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[188900_at] TPR Domain

Description B0464.2 /REP_DB=WormBase Gene ID /WP=CE20456 /TR=SW:Q03560 /GB=CAA79544.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=TPR Domain
Cluster 6grp_highest_10_10 > 75      6grp_high1_10_10 > 56      4grp_highest_8_8 > 44      4grp_high_8_8 > 08      6grp_highest_nonorm > 85      6grp_total > 57      4grp_total > 31      6grp_highest_sub > Cu      6grp_high1_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 386
1 2 3 4 range
A 725.2
(3)
P 		504
(-3)
P 		589.4
(-0.7)
P 		572.6
(-1.1)
P 		221
B 758.1
(3)
P 		436.1
(-3)
P 		538.6
(-1.1)
P 		623.8
(0.5)
P 		322
C 727.8
(3)
P 		371.8
(-3)
P 		524.6
(-0.4)
P 		631.6
(1.4)
P 		356
avr 737
(3) 		437.3
(-3) 		550.9
(-0.7) 		609.3
(0.4) 		300

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 749
1 2 3 4 5 6 range
A 804.5
(3)
P 		571.7
(-1.7)
P 		513.8
(-2.8)
P 		531.9
(-2.5)
P 		505
(-3)
P 		757.3
(2.1)
P 		300
B 819.1
(0.3)
P 		718.8
(-0.6)
P 		641.7
(-1.2)
P 		608.3
(-1.5)
P 		431
(-3)
P 		1144.8
(3)
P 		714
C 594.7
(-1.4)
P 		875
(0.8)
P 		578.1
(-1.6)
P 		559.2
(-1.7)
P 		401.2
(-3)
P 		1150.2
(3)
P 		749
avr 739.4
(0.1) 		721.8
(-0.1) 		577.9
(-1.6) 		566.5
(-1.7) 		445.7
(-3) 		1017.4
(3) 		572
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 180
1 2 3 4 range
A 264
(3)
P 		109.4
(-2.1)
P 		154.1
(-0.7)
P 		83.8
(-3)
P 		180
B 241.7
(3)
P 		107.7
(-3)
P 		124.8
(-2.2)
P 		132.9
(-1.9)
P 		134
C 240.9
(3)
P 		106.9
(-3)
P 		182.8
(0.4)
P 		106.5
(-3)
P 		134
avr 248.9
(3) 		108
(-3) 		153.9
(-1) 		107.7
(-3) 		141

