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[188537_s_at] neprilysin

Description ZK20.6 /REP_DB=WormBase Gene ID /WP=CE06609 /TR=Q18673 /GB=CAA93782.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=neprilysin
Cluster 6grp_highest_10_10 > 09      6grp_high1_10_10 > 80      4grp_highest_8_8 > 21      4grp_high_8_8 > 23      6grp_highest_nonorm > 63      6grp_total > 81      4grp_total > 16      6grp_cgc > 75      6grp_high1_sub > 02_03_04_05      6grp_cgc_sub > 03_04      6grp_total_sub > Hat      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 952
1 2 3 4 range
A 412.7
(-3)
P 		456.9
(-2.4)
P 		707.3
(0.9)
P 		862
(3)
P 		449
B 309.2
(-3)
P 		491.1
(-1.9)
P 		576.4
(-1.3)
P 		1260.9
(3)
P 		952
C 343.4
(-3)
P 		448.9
(-2)
P 		688.2
(0.1)
P 		1006.1
(3)
P 		663
avr 355.1
(-3) 		465.6
(-2) 		657.3
(-0.4) 		1043
(3) 		688

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 512
1 2 3 4 5 6 range
A 260.2
(-3)
P 		666.4
(1.8)
P 		398.3
(-1.4)
P 		764.8
(3)
P 		619
(1.3)
P 		549
(0.4)
P 		505
B 305
(-3)
P 		636.1
(1.2)
P 		457.6
(-1)
P 		772.5
(3)
P 		515.8
(-0.3)
P 		465.2
(-0.9)
P 		468
C 330.1
(-3)
P 		637.6
(1.5)
P 		645.9
(1.6)
P 		682.7
(2.2)
P 		738.3
(3)
P 		515.2
(-0.3)
P 		408
avr 298.4
(-3) 		646.7
(1.7) 		500.6
(-0.3) 		740
(3) 		624.4
(1.4) 		509.8
(-0.1) 		442
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 170
1 2 3 4 range
A 150.3
(0.6)
P 		99.2
(-3)
P 		184.9
(3)
P 		126.2
(-1.1)
P 		86
B 98.6
(-3)
P 		121.3
(-2.2)
P 		133.6
(-1.8)
P 		268.7
(3)
P 		170
C 113.7
(-3)
P 		129.1
(-2.3)
P 		239.9
(3)
P 		169.6
(-0.3)
P 		126
avr 120.9
(-2.6) 		116.5
(-3) 		186.1
(2.8) 		188.2
(3) 		72

