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[189174_at] metalloprotease

Description K09C8.3 /REP_DB=WormBase Gene ID /WP=CE03479 /TR=Q21388 /GB=CAA91996.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster 6grp_highest_10_10 > 87      6grp_high1_10_10 > 77      6grp_highest_nonorm > 94      6grp_total > 78      4grp_total > 02      6grp_highest_sub > Da      6grp_cgc > 49      6grp_high1_sub > Da      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1221
1 2 3 4 range
A 72.9
(-3)
A 		93.1
(-2.9)
A 		65.8
(-3)
A 		1237.4
(3)
P 		1172
B 80.1
(-2.9)
A 		83
(-2.9)
A 		68.5
(-3)
A 		1057.3
(3)
P 		989
C 107.4
(-2.5)
P 		47
(-2.8)
A 		16.7
(-3)
A 		1171.1
(3)
P 		1154
avr 86.8
(-2.8) 		74.4
(-2.9) 		50.3
(-3) 		1155.3
(3) 		1105

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1961
1 2 3 4 5 6 range
A 230
(-2.6)
P 		101.5
(-3)
P 		100.1
(-3)
P 		104.9
(-3)
P 		510.3
(-1.7)
P 		2015.9
(3)
P 		1916
B 190.8
(-2.6)
P 		91.2
(-2.9)
P 		120.4
(-2.8)
P 		55.3
(-3)
P 		552
(-1.4)
P 		1955.8
(3)
P 		1901
C 166.2
(-2.8)
P 		116.3
(-3)
P 		102.7
(-3)
P 		136
(-2.9)
P 		460.4
(-1.7)
P 		1770.6
(3)
P 		1668
avr 195.7
(-2.7) 		103
(-3) 		107.7
(-3) 		98.7
(-3) 		507.6
(-1.6) 		1914.1
(3) 		1815
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 220
1 2 3 4 range
A 26.5
(-2.7)
A 		20.2
(-2.9)
A 		17.2
(-3)
A 		181.1
(3)
P 		164
B 25.5
(-2.7)
A 		20.5
(-2.9)
A 		15.9
(-3)
A 		225.3
(3)
P 		209
C 35.6
(-2.1)
P 		13.5
(-2.8)
A 		5.8
(-3)
A 		197.5
(3)
P 		192
avr 29.2
(-2.5) 		18.1
(-2.8) 		13
(-3) 		201.3
(3) 		188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 715
1 2 3 4 5 6 range
A 42.4
(-2.7)
P 		36.1
(-2.8)
P 		21.8
(-3)
P 		26.6
(-2.9)
P 		154
(-1.3)
P 		490.8
(3)
P 		469
B 66.4
(-2.6)
P 		30.3
(-2.9)
P 		29.2
(-2.9)
P 		14.7
(-3)
P 		224.3
(-1.2)
P 		729.3
(3)
P 		715
C 61.6
(-2.6)
P 		35.5
(-2.9)
P 		26.1
(-3)
P 		27.3
(-3)
P 		149
(-1.7)
P 		592.7
(3)
P 		567
avr 56.8
(-2.7) 		34
(-2.9) 		25.7
(-3) 		22.9
(-3) 		175.8
(-1.4) 		604.3
(3) 		581
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189174_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16527
Sequence Type Exemplar sequence
Representative Public ID K09C8.3 NCBI
Target Description K09C8.3 /REP_DB=WormBase Gene ID /WP=CE03479 /TR=Q21388 /GB=CAA91996.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077431(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077431 NCBI Caenorhabditis elegans K09C8.3 (metalloprotease) mRNA, complete cds. 11/11 None
SNAP00000014653 ENSEMBL cdna:SNAP chromosome:CEL140:X:10960904:10963348:-1 11/11 None
GENEFINDER00000014663 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:10960904:10963576:-1 11/11 None
K09C8.3 ENSEMBL cdna:known chromosome:CEL140:X:10960904:10964647:-1 gene:K09C8.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10960903-10964647(-) 100.0 100.0
Public Domain and Genome References
Gene Title metalloprotease
Gene Symbol nas-10
Ensembl K09C8.3
Entrez Gene 181287 Entrez gene
SwissProt Q21388 EMBL-EBI
WormBase CE03479 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91996 Hypothetical protein K09C8.3 [Caenorhabditis elegans] ref|NP_509832.1| K09C8.3 [Caenorhabditis elegans] sp|Q21388|NAS10_CAEEL Zinc metalloproteinase nas-10 (Nematode astacin 10) 0.0
blast CAE70786 Hypothetical protein CBG17542 [Caenorhabditis briggsae] 0.0
blast AAL16314 Nematode astacin protease protein 9, isoform b [Caenorhabditis elegans] ref|NP_741532.1| Nematode AStacin protease family member (nas-9) [Caenorhabditis elegans] sp|P91137|NAS9_CAEEL Zinc metalloproteinase nas-9 precursor (Nematode astacin 9) 1.0E-142
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 4.6E-95
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 2.0E-12
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 4.6E-95
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 2.0E-12
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 4.6E-95
Pfam IPR003582 EMBL-EBI Metridin-like ShK toxin 2.0E-12
Sequence
Target Sequence 
>C. ELEGANS:189174_AT
ttcaaatattttgcttctccgccaaaagggaaccacattaactaccagaaagtgaactcg
ccatctttttgcggtttgtcatatattggaagagtcgagccagcaaatccagtgtatctt
agttttcaatgtggaaatggaagagggattgcagttcacgaaacaatgcacgcattggga
gttaatcatcaacatttaagaatggatagagacaaacatattaaggttgactggagcaat
attaatcctcagcagtacgatgcatttgtggtggccgattccaaactctacactacatat
ggagttaaatacgcgtatgacagcataatgcattacaatgcatacaccggtgccgtgaac
attgccaaaccaactatgatcccattggtcaatcaacaagctaacattggtttacttgga
cagagagccaagatgagcaatgcggatgttgagattcttaataaaatgtactgcaaatcc
gcaggatgtgatgataagaatgtttactgcggagcatgggctcttcaggatctat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTCAAATATTTTGCTTCTCCGCCAA 523 685 1096 Antisense
GCTTCTCCGCCAAAAGGGAACCACA 441 303 1108 Antisense
GTGAACTCGCCATCTTTTTGCGGTT 571 481 1147 Antisense
GTCGAGCCAGCAAATCCAGTGTATC 19 475 1189 Antisense
AATCCTCAGCAGTACGATGCATTTG 585 167 1339 Antisense
GATGCATTTGTGGTGGCCGATTCCA 196 413 1354 Antisense
CGATTCCAAACTCTACACTACATAT 591 247 1371 Antisense
TACAATGCATACACCGGTGCCGTGA 32 643 1429 Antisense
CGGTGCCGTGAACATTGCCAAACCA 110 241 1443 Antisense
TTGCCAAACCAACTATGATCCCATT 173 701 1457 Antisense
GGAGCATGGGCTCTTCAGGATCTAT 70 521 1606 Antisense
Sequence Source Affymetrix Proprietary Database