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[188732_at] Neprilysin

Description F26G1.6 /REP_DB=WormBase Gene ID /WP=CE02698 /TR=Q19831 /GB=AAK31503.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Neprilysin
Cluster 6grp_high1_10_10 > 33      6grp_total > 30      4grp_total > 50      6grp_high1_sub > 02      6grp_total_sub > Hat      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 191
1 2 3 4 range
A 121
(0)
P 		194.8
(3)
P 		162.6
(1.7)
P 		46.9
(-3)
A 		148
B 98.6
(-2.1)
P 		230.9
(3)
P 		229.3
(2.9)
P 		75.7
(-3)
A 		155
C 122
(-1.8)
P 		237.9
(3)
P 		197.6
(1.3)
P 		93.6
(-3)
A 		144
avr 113.9
(-1.3) 		221.2
(3) 		196.5
(2) 		72.1
(-3) 		149

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 112
1 2 3 4 5 6 range
A 73.2
(-3)
A 		176.8
(3)
P 		102.6
(-1.3)
P 		122.9
(-0.1)
P 		101.5
(-1.4)
P 		83.9
(-2.4)
P 		104
B 120.9
(0.8)
P 		153.6
(3)
P 		125.4
(1.1)
P 		130.4
(1.4)
P 		87.7
(-1.5)
P 		65
(-3)
P 		89
C 78.7
(-3)
P 		152.4
(2.1)
P 		128.1
(0.4)
P 		166
(3)
P 		85.4
(-2.5)
P 		86.1
(-2.5)
P 		87
avr 90.9
(-2.1) 		160.9
(3) 		118.7
(-0.1) 		139.8
(1.5) 		91.5
(-2) 		78.3
(-3) 		83
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 62
1 2 3 4 range
A 44.1
(3)
P 		42.3
(2.7)
P 		42.5
(2.7)
P 		6.9
(-3)
A 		37
B 31.4
(-0.8)
P 		57
(3)
P 		53.1
(2.4)
P 		16.1
(-3)
A 		41
C 40.4
(-0.2)
P 		68.4
(2.9)
P 		68.9
(3)
P 		15.8
(-3)
A 		53
avr 38.6
(0.6) 		55.9
(3) 		54.8
(2.8) 		12.9
(-3) 		43

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 49
1 2 3 4 5 6 range
A 13.5
(-3)
A 		62.9
(3)
P 		22.3
(-1.9)
P 		31.2
(-0.9)
P 		30.6
(-0.9)
P 		20.4
(-2.2)
P 		49
B 42.1
(1)
P 		51.1
(3)
P 		30.4
(-1.6)
P 		34.5
(-0.7)
P 		35.6
(-0.5)
P 		24.3
(-3)
P 		27
C 29.2
(-2.5)
P 		46.5
(3)
P 		32.6
(-1.4)
P 		33.4
(-1.2)
P 		27.6
(-3)
P 		28.8
(-2.6)
P 		19
avr 28.3
(-2.2) 		53.5
(3) 		28.4
(-2.2) 		33
(-1.2) 		31.3
(-1.6) 		24.5
(-3) 		29
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188732_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4912
Sequence Type Exemplar sequence
Representative Public ID F26G1.6 NCBI
Target Description F26G1.6 /REP_DB=WormBase Gene ID /WP=CE02698 /TR=Q19831 /GB=AAK31503.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Neprilysin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062456(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062456 NCBI Caenorhabditis elegans F26G1.6 (Neprilysin) mRNA, complete cds. 11/11 None
SNAP00000000806 ENSEMBL cdna:SNAP chromosome:CEL140:II:4775514:4779542:-1 11/11 None
GENEFINDER00000000816 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:4775514:4779542:-1 11/11 None
F26G1.6 ENSEMBL cdna:known chromosome:CEL140:II:4775283:4781335:-1 gene:F26G1.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:4775512-4779661(-) 99.56 100.0
Public Domain and Genome References
Gene Title Neprilysin
Ensembl F26G1.6
Entrez Gene 173824 Entrez gene
SwissProt Q19831 EMBL-EBI
WormBase CE37363 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4245 neprilysin activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK31503 Hypothetical protein F26G1.6 [Caenorhabditis elegans] ref|NP_494857.2| F26G1.6 [Caenorhabditis elegans] 0.0
blast CAE73207 Hypothetical protein CBG20611 [Caenorhabditis briggsae] 0.0
blast AAO21504 zinc metalloprotease [Manduca sexta] 1.0E-114
Protein Domains
Database ID Description E-Value
Pfam IPR008753 EMBL-EBI Peptidase M13 1.7E-55
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 7.9E-73
Pfam IPR008753 EMBL-EBI Peptidase M13 1.7E-55
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 7.9E-73
Pfam IPR008753 EMBL-EBI Peptidase M13 9.3E-51
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 7.9E-73
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494857.2 1 30-52
F26G1.6 1 30-52
Sequence
Target Sequence 
>C. ELEGANS:188732_AT
gaatgaaattatcttccctgctggaattcttcaattcccaatgtttgtgcccgatgcacc
ggctttctccaattacggagcaatcggaatgggcatcggtcatgaaataacccacggata
cgatgaccttggagctcaatacgacgacaaaggcaatctgcgtggatggtggcatactga
aacaatgacaacattccaaaagaagaaacaatgttttgtggcacaatatggaagtaaaat
cgaaccacaaactggccgaaaagtcgatggaaaaatgacaattggagagaatattgccga
taatggaggattaagagttgcgtttcaagcttatcaattgagatctgatagggaaaagga
aacgagaagactgcctggattaaccgatttcagtccgaatcagctgtttttcctagccta
cgcaaatacatggtgtgaagccctgaaaccatcagcaattgatcatataatggacacaga
tgttcattcattgggaatgtttcgtgtgaatgtgccccttcaaaaccttccagcattttc
t

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATGAAATTATCTTCCCTGCTGGA 615 331 1674 Antisense
CAATTCCCAATGTTTGTGCCCGATG 532 179 1705 Antisense
CACCGGCTTTCTCCAATTACGGAGC 416 199 1730 Antisense
GGAGCAATCGGAATGGGCATCGGTC 120 521 1750 Antisense
CACGGATACGATGACCTTGGAGCTC 456 199 1786 Antisense
AAGACTGCCTGGATTAACCGATTTC 334 153 2040 Antisense
AACCGATTTCAGTCCGAATCAGCTG 267 145 2055 Antisense
GAATCAGCTGTTTTTCCTAGCCTAC 166 327 2070 Antisense
GGTGTGAAGCCCTGAAACCATCAGC 390 499 2105 Antisense
TTTCGTGTGAATGTGCCCCTTCAAA 380 671 2173 Antisense
CCTTCAAAACCTTCCAGCATTTTCT 254 269 2190 Antisense
Sequence Source Affymetrix Proprietary Database