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[188885_at] Exonuclease

Description Y17G7B.12 /REP_DB=WormBase Gene ID /WP=CE19046 /TR=Q9XXI3 /GB=CAA19458.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Exonuclease
Cluster 6grp_highest_10_10 > 67      6grp_high1_10_10 > 75      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 82      6grp_total > 76      4grp_total > 58      6grp_highest_sub > In      6grp_total_sub > Increase      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 316
1 2 3 4 range
A 403.7
(-0.5)
P 		523.8
(3)
P 		394.3
(-0.8)
P 		318.1
(-3)
P 		206
B 424.8
(-1)
P 		494.1
(1.2)
P 		551
(3)
P 		360.4
(-3)
P 		191
C 479.1
(-0)
P 		545.2
(1.3)
P 		634.4
(3)
P 		326.6
(-3)
P 		308
avr 435.9
(0.2) 		521
(2.8) 		526.6
(3) 		335
(-3) 		192

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 387
1 2 3 4 5 6 range
A 208.9
(-3)
P 		266.2
(-0.6)
P 		349.5
(3)
P 		306.6
(1.2)
P 		272.2
(-0.3)
P 		346.2
(2.9)
P 		141
B 275.4
(-3)
P 		324.6
(-1.7)
P 		445.1
(1.5)
P 		325.5
(-1.7)
P 		367.3
(-0.6)
P 		503.3
(3)
P 		228
C 292.6
(-2)
P 		337
(-1.2)
P 		230
(-3)
P 		367.3
(-0.7)
P 		309.3
(-1.7)
P 		595.4
(3)
P 		365
avr 259
(-3) 		309.3
(-1.6) 		341.5
(-0.8) 		333.1
(-1) 		316.3
(-1.5) 		481.6
(3) 		223
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 175
1 2 3 4 range
A 147
(3)
P 		113.7
(1)
P 		103.1
(0.4)
P 		46.6
(-3)
P 		100
B 135.5
(3)
P 		122
(1.6)
P 		127.7
(2.2)
P 		76.8
(-3)
P 		59
C 158.6
(0.7)
P 		156.7
(0.7)
P 		221.1
(3)
P 		55.1
(-3)
P 		166
avr 147
(2.8) 		130.8
(1.7) 		150.6
(3) 		59.5
(-3) 		91

