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[188839_at] Neprilysin

Description F12A10.4 /REP_DB=WormBase Gene ID /WP=CE01907 /TR=Q09946 /GB=AAA68297.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Neprilysin
Cluster 6grp_total > 98      4grp_total > 27      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 18.3
(-0.8)
A 		38.5
(3)
A 		6.3
(-3)
A 		19.9
(-0.5)
A 		32
B 23
(1.5)
A 		15.1
(-0.5)
A 		28.9
(3)
A 		5.1
(-3)
A 		24
C 26.2
(-1.3)
A 		17.2
(-3)
A 		28.6
(-0.8)
A 		48.9
(3)
A 		32
avr 22.5
(-0.8) 		23.6
(1.2) 		21.3
(-3) 		24.6
(3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 64
1 2 3 4 5 6 range
A 33.4
(-0.7)
A 		12.7
(-3)
A 		25.6
(-1.5)
A 		25.1
(-1.6)
A 		66
(3)
A 		56
(1.9)
A 		53
B 4.5
(-2.9)
A 		3.9
(-3)
A 		27.1
(0.6)
A 		15.3
(-1.2)
A 		29.4
(1)
A 		42.5
(3)
A 		39
C 1.7
(-3)
A 		24.4
(-0.4)
A 		27.8
(-0.1)
A 		5.2
(-2.6)
A 		33.8
(0.6)
A 		55.1
(3)
P 		53
avr 13.2
(-3) 		13.7
(-2.9) 		26.8
(-0.9) 		15.2
(-2.7) 		43.1
(1.7) 		51.2
(3) 		38
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 9
1 2 3 4 range
A 6.7
(1.5)
A 		8.4
(3)
A 		1.7
(-3)
A 		2.9
(-1.9)
A 		7
B 7.3
(3)
A 		3.7
(-0.5)
A 		6.7
(2.4)
A 		1.1
(-3)
A 		6
C 8.7
(1.5)
A 		4.9
(-3)
A 		10
(3)
A 		8.2
(0.9)
A 		5
avr 7.6
(3) 		5.7
(-0.3) 		6.1
(0.4) 		4.1
(-3) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 19
1 2 3 4 5 6 range
A 6.2
(-2.3)
A 		4.5
(-3)
A 		5.6
(-2.6)
A 		6.4
(-2.3)
A 		19.9
(3)
A 		13.6
(0.5)
A 		15
B 1.6
(-2.9)
A 		1.3
(-3)
A 		6.6
(-0.8)
A 		4
(-1.9)
A 		11.9
(1.4)
A 		15.8
(3)
A 		15
C 0.6
(-3)
A 		7.5
(-0.7)
A 		7.1
(-0.8)
A 		1
(-2.9)
A 		10.9
(0.5)
A 		18.4
(3)
P 		18
avr 2.8
(-3) 		4.4
(-2.3) 		6.4
(-1.4) 		3.8
(-2.5) 		14.2
(2.2) 		15.9
(3) 		13
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188839_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5909
Sequence Type Exemplar sequence
Representative Public ID F12A10.4 NCBI
Target Description F12A10.4 /REP_DB=WormBase Gene ID /WP=CE01907 /TR=Q09946 /GB=AAA68297.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Neprilysin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062643(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062643 NCBI Caenorhabditis elegans F12A10.4 (Neprilysin) mRNA, complete cds. 11/11 None
SNAP00000033519 ENSEMBL cdna:SNAP chromosome:CEL140:II:5488163:5490576:1 11/11 None
GENEFINDER00000033529 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:5488121:5490576:1 11/11 None
F12A10.4 ENSEMBL cdna:known chromosome:CEL140:II:5488148:5490576:1 gene:F12A10.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5488160-5490574(+) 100.0 100.0
Public Domain and Genome References
Gene Title Neprilysin
Ensembl F12A10.4
Entrez Gene 173933 Entrez gene
SwissProt Q09946 EMBL-EBI
WormBase CE01907 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4245 neprilysin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA68297 Hypothetical protein F12A10.4 [Caenorhabditis elegans] ref|NP_495044.1| F12A10.4 [Caenorhabditis elegans] 0.0
blast CAE59116 Hypothetical protein CBG02411 [Caenorhabditis briggsae] 0.0
blast EAL39199 ENSANGP00000025987 [Anopheles gambiae str. PEST] ref|XP_553645.1| ENSANGP00000025987 [Anopheles gambiae str. PEST] 2.0E-25
blast CAE61200 Hypothetical protein CBG04988 [Caenorhabditis briggsae] 8.0E-25
Protein Domains
Database ID Description E-Value
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.4E-9
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 3.8E-8
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.4E-9
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 3.8E-8
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.4E-9
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 3.8E-8
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495044.1 1 48-70
F12A10.4 1 48-70
SNAP00000033519 1 48-70
GENEFINDER00000033529 1 62-84
Sequence
Target Sequence 
>C. ELEGANS:188839_AT
ctccattatcctttcatgtctgcaaaccttccaaactatacaaatttcgcaactatcgcg
tccaaaattcttccccaaatgatacacattttcgatgaacgtggcaggttctacgattcg
gacgggaatcatcgtaattggtggaatactgaaacagaacgatacttccaaataatagta
caatgcttcgatgggatgatgcaaaacgtctttggcgtcagcgtcagtattggatggaat
gcttatgattcaactaaagaaccatatgccacgctcccaggaatccagcaatcatcagat
gaagctttgtttttctacagcatggtgaagacaatgtgcacctcggatccggataacgtg
aatgaagctctagcgagtgttccacaattcaattcggcgttta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTCCATTATCCTTTCATGTCTGCAA 634 235 1531 Antisense
ATGTCTGCAAACCTTCCAAACTATA 27 47 1546 Antisense
GCAACTATCGCGTCCAAAATTCTTC 620 319 1579 Antisense
AATTCTTCCCCAAATGATACACATT 257 177 1596 Antisense
GGCAGGTTCTACGATTCGGACGGGA 452 497 1633 Antisense
GTCTTTGGCGTCAGCGTCAGTATTG 17 469 1738 Antisense
ACTAAAGAACCATATGCCACGCTCC 415 101 1783 Antisense
GCTCCCAGGAATCCAGCAATCATCA 3 299 1803 Antisense
TGAAGACAATGTGCACCTCGGATCC 589 573 1856 Antisense
GAAGCTCTAGCGAGTGTTCCACAAT 148 343 1894 Antisense
GTTCCACAATTCAATTCGGCGTTTA 17 439 1909 Antisense
Sequence Source Affymetrix Proprietary Database