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[189089_at] CDC20 protein

Description ZK1307.6 /REP_DB=WormBase Gene ID /WP=CE01695 /TR=Q09649 /GB=CAA87433.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=CDC20 protein
Cluster 6grp_high1_10_10 > 56      4grp_high_8_8 > 20      6grp_total > 46      4grp_total > 19      6grp_cgc > 19      6grp_high1_sub > Cu      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 165
1 2 3 4 range
A 143.2
(-1.8)
P 		165.5
(-0.5)
P 		121.9
(-3)
P 		226.3
(3)
P 		104
B 126.2
(-0.5)
P 		143.9
(0.2)
A 		61.3
(-3)
P 		215.9
(3)
P 		155
C 127
(-2)
P 		170.1
(1)
A 		112.4
(-3)
A 		198.4
(3)
P 		86
avr 132.1
(-1.2) 		159.8
(0.2) 		98.5
(-3) 		213.5
(3) 		115

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 133
1 2 3 4 5 6 range
A 133.4
(-1.9)
P 		127.6
(-2.8)
P 		134.6
(-1.7)
P 		126.5
(-3)
P 		130.8
(-2.3)
P 		164.7
(3)
P 		38
B 166.6
(0.9)
P 		190.6
(3)
P 		141.5
(-1.3)
P 		122.3
(-3)
P 		142.1
(-1.3)
P 		183.6
(2.4)
P 		68
C 144.9
(0.7)
P 		196.1
(3)
P 		62.8
(-3)
A 		160.8
(1.4)
P 		116.1
(-0.6)
P 		191.5
(2.8)
P 		133
avr 148.3
(0.2) 		171.4
(2.2) 		113
(-3) 		136.5
(-0.9) 		129.7
(-1.5) 		179.9
(3) 		67
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 38
1 2 3 4 range
A 52.2
(3)
P 		35.9
(-1.8)
P 		31.9
(-3)
P 		33.1
(-2.6)
P 		20
B 40.3
(1.9)
P 		35.5
(1)
A 		14.2
(-3)
P 		46
(3)
P 		32
C 42
(0.3)
P 		48.9
(3)
A 		39.2
(-0.8)
A 		33.5
(-3)
P 		15
avr 44.8
(3) 		40.1
(1.3) 		28.4
(-3) 		37.5
(0.3) 		16

