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[188912_s_at] RAS protein

Description R07G3.1 /REP_DB=WormBase Gene ID /WP=CE02020 /GEN=cdc-42 /GB=AAK31543.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=RAS protein
Cluster 6grp_highest_10_10 > 50      6grp_high1_10_10 > 16      4grp_highest_8_8 > 41      4grp_high_8_8 > 49      6grp_highest_nonorm > 40      6grp_total > 06      4grp_total > 62      6grp_highest_sub > De      6grp_cgc > 21      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 503
1 2 3 4 range
A 851.2
(3)
P 		602.9
(-0.5)
P 		629.3
(-0.1)
P 		428.2
(-3)
P 		423
B 901.4
(3)
P 		673.1
(-1)
P 		647.4
(-1.4)
P 		556.9
(-3)
P 		345
C 931.2
(3)
P 		762.8
(0.6)
P 		799
(1.1)
P 		518.1
(-3)
P 		413
avr 894.6
(3) 		679.6
(-0.3) 		691.9
(-0.1) 		501.1
(-3) 		394

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 775
1 2 3 4 5 6 range
A 677.1
(0.4)
P 		825.7
(3)
P 		511.7
(-2.4)
P 		477.8
(-3)
P 		498.8
(-2.6)
P 		550.3
(-1.7)
P 		348
B 728.5
(3)
P 		663.4
(1.5)
P 		723.8
(2.9)
P 		555.5
(-0.9)
P 		512
(-1.8)
P 		459.2
(-3)
P 		269
C 1233.7
(3)
P 		687.9
(-1.5)
P 		682.7
(-1.5)
P 		524.6
(-2.8)
P 		499.4
(-3)
P 		548.7
(-2.6)
P 		734
avr 879.8
(3) 		725.7
(0.5) 		639.4
(-0.8) 		519.3
(-2.7) 		503.4
(-3) 		519.4
(-2.7) 		376
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 247
1 2 3 4 range
A 309.9
(3)
P 		130.9
(-1.3)
P 		164.5
(-0.5)
P 		62.7
(-3)
P 		247
B 287.4
(3)
P 		166.2
(-1.3)
P 		150
(-1.9)
P 		118.7
(-3)
P 		169
C 308.3
(3)
P 		219.3
(0.6)
P 		278.5
(2.2)
P 		87.4
(-3)
P 		221
avr 301.9
(3) 		172.1
(-0.7) 		197.7
(0.1) 		89.6
(-3) 		212

