisense
GAGGGAATCTCGTATGTCATGGACC 60 403 814 Antisense
GTTGGTTGGCTCCGGAGACGTTGAA 503 435 860 Antisense
GAGCCGTACCCAGACATGAGAGTTG 109 385 961 Antisense
CATGAGAGTTGCTGACGTCGTCGGA 142 209 975 Antisense
TGTGGACTTCAGATTCGGCGACTAT 397 555 1041 Antisense
CGACTATGTCACGAAGCACTGCTGG 37 253 1059 Antisense
ACTGCTGGGCTGAAAATCCGGCGGA 134 99 1076 Antisense
GCATGGCGGATGTTCTGCGCTATCT 177 311 1109 Antisense
GATGAAGCCGCCAATGTTCTCGGTG 205 413 1212 Antisense
Sequence Source Affymetrix Proprietary Database