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[188101_at]

Description F18C5.2 /REP_DB=WormBase Gene ID /WP=CE02651 /GEN=wrn-1 /TR=Q19546 /GB=AAA68410.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation
Cluster 6grp_highest_10_10 > 77      6grp_high1_10_10 > 77      4grp_high_8_8 > 16      6grp_highest_nonorm > 91      6grp_total > 77      4grp_total > 39      6grp_highest_sub > Da      6grp_cgc > 48      6grp_high1_sub > Da      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 155
1 2 3 4 range
A 173.4
(3)
P 		140.2
(-1)
A 		124.1
(-3)
P 		133
(-1.9)
A 		49
B 250.3
(3)
P 		128.2
(-3)
P 		127.6
(-3)
P 		175.5
(-0.7)
P 		123
C 260.2
(3)
P 		105.7
(-3)
A 		175.8
(-0.3)
P 		151.6
(-1.2)
M 		155
avr 228
(3) 		124.7
(-3) 		142.5
(-2) 		153.4
(-1.3) 		103

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 251
1 2 3 4 5 6 range
A 194.5
(-2.4)
P 		193.8
(-2.4)
P 		168.7
(-3)
P 		219.9
(-1.7)
P 		237.4
(-1.3)
P 		412.1
(3)
P 		243
B 160.9
(-3)
P 		180
(-2.5)
P 		203.7
(-1.9)
P 		195.7
(-2.1)
P 		195.5
(-2.1)
P 		388.5
(3)
P 		228
C 207.4
(-2)
P 		174.5
(-3)
P 		193.7
(-2.4)
P 		187
(-2.6)
P 		218.2
(-1.7)
P 		372.1
(3)
P 		198
avr 187.6
(-2.9) 		182.8
(-3) 		188.7
(-2.8) 		200.9
(-2.5) 		217
(-2) 		390.9
(3) 		208
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 67
1 2 3 4 range
A 63.1
(3)
P 		30.4
(-1.5)
A 		32.4
(-1.2)
P 		19.5
(-3)
A 		44
B 79.8
(3)
P 		31.7
(-2.7)
P 		29.6
(-3)
P 		37.4
(-2.1)
P 		50
C 86.1
(3)
P 		30.4
(-2.5)
A 		61.3
(0.5)
P 		25.6
(-3)
M 		61
avr 76.3
(3) 		30.8
(-2.6) 		41.1
(-1.3) 		27.5
(-3) 		49

