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[189029_s_at] Prohibitin

Description T24H7.1 /REP_DB=WormBase Gene ID /WP=CE02883 /TR=SW:P50093 /GB=AAA68353.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Prohibitin
Cluster 6grp_highest_10_10 > 12      6grp_high1_10_10 > 20      4grp_highest_8_8 > 17      4grp_high_8_8 > 61      6grp_highest_nonorm > 26      6grp_total > 40      4grp_total > 59      6grp_cgc > 71      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S2      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 6623
1 2 3 4 range
A 7265.4
(0.6)
P 		8651.6
(2)
P 		9708
(3)
P 		3627.1
(-3)
P 		6081
B 7415.9
(0.6)
P 		8456.5
(1.7)
P 		9721
(3)
P 		3952.7
(-3)
P 		5768
C 7225.5
(0.8)
P 		8627.2
(2)
P 		9678.6
(3)
P 		3097.9
(-3)
P 		6581
avr 7302.3
(0.7) 		8578.4
(1.9) 		9702.5
(3) 		3559.2
(-3) 		6143

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2600
1 2 3 4 5 6 range
A 7021.9
(3)
P 		6366.5
(1.5)
P 		6362.7
(1.5)
P 		6323.6
(1.4)
P 		4696.2
(-2.4)
P 		4421.8
(-3)
P 		2600
B 6398.6
(2)
P 		6791.3
(3)
P 		6564.9
(2.4)
P 		5902.3
(0.6)
P 		4530.4
(-3)
P 		4732
(-2.5)
P 		2261
C 5875.7
(0.6)
P 		6466.5
(2.2)
P 		6481.2
(2.2)
P 		6779.1
(3)
P 		4496.7
(-3)
P 		4854.1
(-2.1)
P 		2282
avr 6432.1
(2.7) 		6541.4
(3) 		6469.6
(2.8) 		6335
(2.4) 		4574.4
(-3) 		4669.3
(-2.7) 		1967
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2851
1 2 3 4 range
A 2645.3
(3)
P 		1878
(0.8)
P 		2537.9
(2.7)
P 		530.9
(-3)
P 		2114
B 2364.9
(3)
P 		2088.6
(1.9)
P 		2252.6
(2.6)
P 		842.3
(-3)
P 		1523
C 2391.9
(0.9)
P 		2480.4
(1.1)
P 		3373.3
(3)
P 		522.3
(-3)
P 		2851
avr 2467.4
(2.3) 		2149
(1.4) 		2721.3
(3) 		631.8
(-3) 		2090

