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[189208_at] GARS/AIRS/GART

Description F38B6.4 /REP_DB=WormBase Gene ID /WP=CE28304 /TR=Q20143 /GB=AAA81142.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=GARS-AIRS-GART
Cluster 6grp_highest_10_10 > 68      6grp_high1_10_10 > 85      4grp_highest_8_8 > 29      4grp_high_8_8 > 07      6grp_highest_nonorm > 95      6grp_total > 76      4grp_total > 0      6grp_highest_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 197
1 2 3 4 range
A 301.7
(-3)
P 		309.2
(-2.6)
P 		355.2
(-0.3)
P 		420.3
(3)
P 		119
B 323.8
(-0.1)
P 		271.8
(-3)
P 		324.6
(-0.1)
P 		380.8
(3)
P 		109
C 281.2
(-0.5)
P 		222.9
(-3)
P 		341.7
(2.2)
P 		361.2
(3)
P 		138
avr 302.2
(-1.3) 		268
(-3) 		340.5
(0.6) 		387.4
(3) 		119

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 920
1 2 3 4 5 6 range
A 451.3
(-3)
P 		508.8
(-2.5)
P 		688.6
(-0.8)
P 		813.6
(0.3)
P 		657.4
(-1.1)
P 		1106
(3)
P 		655
B 331.6
(-3)
P 		565.4
(-1.3)
P 		631.4
(-0.9)
P 		836.9
(0.6)
P 		787.6
(0.3)
P 		1172.8
(3)
P 		841
C 297.9
(-3)
P 		624.8
(-0.9)
P 		770.5
(0.1)
P 		660.7
(-0.6)
P 		812.9
(0.4)
P 		1218.1
(3)
P 		920
avr 360.3
(-3) 		566.3
(-1.5) 		696.8
(-0.5) 		770.4
(0.1) 		752.6
(-0.1) 		1165.6
(3) 		805
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 58
1 2 3 4 range
A 109.8
(3)
P 		67.1
(-2.3)
P 		92.9
(0.9)
P 		61.5
(-3)
P 		48
B 103.3
(3)
P 		67.1
(-3)
P 		75.2
(-1.7)
P 		81.1
(-0.7)
P 		36
C 93.1
(0.3)
P 		64.1
(-2.7)
P 		119.1
(3)
P 		60.9
(-3)
P 		58
avr 102.1
(3) 		66.1
(-3) 		95.7
(1.9) 		67.8
(-2.7) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 354
1 2 3 4 5 6 range
A 83.2
(-3)
P 		181
(0.2)
P 		150
(-0.8)
P 		206.4
(1)
P 		198.4
(0.7)
P 		269.3
(3)
P 		186
B 115.4
(-3)
P 		188.2
(-1.6)
P 		153.3
(-2.3)
P 		221.7
(-1)
P 		320
(0.8)
P 		437.3
(3)
P 		322
C 110.4
(-3)
P 		190.6
(-1.4)
P 		196.1
(-1.3)
P 		132.9
(-2.5)
P 		263
(0.1)
P 		407.8
(3)
P 		297
avr 103
(-3) 		186.6
(-1.1) 		166.5
(-1.6) 		187
(-1.1) 		260.5
(0.5) 		371.5
(3) 		269
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189208_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16893
Sequence Type Exemplar sequence
Representative Public ID F38B6.4 NCBI
Target Description F38B6.4 /REP_DB=WormBase Gene ID /WP=CE28304 /TR=Q20143 /GB=AAA81142.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=GARS-AIRS-GART
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076721(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076721 NCBI Caenorhabditis elegans F38B6.4 (GARS/AIRS/GART) mRNA, complete cds. 11/11 A 
SNAP00000034002 ENSEMBL cdna:SNAP chromosome:CEL140:X:6674831:6679739:1 11/11 None
GENEFINDER00000034012 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:6674831:6679739:1 11/11 None
F38B6.4 ENSEMBL cdna:known chromosome:CEL140:X:6674831:6679780:1 gene:F38B6.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:6674830-6679739(+) 100.0 100.0
Public Domain and Genome References
Gene Title GARS/AIRS/GART
Ensembl F38B6.4
Entrez Gene 180935 Entrez gene
SwissProt Q20143 EMBL-EBI
WormBase CE28304 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:264675_AT phosphoribosylamine--glycine ligase (PUR2) at
ATGENOME1:12010_I_AT phosphoribosylamine--glycine ligase (PUR2) at
ATGENOME1:12011_S_AT phosphoribosylamine--glycine ligase (PUR2) at
DROSOPHILA_2:1637037_AT adenosine 3 dm
DROSGENOME1:143062_AT adenosine 3 dm
CHICKEN:GGA.4704.1.S1_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase gga
CHICKEN:GGA.4704.2.S1_A_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase gga
CHICKEN:GGAAFFX.20713.1.S1_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase gga
HG-U133_PLUS_2:217445_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A_2:217445_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A:217445_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A:210005_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A_2:210005_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:210005_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HU35KSUBD:RC_D51691_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HUGENEFL:X54199_S_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:G509032_3P_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:HS.82285.2.S1_3P_A_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:HS.82285.1.S2_3P_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:HS.82285.1.S1_3P_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A_2:212378_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-FOCUS:212378_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:212378_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A:212378_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A_2:212379_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:212379_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A:212379_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U95AV2:38384_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U95E:75543_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U95E:87571_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:216990_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A_2:216990_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133A:216990_AT phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133B:230097_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:230097_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:236969_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133B:236969_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133_PLUS_2:244822_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U133B:244822_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
