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[188411_at] C2 domain

Description F25H2.1 /REP_DB=WormBase Gene ID /WP=CE09646 /TR=Q93565 /GB=CAB02090.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=C2 domain
Cluster 6grp_total > 10      4grp_total > 19      6grp_cgc > 64      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 35
1 2 3 4 range
A 18.5
(2.6)
A 		12.8
(0.4)
A 		4.3
(-3)
A 		19.4
(3)
A 		15
B 22.9
(3)
A 		22.3
(2.8)
A 		2.1
(-3)
A 		22.8
(3)
A 		21
C 3.6
(-3)
A 		23.9
(0.6)
A 		25.6
(0.9)
A 		37.1
(3)
P 		34
avr 15
(-1.4) 		19.7
(0.4) 		10.7
(-3) 		26.4
(3) 		16

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 40
1 2 3 4 5 6 range
A 10.9
(-1.1)
A 		1.9
(-2.8)
A 		31.6
(3)
A 		8
(-1.6)
A 		25.1
(1.7)
A 		1.1
(-3)
A 		31
B 1
(-3)
A 		15.9
(2.3)
A 		1.8
(-2.7)
A 		3.2
(-2.2)
A 		17.8
(3)
A 		9.4
(0)
A 		17
C 3.3
(-2.9)
A 		40.5
(3)
A 		31.3
(1.5)
A 		2.5
(-3)
A 		31.1
(1.5)
A 		4.9
(-2.6)
A 		38
avr 5.1
(-2.9) 		19.4
(1.4) 		21.6
(2.1) 		4.6
(-3) 		24.7
(3) 		5.1
(-2.9) 		20
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 8
1 2 3 4 range
A 6.7
(3)
A 		2.8
(-1.2)
A 		1.1
(-3)
A 		2.8
(-1.2)
A 		6
B 7.3
(3)
A 		5.5
(1.4)
A 		0.5
(-3)
A 		4.9
(0.9)
A 		7
C 1.2
(-3)
A 		6.9
(1.4)
A 		8.9
(3)
A 		6.3
(1)
P 		8
avr 5.1
(3) 		5.1
(3) 		3.5
(-3) 		4.7
(1.5) 		2