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 352
1 2 3 4 5 6 range
A 124.8
(-2.6)
P 		293.7
(3)
P 		111.4
(-3)
P 		121.2
(-2.7)
P 		150.5
(-1.7)
P 		134
(-2.3)
P 		182
B 253.5
(3)
P 		220.8
(1.2)
P 		175.7
(-1.4)
P 		147.1
(-3)
P 		208
(0.4)
P 		171.2
(-1.6)
P 		106
C 457.3
(3)
P 		209.9
(-1.2)
P 		173.7
(-1.8)
P 		105.5
(-3)
P 		161.6
(-2)
P 		183.7
(-1.7)
P 		352
avr 278.5
(3) 		241.5
(1.6) 		153.6
(-1.9) 		124.6
(-3) 		173.4
(-1.1) 		163
(-1.5) 		154
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 188912_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5334
Sequence Type Exemplar sequence
Representative Public ID R07G3.1 NCBI
Target Description R07G3.1 /REP_DB=WormBase Gene ID /WP=CE02020 /GEN=cdc-42 /GB=AAK31543.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=RAS protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq,GenBank identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063197(11), L10078(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063197 NCBI Caenorhabditis elegans Cell Division Cycle related family member (cdc-42) (cdc-42) mRNA, complete cds. 11/11 None
L10078 NCBI Caenorhabditis elegans guanine nucleotide regulatory protein (CDC42) mRNA, complete cds. 11/11 None
SNAP00000041809 ENSEMBL cdna:SNAP chromosome:CEL140:II:7616379:7617403:1 11/11 None
GENEFINDER00000041814 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7616379:7617403:1 11/11 None
R07G3.1 ENSEMBL cdna:known chromosome:CEL140:II:7616374:7618152:1 gene:R07G3.1 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7616375-7617400(+) 100.0 100.0
Public Domain and Genome References
Gene Title RAS protein
Gene Symbol cdc-42
Ensembl R07G3.1
Entrez Gene 174233 Entrez gene
SwissProt Q05062 EMBL-EBI
WormBase CE02020 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15592_S_AT Rac-like GTP-binding protein (ARAC1) (ATGP2) at
ATH1-121501:264593_AT Rac-like GTP-binding protein (ARAC1) (ATGP2) at
CANINE_2:CFA.15509.2.S1_AT cell division cycle 42 (GTP binding protein, 25kDa) cfa
CANINE_2:CFAAFFX.12195.1.S1_S_AT cell division cycle 42 (GTP binding protein, 25kDa) cfa
CANINE_2:CFAAFFX.8605.1.S1_AT cell division cycle 42 (GTP binding protein, 25kDa) cfa
CANINE:1586305_AT CDC42 GTP-binding protein cfa
DROSOPHILA_2:1633543_S_AT Cdc42 dm
DROSGENOME1:143599_AT Cdc42 dm
CHICKEN:GGA.4438.1.S1_AT cell division cycle 42 (GTP binding protein, 25kDa) gga
HG-U133_PLUS_2:208728_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A_2:208728_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A:208728_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-FOCUS:208728_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133_PLUS_2:210232_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A:210232_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A_2:210232_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133_PLUS_2:208727_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A_2:208727_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A:208727_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U95AV2:39736_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HU35KSUBD:RC_T65061_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HU35KSUBD:RC_H18237_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:G182856_3P_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:G13277547_3P_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:G13277547_3P_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:G12803746_3P_A_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:HS.146409.3.S1_3P_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:208728_3P_S_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A_2:214230_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133_PLUS_2:214230_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133A:214230_AT cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:HS2.384596.1.S1_3P_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133_PLUS_2:1556931_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133_PLUS_2:226400_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
HG-U133B:226400_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
HU35KSUBA:AA031548_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
U133_X3P:HS.146409.2.S1_3P_AT Cell division cycle 42 (GTP binding protein, 25kDa) hs
MOE430A:1435807_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430A_2:1435807_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430_2:1435807_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBA:C79507_RC_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBA:U37720_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.1718.0_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.15668.0_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.4416.0_S_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.13929.0_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.27774.0_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.24833.0_S_AT cell division cycle 42 homolog (S. cerevisiae) mm
MU11KSUBB:MSA.20163.0_F_AT cell division cycle 42 homolog (S. cerevisiae) mm
MG-U74AV2:94105_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOE430A:1449574_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430A_2:1449574_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430_2:1449574_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOE430A:1460708_S_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430A_2:1460708_S_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430_2:1460708_S_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOE430A:1415724_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOE430B:1415724_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430A_2:1415724_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MOUSE430_2:1415724_A_AT cell division cycle 42 homolog (S. cerevisiae) mm
MG-U74BV2:116676_AT Cell division cycle 42 homolog (S. cerevisiae) (Cdc42), mRNA mm
MU19KSUBB:TC30325_AT Cell division cycle 42 homolog (S. cerevisiae) (Cdc42), mRNA mm
MU19KSUBC:TC35969_F_AT Cell division cycle 42 homolog (S. cerevisiae) (Cdc42), mRNA mm
RT-U34:RC_AA925473_AT cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34A:RC_AA925473_AT cell division cycle 42 homolog (S. cerevisiae) rn
RT-U34:RC_AI227887_AT cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34A:RC_AI227887_AT cell division cycle 42 homolog (S. cerevisiae) rn
RT-U34:RC_AA925473_G_AT cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34A:RC_AA925473_G_AT cell division cycle 42 homolog (S. cerevisiae) rn
RT-U34:RC_AI227887_G_AT cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34A:RC_AI227887_G_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAE230A:1370825_A_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAT230_2:1370825_A_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAE230A:1367475_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAE230B:1367475_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAT230_2:1367475_AT cell division cycle 42 homolog (S. cerevisiae) rn
RAE230B:1391127_AT Cell division cycle 42 homolog (S. cerevisiae) rn
RAT230_2:1391127_AT Cell division cycle 42 homolog (S. cerevisiae) rn
RT-U34:RC_AI176308_AT Cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34A:RC_AI176308_AT Cell division cycle 42 homolog (S. cerevisiae) rn
RG-U34C:RC_AI227676_AT Cell division cycle 42 homolog (S. cerevisiae) rn
YEAST_2:1775432_AT Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7264 small GTPase mediated signal transduction inferred from electronic annotation QuickGO AmiGO
15031 protein transport inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
3924 GTPase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK31543 Cell division cycle related protein 42 [Caenorhabditis elegans] ref|NP_495598.1| Cell Division Cycle related family member (cdc-42) [Caenorhabditis elegans] sp|Q05062|CDC42_CAEEL Cell division control protein 42 homolog (CDC42CE) pir||T16707 hypothetical protein R07G3.1 - Caenorhabditis elegans 1.0E-107
blast CAE67503 Hypothetical protein CBG13013 [Caenorhabditis briggsae] 1.0E-106
blast AAA51433 guanine nucleotide regulatory protein 1.0E-105
Protein Domains
Database ID Description E-Value
Pfam IPR001806 EMBL-EBI Ras GTPase superfamily 1.2E-90
Pfam IPR001806 EMBL-EBI Ras GTPase superfamily 1.2E-90
Sequence
Target Sequence 
>C. ELEGANS:188912_S_AT
gtaaaacttgtctcctgatcagctataccacaaacaagtttccttctgagtatgtgccga
cagtcttcgacaattacgccgtcacagtaatgatcggtggcgagccatacacattaggat
tgtttgatactgctggacaggaagattacgatcgattaaggcctctatcgtatccacaga
ccgacgtgtttcttgtttgcttctccgtggttgctccagcttcattcgagaatgtccgag
aaaaatgggtgcctgaaatttcgcatcattgctcaaagaccccattcttgttagttggta
ctcaagtcgatctcagggatgatccaggaatgctcgagaaactggcaaaaaacaagcaga
aaccagtgtcaacggatgttggagagaagttggcaaaggaattgaaagcagtgaaatacg
ttgaatgctcagcgttgacgcagaagggactgaaaaatgtattcgacgaagccattctgg
ccgct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTAAAACTTGTCTCCTGATCAGCTA 182 461 56 Antisense
AGTTTCCTTCTGAGTATGTGCCGAC 466 61 92 Antisense
GACAGTCTTCGACAATTACGCCGTC 457 367 114 Antisense
GATTACGATCGATTAAGGCCTCTAT 538 429 199 Antisense
CTCTATCGTATCCACAGACCGACGT 228 229 218 Antisense
AGACCGACGTGTTTCTTGTTTGCTT 380 69 233 Antisense
GGTGCCTGAAATTTCGCATCATTGC 700 501 303 Antisense
GACCCCATTCTTGTTAGTTGGTACT 334 81 333 Antisense
GTTGGTACTCAAGTCGATCTCAGGG 266 437 349 Antisense
CGTTGAATGCTCAGCGTTGACGCAG 647 247 474 Antisense
ATTCGACGAAGCCATTCTGGCCGCT 510 9 516 Antisense
Sequence Source Affymetrix Proprietary Database