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[188402_at] protease

Description T05A8.4 /REP_DB=WormBase Gene ID /WP=CE18200 /TR=O44857 /GB=AAB95021.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=protease
Cluster 6grp_total > 17      4grp_total > 62      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 105
1 2 3 4 range
A 116.9
(3)
P 		78.8
(-2.1)
A 		116.3
(2.9)
P 		71.8
(-3)
A 		45
B 93.2
(3)
P 		83.9
(2.3)
M 		70.1
(1.3)
P 		11.9
(-3)
A 		81
C 104.4
(3)
P 		76.8
(-1.3)
A 		66.2
(-3)
A 		75.6
(-1.5)
P 		38
avr 104.8
(3) 		79.8
(0.1) 		84.2
(0.6) 		53.1
(-3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 72
1 2 3 4 5 6 range
A 58.8
(3)
A 		47.3
(1.7)
A 		4.5
(-3)
A 		26.2
(-0.6)
A 		45.4
(1.5)
A 		44.4
(1.4)
A 		54
B 73.3
(3)
A 		38.5
(-2.2)
A 		65.2
(1.8)
A 		33.5
(-3)
A 		38.9
(-2.2)
A 		34.5
(-2.8)
A 		40
C 49.1
(0.4)
A 		41.6
(-0.3)
A 		76.7
(3)
A 		13.5
(-3)
A 		26.2
(-1.8)
A 		37.9
(-0.7)
A 		63
avr 60.4
(3) 		42.5
(0) 		48.8
(1.1) 		24.4
(-3) 		36.8
(-0.9) 		38.9
(-0.6) 		36
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 40
1 2 3 4 range
A 42.6
(3)
P 		17.1
(-1.8)
A 		30.4
(0.7)
P 		10.5
(-3)
A 		32
B 29.7
(3)
P 		20.7
(1)
M 		16.2
(0)
P 		2.5
(-3)
A 		27
C 34.6
(3)
P 		22.1
(-0.4)
A 		23.1
(-0.2)
A 		12.7
(-3)
P 		22
avr 35.6
(3) 		20
(-0.5) 		23.2
(0.2) 		8.6
(-3) 		27

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 25
1 2 3 4 5 6 range
A 10.8
(0.7)
A 		16.8
(3)
A 		1
(-3)
A 		6.7
(-0.8)
A 		13.7
(1.8)
A 		10.8
(0.7)
A 		16
B 25.5
(3)
A 		12.8
(-1.6)
A 		15.8
(-0.5)
A 		8.9
(-3)
A 		15.8
(-0.5)
A 		12.9
(-1.6)
A 		17
C 18.2
(2.5)
A 		12.7
(0.6)
A 		19.5
(3)
A 		2.7
(-3)
A 		8.5
(-0.9)
A 		12.7
(0.6)
A 		17
avr 18.2
(3) 		14.1
(1) 		12.1
(-0) 		6.1
(-3) 		12.7
(0.3) 		12.1
(-0) 		12
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188402_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4109
Sequence Type Exemplar sequence
Representative Public ID T05A8.4 NCBI
Target Description T05A8.4 /REP_DB=WormBase Gene ID /WP=CE18200 /TR=O44857 /GB=AAB95021.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=protease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_061942(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_061942 NCBI Caenorhabditis elegans T05A8.4 (protease) mRNA, complete cds. 11/11 None
SNAP00000017323 ENSEMBL cdna:SNAP chromosome:CEL140:II:2719098:2724779:-1 9/11 None
GENEFINDER00000017332 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:2717615:2728351:-1 11/11 None
T05A8.4 ENSEMBL cdna:known chromosome:CEL140:II:2717615:2725541:-1 gene:T05A8.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:2717613-2725540(-) 100.0 100.0
Public Domain and Genome References
Gene Title protease
Ensembl T05A8.4
Entrez Gene 188090 Entrez gene
SwissProt O44857 EMBL-EBI
WormBase CE30162 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.29754.1.S1_S_AT similar to mel transforming oncogene-like 1 cfa