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 12
1 2 3 4 5 6 range
A 2
(-1.6)
A 		0.7
(-2.7)
A 		6.9
(2.4)
A 		2
(-1.6)
A 		7.6
(3)
A 		0.3
(-3)
A 		7
B 0.4
(-3)
A 		5.3
(1.3)
A 		0.4
(-3)
A 		0.9
(-2.6)
A 		7.2
(3)
A 		3.5
(-0.3)
A 		7
C 1.2
(-2.6)
A 		12.4
(3)
A 		8
(0.8)
A 		0.5
(-3)
A 		10.1
(1.8)
A 		1.6
(-2.4)
A 		12
avr 1.2
(-2.9) 		6.1
(1.2) 		5.1
(0.3) 		1.1
(-3) 		8.3
(3) 		1.8
(-2.4) 		7
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188411_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2062
Sequence Type Exemplar sequence
Representative Public ID F25H2.1 NCBI
Target Description F25H2.1 /REP_DB=WormBase Gene ID /WP=CE09646 /TR=Q93565 /GB=CAB02090.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=C2 domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060356(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060356 NCBI Caenorhabditis elegans ToLlIp homolog family member (tli-1) (tli-1) mRNA, complete cds. 11/11 None
F25H2.1 ENSEMBL cdna:known chromosome:CEL140:I:10543365:10546168:-1 gene:F25H2.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:10543295-10546099(-) 100.0 100.0
Public Domain and Genome References
Gene Title C2 domain
Gene Symbol tli-1
Ensembl F25H2.1
Entrez Gene 172936 Entrez gene
SwissProt Q93565 EMBL-EBI
WormBase CE09646 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.17883.1.S1_S_AT similar to toll interacting protein cfa
CANINE_2:CFAAFFX.15654.1.S1_S_AT similar to toll interacting protein cfa
CHICKEN:GGA.15338.1.S1_AT toll interacting protein gga
CHICKEN:GGAAFFX.12382.1.S1_S_AT toll interacting protein gga
HG-U133B:222469_S_AT toll interacting protein hs
HG-U133_PLUS_2:222469_S_AT toll interacting protein hs
HG-U133_PLUS_2:217930_S_AT toll interacting protein hs
HG-U133A:217930_S_AT toll interacting protein hs
HG-FOCUS:217930_S_AT toll interacting protein hs
HG-U133A_2:217930_S_AT toll interacting protein hs
HG-U133B:233881_S_AT toll interacting protein hs
HG-U133_PLUS_2:233881_S_AT toll interacting protein hs
HU35KSUBA:RC_AA126871_S_AT toll interacting protein hs
HU35KSUBB:RC_T23430_AT toll interacting protein hs
HU35KSUBD:RC_D51199_AT toll interacting protein hs
HU35KSUBD:RC_AA463462_AT toll interacting protein hs
U133_X3P:G9506854_3P_A_AT toll interacting protein hs
U133_X3P:G12053176_3P_A_AT toll interacting protein hs
U133_X3P:HS.25413.1.S1_3P_A_AT toll interacting protein hs
HG-U95B:45728_AT toll interacting protein hs
HG-U95E:91328_AT toll interacting protein hs
HG-U95D:87071_AT Toll interacting protein hs
MU11KSUBA:C80615_RC_AT toll interacting protein mm
MG-U74AV2:93886_AT toll interacting protein mm
MG-U74AV2:160809_AT toll interacting protein mm
MOE430A:1423047_AT toll interacting protein mm
MOUSE430A_2:1423047_AT toll interacting protein mm
MOUSE430_2:1423047_AT toll interacting protein mm
MOE430A:1423048_A_AT toll interacting protein mm
MOUSE430A_2:1423048_A_AT toll interacting protein mm
MOUSE430_2:1423048_A_AT toll interacting protein mm
MU19KSUBA:TC23797_AT Toll interacting protein (Tollip), mRNA mm
MU19KSUBA:TC23797_G_AT Toll interacting protein (Tollip), mRNA mm
RG-U34B:RC_AA956943_AT toll interacting protein (predicted) rn
RAE230B:1378572_AT toll interacting protein (predicted) rn
RAT230_2:1378572_AT toll interacting protein (predicted) rn
RAE230B:1380808_AT Toll interacting protein (predicted) rn
RAT230_2:1380808_AT Toll interacting protein (predicted) rn
RAE230A:1399052_AT Toll interacting protein (predicted) rn
RAT230_2:1399052_AT Toll interacting protein (predicted) rn
RG-U34C:RC_AI227705_AT Toll interacting protein (predicted) rn
Protein Similarities
Method ID Description E-Value
blast CAB02090 Hypothetical protein F25H2.1 [Caenorhabditis elegans] ref|NP_492757.1| ToLlIp homolog family member (tli-1) [Caenorhabditis elegans] 0.0
blast CAE58969 Hypothetical protein CBG02241 [Caenorhabditis briggsae] 1.0E-105
blast AAH46009 Zgc:76985 protein [Danio rerio] 4.0E-39
Protein Domains
Database ID Description E-Value
Pfam IPR000008 EMBL-EBI C2 domain 3.4E-14
Pfam IPR003892 EMBL-EBI Ubiquitin system component Cue 2.3E-11
Sequence
Target Sequence 
>C. ELEGANS:188411_AT
ttgacgcatatgtttctggtagcccttatgtattcgtcaataaaaaaattgggaaaagat
ggaagttcaaagttcattctgatgcacacaacaaaaccatttcggaaactactcttgatt
atgcacttcaagaaaagattaggagtatctatgctgaatatcctgtgaatgaatgtatgt
caattactgagtacgtaatggatgttcttaactgtcaattgaactattttcaaattacta
tgaataatttcgatttcggatttcaaaatcaacaaattattagctggttggcatcgagac
tagaaaaaattagacatttaagtgtttctggatggtatatttcaaaagaagatttttcat
ctactttgacgaagttggcagtgtgtcaccttcatttttctgtttctgtaagagagaaat
gtgataataaaataataatcagcgcagaaaggtttcatgcttcagaggccccatggatta
cat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGACGCATATGTTTCTGGTAGCCC 211 705 860 Antisense
CTGGTAGCCCTTATGTATTCGTCAA 264 241 875 Antisense
GTTCAAAGTTCATTCTGATGCACAC 191 445 924 Antisense
GATGCACACAACAAAACCATTTCGG 452 413 940 Antisense
GGAAACTACTCTTGATTATGCACTT 43 529 963 Antisense
GGAGTATCTATGCTGAATATCCTGT 560 517 1001 Antisense
TTATTAGCTGGTTGGCATCGAGACT 163 679 1136 Antisense
GATTTTTCATCTACTTTGACGAAGT 378 429 1210 Antisense
TGGCAGTGTGTCACCTTCATTTTTC 21 547 1235 Antisense
GAAAGGTTTCATGCTTCAGAGGCCC 376 359 1306 Antisense
GCTTCAGAGGCCCCATGGATTACAT 124 305 1318 Antisense
Sequence Source Affymetrix Proprietary Database