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[188787_at] TPR domain

Description C17G10.2 /REP_DB=WormBase Gene ID /WP=CE01786 /TR=Q09974 /GB=AAB93452.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=TPR domain
Cluster 6grp_highest_10_10 > 79      6grp_high1_10_10 > 97      4grp_highest_8_8 > 04      4grp_high_8_8 > 29      6grp_highest_nonorm > 93      6grp_total > 97      4grp_total > 34      6grp_highest_sub > In      6grp_high1_sub > In      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 207
1 2 3 4 range
A 442.9
(-3)
P 		495.6
(-1.1)
P 		608.5
(3)
P 		593
(2.4)
P 		166
B 537
(2.9)
P 		540.2
(3)
P 		402
(-3)
P 		506.9
(1.6)
P 		138
C 443.7
(-3)
P 		592.4
(3)
P 		477
(-1.7)
P 		484.9
(-1.3)
P 		149
avr 474.5
(-3) 		542.7
(3) 		495.8
(-1.1) 		528.3
(1.7) 		68

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 360
1 2 3 4 5 6 range
A 317.4
(-3)
P 		351.7
(-2.1)
P 		323.4
(-2.8)
P 		376.9
(-1.4)
P 		541.6
(3)
P 		540.8
(3)
P 		224
B 416.3
(-2)
P 		441
(-1.2)
P 		385.4
(-3)
P 		444.6
(-1)
P 		556.5
(2.7)
P 		565.8
(3)
P 		180
C 254.6
(-3)
P 		444.1
(0.2)
P 		316.1
(-2)
P 		364.4
(-1.2)
P 		321.1
(-1.9)
P 		615
(3)
P 		360
avr 329.4
(-3) 		412.3
(-1) 		341.6
(-2.7) 		395.3
(-1.4) 		473.1
(0.5) 		573.9
(3) 		245
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 89
1 2 3 4 range
A 161.3
(3)
P 		107.6
(-1.3)
P 		159.1
(2.8)
P 		86.8
(-3)
P 		75
B 171.2
(3)
P 		133.4
(0.1)
P 		93.1
(-3)
P 		108
(-1.9)
P 		78
C 146.9
(1.4)
P 		170.3
(3)
P 		166.3
(2.7)
P 		81.8
(-3)
P 		89
avr 159.8
(3) 		137.1
(1) 		139.5
(1.2) 		92.2
(-3) 		68

