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[188650_at]

Description T05E11.4 /REP_DB=WormBase Gene ID /WP=CE06363 /GEN=spo-11 /TR=SW:Q22236 /GB=CAA92974.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation
Cluster 6grp_total > 87      4grp_total > 18      6grp_cgc > 58      6grp_cgc_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 136
1 2 3 4 range
A 48.6
(-1.6)
A 		48
(-1.7)
A 		28.8
(-3)
A 		114.8
(3)
P 		86
B 29.4
(-3)
A 		85.4
(0.5)
A 		48.4
(-1.8)
A 		125.6
(3)
P 		96
C 72.5
(-2.8)
P 		74.8
(-2.6)
A 		68.6
(-3)
A 		164.7
(3)
P 		96
avr 50.2
(-2.9) 		69.4
(-1.6) 		48.6
(-3) 		135
(3) 		86

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 272
1 2 3 4 5 6 range
A 36.1
(-2.5)
A 		22.3
(-3)
A 		47.4
(-2.2)
P 		97.8
(-0.5)
M 		134
(0.7)
P 		201.9
(3)
P 		180
B 15.7
(-3)
A 		40.8
(-2.4)
A 		41.6
(-2.4)
A 		62.3
(-1.9)
P 		139.2
(-0.1)
P 		273.6
(3)
P 		258
C 44.6
(-2.8)
A 		35.6
(-3)
A 		59
(-2.4)
P 		102.1
(-1.4)
P 		126.1
(-0.8)
P 		287.9
(3)
P 		252
avr 32.1
(-3) 		32.9
(-3) 		49.3
(-2.5) 		87.4
(-1.5) 		133.1
(-0.3) 		254.5
(3) 		222
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 20
1 2 3 4 range
A 17.7
(3)
A 		10.4
(-1.3)
A 		7.5
(-3)
A 		16.8
(2.5)
P 		10
B 9.4
(-3)
A 		21.1
(1)
A 		11.2
(-2.4)
A 		26.8
(3)
P 		17
C 24
(-0.6)
P 		21.5
(-3)
A 		23.9
(-0.7)
A 		27.8
(3)
P 		6
avr 17
(-1.3) 		17.7
(-0.8) 		14.2
(-3) 		23.8
(3) 		10