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 315
1 2 3 4 5 6 range
A 148.3
(-0.6)
P 		203.3
(3)
P 		111.9
(-3)
P 		134.9
(-1.5)
P 		152.4
(-0.3)
P 		184.4
(1.8)
P 		91
B 285
(-0.1)
P 		239.3
(-1.2)
P 		155.8
(-3)
P 		161.1
(-2.9)
P 		175.1
(-2.6)
P 		426.9
(3)
P 		271
C 220.4
(-0.6)
P 		267
(0.4)
P 		147.1
(-2.2)
P 		112.4
(-3)
P 		129.8
(-2.6)
P 		385
(3)
P 		273
avr 217.9
(-0.5) 		236.5
(0.1) 		138.3
(-2.9) 		136.1
(-3) 		152.4
(-2.5) 		332.1
(3) 		196
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188900_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7190
Sequence Type Exemplar sequence
Representative Public ID B0464.2 NCBI
Target Description B0464.2 /REP_DB=WormBase Gene ID /WP=CE20456 /TR=SW:Q03560 /GB=CAA79544.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=TPR Domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066689(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066689 NCBI Caenorhabditis elegans B0464.2 (B0464.2) mRNA, complete cds. 11/11 None
SNAP00000014951 ENSEMBL cdna:SNAP chromosome:CEL140:III:9491554:9496767:1 11/11 None
GENEFINDER00000014959 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9491554:9496767:1 11/11 None
B0464.2 ENSEMBL cdna:known chromosome:CEL140:III:9491536:9496942:1 gene:B0464.2 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9491549-9496763(+) 97.71 100.0
Public Domain and Genome References
Gene Title TPR Domain
Ensembl B0464.2
Entrez Gene 176335 Entrez gene
SwissProt Q03560 EMBL-EBI
WormBase CE20456 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:20484_AT phosphoprotein-related at
ATH1-121501:265522_AT phosphoprotein-related at
CANINE:1604110_AT similar to SH2 domain binding protein 1 cfa
CANINE:1604102_AT similar to SH2 domain binding protein 1 cfa
CANINE_2:CFA.18250.1.S1_S_AT similar to SH2 domain binding protein 1 cfa
CANINE_2:CFA.19593.1.S1_S_AT similar to SH2 domain binding protein 1 cfa
CANINE_2:CFA.20126.1.S1_S_AT similar to SH2 domain binding protein 1 cfa
CANINE_2:CFAAFFX.12331.1.S1_S_AT similar to SH2 domain binding protein 1 cfa
DROSOPHILA_2:1626933_S_AT dm
DROSGENOME1:154224_AT dm
CHICKEN:GGA.2157.1.S1_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) gga
CHICKEN:GGAAFFX.26544.1.S1_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) gga
HG-U133_PLUS_2:202060_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
HG-U133A:202060_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
HG-U133A_2:202060_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
HU35KSUBB:RC_AA040367_S_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
HUGENEFL:D63875_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
U133_X3P:G7661949_3P_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
HG-U95AV2:40844_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) hs
MU11KSUBA:L49502_S_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MG-U74AV2:100460_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOE430A:1422679_S_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430A_2:1422679_S_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430_2:1422679_S_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOE430A:1422681_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430A_2:1422681_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430_2:1422681_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOE430A:1422680_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430A_2:1422680_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430_2:1422680_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOE430B:1442240_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOUSE430_2:1442240_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) mm
MOE430A:1448076_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (Sh2bp1), mRNA mm
MOUSE430A_2:1448076_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (Sh2bp1), mRNA mm
MOUSE430_2:1448076_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (Sh2bp1), mRNA mm
MG-U74AV2:95962_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (Sh2bp1), mRNA mm
RG-U34B:RC_AA900688_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RG-U34C:H33842_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAE230A:1389249_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAT230_2:1389249_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAE230B:1385970_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAT230_2:1385970_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAE230A:1390086_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RAT230_2:1390086_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
RG-U34B:RC_AI043763_AT SH2 domain binding protein 1 (tetratricopeptide repeat containing) (predicted) rn
Protein Similarities
Method ID Description E-Value
blast CAA79544 Hypothetical protein B0464.2 [Caenorhabditis elegans] ref|NP_499090.1| B0464.2 [Caenorhabditis elegans] sp|Q03560|YKD1_CAEEL Hypothetical protein B0464.2 in chromosome III 0.0
blast CAE65200 Hypothetical protein CBG10075 [Caenorhabditis briggsae] 0.0
blast XP_396581 PREDICTED: similar to putative TPR-containing phosphoprotein [Apis mellifera] 0.0
blast XP_420968 PREDICTED: similar to SH2 domain binding protein 1; TPR-containing, SH2-binding phosphoprotein [Gallus gallus] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001440 EMBL-EBI TPR repeat 0.0034
Pfam IPR001440 EMBL-EBI TPR repeat 2.5E-7
Pfam IPR001440 EMBL-EBI TPR repeat 9.6E-4
Pfam IPR001440 EMBL-EBI TPR repeat 6.2E-7
Pfam IPR001440 EMBL-EBI TPR repeat 5.7E-7
Pfam IPR001440 EMBL-EBI TPR repeat 0.072
Pfam IPR001440 EMBL-EBI TPR repeat 0.0020
Pfam IPR001440 EMBL-EBI TPR repeat 0.05
Pfam IPR001440 EMBL-EBI TPR repeat 0.0034
Pfam IPR001440 EMBL-EBI TPR repeat 2.5E-7
Pfam IPR001440 EMBL-EBI TPR repeat 9.6E-4
Pfam IPR001440 EMBL-EBI TPR repeat 6.2E-7
Pfam IPR001440 EMBL-EBI TPR repeat 5.7E-7
Pfam IPR001440 EMBL-EBI TPR repeat 0.072
Pfam IPR001440 EMBL-EBI TPR repeat 0.0020
Pfam IPR001440 EMBL-EBI TPR repeat 0.05
Pfam IPR001440 EMBL-EBI TPR repeat 0.0034
Pfam IPR001440 EMBL-EBI TPR repeat 2.5E-7
Pfam IPR001440 EMBL-EBI TPR repeat 9.6E-4
Pfam IPR001440 EMBL-EBI TPR repeat 6.2E-7
Pfam IPR001440 EMBL-EBI TPR repeat 5.7E-7
Pfam IPR001440 EMBL-EBI TPR repeat 0.072
Pfam IPR001440 EMBL-EBI TPR repeat 0.0020
Pfam IPR001440 EMBL-EBI TPR repeat 0.05
Sequence
Target Sequence 
>C. ELEGANS:188900_AT
gatagtggtggacctgattcgaacagaagagatgagaaaaagagaaagaggaaggaagag
agggatcgaaaactacaggagaagctctcagcaaaacaatcagcaaagataaaatctcgt
gcattcttatcttcatcggaatcttctgatgatgacaaaccaaagcctgctgctgattca
tcggatgatgaggttgatccgcggccgccagttgatgagtttgatagtccaacccgaact
gacagtgatagtgatcgtgagacaactacaaaaaagaaaaagaagaaggctgttgtggat
tctgatgaaggatcagtctccggatctggctctggatcggataatgatgataagccaatt
attggaggttctgatgatgatgatgatgataaacctgctggtggaaactcca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATAGTGGTGGACCTGATTCGAACA 164 425 2995 Antisense
AAATCTCGTGCATTCTTATCTTCAT 78 119 3106 Antisense
CTTATCTTCATCGGAATCTTCTGAT 212 223 3120 Antisense
GACAAACCAAAGCCTGCTGCTGATT 661 363 3148 Antisense
GGATGATGAGGTTGATCCGCGGCCG 699 513 3177 Antisense
CGGCCGCCAGTTGATGAGTTTGATA 636 241 3196 Antisense
GATAGTCCAACCCGAACTGACAGTG 219 423 3217 Antisense
AAGGCTGTTGTGGATTCTGATGAAG 570 161 3280 Antisense
TGAAGGATCAGTCTCCGGATCTGGC 493 575 3300 Antisense
TCCGGATCTGGCTCTGGATCGGATA 148 593 3313 Antisense
GATAAACCTGCTGGTGGAAACTCCA 176 423 3382 Antisense
Sequence Source Affymetrix Proprietary Database