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[189183_at] intercellular signal protein

Description Y73C8B.4 /REP_DB=WormBase Gene ID /WP=CE22970 /GEN=lag-2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=intercellular signal protein
Cluster 4grp_high_8_8 > 28      6grp_total > 18      4grp_total > 27      6grp_cgc > 12      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 107
1 2 3 4 range
A 149.2
(-0.4)
P 		156.1
(0.2)
P 		119.1
(-3)
P 		187.7
(3)
P 		69
B 122
(0.7)
P 		142.2
(3)
P 		90.3
(-3)
M 		140.5
(2.8)
P 		52
C 80.8
(-3)
P 		180.1
(3)
P 		99.9
(-1.8)
P 		145.9
(0.9)
P 		99
avr 117.3
(-1.5) 		159.5
(3) 		103.1
(-3) 		158
(2.8) 		56

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 257
1 2 3 4 5 6 range
A 241.1
(3)
P 		105
(-0.9)
P 		44.6
(-2.7)
A 		33.8
(-3)
A 		102.3
(-1)
P 		64
(-2.1)
A 		207
B 233.1
(3)
P 		80.8
(-1.9)
P 		53.2
(-2.8)
P 		47.7
(-3)
A 		91.2
(-1.6)
P 		75.9
(-2.1)
P 		185
C 290.4
(3)
P 		110.2
(-1.6)
P 		116.6
(-1.4)
P 		54.5
(-3)
A 		82.1
(-2.3)
A 		57.1
(-2.9)
P 		236
avr 254.9
(3) 		98.7
(-1.5) 		71.5
(-2.3) 		45.3
(-3) 		91.9
(-1.7) 		65.7
(-2.4) 		210
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 33
1 2 3 4 range
A 54.3
(3)
P 		33.9
(-1.6)
P 		31.1
(-2.2)
P 		27.5
(-3)
P 		27
B 38.9
(3)
P 		35.1
(1.7)
P 		20.9
(-3)
M 		29.9
(0)
P 		18
C 26.7
(-2.5)
P 		51.8
(3)
P 		34.8
(-0.8)
P 		24.6
(-3)
P 		27
avr 40
(2.9) 		40.3
(3) 		28.9
(-2.3) 		27.3
(-3) 		13

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 99
1 2 3 4 5 6 range
A 44.5
(3)
P 		37.3
(1.8)
P 		9.7
(-2.8)
A 		8.6
(-3)
A 		30.9
(0.7)
P 		15.6
(-1.8)
A 		36
B 81.1
(3)
P 		26.9
(-1.7)
P 		12.9
(-3)
P 		12.6
(-3)
A 		37.1
(-0.9)
P 		28.3
(-1.6)
P 		69
C 107.6
(3)
P 		33.6
(-1.6)
P 		29.7
(-1.8)
P 		11
(-3)
A 		26.6
(-2)
A 		19.1
(-2.5)
P 		97
avr 77.7
(3) 		32.6
(-1) 		17.4
(-2.4) 		10.7
(-3) 		31.5
(-1.1) 		21
(-2.1) 		67
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189183_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.15932
Sequence Type Exemplar sequence
Representative Public ID Y73C8B.4 NCBI
Target Description Y73C8B.4 /REP_DB=WormBase Gene ID /WP=CE22970 /GEN=lag-2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=intercellular signal protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_071476(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_071476 NCBI Caenorhabditis elegans Lin-12 And Glp-1 phenotype family member (lag-2) (lag-2) mRNA, complete cds. 11/11 None
SNAP00000021840 ENSEMBL cdna:SNAP chromosome:CEL140:V:3188177:3189668:1 11/11 None
GENEFINDER00000021847 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:3188177:3189668:1 11/11 None
Y73C8B.4 ENSEMBL cdna:known chromosome:CEL140:V:3188177:3189668:1 gene:Y73C8B.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:3188176-3189668(+) 100.0 100.0
Public Domain and Genome References
Gene Title intercellular signal protein
Gene Symbol lag-2
Ensembl Y73C8B.4
Entrez Gene 178755 Entrez gene
SwissProt P45442 EMBL-EBI
WormBase CE22970 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7154 cell communication inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAF36047 Lin-12 and glp-1 phenotype protein 2 [Caenorhabditis elegans] ref|NP_503877.1| Lin-12 And Glp-1 phenotype family member (lag-2) [Caenorhabditis elegans] sp|P45442|LAG2_CAEEL Lag-2 protein precursor emb|CAA54629.1| lag-2 [Caenorhabditis elegans] prf||2007429A lag-2 gene 0.0
blast CAE74188 Hypothetical protein CBG21862 [Caenorhabditis briggsae] 1.0E-135
blast NP_500054 Delta/Serrate/Lag-2 domain family member (dsl-1) [Caenorhabditis elegans] gb|AAC04450.1| Delta/serrate/lag-2 domain protein 1 [Caenorhabditis elegans] 4.0E-13
Protein Domains
Database ID Description E-Value
Pfam IPR006209 EMBL-EBI EGF-like domain 8.8E-7
Pfam IPR001774 EMBL-EBI Delta/Serrate/lag-2 (DSL) protein 3.0E-36
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_503877.1 1 285-307
Y73C8B.4 1 285-307
SNAP00000021840 1 285-307
GENEFINDER00000021847 1 285-307
Sequence
Target Sequence 
>C. ELEGANS:189183_AT
tgatctgcgaatgcaccaacggcttcaccggcactcgttgcgaaattttcggcttcaatc
agttccagctgaccgcgccccgaccagatgcttgcagtgtcaaagacgcctgcttgaatg
gcgccaaatgcttcccaaacggtccgaaagtcttctgctcctgcgctgtcggcttcatcg
gtgaattctgtgaaatctcactcaccaccaccaccccaactaccgtggagattaccgtct
ctacctcgggatactccagcgccgtctacatcacagttgctctcttcgtgatcttctcca
tcatcatcggatgcttcaagtacaagttcaagccgatgagacagcaggccttggctcgtg
gacaggtaccagagccctacaagatgcctgagacaaagtcgatgctgatcgatccggaag
cttcagaggctcagaagaaggtgttcaccatcgagggcagt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGATCTGCGAATGCACCAACGGCTT 5 567 617 Antisense
TTCACCGGCACTCGTTGCGAAATTT 487 685 640 Antisense
TTTTCGGCTTCAATCAGTTCCAGCT 249 677 662 Antisense
TGAATGGCGCCAAATGCTTCCCAAA 354 575 731 Antisense
CAAACGGTCCGAAAGTCTTCTGCTC 281 191 752 Antisense
TTCTGTGAAATCTCACTCACCACCA 490 693 802 Antisense
ACCGTGGAGATTACCGTCTCTACCT 677 87 838 Antisense
TCACAGTTGCTCTCTTCGTGATCTT 66 627 887 Antisense
GTACCAGAGCCCTACAAGATGCCTG 645 457 982 Antisense
GATGCTGATCGATCCGGAAGCTTCA 602 411 1017 Antisense
GAAGGTGTTCACCATCGAGGGCAGT 582 333 1053 Antisense
Sequence Source Affymetrix Proprietary Database