HG-U95D:82304_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:HS.144097.0.A1_3P_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
U133_X3P:HS.164168.0.A1_3P_AT Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase hs
MOE430A:1424436_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430A_2:1424436_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430_2:1424436_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430_2:1441911_X_AT phosphoribosylglycinamide formyltransferase mm
MOE430B:1441911_X_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430A_2:1424435_A_AT phosphoribosylglycinamide formyltransferase mm
MOE430A:1424435_A_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430_2:1424435_A_AT phosphoribosylglycinamide formyltransferase mm
MU11KSUBA:U01024_S_AT phosphoribosylglycinamide formyltransferase mm
MG-U74AV2:100066_AT phosphoribosylglycinamide formyltransferase mm
MOE430A:1416283_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430A_2:1416283_AT phosphoribosylglycinamide formyltransferase mm
MOUSE430_2:1416283_AT phosphoribosylglycinamide formyltransferase mm
MU19KSUBA:TC19934_AT Phosphoribosylglycinamide formyltransferase (Gart), mRNA mm
MU19KSUBA:TC19934_G_AT Phosphoribosylglycinamide formyltransferase (Gart), mRNA mm
MU19KSUBA:TC20128_F_AT Phosphoribosylglycinamide formyltransferase (Gart), mRNA mm
RG-U34C:RC_AI230323_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RG-U34C:RC_AI103988_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RAE230A:1388641_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RAT230_2:1388641_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RAE230B:1390787_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RAT230_2:1390787_AT phosphoribosylglycinamide formyltransferase (predicted) rn
RAT230_2:1394839_AT Phosphoribosylglycinamide formyltransferase (predicted) rn
RAE230B:1394839_AT Phosphoribosylglycinamide formyltransferase (predicted) rn
YEAST_2:1778252_AT Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6189 'de novo' IMP biosynthesis inferred from electronic annotation QuickGO AmiGO
9058 biosynthesis inferred from electronic annotation QuickGO AmiGO
9113 purine base biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
4637 phosphoribosylamine-glycine ligase activity inferred from electronic annotation QuickGO AmiGO
4641 phosphoribosylformylglycinamidine cyclo-ligase activity inferred from electronic annotation QuickGO AmiGO
4644 phosphoribosylglycinamide formyltransferase activity inferred from electronic annotation QuickGO AmiGO
16742 hydroxymethyl-, formyl- and related transferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA81142 Hypothetical protein F38B6.4 [Caenorhabditis elegans] ref|NP_509122.1| F38B6.4 [Caenorhabditis elegans] 0.0
blast CAE65771 Hypothetical protein CBG10863 [Caenorhabditis briggsae] 0.0
blast CAA39779 GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE-AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE-GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE [Gallus gallus] emb|CAA38120.1| glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase [Gallus gallus] ref|NP_001001469.1| phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Gallus gallus] sp|P21872|PUR2_CHICK Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 3.0E-60
Pfam IPR010918 EMBL-EBI AIR synthase related protein, C-terminal 3.8E-50
Pfam IPR002376 EMBL-EBI Formyl transferase, N-terminal 4.9E-62
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 7.3E-83
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 5.9E-44
Pfam IPR000728 EMBL-EBI AIR synthase related protein 3.9E-56
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 1.9E-57
Pfam IPR010918 EMBL-EBI AIR synthase related protein, C-terminal 3.8E-50
Pfam IPR002376 EMBL-EBI Formyl transferase, N-terminal 4.9E-62
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 2.6E-85
Pfam IPR000728 EMBL-EBI AIR synthase related protein 3.9E-56
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 1.9E-57
Pfam IPR010918 EMBL-EBI AIR synthase related protein, C-terminal 3.8E-50
Pfam IPR002376 EMBL-EBI Formyl transferase, N-terminal 4.9E-62
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 2.6E-85
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 1.2E-22
Pfam IPR000728 EMBL-EBI AIR synthase related protein 3.9E-56
Pfam IPR000115 EMBL-EBI Phosphoribosylglycinamide synthetase 1.9E-57
Sequence
Target Sequence 
>C. ELEGANS:189208_AT
aaatacacaacacagcgaaaacgcgtgagagtagctattttgatatctggtacagggacg
aacatgcaaaaattaattgagagatcaaaaactccagacagtaattgtgatgttgtgctt
gttgtatcaaacaaggaaggcgctggaggcttgacaattgccgcttcctatggtattcca
actaaagttgttcctcacacagctgatagagtcacaggagacactgaacttgctcaagtt
ttgaaagattttggtacagagctggtttgcctcggtggttatatgaggatattgagtcca
tgtttcatttcacagtttccttcgagaataatcaatattcatccatctctactgcctgct
ttcaaagga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAATACACAACACAGCGAAAACGCG 5 117 2260 Antisense
TATCTGGTACAGGGACGAACATGCA 434 657 2303 Antisense
AGGAAGGCGCTGGAGGCTTGACAAT 285 55 2393 Antisense
TGGAGGCTTGACAATTGCCGCTTCC 633 549 2403 Antisense
CCGCTTCCTATGGTATTCCAACTAA 469 263 2420 Antisense
TAAAGTTGTTCCTCACACAGCTGAT 364 641 2442 Antisense
CAGGAGACACTGAACTTGCTCAAGT 227 209 2474 Antisense
TTGGTACAGAGCTGGTTTGCCTCGG 171 709 2510 Antisense
CTGGTTTGCCTCGGTGGTTATATGA 423 241 2521 Antisense
GTCCATGTTTCATTTCACAGTTTCC 508 477 2555 Antisense
ATCTCTACTGCCTGCTTTCAAAGGA 250 33 2604 Antisense
Sequence Source Affymetrix Proprietary Database