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[189187_at] metalloprotease

Description F39D8.4 /REP_DB=WormBase Gene ID /WP=CE28310 /TR=Q20191 /GB=CAA93663.2 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster 6grp_total > 10      4grp_total > 50      6grp_cgc > 64      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 158
1 2 3 4 range
A 29.9
(-2.4)
A 		160.3
(3)
A 		65
(-0.9)
A 		14.8
(-3)
A 		146
B 31.7
(0.6)
A 		8.9
(-2.2)
A 		51.3
(3)
A 		2.1
(-3)
A 		49
C 19.7
(-2.8)
A 		51.7
(0.1)
A 		84.5
(3)
A 		17.5
(-3)
A 		67
avr 27.1
(-1.5) 		73.6
(3) 		66.9
(2.4) 		11.5
(-3) 		62

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 33.1
(0.4)
A 		9.7
(-3)
A 		50.8
(3)
A 		12.9
(-2.5)
A 		39.2
(1.3)
A 		24.8
(-0.8)
A 		41
B 71.4
(2.2)
A 		73.8
(2.6)
A 		50.7
(-0.6)
A 		71.2
(2.2)
A 		77.1
(3)
A 		33.1
(-3)
A 		44
C 5.9
(-3)
A 		103
(3)
A 		45.2
(-0.6)
A 		62.7
(0.5)
P 		34.2
(-1.3)
A 		69.9
(1)
A 		97
avr 36.8
(-3) 		62.2
(3) 		48.9
(-0.1) 		48.9
(-0.1) 		50.2
(0.2) 		42.6
(-1.6) 		25
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 34
1 2 3 4 range
A 10.9
(-1.4)
A 		34.8
(3)
A 		17
(-0.3)
A 		2.2
(-3)
A 		33
B 10.1
(2.1)
A 		2.2
(-2.1)
A 		11.9
(3)
A 		0.5
(-3)
A 		11
C 6.5
(-2.2)
A 		14.9
(-0.3)
A 		29.4
(3)
A 		2.9
(-3)
A 		27
avr 9.2
(-0.5) 		17.3
(2.3) 		19.4
(3) 		1.9
(-3) 		18

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 29
1 2 3 4 5 6 range
A 6.1
(-1)
A 		3.4
(-2.9)
A 		11.1
(2.5)
A 		3.3
(-3)
A 		11.8
(3)
A 		6
(-1.1)
A 		9
B 24.9
(1)
A 		24.6
(0.9)
A 		12.3
(-3)
A 		18.9
(-0.9)
A 		31.3
(3)
A 		12.4
(-3)
A 		19
C 2.2
(-3)
A 		31.4
(3)
A 		11.5
(-1.1)
A 		12.6
(-0.9)
P 		11.1
(-1.2)
A 		23.4
(1.4)
A 		29
avr 11.1
(-3) 		19.8
(3) 		11.6
(-2.7) 		11.6
(-2.7) 		18.1
(1.8) 		13.9
(-1.1) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189187_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17359
Sequence Type Exemplar sequence
Representative Public ID F39D8.4 NCBI
Target Description F39D8.4 /REP_DB=WormBase Gene ID /WP=CE28310 /TR=Q20191 /GB=CAA93663.2 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078148(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078148 NCBI Caenorhabditis elegans F39D8.4 (metalloprotease) mRNA, complete cds. 9/11 None
F39D8.4 ENSEMBL cdna:known chromosome:CEL140:X:15425191:15428469:-1 gene:F39D8.4 9/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:15425066-15428469(-) 98.77 100.0
Public Domain and Genome References
Gene Title metalloprotease
Gene Symbol nas-13
Ensembl F39D8.4
Entrez Gene 185492 Entrez gene
SwissProt Q20191 EMBL-EBI
WormBase CE35874 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1637986_AT dm
DROSGENOME1:144330_AT dm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93663 Hypothetical protein F39D8.4 [Caenorhabditis elegans] emb|CAA93676.3| Hypothetical protein F39D8.4 [Caenorhabditis elegans] ref|NP_510549.2| F39D8.4 [Caenorhabditis elegans] sp|Q20191|NAS13_CAEEL Zinc metalloproteinase nas-13 precursor (Nematode astacin 13) 0.0
blast CAE63308 Hypothetical protein CBG07697 [Caenorhabditis briggsae] 0.0
blast NP_508154 Nematode AStacin protease family member (nas-15) [Caenorhabditis elegans] gb|AAA82461.2| Nematode astacin protease protein 15 [Caenorhabditis elegans] sp|P55115|NAS15_CAEEL Zinc metalloproteinase nas-15 precursor (Nematode astacin 15) 2.0E-80
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 2.5E-113
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 3.5E-15
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 1.3E-12
Sequence
Target Sequence 
>C. ELEGANS:189187_AT
tgctctacaattgcccaactttcactgcaaccacacttgctccagaaaatacaaaacggg
tgaaaagcattacgaagaaagtgacgtcagcgacaggaagtccgctctcaaaaaaaggag
agattggatcatcaattggggacaaaggagatcggggggacaactcagtattaagttcac
tgatttcaattcattccggtcttggcaaatgtgaagacaggcggaaggattgtgaatttc
ttgcaagagctggacattgtgaaagccgattcagtatacgttttatgacagaaaattgtg
cgaatagttgtggaaaatgtatagccgaggagaagagaaaagaagtctgcgaagatgcaa
ggttggtcgagcttcaaaatttaatctcaaaaaaaaatttaaatttcagaacttggacta
tatgcgacagaaatgtgcgaagagctgtaacttctgtta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGCTCTACAATTGCCCAACTTTCAC 93 579 1376 Antisense
CAACTTTCACTGCAACCACACTTGC 236 189 1391 Antisense
GTGACGTCAGCGACAGGAAGTCCGC 201 483 1456 Antisense
GACAGGAAGTCCGCTCTCAAAAAAA 426 367 1467 Antisense
AGATCGGGGGGACAACTCAGTATTA 157 59 1524 Antisense
TCAATTCATTCCGGTCTTGGCAAAT 675 633 1561 Antisense
ATTTCTTGCAAGAGCTGGACATTGT 508 15 1611 Antisense
GAAAGCCGATTCAGTATACGTTTTA 388 357 1636 Antisense
GATGCAAGGTTGGTCGAGCTTCAAA 616 411 1729 Antisense
CAGAACTTGGACTATATGCGACAGA 69 205 1782 Antisense
GTGCGAAGAGCTGTAACTTCTGTTA 420 477 1810 Antisense
Sequence Source Affymetrix Proprietary Database