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[189080_at] dehydrogenase

Description R02D3.1 /REP_DB=WormBase Gene ID /WP=CE18095 /TR=O44503 /GB=AAB94142.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=dehydrogenase
Cluster 6grp_highest_10_10 > 22      6grp_high1_10_10 > 02      4grp_highest_8_8 > 43      4grp_high_8_8 > 24      6grp_highest_nonorm > 12      6grp_total > 23      4grp_total > 39      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2624
1 2 3 4 range
A 4419.3
(3)
P 		2004.4
(-3)
P 		2242
(-2.4)
P 		2536.7
(-1.7)
P 		2415
B 3889.7
(3)
P 		1795
(-3)
P 		2404.3
(-1.3)
P 		2286.1
(-1.6)
P 		2095
C 3560.4
(3)
P 		1888.1
(-3)
P 		2221.9
(-1.8)
P 		2493.5
(-0.8)
P 		1672
avr 3956.5
(3) 		1895.8
(-3) 		2289.4
(-1.9) 		2438.8
(-1.4) 		2061

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2118
1 2 3 4 5 6 range
A 2869.3
(3)
P 		2236.7
(1.2)
P 		2423.7
(1.7)
P 		1321.4
(-1.5)
P 		814.3
(-3)
P 		874.1
(-2.8)
P 		2055
B 2906.4
(3)
P 		2277.1
(1.2)
P 		2483
(1.8)
P 		1519.6
(-1)
P 		823.9
(-3)
P 		1032.8
(-2.4)
P 		2083
C 2335.4
(2.7)
P 		2414.3
(3)
P 		2288.6
(2.5)
P 		1673.3
(0.3)
P 		788
(-3)
P 		891.4
(-2.6)
P 		1626
avr 2703.7
(3) 		2309.4
(1.8) 		2398.4
(2) 		1504.8
(-0.8) 		808.7
(-3) 		932.8
(-2.6) 		1895
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1238
1 2 3 4 range
A 1609.1
(3)
P 		435.1
(-2.7)
P 		586.1
(-2)
P 		371.3
(-3)
P 		1238
B 1240.4
(3)
P 		443.3
(-3)
P 		557.1
(-2.1)
P 		487.2
(-2.7)
P 		797
C 1178.6
(3)
P 		542.8
(-2)
P 		774.4
(-0.2)
P 		420.4
(-3)
P 		758
avr 1342.7
(3) 		473.7
(-2.7) 		639.2
(-1.6) 		426.3
(-3) 		916