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 191
1 2 3 4 5 6 range
A 48
(-3)
P 		237
(3)
P 		86.7
(-1.8)
P 		194
(1.6)
P 		186.8
(1.4)
P 		133.7
(-0.3)
P 		189
B 106.1
(-3)
P 		211.7
(3)
P 		111.1
(-2.7)
P 		204.6
(2.6)
P 		209.6
(2.9)
P 		173.5
(0.8)
P 		106
C 122.4
(-3)
P 		194.5
(0.7)
P 		164.4
(-0.8)
P 		137.3
(-2.2)
P 		238.9
(3)
P 		172.5
(-0.4)
P 		117
avr 92.2
(-3) 		214.4
(3) 		120.7
(-1.6) 		178.6
(1.2) 		211.8
(2.9) 		159.9
(0.3) 		122
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 188537_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3274
Sequence Type Exemplar sequence
Representative Public ID ZK20.6 NCBI
Target Description ZK20.6 /REP_DB=WormBase Gene ID /WP=CE06609 /TR=Q18673 /GB=CAA93782.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=neprilysin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064089(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064089 NCBI Caenorhabditis elegans ZK20.6 (neprilysin) mRNA, complete cds. 11/11 None
SNAP00000023900 ENSEMBL cdna:SNAP chromosome:CEL140:II:11654878:11657072:-1 9/11 None
ZK20.6 ENSEMBL cdna:known chromosome:CEL140:II:11654129:11657354:-1 gene:ZK20.6 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000023915 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:11654374-11657351(-) 100.0 100.0
Public Domain and Genome References
Gene Title neprilysin
Gene Symbol nep-1
Ensembl ZK20.6
Entrez Gene 174787 Entrez gene
WormBase CE39118 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.19432.1.S1_AT similar to endothelin converting enzyme 2 isoform 2b-2 cfa
CANINE_2:CFAAFFX.19491.1.S1_S_AT similar to endothelin converting enzyme 2 isoform 2b-2 cfa
HG-U133_PLUS_2:206728_AT endothelin converting enzyme 2 hs
HG-U133A_2:206728_AT endothelin converting enzyme 2 hs
HG-U133A:206728_AT endothelin converting enzyme 2 hs
U133_X3P:G7662199_3P_AT endothelin converting enzyme 2 hs
U133_X3P:HS2.129801.4.S1_3P_S_AT endothelin converting enzyme 2 hs
HG-U133_PLUS_2:1555306_A_AT endothelin converting enzyme 2 hs
HG-U95AV2:35536_AT endothelin converting enzyme 2 hs
HG-U95C:49794_S_AT Endothelin converting enzyme 2 hs
MG-U74CV2:138204_AT endothelin converting enzyme 2 mm
MG-U74CV2:168619_R_AT endothelin converting enzyme 2 mm
MOE430A:1424561_AT endothelin converting enzyme 2 mm
MOUSE430A_2:1424561_AT endothelin converting enzyme 2 mm
MOUSE430_2:1424561_AT endothelin converting enzyme 2 mm
RAE230B:1386749_AT endothelin converting enzyme 2 rn
RAT230_2:1386749_AT endothelin converting enzyme 2 rn
Protein Similarities
Method ID Description E-Value
blast NP_496490 ZK20.6 [Caenorhabditis elegans] 0.0
blast CAA93770 Hypothetical protein ZK20.6 [Caenorhabditis elegans] emb|CAA93782.2| Hypothetical protein ZK20.6 [Caenorhabditis elegans] 0.0
blast CAE59457 Hypothetical protein CBG02837 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR008753 EMBL-EBI Peptidase M13 3.4E-82
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 5.4E-94
Pfam IPR008753 EMBL-EBI Peptidase M13 3.4E-82
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 1.4E-63
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496490.1 1 17-39
ZK20.6 1 17-39
SNAP00000023900 1 5-27
Sequence
Target Sequence 
>C. ELEGANS:188537_S_AT
gcattcccagctggaatccttcaacagccattctttgatgctcgtttcccgaaagctctc
aactacggaggaattggtgcagttattggacacgagatcacccacggattcgatgatacc
ggacgtcaattcgacaatgtcggaaatcttcgtgattggtgggataacaccacctcttcc
aaattcaatgagcgaacccaatgcattatcgagcagtacgctgatgtgaaactccgtgga
actgatctccgaatcaatggaaagttgacccagggagaaaatatcgcagataatggtgga
atcaagcaagctttcaaggcctacaagtcatatctggagaaacacggaggccaagaagct
cgtcttccacaatttgaaagtctcaccaatgagcagctcttcttcgttggatatgctcaa
gtttggtgtggagccaagacgccagagaccaagactttattgctactcactgatcctcac
tcaccagaaactgcaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCATTCCCAGCTGGAATCCTTCAAC 477 307 1717 Antisense
CAGCCATTCTTTGATGCTCGTTTCC 293 203 1741 Antisense
GTTTCCCGAAAGCTCTCAACTACGG 580 449 1760 Antisense
ACACGAGATCACCCACGGATTCGAT 678 107 1806 Antisense
GATGATACCGGACGTCAATTCGACA 42 411 1828 Antisense
GAGCGAACCCAATGCATTATCGAGC 53 387 1906 Antisense
GAAACTCCGTGGAACTGATCTCCGA 240 357 1944 Antisense
ACACGGAGGCCAAGAAGCTCGTCTT 315 107 2058 Antisense
GCAGCTCTTCTTCGTTGGATATGCT 698 313 2109 Antisense
GAGCCAAGACGCCAGAGACCAAGAC 307 385 2147 Antisense
ATCCTCACTCACCAGAAACTGCAAG 28 39 2189 Antisense
Sequence Source Affymetrix Proprietary Database