DROSOPHILA_2:1639483_S_AT Neprilysin 1 dm
DROSGENOME1:151911_AT Neprilysin 1 dm
DROSGENOME1:144576_S_AT Neprilysin 1 dm
CHICKEN:GGAAFFX.701.1.S1_AT similar to membrane metallo-endopeptidase-like 2; zinc metallopeptidase gga
CHICKEN:GGAAFFX.751.1.S1_S_AT similar to membrane metallo-endopeptidase-like 2; zinc metallopeptidase gga
U133_X3P:HS2.380483.1.S1_3P_AT mel transforming oncogene-like 1 hs
HG-U133_PLUS_2:1552930_AT mel transforming oncogene-like 1 hs
MOE430A:1449432_A_AT mel transforming oncogene-like 1 mm
MOUSE430_2:1449432_A_AT mel transforming oncogene-like 1 mm
MOUSE430A_2:1449432_A_AT mel transforming oncogene-like 1 mm
MG-U74BV2:105530_AT Neprilysin-like metallopeptidase 1 (Nl1) mm
RAE230B:1384748_AT mel transforming oncogene-like 1 (predicted) rn
RAT230_2:1384748_AT mel transforming oncogene-like 1 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4245 neprilysin activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_494343 T05A8.4 [Caenorhabditis elegans] gb|AAB95021.2| Hypothetical protein T05A8.4 [Caenorhabditis elegans] 0.0
blast D88082 protein T05A8.4 [imported] - Caenorhabditis elegans 0.0
blast CAE72406 Hypothetical protein CBG19565 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR008753 EMBL-EBI Peptidase M13 1.9E-70
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 3.1E-57
Pfam IPR008753 EMBL-EBI Peptidase M13 1.9E-70
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.0E-64
Pfam IPR008753 EMBL-EBI Peptidase M13 1.9E-70
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 3.8E-73
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494343.2 1 20-42
T05A8.4 1 20-42
GENEFINDER00000017332 1 108-130
Sequence
Target Sequence 
>C. ELEGANS:188402_AT
ggaatcttgcaaccagtgttctacagcaaagacttcccgtcttcgatgaacttcggaggc
atcggagtagttatcggacacgaaatcacacatggttttgatgatagaggacgcctgtac
gataaccttggaaatattcgccaatggtgggacaacgccacaatttcaaagtttgagcat
aaggcgcagtgcattgaaaagcagtactccagctatgtgctcgaccagataaatatgcaa
attaatggaaaatccacaaaaggagaaaatatcgctgataatggaggtctaaagcaggct
tatagagcctacaaaaaatacgaaaaacggcattcgcgcccaccacggctacccggagtg
aacctcacacacgatcagctcttcttcctgaactacgcacaaatctggtgtggaaccatg
aacgacaaggaggcgatccgcaagctgagaacttccgagcactctccgggacctattcga
gtcaaaggcccactctccaacagttacgatttc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAATCTTGCAACCAGTGTTCTACA 576 533 1687 Antisense
GTTCTACAGCAAAGACTTCCCGTCT 643 443 1704 Antisense
ACTTCCCGTCTTCGATGAACTTCGG 300 101 1718 Antisense
GGCATCGGAGTAGTTATCGGACACG 249 537 1744 Antisense
GGACGCCTGTACGATAACCTTGGAA 239 523 1795 Antisense
AGCAGTACTCCAGCTATGTGCTCGA 615 77 1886 Antisense
TACGAAAAACGGCATTCGCGCCCAC 646 193 2005 Antisense
CTTCTTCCTGAACTACGCACAAATC 598 221 2067 Antisense
GCAAGCTGAGAACTTCCGAGCACTC 356 321 2126 Antisense
CTCTCCGGGACCTATTCGAGTCAAA 8 231 2148 Antisense
CCCACTCTCCAACAGTTACGATTTC 145 257 2175 Antisense
Sequence Source Affymetrix Proprietary Database