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 6.6
(-3)
A 		7.9
(-2.8)
A 		10.3
(-2.5)
P 		24.8
(-0.4)
M 		40.4
(1.8)
P 		49.2
(3)
P 		43
B 5.5
(-3)
A 		13.6
(-2.5)
A 		10.1
(-2.7)
A 		16.5
(-2.3)
P 		56.6
(0.2)
P 		102
(3)
P 		97
C 16.5
(-2.6)
A 		10.9
(-3)
A 		15
(-2.7)
P 		20.5
(-2.3)
P 		40.8
(-0.9)
P 		96.4
(3)
P 		86
avr 9.5
(-3) 		10.8
(-2.9) 		11.8
(-2.8) 		20.6
(-2.1) 		45.9
(-0) 		82.5
(3) 		73
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188650_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9381
Sequence Type Exemplar sequence
Representative Public ID T05E11.4 NCBI
Target Description T05E11.4 /REP_DB=WormBase Gene ID /WP=CE06363 /GEN=spo-11 /TR=SW:Q22236 /GB=CAA92974.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069680(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069680 NCBI Caenorhabditis elegans homolog of yeast SPOrulation gene family member (spo-11) (spo-11) mRNA, complete cds. 11/11 None
SNAP00000031864 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11123131:11124830:-1 9/11 None
GENEFINDER00000031869 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11123131:11124707:-1 11/11 None
T05E11.4 ENSEMBL cdna:known chromosome:CEL140:IV:11123131:11124707:-1 gene:T05E11.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11123136-11124713(-) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol spo-11
Ensembl T05E11.4
Entrez Gene 191771 Entrez gene
SwissProt Q22236 EMBL-EBI
WormBase CE06363 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6259 DNA metabolism inferred from electronic annotation QuickGO AmiGO
6265 DNA topological change inferred from electronic annotation QuickGO AmiGO
6304 DNA modification inferred from electronic annotation QuickGO AmiGO
7131 meiotic recombination inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3676 nucleic acid binding inferred from electronic annotation QuickGO AmiGO
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
3918 DNA topoisomerase (ATP-hydrolyzing) activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92974 Hypothetical protein T05E11.4 [Caenorhabditis elegans] ref|NP_502081.1| homolog of yeast SPOrulation gene family member (spo-11) [Caenorhabditis elegans] sp|Q22236|SPO11_CAEEL Meiotic recombination protein spo-11 0.0
blast CAE62007 Hypothetical protein CBG06015 [Caenorhabditis briggsae] 1.0E-126
blast CAA92974 Hypothetical protein T05E11.4 [Caenorhabditis elegans] ref|NP_502081.1| homolog of yeast SPOrulation gene family member (spo-11) [Caenorhabditis elegans] sp|Q22236|SPO11_CAEEL Meiotic recombination protein spo-11 2.0E-92
blast CAE62007 Hypothetical protein CBG06015 [Caenorhabditis briggsae] 3.0E-89
blast NP_036176 sporulation protein, meiosis-specific, SPO11 homolog [Mus musculus] gb|AAF87096.1| SPO11 protein [Mus musculus] gb|AAD52563.1| SPO11 [Mus musculus] sp|Q9WTK8|SPOB_MOUSE Meiotic recombination protein SPO11 4.0E-44
Protein Domains
Database ID Description E-Value
Pfam IPR006171 EMBL-EBI TOPRIM 3.0E-8
Pfam IPR002815 EMBL-EBI DNA topoisomerase, type II 3.4E-27
Pfam IPR002815 EMBL-EBI DNA topoisomerase, type II 5.4E-27
Sequence
Target Sequence 
>C. ELEGANS:188650_AT
tccacgtgggattctagcaacttcgaaaggatatccggatattgcaactcgaaatgttct
gaaaatgttgagtgaaaaaagaaaatttccaatatacggactgtttgacgctgatccgca
tggtattgaaatctacttgacttacaaatatggacctacgaaagaatttgccgaaggccg
aggagcctttgttccaacgattgaatggatcggtcttttcccaactgattttcatcgttt
caccatcgatcaatcacaatgtcttccattggttcgaactgattttgtgaaaattgagaa
gatgattcctcgatcgattcaactcggagaaatagtggtgacacgagaattagactggat
gattcagaataaatttaaaatggaacttgaatcaataaatatgtgcggacaggagtatat
ggctcgattcttgattgctccgagagtcatgtcgatagaaaaagaaattccgattcaacc
agagacgattataaacgagtaccacgaagattcacaatgttcgctgtcgaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCCACGTGGGATTCTAGCAACTTCG 420 589 669 Antisense
GTTTGACGCTGATCCGCATGGTATT 333 451 771 Antisense
GAAGGCCGAGGAGCCTTTGTTCCAA 654 331 841 Antisense
TCTTTTCCCAACTGATTTTCATCGT 129 615 882 Antisense
GATTTTCATCGTTTCACCATCGATC 372 429 895 Antisense
AATGTCTTCCATTGGTTCGAACTGA 62 165 926 Antisense
GATGATTCCTCGATCGATTCAACTC 253 411 969 Antisense
TATGGCTCGATTCTTGATTGCTCCG 405 655 1086 Antisense
GATTGCTCCGAGAGTCATGTCGATA 679 433 1101 Antisense
AAATTCCGATTCAACCAGAGACGAT 311 115 1133 Antisense
AGATTCACAATGTTCGCTGTCGACA 663 65 1176 Antisense
Sequence Source Affymetrix Proprietary Database