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 109
1 2 3 4 5 6 range
A 35.8
(-3)
P 		68.9
(0.1)
P 		36.7
(-2.9)
P 		55.8
(-1.1)
P 		71.6
(0.3)
P 		100.3
(3)
P 		65
B 56
(-2.6)
P 		59.9
(-2.3)
P 		49.5
(-3)
P 		51.8
(-2.9)
P 		79.4
(-1.1)
P 		144.9
(3)
P 		95
C 76.9
(-0.3)
P 		53.2
(-1.9)
P 		49.3
(-2.2)
P 		37.6
(-3)
P 		70.6
(-0.7)
P 		124.6
(3)
P 		87
avr 56.2
(-2.2) 		60.7
(-1.8) 		45.2
(-3) 		48.4
(-2.8) 		73.9
(-0.8) 		123.3
(3) 		78
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 188101_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4247
Sequence Type Exemplar sequence
Representative Public ID F18C5.2 NCBI
Target Description F18C5.2 /REP_DB=WormBase Gene ID /WP=CE02651 /GEN=wrn-1 /TR=Q19546 /GB=AAA68410.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062923(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062923 NCBI Caenorhabditis elegans human WRN (Werner's syndrome) related family member (wrn-1) (wrn-1) mRNA, complete cds. 11/11 None
SNAP00000016657 ENSEMBL cdna:SNAP chromosome:CEL140:II:6554922:6559092:1 11/11 None
GENEFINDER00000016666 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:6554922:6559092:1 11/11 None
F18C5.2 ENSEMBL cdna:known chromosome:CEL140:II:6554922:6559200:1 gene:F18C5.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:6554918-6559089(+) 100.0 100.0
Public Domain and Genome References
Gene Title
Gene Symbol wrn-1
Ensembl F18C5.2
Entrez Gene 174081 Entrez gene
SwissProt Q19546 EMBL-EBI
WormBase CE31791 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.16230.1.S1_S_AT Werner syndrome cfa
CANINE_2:CFAAFFX.10617.1.S1_S_AT Werner syndrome cfa
CHICKEN:GGA.12337.1.S1_S_AT Werner syndrome gga
CHICKEN:GGA.12337.3.S1_S_AT Werner syndrome gga
CHICKEN:GGAAFFX.12946.1.S1_AT Werner syndrome gga
CHICKEN:GGA.12337.2.S1_AT Werner syndrome gga
CHICKEN:GGA.12337.3.S1_A_AT Werner syndrome gga
CHICKEN:GGA.12337.3.A1_AT Werner syndrome gga
HG-U133_PLUS_2:205667_AT Werner syndrome hs
HG-U133A:205667_AT Werner syndrome hs
HG-FOCUS:205667_AT Werner syndrome hs
HG-U133A_2:205667_AT Werner syndrome hs
HU35KSUBD:RC_N64051_S_AT Werner syndrome hs
HUGENEFL:L76937_RNA1_AT Werner syndrome hs
U133_X3P:G5739523_3P_AT Werner syndrome hs
HG-U95AV2:38136_AT Werner syndrome hs
HG-U95C:61207_AT Werner syndrome hs
MG-U74BV2:113110_AT Werner syndrome homolog (human) mm
MOE430A:1425074_AT Werner syndrome homolog (human) mm
MOUSE430A_2:1425074_AT Werner syndrome homolog (human) mm
MOUSE430_2:1425074_AT Werner syndrome homolog (human) mm
MU11KSUBA:D86526_S_AT Werner syndrome homolog (human) mm
MG-U74AV2:102891_AT Werner syndrome homolog (human) mm
MG-U74CV2:136677_AT Werner syndrome homolog (human) mm
MOE430A:1450163_A_AT Werner syndrome homolog (human) mm
MOUSE430A_2:1450163_A_AT Werner syndrome homolog (human) mm
MOUSE430_2:1450163_A_AT Werner syndrome homolog (human) mm
MOE430A:1425982_A_AT Werner syndrome homolog (human) mm
MOUSE430A_2:1425982_A_AT Werner syndrome homolog (human) mm
MOUSE430_2:1425982_A_AT Werner syndrome homolog (human) mm
MG-U74CV2:135775_AT WRN protein (Wrn) mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6259 DNA metabolism inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3676 nucleic acid binding inferred from electronic annotation QuickGO AmiGO
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
4386 helicase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
8026 ATP-dependent helicase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA68410 Human wrn (werner's syndrome) related protein 1 [Caenorhabditis elegans] ref|NP_495324.2| human WRN (Werner's syndrome) related family member (wrn-1) [Caenorhabditis elegans] sp|Q19546|WRN_CAEEL Probable Werner syndrome helicase homolog 0.0
blast CAE59344 Hypothetical protein CBG02689 [Caenorhabditis briggsae] 0.0
blast AAR05448 Werner syndrome [Homo sapiens] 1.0E-109
Protein Domains
Database ID Description E-Value
Pfam IPR001650 EMBL-EBI Helicase, C-terminal 5.9E-25
Pfam IPR001410 EMBL-EBI DEAD/DEAH box helicase 2.7E-35
Pfam IPR001650 EMBL-EBI Helicase, C-terminal 8.2E-30
Pfam IPR001410 EMBL-EBI DEAD/DEAH box helicase 1.1E-37
Sequence
Target Sequence 
>C. ELEGANS:188101_AT
tacctcagcctcgaatctcgaaatgattgatggaatgtcggctcagcagaaatctagata
cggaaaacgatttgtcgattgtgttgtacaattttcaaaggaaactggcattgcaacaaa
cgtcaatgccaacgatatgataccccctgaacttatttcaaaaatgcagaaagttctctc
ggatgcggtgagaagagtatacacagagcatcttatttcgagatccactgcgaaagaagt
ggcaactgctcgaggaattagtgagggtactgtatattcatatctcgcgatggcggtaga
aaaaggattacctcttcacttagacaagttaaatgtctccagaaagaatattgcaatggc
tctaaatgcagttagagtacatttaggatcaaatgttgccgtactgacaccatgggttga
agctatgggagtcgtacctgattttaatcagttgaaattgatccgggcaattcttattta
cgaatatggattggatacgagtgagaaccaagagaagccagacatccaatctatgccgtc
cacttcaaatccatccaccatcaaaacagttccatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACCTCAGCCTCGAATCTCGAAATG 687 647 2346 Antisense
ATATGATACCCCCTGAACTTATTTC 9 21 2480 Antisense
CAGAAAGTTCTCTCGGATGCGGTGA 159 203 2512 Antisense
GCATCTTATTTCGAGATCCACTGCG 38 309 2553 Antisense
GTATATTCATATCTCGCGATGGCGG 350 453 2617 Antisense
GGATTACCTCTTCACTTAGACAAGT 45 507 2650 Antisense
CAAATGTTGCCGTACTGACACCATG 260 193 2735 Antisense
GCTATGGGAGTCGTACCTGATTTTA 634 301 2767 Antisense
TGATCCGGGCAATTCTTATTTACGA 612 565 2804 Antisense
AGCCAGACATCCAATCTATGCCGTC 192 85 2861 Antisense
CATCCACCATCAAAACAGTTCCATC 367 211 2897 Antisense
Sequence Source Affymetrix Proprietary Database