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 52
1 2 3 4 5 6 range
A 24.6
(-3)
P 		45.4
(3)
P 		29.3
(-1.6)
P 		32.1
(-0.8)
P 		39.5
(1.3)
P 		40.1
(1.5)
P 		21
B 58
(1.3)
P 		63.4
(2.2)
P 		34.4
(-2.7)
P 		32.4
(-3)
P 		57.7
(1.2)
P 		68.4
(3)
P 		36
C 53.7
(1.7)
P 		59.8
(2.5)
P 		16
(-3)
A 		32.3
(-1)
P 		37.6
(-0.3)
P 		64.1
(3)
P 		48
avr 45.4
(0.7) 		56.2
(2.7) 		26.6
(-3) 		32.3
(-1.9) 		44.9
(0.6) 		57.5
(3) 		31
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189089_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3760
Sequence Type Exemplar sequence
Representative Public ID ZK1307.6 NCBI
Target Description ZK1307.6 /REP_DB=WormBase Gene ID /WP=CE01695 /TR=Q09649 /GB=CAA87433.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=CDC20 protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063674(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063674 NCBI Caenorhabditis elegans FiZzy Related family member (fzr-1) (fzr-1) mRNA, complete cds. 11/11 None
SNAP00000021422 ENSEMBL cdna:SNAP chromosome:CEL140:II:9640906:9644335:-1 11/11 None
GENEFINDER00000021437 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9640906:9644335:-1 11/11 None
ZK1307.6 ENSEMBL cdna:known chromosome:CEL140:II:9640078:9644377:-1 gene:ZK1307.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9640902-9644332(-) 96.35 100.0
Public Domain and Genome References
Gene Title CDC20 protein
Gene Symbol fzr-1
Ensembl ZK1307.6
Entrez Gene 174516 Entrez gene
SwissProt Q09649 EMBL-EBI
WormBase CE01695 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:18138_AT WD-40 repeat family protein at
ATH1-121501:254871_AT WD-40 repeat family protein at
CANINE_2:CFAAFFX.29327.1.S1_AT similar to Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) cfa
DROSOPHILA_2:1629844_S_AT retina aberrant in pattern dm
DROSGENOME1:142823_AT retina aberrant in pattern dm
CHICKEN:GGA.913.1.S1_AT fizzy/cell division cycle 20 related 1 (Drosophila) gga
CHICKEN:GGA.913.1.S1_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) gga
CHICKEN:GGA.914.1.S1_A_AT fizzy/cell division cycle 20 related 1 (Drosophila) gga
HG-U95AV2:41623_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133_PLUS_2:211865_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A:211865_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A_2:211865_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95AV2:41624_R_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HU35KSUBA:RC_AA059386_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HU35KSUBD:RC_AA621026_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A:209416_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133_PLUS_2:209416_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A_2:209416_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:G6463684_3P_A_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:G5813826_3P_X_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:G5813826_3P_A_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:HS.268384.0.S4_3P_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:HS.268384.0.S3_3P_X_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:HS.268384.0.S3_3P_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:209416_3P_S_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A_2:209414_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133_PLUS_2:209414_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A:209414_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A_2:209415_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133_PLUS_2:209415_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133A:209415_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95AV2:39855_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95D:77105_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95E:78663_R_AT fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133_PLUS_2:240849_AT Fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U133B:240849_AT Fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95C:64054_AT Fizzy/cell division cycle 20 related 1 (Drosophila) hs
HG-U95C:64274_AT Fizzy/cell division cycle 20 related 1 (Drosophila) hs
U133_X3P:HS.283307.0.A1_3P_AT Fizzy/cell division cycle 20 related 1 (Drosophila) hs
MG-U74BV2:106556_AT fizzy/cell division cycle 20 related 1 (Drosophila) mm
MG-U74CV2:170930_R_AT fizzy/cell division cycle 20 related 1 (Drosophila) mm
MOE430A:1419451_AT fizzy/cell division cycle 20 related 1 (Drosophila) mm
MOUSE430A_2:1419451_AT fizzy/cell division cycle 20 related 1 (Drosophila) mm
MOUSE430_2:1419451_AT fizzy/cell division cycle 20 related 1 (Drosophila) mm
MU19KSUBA:TC22542_AT Fizzy/cell division cycle 20 related 1 (Drosophila), mRNA (cDNA clone MGC:11723 IMAGE:3967009) mm
MU19KSUBB:TC26978_AT Fizzy/cell division cycle 20 related 1 (Drosophila), mRNA (cDNA clone MGC:11723 IMAGE:3967009) mm
MU19KSUBC:TC37767_AT Fizzy/cell division cycle 20 related 1 (Drosophila), mRNA (cDNA clone MGC:11723 IMAGE:3967009) mm
MU19KSUBC:TC37767_G_AT Fizzy/cell division cycle 20 related 1 (Drosophila), mRNA (cDNA clone MGC:11723 IMAGE:3967009) mm
RG-U34B:RC_AI009616_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RG-U34B:RC_AA996835_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAE230A:1375546_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAT230_2:1375546_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAE230B:1381189_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAT230_2:1381189_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAE230B:1382435_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
RAT230_2:1382435_AT fizzy/cell division cycle 20 related 1 (Drosophila) (predicted) rn
YEAST_2:1775069_AT Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of mitotic cyclins resulting in exit from mitosis; targets the APC/C to specific substrates including CDC20, ASE1 and CIN8 Sc
Protein Similarities
Method ID Description E-Value
blast CAA87433 Hypothetical protein ZK1307.6 [Caenorhabditis elegans] ref|NP_496075.1| FiZzy Related family member (fzr-1) [Caenorhabditis elegans] 0.0
blast CAE56991 Hypothetical protein CBG24857 [Caenorhabditis briggsae] 0.0
blast XP_623291 PREDICTED: similar to GA15568-PA [Apis mellifera] 1.0E-140
Protein Domains
Database ID Description E-Value
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.04
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 1.6E-8
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 1.0E-8
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 8.7E-5
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 2.1E-7
Sequence
Target Sequence 
>C. ELEGANS:189089_AT
gtggtcacctgataagcaacttctcgcatccggtggaaatgataatcaattacttgtctg
gaatctgagaagaaacgagccaattcagacatacactcagcacaatgcagctgtgaaagc
gctcgcgtggtcgccacatcatcatggacttcttgtttctggtggaggtactgctgatcg
atgcttgagattctggaatacgttgactgcgcagccgatgcaatgtgttgatactggatc
acaggtttgcaatgtggcatggtcgaagcatagcagcgagctcgtctctacgcacggtta
ttcatttaatcatgtaatcatctggaaatacccaagtcttcagcctgtaaccaagttggt
tgggcatcagtatcgtgtattgtaccttgcaatgtcaccagatggcgaatcgatcgtaac
tggagccggtgatgagactcttcgattctggcac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGGTCACCTGATAAGCAACTTCTC 489 489 1599 Antisense
CAACTTCTCGCATCCGGTGGAAATG 679 187 1615 Antisense
TGGTCGCCACATCATCATGGACTTC 133 553 1726 Antisense
CATGGACTTCTTGTTTCTGGTGGAG 622 209 1741 Antisense
GGAGGTACTGCTGATCGATGCTTGA 198 517 1762 Antisense
TTGACTGCGCAGCCGATGCAATGTG 415 687 1801 Antisense
CGAAGCATAGCAGCGAGCTCGTCTC 168 253 1862 Antisense
TCGTCTCTACGCACGGTTATTCATT 177 605 1880 Antisense
TACCCAAGTCTTCAGCCTGTAACCA 689 617 1927 Antisense
GTACCTTGCAATGTCACCAGATGGC 72 459 1980 Antisense
TGATGAGACTCTTCGATTCTGGCAC 347 567 2028 Antisense
Sequence Source Affymetrix Proprietary Database