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 799
1 2 3 4 5 6 range
A 528.9
(0.3)
P 		795.5
(3)
P 		527.8
(0.2)
P 		335.1
(-1.7)
P 		245.7
(-2.7)
P 		212.8
(-3)
P 		583
B 1011.3
(3)
P 		758
(0.8)
P 		602.9
(-0.6)
P 		402.5
(-2.4)
P 		334.7
(-3)
P 		385.1
(-2.6)
P 		677
C 865.6
(3)
P 		736.7
(1.7)
P 		582.5
(0.2)
P 		336.5
(-2.2)
P 		255
(-3)
P 		298.4
(-2.6)
P 		611
avr 801.9
(3) 		763.4
(2.6) 		571.1
(0.4) 		358
(-2.1) 		278.5
(-3) 		298.8
(-2.8) 		523
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189080_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10862
Sequence Type Exemplar sequence
Representative Public ID R02D3.1 NCBI
Target Description R02D3.1 /REP_DB=WormBase Gene ID /WP=CE18095 /TR=O44503 /GB=AAB94142.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067483(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067483 NCBI Caenorhabditis elegans R02D3.1 (dehydrogenase) mRNA, complete cds. 11/11 None
SNAP00000011017 ENSEMBL cdna:SNAP chromosome:CEL140:IV:245197:251718:1 11/11 None
GENEFINDER00000011028 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:245197:251718:1 11/11 None
R02D3.1 ENSEMBL cdna:known chromosome:CEL140:IV:245121:251924:1 gene:R02D3.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:245196-251718(+) 100.0 100.0
Public Domain and Genome References
Gene Title dehydrogenase
Ensembl R02D3.1
Entrez Gene 176842 Entrez gene
SwissProt O44503 EMBL-EBI
WormBase CE18095 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605044_AT similar to aminoadipate-semialdehyde synthase cfa
CANINE_2:CFA.2391.1.S1_AT similar to aminoadipate-semialdehyde synthase cfa
CANINE_2:CFAAFFX.6230.1.S1_AT similar to aminoadipate-semialdehyde synthase cfa
CANINE_2:CFAAFFX.6232.1.S1_S_AT similar to aminoadipate-semialdehyde synthase cfa
DROSOPHILA_2:1623787_AT dm
DROSGENOME1:141497_AT dm
CHICKEN:GGAAFFX.5645.1.S1_AT similar to aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase gga
CHICKEN:GGAAFFX.5645.2.S1_AT similar to aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase gga
CHICKEN:GGAAFFX.5645.2.S1_S_AT similar to aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase gga
HG-U133_PLUS_2:210852_S_AT aminoadipate-semialdehyde synthase hs
HG-U133A:210852_S_AT aminoadipate-semialdehyde synthase hs
HG-FOCUS:210852_S_AT aminoadipate-semialdehyde synthase hs
HG-U133A_2:210852_S_AT aminoadipate-semialdehyde synthase hs
U133_X3P:G7264723_3P_S_AT aminoadipate-semialdehyde synthase hs
U133_X3P:HS.323091.0.S1_3P_AT aminoadipate-semialdehyde synthase hs
HG-U133A_2:214829_AT aminoadipate-semialdehyde synthase hs
HG-U133_PLUS_2:214829_AT aminoadipate-semialdehyde synthase hs
HG-U133A:214829_AT aminoadipate-semialdehyde synthase hs
HG-U95AV2:35870_AT aminoadipate-semialdehyde synthase hs
HG-U95E:91550_R_AT aminoadipate-semialdehyde synthase hs
HG-U95E:85798_AT Aminoadipate-semialdehyde synthase hs
HU35KSUBC:RC_W20467_F_AT Aminoadipate-semialdehyde synthase hs
MG-U74AV2:103389_AT aminoadipate-semialdehyde synthase mm
MOE430A:1423523_AT aminoadipate-semialdehyde synthase mm
MOUSE430A_2:1423523_AT aminoadipate-semialdehyde synthase mm
MOUSE430_2:1423523_AT aminoadipate-semialdehyde synthase mm
MOE430B:1445042_AT Aminoadipate-semialdehyde synthase, mRNA (cDNA clone MGC:5717 IMAGE:3600654) mm
MOUSE430_2:1445042_AT Aminoadipate-semialdehyde synthase, mRNA (cDNA clone MGC:5717 IMAGE:3600654) mm
MU19KSUBB:TC31046_AT Aminoadipate-semialdehyde synthase, mRNA (cDNA clone MGC:5717 IMAGE:3600654) mm
RG-U34B:RC_AA944898_AT aminoadipate-semialdehyde synthase (predicted) rn
RAE230A:1377375_AT aminoadipate-semialdehyde synthase (predicted) rn
RAT230_2:1377375_AT aminoadipate-semialdehyde synthase (predicted) rn
YEAST_2:1772003_AT Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB94142 Hypothetical protein R02D3.1 [Caenorhabditis elegans] ref|NP_499884.1| R02D3.1 [Caenorhabditis elegans] 0.0
blast CAE67946 Hypothetical protein CBG13546 [Caenorhabditis briggsae] 0.0
blast EAA10176 ENSANGP00000013147 [Anopheles gambiae str. PEST] ref|XP_314728.2| ENSANGP00000013147 [Anopheles gambiae str. PEST] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR007698 EMBL-EBI Alanine dehydrogenase/PNT, C-terminal 1.5E-69
Pfam IPR005097 EMBL-EBI Saccharopine dehydrogenase 1.0E-126
Pfam IPR007886 EMBL-EBI Alanine dehydrogenase/PNT, N-terminal 2.4E-51
Pfam IPR007698 EMBL-EBI Alanine dehydrogenase/PNT, C-terminal 1.5E-69
Pfam IPR005097 EMBL-EBI Saccharopine dehydrogenase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:189080_AT
tactgttaaggcccttcactctgttggacttctctctggcgacaacattgattcatttac
atctaacattggaccagatttgacatggaaagaattgattgcctcattgagtaaccagaa
gctcgatatcttcccagactctttgagacacattattgaggagaaagttggtggaaaggg
cttatctgcgcttgaaaatcttggcttgttctctgacaaggttgtagatcgtcacggaac
tccgatcgatactcttgctcagtatttggcaaagattcttgctttcaaggatcatgaatc
ggatttggttgtgttgaatcatgatattggtgctcagttgccaggtggaaactctgaacg
tcatcgtatcagtttggttcaatacggcaatccaaatggtttctccgctatggctcgtac
tgttggttacacaactgccatcgtctcacacatggttctaaacaatgaaattcaaagagc
aggaattcaacgaccaattctgaaggaagtctaccgtccagcattgaagcgtcttcgtga
ctttggaatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACTGTTAAGGCCCTTCACTCTGTT 48 647 2238 Antisense
ACTTCTCTCTGGCGACAACATTGAT 553 103 2265 Antisense
GATATCTTCCCAGACTCTTTGAGAC 24 427 2362 Antisense
GTGGAAAGGGCTTATCTGCGCTTGA 462 491 2408 Antisense
GAAAATCTTGGCTTGTTCTCTGACA 523 353 2431 Antisense
CACGGAACTCCGATCGATACTCTTG 121 199 2470 Antisense
ATTGGTGCTCAGTTGCCAGGTGGAA 706 1 2563 Antisense
CGCTATGGCTCGTACTGTTGGTTAC 375 253 2643 Antisense
TGCCATCGTCTCACACATGGTTCTA 404 585 2673 Antisense
TACCGTCCAGCATTGAAGCGTCTTC 61 649 2749 Antisense
GAAGCGTCTTCGTGACTTTGGAATT 567 335 2763 Antisense
Sequence Source Affymetrix Proprietary Database