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1188
1 2 3 4 5 6 range
A 1294.4
(-1.9)
P 		2264.2
(3)
P 		1385.7
(-1.4)
P 		1603.8
(-0.3)
P 		1417.1
(-1.3)
P 		1076.6
(-3)
P 		1188
B 2226.4
(2.7)
P 		2260.5
(3)
P 		1594.2
(-2.7)
P 		1563.3
(-3)
P 		1840.6
(-0.6)
P 		1764.5
(-1.3)
P 		697
C 2177.9
(3)
P 		1973.1
(1.5)
P 		1649.6
(-0.9)
P 		1363.3
(-3)
P 		1455.1
(-2.3)
P 		1624.9
(-1.1)
P 		815
avr 1899.6
(0.6) 		2165.9
(3) 		1543.2
(-2.5) 		1510.1
(-2.8) 		1570.9
(-2.3) 		1488.7
(-3) 		677
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 189029_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5462
Sequence Type Exemplar sequence
Representative Public ID T24H7.1 NCBI
Target Description T24H7.1 /REP_DB=WormBase Gene ID /WP=CE02883 /TR=SW:P50093 /GB=AAA68353.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Prohibitin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062849(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062849 NCBI Caenorhabditis elegans T24H7.1 (Prohibitin) mRNA, complete cds. 11/11 None
SNAP00000031002 ENSEMBL cdna:SNAP chromosome:CEL140:II:6251364:6252484:1 11/11 None
GENEFINDER00000031008 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:6251364:6252484:1 11/11 None
T24H7.1 ENSEMBL cdna:known chromosome:CEL140:II:6251353:6252798:1 gene:T24H7.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:6251384-6252481(+) 100.0 100.0
Public Domain and Genome References
Gene Title Prohibitin
Gene Symbol phb-2
Ensembl T24H7.1
Entrez Gene 174034 Entrez gene
SwissProt P50093 EMBL-EBI
WormBase CE02883 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:265037_AT prohibitin, putative at
ATGENOME1:15655_S_AT prohibitin, putative at
CANINE_2:CFAAFFX.22298.1.S1_S_AT similar to B-cell receptor-associated protein 37 cfa
DROSOPHILA_2:1637342_S_AT dm
DROSGENOME1:155162_AT dm
HG-FOCUS:201600_AT prohibitin 2 hs
HG-U133A_2:201600_AT prohibitin 2 hs
HG-U133A:201600_AT prohibitin 2 hs
HG-U133_PLUS_2:201600_AT prohibitin 2 hs
HG-U95AV2:37364_AT prohibitin 2 hs
HUGENEFL:U72511_AT prohibitin 2 hs
U133_X3P:G6005853_3P_AT prohibitin 2 hs
HUGENEFL:U72512_AT Prohibitin 2 hs
HG-U133_PLUS_2:237430_AT Prohibitin 2 hs
HG-U133B:237430_AT Prohibitin 2 hs
HG-U95E:86493_AT Prohibitin 2 hs
U133_X3P:HS.200182.0.A1_3P_AT Prohibitin 2 hs
MOE430A:1416202_AT prohibitin 2 mm
MOUSE430_2:1416202_AT prohibitin 2 mm
MOUSE430A_2:1416202_AT prohibitin 2 mm
MOUSE430_2:1438938_X_AT prohibitin 2 mm
MOE430A:1438938_X_AT prohibitin 2 mm
MOUSE430A_2:1438938_X_AT prohibitin 2 mm
MOUSE430A_2:1455713_X_AT prohibitin 2 mm
MOE430A:1455713_X_AT prohibitin 2 mm
MOUSE430_2:1455713_X_AT prohibitin 2 mm
MU11KSUBA:AC002397_GENEBAP_F_AT prohibitin 2 mm
MU11KSUBB:MSA.2170.0_F_AT prohibitin 2 mm
MG-U74AV2:98545_AT prohibitin 2 mm
MOE430B:1460035_AT prohibitin 2 mm
MOUSE430_2:1460035_AT prohibitin 2 mm
MG-U74BV2:105857_AT Prohibitin 2 (Phb2), mRNA mm
MU19KSUBB:TC34951_AT Prohibitin 2 (Phb2), mRNA mm
MU19KSUBC:TC39363_F_AT Prohibitin 2 (Phb2), mRNA mm
MU19KSUBC:TC39364_AT Prohibitin 2 (Phb2), mRNA mm
MU19KSUBC:TC39365_AT Prohibitin 2 (Phb2), mRNA mm
RAT230_2:1367463_AT B-cell receptor-associated protein 37 rn
RAE230A:1367463_AT B-cell receptor-associated protein 37 rn
RAE230B:1367463_AT B-cell receptor-associated protein 37 rn
RG-U34A:U75392_S_AT B-cell receptor-associated protein 37 rn
RG-U34C:RC_AI235510_AT B-cell receptor-associated protein 37 rn
YEAST_2:1779475_AT Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation Sc
Protein Similarities
Method ID Description E-Value
blast CAE59273 Hypothetical protein CBG02605 [Caenorhabditis briggsae] 1.0E-136
blast AAA68353 Mitochondrial prohibitin complex protein 2 [Caenorhabditis elegans] ref|NP_495250.1| T24H7.1 [Caenorhabditis elegans] sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2) 1.0E-135
blast CAE59273 Hypothetical protein CBG02605 [Caenorhabditis briggsae] 1.0E-131
blast AAL29056 LD46344p [Drosophila melanogaster] 4.0E-90
Protein Domains
Database ID Description E-Value
Pfam IPR001107 EMBL-EBI Band 7 protein 6.6E-62
Pfam IPR001107 EMBL-EBI Band 7 protein 6.6E-62
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495250.1 1 12-34
T24H7.1 1 12-34
SNAP00000031002 1 20-42
GENEFINDER00000031008 1 20-42
Sequence
Target Sequence 
>C. ELEGANS:189029_S_AT
ggtcaacattggactccgtgttctctctcgaccaaatcctgaacatctcgttcatatcta
cagaactctcggacaaaactgggaagagcgtgttcttccatcgatttgcaatgaagttct
taaaggagttgtcgccaaattcaatgcttcacaacttatcactcaacgccaacaggtttc
tatgttggttcgcaaaacattgatcgagcgggctcttgacttcaacattatcctcgatga
tgtttccctcaccgagctcgctttctctccacaatactctgcagctgtggaagctaagca
agttgccgcacaggaagcacaaagagcaaccttctatgttgaacgtgctaagcaacagaa
gcaagagaagatcgttcaagctgaaggagaagctgagtctgcaaaacttttgggagaggc
catgaagaacgatccaggatttttgaagcttagaaaaatccgtgctgctcaaaaaattgc
tcgtatcgtgtctgagtctggaaacaagacttatctcccaacaggaggattgatgttgaa
tattgccgacaccgac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGTCAACATTGGACTCCGTGTTCTC 662 503 288 Antisense
GTTCTCTCTCGACCAAATCCTGAAC 490 443 307 Antisense
GTTGTCGCCAAATTCAATGCTTCAC 532 437 415 Antisense
CAATGCTTCACAACTTATCACTCAA 92 183 429 Antisense
CACTCAACGCCAACAGGTTTCTATG 670 195 447 Antisense
GATCGAGCGGGCTCTTGACTTCAAC 706 415 489 Antisense
CATTATCCTCGATGATGTTTCCCTC 682 215 513 Antisense
CTCTCCACAATACTCTGCAGCTGTG 233 231 552 Antisense
ATTGCTCGTATCGTGTCTGAGTCTG 181 7 763 Antisense
GAAACAAGACTTATCTCCCAACAGG 483 355 788 Antisense
GATGTTGAATATTGCCGACACCGAC 46 409 819 Antisense
Sequence Source Affymetrix Proprietary Database