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[189095_at] pyruvate kinase

Description ZK593.1 /REP_DB=WormBase Gene ID /WP=CE24731 /TR=Q23539 /GB=CAA93424.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=pyruvate kinase
Cluster 6grp_highest_10_10 > 65      6grp_high1_10_10 > 55      4grp_highest_8_8 > 51      4grp_high_8_8 > 24      6grp_highest_nonorm > 87      6grp_total > 56      4grp_total > 39      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 370
1 2 3 4 range
A 1238.3
(3)
P 		1090.7
(-0.1)
P 		954.4
(-3)
P 		1026.9
(-1.5)
P 		284
B 1176
(3)
P 		902.1
(-2.8)
P 		895
(-3)
P 		1115.3
(1.7)
P 		281
C 1265.1
(3)
P 		935.7
(-2.7)
P 		1103.5
(0.2)
P 		921.3
(-3)
P 		344
avr 1226.5
(3) 		976.2
(-3) 		984.3
(-2.8) 		1021.2
(-1.9) 		250

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 781
1 2 3 4 5 6 range
A 1185.5
(0.8)
P 		1330.6
(2.5)
P 		1306.6
(2.2)
P 		1298.2
(2.1)
P 		870.5
(-3)
P 		1372.4
(3)
P 		502
B 1335
(0.2)
P 		1286.4
(-0.3)
P 		1307.1
(-0.1)
P 		1044.5
(-2.9)
P 		1033.3
(-3)
P 		1603.7
(3)
P 		570
C 1266.9
(0.7)
P 		1330.2
(1.2)
P 		1260.8
(0.7)
P 		1142.9
(-0.3)
P 		822.4
(-3)
P 		1542.1
(3)
P 		720
avr 1262.5
(0.6) 		1315.7
(1.1) 		1291.5
(0.8) 		1161.9
(-0.5) 		908.7
(-3) 		1506.1
(3) 		597
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 301
1 2 3 4 range
A 450.9
(3)
P 		236.8
(-1.3)
P 		249.5
(-1)
P 		150.3
(-3)
P 		301
B 375
(3)
P 		222.8
(-2.4)
P 		207.4
(-3)
P 		237.7
(-1.9)
P 		168
C 418.8
(3)
P 		269
(-0.4)
P 		384.6
(2.2)
P 		155.3
(-3)
P 		264
avr 414.9
(3) 		242.9
(-1.4) 		280.5
(-0.4) 		181.1
(-3) 		234