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 161
1 2 3 4 5 6 range
A 38.5
(-3)
P 		94.7
(3)
P 		76.1
(1)
P 		77.8
(1.2)
P 		82.1
(1.7)
P 		84.3
(1.9)
P 		56
B 95.8
(-2.4)
P 		108
(-1.7)
P 		108.1
(-1.7)
P 		86.2
(-3)
P 		149.2
(0.7)
P 		187.7
(3)
P 		102
C 108.5
(-0.9)
P 		102.8
(-1.1)
P 		58.5
(-3)
P 		73.9
(-2.3)
P 		100.1
(-1.2)
P 		199.3
(3)
P 		141
avr 80.9
(-2.9) 		101.8
(-1.3) 		80.9
(-2.9) 		79.3
(-3) 		110.5
(-0.6) 		157.1
(3) 		78
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188885_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2882
Sequence Type Exemplar sequence
Representative Public ID Y17G7B.12 NCBI
Target Description Y17G7B.12 /REP_DB=WormBase Gene ID /WP=CE19046 /TR=Q9XXI3 /GB=CAA19458.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Exonuclease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064159(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064159 NCBI Caenorhabditis elegans Y17G7B.12 (Exonuclease) mRNA, complete cds. 11/11 None
SNAP00000030321 ENSEMBL cdna:SNAP chromosome:CEL140:II:12023769:12025745:1 11/11 None
GENEFINDER00000030393 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:12023769:12025745:1 11/11 None
Y17G7B.12 ENSEMBL cdna:known chromosome:CEL140:II:12023764:12025778:1 gene:Y17G7B.12 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:12023765-12025742(+) 100.0 100.0
Public Domain and Genome References
Gene Title Exonuclease
Ensembl Y17G7B.12
Entrez Gene 174842 Entrez gene
SwissProt Q9XXI3 EMBL-EBI
WormBase CE19046 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:257211_AT exonuclease family protein at
CANINE:1605817_AT similar to Probable exonuclease XPMC2 (hPMC2) (Prevents mitotic catastrophe 2 protein homolog) cfa
CANINE_2:CFA.18180.1.S1_AT similar to Probable exonuclease XPMC2 (hPMC2) (Prevents mitotic catastrophe 2 protein homolog) cfa
CANINE_2:CFAAFFX.30234.1.S1_S_AT similar to Probable exonuclease XPMC2 (hPMC2) (Prevents mitotic catastrophe 2 protein homolog) cfa
DROSOPHILA_2:1632262_AT dm
DROSGENOME1:152845_AT dm
CHICKEN:GGA.9458.1.S1_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) gga
CHICKEN:GGA.9458.1.S1_AT similar to XPMC2 prevents mitotic catastrophe 2 homolog; Xenopus prevents mitotic catastrophe 2 homolog gga
HG-FOCUS:218767_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U133_PLUS_2:218767_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U133A:218767_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U133A_2:218767_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HU35KSUBB:RC_N94361_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
U133_X3P:G9966856_3P_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U95B:44802_S_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U95C:60516_I_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U95E:87980_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
HG-U95D:91534_AT REX4, RNA exonuclease 4 homolog (S. cerevisiae) hs
YEAST_2:1773490_AT Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly Sc
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4527 exonuclease activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA19458 Hypothetical protein Y17G7B.12 [Caenorhabditis elegans] ref|NP_496560.1| Y17G7B.12 [Caenorhabditis elegans] 1.0E-128
blast CAE73551 Hypothetical protein CBG21020 [Caenorhabditis briggsae] 1.0E-114
blast AAA82179 XPMC2 protein 7.0E-46
Protein Domains
Database ID Description E-Value
Pfam IPR006055 EMBL-EBI Exonuclease 5.5E-30
Sequence
Target Sequence 
>C. ELEGANS:188885_AT
ggagagctcaggaggctcttgccgccgcttcggaggtcaaacgagttcatcatgatattc
cggtggttattgaagattcagaaagaggagagctgacaaaagtaatcgcaatcgattgtg
aatacgtcggagccggaatgggtggaacaacggatattttggcgagaatttcgattgtca
atgagctcggcaagatcgtgtacgacaaattcgtgaagccaaccgaaaaagtcacggatt
tccgtactgcggtgtctggaattcgcccggaaaatatgataaaagcgattccatttgata
gagcacaaactgaagtttcaaagttgattgatggaagaattgtgattggacatgctgttc
ataatgattttagggttctgaaactgaatcacattcgaaaactgacccgagacactgcga
aatgcacaattctcaagaatatggctaatcatcacggtaccccgtcactgaaaaaactgg
caaaagaagtactgggaattgagattcagcgaggagaacacgattcgatcaccgacgctc
gagtggctcttcgtctctacgaggccgtcaaaaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAGAGCTCAGGAGGCTCTTGCCGC 289 519 215 Antisense
GCCGCTTCGGAGGTCAAACGAGTTC 216 285 238 Antisense
GTTCATCATGATATTCCGGTGGTTA 559 443 259 Antisense
ATTGTGAATACGTCGGAGCCGGAAT 442 3 329 Antisense
GAGCTCGGCAAGATCGTGTACGACA 615 387 397 Antisense
AAGTCACGGATTTCCGTACTGCGGT 542 153 443 Antisense
TACTGCGGTGTCTGGAATTCGCCCG 250 647 459 Antisense
TGACCCGAGACACTGCGAAATGCAC 549 569 617 Antisense
ATATGGCTAATCATCACGGTACCCC 49 21 653 Antisense
AGAACACGATTCGATCACCGACGCT 132 73 729 Antisense
TTCGTCTCTACGAGGCCGTCAAAAA 570 693 764 Antisense
Sequence Source Affymetrix Proprietary Database