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[189037_at] p-glycoprotein

Description T21E8.3 /REP_DB=WormBase Gene ID /WP=CE06485 /TR=Q17646 /GB=CAA94203.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein
Cluster 6grp_total > 07      4grp_total > 37      6grp_cgc > 10      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 69.8
(3)
P 		51.7
(-0.3)
A 		37
(-3)
A 		55.3
(0.3)
A 		33
B 53.8
(1.9)
A 		45.7
(0.6)
A 		22.8
(-3)
A 		60.5
(3)
A 		38
C 51.4
(-0.3)
A 		74.2
(3)
A 		61.1
(1.1)
A 		32.9
(-3)
A 		41
avr 58.3
(3) 		57.2
(2.6) 		40.3
(-3) 		49.6
(0.1) 		18

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 128
1 2 3 4 5 6 range
A 136.4
(3)
M 		66
(-0.4)
A 		51.1
(-1.2)
P 		81.4
(0.3)
A 		43.3
(-1.5)
A 		13.1
(-3)
A 		123
B 100.2
(3)
M 		46.1
(-0.6)
A 		71.3
(1.1)
A 		44.2
(-0.7)
A 		29.7
(-1.6)
A 		8.8
(-3)
A 		91
C 92.6
(3)
P 		47.1
(-0.6)
A 		77.6
(1.8)
A 		16.6
(-3)
A 		39.3
(-1.2)
A 		41.9
(-1)
M 		76
avr 109.7
(3) 		53.1
(-0.8) 		66.7
(0.1) 		47.4
(-1.2) 		37.4
(-1.9) 		21.3
(-3) 		88
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 20
1 2 3 4 range
A 25.4
(3)
P 		11.2
(-1.9)
A 		9.7
(-2.4)
A 		8.1
(-3)
A 		17
B 17.2
(3)
A 		11.3
(0)
A 		5.3
(-3)
A 		12.9
(0.8)
A 		12
C 17
(1.4)
A 		21.3
(3)
A 		21.3
(3)
A 		5.5
(-3)
A 		16
avr 19.9
(3) 		14.6
(0.1) 		12.1
(-1.2) 		8.8
(-3) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 32
1 2 3 4 5 6 range
A 25.1
(3)
M 		23.5
(2.6)
A 		11.1
(-0.8)
P 		20.6
(1.8)
A 		13.1
(-0.3)
A 		3.2
(-3)
A 		22
B 34.8
(3)
M 		15.4
(-0.7)
A 		17.3
(-0.3)
A 		11.7
(-1.4)
A 		12.1
(-1.3)
A 		3.3
(-3)
A 		32
C 34.3
(3)
P 		14.4
(-0.9)
A 		19.7
(0.2)
A 		3.3
(-3)
A 		12.7
(-1.2)
A 		14
(-0.9)
M 		31
avr 31.4
(3) 		17.8
(-0.3) 		16
(-0.8) 		11.9
(-1.8) 		12.6
(-1.6) 		6.8
(-3) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 189037_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16445
Sequence Type Exemplar sequence
Representative Public ID T21E8.3 NCBI
Target Description T21E8.3 /REP_DB=WormBase Gene ID /WP=CE06485 /TR=Q17646 /GB=CAA94203.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=p-glycoprotein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077410(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077410 NCBI Caenorhabditis elegans T21E8.3 (p-glycoprotein) mRNA, complete cds. 11/11 None
T21E8.3 ENSEMBL cdna:known chromosome:CEL140:X:10859274:10864345:-1 gene:T21E8.3 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000028870 1/11 Cross Hyb Matching Probes None
GENEFINDER00000028881 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10859432-10864327(-) 100.0 100.0
Public Domain and Genome References
Gene Title p-glycoprotein
Gene Symbol pgp-8
Ensembl T21E8.3
Entrez Gene 181277 Entrez gene
SwissProt Q17646 EMBL-EBI
WormBase CE31624 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94221 Hypothetical protein T21E8.3 [Caenorhabditis elegans] emb|CAA94203.2| Hypothetical protein T21E8.3 [Caenorhabditis elegans] ref|NP_509811.2| T21E8.3 [Caenorhabditis elegans] 0.0
blast CAE70808 Hypothetical protein CBG17570 [Caenorhabditis briggsae] 0.0
blast CAA94219 Hypothetical protein T21E8.2 [Caenorhabditis elegans] ref|NP_509812.2| T21E8.2 [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 9.0E-23
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 5.6E-31
Pfam IPR003439 EMBL-EBI ABC transporter 3.6E-69
Pfam IPR003439 EMBL-EBI ABC transporter 7.6E-56
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509811.2 9 38-60,99-121,175-194,198-220,285-307,322-344,681-703,723-745,801-823
T21E8.3 9 38-60,99-121,175-194,198-220,285-307,322-344,681-703,723-745,801-823
Sequence
Target Sequence 
>C. ELEGANS:189037_AT
aatctacaataatttctctcctcgaaatgttttatcgtgccgatcaaggatttattaaaa
ttgacaacgacaatgtggaaaatatcaatttggatcacttacgatcaaatctgggactgg
tatcacaaggaccagtattattcaattgttcaattagagacaacattttgtacgggctca
caagaaacatatcgcaaacagaaatagaaaacgcgttgcaaatcgcaaatgcttttaatt
ttgtgtttcagttgccgcaggggttagatactattgttggggaccgaggcgctcagctgt
ctggtggtcaaaagcaaagaattgccataaccagagcaattcttcggaacccaaaactgc
tgcttctagatgaagcgacaagtgctctggataccgaaagtgagaaaatagtacaaaatg
cactggacacagcaagcgagcgcttatctaccatagttgtggctcatcggttatctacta
ttatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AATCTACAATAATTTCTCTCCTCGA 141 171 3125 Antisense
AATCTGGGACTGGTATCACAAGGAC 500 169 3232 Antisense
GAGACAACATTTTGTACGGGCTCAC 409 393 3281 Antisense
AATTTTGTGTTTCAGTTGCCGCAGG 326 173 3361 Antisense
TACTATTGTTGGGGACCGAGGCGCT 315 645 3393 Antisense
CGCTCAGCTGTCTGGTGGTCAAAAG 554 253 3414 Antisense
ACCAGAGCAATTCTTCGGAACCCAA 674 37 3454 Antisense
GAACCCAAAACTGCTGCTTCTAGAT 231 347 3471 Antisense
GCACTGGACACAGCAAGCGAGCGCT 92 315 3544 Antisense
CGAGCGCTTATCTACCATAGTTGTG 341 249 3561 Antisense
GGCTCATCGGTTATCTACTATTATC 348 539 3585 Antisense
Sequence Source Affymetrix Proprietary Database