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 380
1 2 3 4 5 6 range
A 218.5
(-3)
P 		473.2
(3)
P 		284.5
(-1.4)
P 		329.3
(-0.4)
P 		262.7
(-2)
P 		334.1
(-0.3)
P 		255
B 464.5
(0.5)
P 		428.2
(-0.2)
P 		317.4
(-2.2)
P 		276.6
(-3)
P 		419.8
(-0.3)
P 		598
(3)
P 		321
C 469.6
(2)
P 		405.9
(0.7)
P 		320.9
(-1.1)
P 		229.8
(-3)
P 		266.1
(-2.2)
P 		516.2
(3)
P 		286
avr 384.2
(0.1) 		435.8
(1.6) 		307.6
(-2.1) 		278.6
(-3) 		316.2
(-1.9) 		482.8
(3) 		204
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189095_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9323
Sequence Type Exemplar sequence
Representative Public ID ZK593.1 NCBI
Target Description ZK593.1 /REP_DB=WormBase Gene ID /WP=CE24731 /TR=Q23539 /GB=CAA93424.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=pyruvate kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069628(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069628 NCBI Caenorhabditis elegans ZK593.1 (ZK593.1) mRNA, complete cds. 11/11 None
SNAP00000042091 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10909989:10912969:1 11/11 None
GENEFINDER00000042104 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10909989:10912969:1 11/11 None
ZK593.1 ENSEMBL cdna:known chromosome:CEL140:IV:10909885:10913037:1 gene:ZK593.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10909921-10912975(+) 100.0 100.0
Public Domain and Genome References
Gene Title pyruvate kinase
Ensembl ZK593.1
Entrez Gene 177984 Entrez gene
SwissProt Q23539 EMBL-EBI
WormBase CE24731 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:247338_AT pyruvate kinase, putative at
CANINE:1604350_AT pyruvate kinase, muscle cfa
CANINE:1583065_AT pyruvate kinase, muscle cfa
CANINE_2:CFA.4353.1.S1_S_AT pyruvate kinase, muscle cfa
CANINE_2:CFAAFFX.27014.1.S1_AT pyruvate kinase, muscle cfa
CANINE:1583064_AT pyruvate kinase, muscle cfa
DROSOPHILA_2:1628027_A_AT Pyruvate kinase dm
DROSGENOME1:141674_AT Pyruvate kinase dm
CHICKEN:GGA.4299.1.S1_AT pyruvate kinase, muscle gga
HG-U133A:201251_AT pyruvate kinase, muscle hs
HG-U133_PLUS_2:201251_AT pyruvate kinase, muscle hs
HG-FOCUS:201251_AT pyruvate kinase, muscle hs
HG-U133A_2:201251_AT pyruvate kinase, muscle hs
HU35KSUBD:RC_T03580_F_AT pyruvate kinase, muscle hs
HU35KSUBD:RC_H20989_S_AT pyruvate kinase, muscle hs
HUGENEFL:X56494_AT pyruvate kinase, muscle hs
U133_X3P:G4505838_3P_X_AT pyruvate kinase, muscle hs
U133_X3P:G4505838_3P_AT pyruvate kinase, muscle hs
HG-U95AV2:32378_AT pyruvate kinase, muscle hs
HG-U133A_2:213700_S_AT Pyruvate kinase, muscle hs
HG-U133_PLUS_2:213700_S_AT Pyruvate kinase, muscle hs
HG-U133A:213700_S_AT Pyruvate kinase, muscle hs
HG-U133A_2:217581_AT Pyruvate kinase, muscle hs
HG-U133_PLUS_2:217581_AT Pyruvate kinase, muscle hs
HG-U133A:217581_AT Pyruvate kinase, muscle hs
HG-U95AV2:32379_F_AT Pyruvate kinase, muscle hs
HG-U95AV2:40925_AT Pyruvate kinase, muscle hs
HG-U95D:75145_R_AT Pyruvate kinase, muscle hs
HG-U95E:85992_AT Pyruvate kinase, muscle hs
U133_X3P:HS.256155.0.A1_3P_AT Pyruvate kinase, muscle hs
U133_X3P:HS.256155.0.A1_3P_X_AT Pyruvate kinase, muscle hs
U133_X3P:HS.8173.2.A1_3P_A_AT Pyruvate kinase, muscle hs
MOE430A:1417308_AT pyruvate kinase, muscle mm
MOUSE430A_2:1417308_AT pyruvate kinase, muscle mm
MOUSE430_2:1417308_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.18114.0_F_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.42674.0_F_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.40910.0_S_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.33222.0_F_AT pyruvate kinase, muscle mm
MU11KSUBB:X97047_F_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.2087.0_F_AT pyruvate kinase, muscle mm
MU11KSUBB:MSA.10820.0_F_AT pyruvate kinase, muscle mm
MG-U74AV2:96066_S_AT pyruvate kinase, muscle mm
MG-U74CV2:137220_F_AT pyruvate kinase, muscle mm
MG-U74AV2:162032_F_AT pyruvate kinase, muscle mm
MOE430B:1443186_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
MOUSE430_2:1443186_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
MU19KSUBC:TC36124_F_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
MU19KSUBC:TC36125_F_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
MU19KSUBC:TC36126_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
MU19KSUBC:TC36127_AT Pyruvate kinase, muscle, mRNA (cDNA clone MGC:11908 IMAGE:3598842) mm
RG-U34B:RC_AA998722_S_AT pyruvate kinase, muscle rn
YEAST_2:1770962_AT Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6096 glycolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4743 pyruvate kinase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93424 Hypothetical protein ZK593.1 [Caenorhabditis elegans] ref|NP_502029.1| ZK593.1 [Caenorhabditis elegans] 0.0
blast CAE61956 Hypothetical protein CBG05956 [Caenorhabditis briggsae] 0.0
blast CAE70385 Hypothetical protein CBG16947 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001697 EMBL-EBI Pyruvate kinase 4.1E-49
Pfam IPR001697 EMBL-EBI Pyruvate kinase 1.0E-126
Pfam IPR001697 EMBL-EBI Pyruvate kinase 4.1E-49
Pfam IPR001697 EMBL-EBI Pyruvate kinase 1.0E-126
Pfam IPR001697 EMBL-EBI Pyruvate kinase 8.4E-45
Sequence
Target Sequence 
>C. ELEGANS:189095_AT
tgtgcaacccagatgctcgagagcatgatcaccaaacctcgtccgactagagcagaatgc
agtgacgtggcaaacgctgtcttggatggagttgactgtgtgatgttgagtggagaaact
gcaaaaggagattatccagttgaagcattggcgattatgcataatatctgcaaagaagca
gaatctgcattcttccatatgaaacattttgaagagcttattcttcataccaagaaacca
actggaatgactcatacaactgcaattgcagctgtttctgcaacaatcacatgccgtgct
gtcgctattattctcatcacaacaacgggaaaaaccgcccgtctatgttcccgataccgt
ccaccagttccaattattactgtttctcgtgatgaacgaatctctcgtcaacttcatctt
cacagaggaatctttcctgtttactatccaaagggacgtattgatgaatgggatgttgat
gttgaggaacgtgtgcaatacggagtaaatcttggtaagacacgtggattcattcatctt
ggagatccact

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTGCAACCCAGATGCTCGAGAGCA 158 557 940 Antisense
GAGAGCATGATCACCAAACCTCGTC 307 395 958 Antisense
AAACCTCGTCCGACTAGAGCAGAAT 561 125 973 Antisense
GTGACGTGGCAAACGCTGTCTTGGA 85 483 1001 Antisense
GGAATGACTCATACAACTGCAATTG 617 531 1183 Antisense
CAACAATCACATGCCGTGCTGTCGC 402 189 1220 Antisense
GTGCTGTCGCTATTATTCTCATCAC 538 479 1235 Antisense
GTTCCAATTATTACTGTTTCTCGTG 171 441 1306 Antisense
TCAACTTCATCTTCACAGAGGAATC 305 631 1347 Antisense
GAATCTTTCCTGTTTACTATCCAAA 296 329 1367 Antisense
GATTCATTCATCTTGGAGATCCACT 146 431 1466 Antisense
Sequence Source Affymetrix Proprietary Database