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 168
1 2 3 4 5 6 range
A 58.5
(-3)
P 		125.1
(0.8)
P 		70.4
(-2.3)
P 		95.6
(-0.9)
P 		163.4
(3)
P 		131.7
(1.2)
P 		105
B 144.8
(-0.7)
P 		146.8
(-0.6)
P 		93.6
(-3)
P 		117.8
(-1.9)
P 		226.1
(3)
P 		211
(2.3)
P 		133
C 94.4
(-2)
P 		135.5
(-0.2)
P 		80.4
(-2.7)
P 		73.3
(-3)
P 		103.9
(-1.6)
P 		205.9
(3)
P 		133
avr 99.2
(-2) 		135.8
(0.2) 		81.5
(-3) 		95.6
(-2.2) 		164.5
(1.9) 		182.9
(3) 		101
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188787_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4069
Sequence Type Exemplar sequence
Representative Public ID C17G10.2 NCBI
Target Description C17G10.2 /REP_DB=WormBase Gene ID /WP=CE01786 /TR=Q09974 /GB=AAB93452.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=TPR domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062686(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062686 NCBI Caenorhabditis elegans C17G10.2 (C17G10.2) mRNA, complete cds. 11/11 None
SNAP00000029023 ENSEMBL cdna:SNAP chromosome:CEL140:II:5595045:5596307:1 11/11 None
GENEFINDER00000029037 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:5594684:5596307:1 11/11 None
C17G10.2 ENSEMBL cdna:known chromosome:CEL140:II:5594705:5596326:1 gene:C17G10.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:5594702-5596305(+) 100.0 100.0
Public Domain and Genome References
Gene Title TPR domain
Ensembl C17G10.2
Entrez Gene 173946 Entrez gene
SwissProt Q09974 EMBL-EBI
WormBase CE29583 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:264331_AT tetratricopeptide repeat (TPR)-containing protein at
CANINE_2:CFAAFFX.29020.1.S1_AT similar to Tetratricopeptide repeat protein 4 (TPR repeat protein 4) cfa
DROSOPHILA_2:1636273_AT DNA polymerase interacting tpr containing protein of 47kD dm
DROSGENOME1:146680_AT DNA polymerase interacting tpr containing protein of 47kD dm
CHICKEN:GGA.13219.1.S1_AT similar to Tetratricopeptide repeat protein 4 (My044 protein) gga
HG-U133_PLUS_2:218442_AT tetratricopeptide repeat domain 4 hs
HG-U133A:218442_AT tetratricopeptide repeat domain 4 hs
HG-U133A_2:218442_AT tetratricopeptide repeat domain 4 hs
HU35KSUBB:RC_W60480_AT tetratricopeptide repeat domain 4 hs
U133_X3P:G4759271_3P_S_AT tetratricopeptide repeat domain 4 hs
U133_X3P:46167_3P_AT tetratricopeptide repeat domain 4 hs
HG-U133A_2:46167_AT tetratricopeptide repeat domain 4 hs
HG-FOCUS:46167_AT tetratricopeptide repeat domain 4 hs
HG-U133_PLUS_2:46167_AT tetratricopeptide repeat domain 4 hs
HG-U133A:46167_AT tetratricopeptide repeat domain 4 hs
HG-U95B:46167_AT tetratricopeptide repeat domain 4 hs
HG-U95C:65218_AT tetratricopeptide repeat domain 4 hs
MG-U74AV2:160212_AT tetratricopeptide repeat domain 4 mm
MOE430A:1451193_X_AT tetratricopeptide repeat domain 4 mm
MOUSE430A_2:1451193_X_AT tetratricopeptide repeat domain 4 mm
MOUSE430_2:1451193_X_AT tetratricopeptide repeat domain 4 mm
MOE430A:1451192_A_AT tetratricopeptide repeat domain 4 mm
MOUSE430A_2:1451192_A_AT tetratricopeptide repeat domain 4 mm
MOUSE430_2:1451192_A_AT tetratricopeptide repeat domain 4 mm
MU19KSUBB:TC32572_AT Tetratricopeptide repeat domain 4, mRNA (cDNA clone MGC:29300 IMAGE:5004463) mm
RAE230A:1391733_AT Tetratricopeptide repeat domain 4 (predicted) rn
RAT230_2:1391733_AT Tetratricopeptide repeat domain 4 (predicted) rn
RG-U34A:RC_AA875437_AT Tetratricopeptide repeat domain 4 (predicted) rn
YEAST_2:1775130_AT TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion Sc
Protein Similarities
Method ID Description E-Value
blast AAB93452 Hypothetical protein C17G10.2 [Caenorhabditis elegans] ref|NP_495087.1| C17G10.2 [Caenorhabditis elegans] 0.0
blast CAE59146 Hypothetical protein CBG02451 [Caenorhabditis briggsae] 0.0
blast CAE59146 Hypothetical protein CBG02451 [Caenorhabditis briggsae] 1.0E-170
blast BAC40504.1 unnamed protein product [Mus musculus] 1.0E-47
Sequence
Target Sequence 
>C. ELEGANS:188787_AT
ggaatttgaatttatgtccccgcgttccgtttgatcgtcccgaactcatggatatggcga
gacttaccgtatcccttccgttgatgcattcacatgaatgtgtcaaattcgatgatgatc
taaatcttgtatggccgatccttctacaatatcccgaagctggtcaaactgatgttctta
ccgagacaaatgaattaacaaccgtcggagaattgttaaaagaagtgttaaattcaccag
ctcagtgggatccggagcacaaattcaattttgagaatgttcggttcttcgtatcggatg
aatatgatgaatatttgatggaagtgtacgaatggaatgatttcaaatcggtgcttagca
tgccaggatatcaaataaaacaggggcttcctgtaattatgattatgaccaaagaaaaag
ccgcaagttccctagaagcatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAATTTGAATTTATGTCCCCGCGT 500 533 677 Antisense
TTTGATCGTCCCGAACTCATGGATA 136 667 706 Antisense
GATATGGCGAGACTTACCGTATCCC 192 425 727 Antisense
CCCTTCCGTTGATGCATTCACATGA 346 259 749 Antisense
TAAATCTTGTATGGCCGATCCTTCT 387 641 797 Antisense
GATCCTTCTACAATATCCCGAAGCT 701 415 813 Antisense
AGCTGGTCAAACTGATGTTCTTACC 224 81 834 Antisense
ATTCACCAGCTCAGTGGGATCCGGA 19 13 908 Antisense
GAATGTTCGGTTCTTCGTATCGGAT 160 331 951 Antisense
CGGTGCTTAGCATGCCAGGATATCA 411 243 1025 Antisense
AAGCCGCAAGTTCCCTAGAAGCATT 550 149 1094 Antisense
Sequence Source Affymetrix Proprietary Database