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[187958_at] transient receptor protein

Description T01H8.3 /REP_DB=WormBase Gene ID /WP=CE13018 /GEN=gon-2 /TR=Q93970 /GB=CAB02300.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation
Cluster 6grp_total > 08      4grp_total > 01      6grp_cgc > 0      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 66
1 2 3 4 range
A 7.5
(-2.7)
A 		4.5
(-3)
A 		7.2
(-2.8)
A 		70.3
(3)
A 		66
B 6.3
(-1.9)
A 		6.1
(-2.2)
A 		9.5
(3)
A 		5.6
(-3)
A 		4
C 4.2
(-3)
A 		6.4
(0.4)
A 		5.5
(-1)
A 		8.1
(3)
A 		4
avr 6
(-2.9) 		5.7
(-3) 		7.4
(-2.5) 		28
(3) 		22

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 10
1 2 3 4 5 6 range
A 12.3
(3)
A 		5
(-1.3)
A 		3.1
(-2.4)
A 		8
(0.5)
A 		2
(-3)
A 		6.8
(-0.2)
A 		10
B 7.2
(0.4)
A 		4.9
(-2.4)
A 		6.2
(-0.8)
A 		9.4
(3)
A 		4.4
(-3)
A 		5.2
(-2)
A 		5
C 4.4
(0.8)
A 		2.8
(-3)
A 		5.3
(3)
A 		3
(-2.5)
A 		4.5
(1.1)
A 		3.8
(-0.6)
A 		3
avr 8
(3) 		4.2
(-2.2) 		4.9
(-1.2) 		6.8
(1.4) 		3.6
(-3) 		5.3
(-0.7) 		4
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 9
1 2 3 4 range
A 2.7
(-1.9)
A 		1
(-3)
A 		1.9
(-2.4)
A 		10.3
(3)
A 		9
B 2
(1.8)
A 		1.5
(-1.2)
A 		2.2
(3)
A 		1.2
(-3)
A 		1
C 1.4
(-3)
A 		1.8
(1.8)
A 		1.9
(3)
A 		1.4
(-3)
A 		1
avr 2
(-1.8) 		1.4
(-3) 		2
(-1.8) 		4.3
(3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2
1 2 3 4 5 6 range
A 2.3
(3)
A 		1.8
(1.2)
A 		0.7
(-2.6)
A 		2
(1.9)
A 		0.6
(-3)
A 		1.7
(0.9)
A 		2
B 2.5
(3)
A 		1.6
(-2.4)
A 		1.5
(-3)
A 		2.5
(3)
A 		1.8
(-1.2)
A 		1.9
(-0.6)
A 		1
C 1.6
(3)
A 		0.9
(-1.2)
A 		1.3
(1.2)
A 		0.6
(-3)
A 		1.4
(1.8)
A 		1.3
(1.2)
A 		1
avr 2.1
(3) 		1.4
(-1.7) 		1.2
(-3) 		1.7
(0.3) 		1.3
(-2.3) 		1.6
(-0.3) 		1
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 187958_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.598
Sequence Type Exemplar sequence
Representative Public ID T01H8.3 NCBI
Target Description T01H8.3 /REP_DB=WormBase Gene ID /WP=CE13018 /GEN=gon-2 /TR=Q93970 /GB=CAB02300.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059914(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059914 NCBI Caenorhabditis elegans abnormal GONad development family member (gon-2) (gon-2) mRNA, complete cds. 11/11 A 
SNAP00000010897 ENSEMBL cdna:SNAP chromosome:CEL140:I:8571513:8572263:-1 9/11 None
GENEFINDER00000010902 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:8571513:8572263:-1 9/11 None
T01H8.5 ENSEMBL cdna:known chromosome:CEL140:I:8557655:8579082:-1 gene:T01H8.5 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000010903 1/11 Cross Hyb Matching Probes None
SNAP00000010898 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8571443-8574231(-) 100.0 100.0
Public Domain and Genome References
Gene Title transient receptor protein
Gene Symbol gon-2
Ensembl T01H8.5
Entrez Gene 172646 Entrez gene
SwissProt Q93971 EMBL-EBI
WormBase CE30390 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.16158.1.S1_AT similar to transient receptor potential cation channel, subfamily M, member 1 cfa
CANINE_2:CFAAFFX.16161.1.S1_S_AT similar to transient receptor potential cation channel, subfamily M, member 1 cfa
CHICKEN:GGAAFFX.2399.1.S1_S_AT similar to transient receptor potential cation channel, subfamily M, member 1; melastatin 1 gga
CHICKEN:GGAAFFX.2399.2.S1_AT similar to transient receptor potential cation channel, subfamily M, member 1; melastatin 1 gga
CHICKEN:GGAAFFX.2399.3.S1_S_AT similar to transient receptor potential cation channel, subfamily M, member 1; melastatin 1 gga
HG-U133_PLUS_2:206479_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133A:206479_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133A_2:206479_AT transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBA:AA455860_S_AT transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_N20535_AT transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_N21111_AT transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_AA436463_AT transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:G6006023_3P_AT transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:HS.166845.0.A1_3P_S_AT transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:HS.166845.0.A1_3P_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133_PLUS_2:237069_S_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133B:237069_S_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133_PLUS_2:237070_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133B:237070_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95AV2:41564_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95B:49609_R_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95C:62717_AT transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133_PLUS_2:214410_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133A_2:214410_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-FOCUS:214410_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133A:214410_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133_PLUS_2:240386_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133B:240386_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133_PLUS_2:243741_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U133B:243741_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95AV2:41563_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95B:44502_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95C:52604_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95C:66560_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95D:81181_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95E:82726_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95D:87766_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95D:88401_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HG-U95D:91463_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBA:N28643_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_N31576_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_AA458649_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_H98835_AT Transient receptor potential cation channel, subfamily M, member 1 hs
HU35KSUBC:RC_N23401_AT Transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:HS.145268.0.A1_3P_AT Transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:HS.40930.0.A1_3P_AT Transient receptor potential cation channel, subfamily M, member 1 hs
U133_X3P:HS.43265.1.A1_3P_AT Transient receptor potential cation channel, subfamily M, member 1 hs
RAT230_2:1375596_AT similar to transient receptor potential cation channel, subfamily M, member 1 rn
RAE230A:1375596_AT similar to transient receptor potential cation channel, subfamily M, member 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6811 ion transport inferred from electronic annotation QuickGO AmiGO
6812 cation transport inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
5886 plasma membrane inferred from sequence similarity QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5216 ion channel activity inferred from electronic annotation QuickGO AmiGO
8324 cation transporter activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02303 Hypothetical protein T01H8.5 [Caenorhabditis elegans] emb|CAB05572.2| Hypothetical protein T01H8.5 [Caenorhabditis elegans] ref|NP_492315.4| abnormal GONad development family member (gon-2) [Caenorhabditis elegans] sp|Q93971|TRPG_CAEEL Transient receptor potential channel (Abnormal gonad development protein 2) 0.0
blast CAC81668 putative TRP homologous cation channel [Caenorhabditis elegans] 0.0
blast T23707 hypothetical protein T01H8.5 - Caenorhabditis elegans 0.0
blast T24339 hypothetical protein T01H8.3 - Caenorhabditis elegans 1.0E-64
blast CAC81668 putative TRP homologous cation channel [Caenorhabditis elegans] 1.0E-46
blast CAB02303 Hypothetical protein T01H8.5 [Caenorhabditis elegans] emb|CAB05572.2| Hypothetical protein T01H8.5 [Caenorhabditis elegans] ref|NP_492315.4| abnormal GONad development family member (gon-2) [Caenorhabditis elegans] sp|Q93971|TRPG_CAEEL Transient receptor potential channel (Abnormal gonad development protein 2) 1.0E-46
Protein Domains
Database ID Description E-Value
Pfam IPR005821 EMBL-EBI Ion transport protein 3.3E-19
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492315.4 5 1308-1330,1337-1355,1370-1392,1443-1465,1537-1559
T01H8.5 5 1308-1330,1337-1355,1370-1392,1443-1465,1537-1559
Sequence
Target Sequence 
>C. ELEGANS:187958_AT
gcggcgtcgttttgaaaagcttcgacgtgaaaagaaagaagagaagaaactgctggcgga
tgatgaaaaggattttgatgaagacgatgatgtttttgaagatggagaaggtttacagat
gcgaacgttccagccgaacgcatcgattcgagacgaaaatggatcgatgcccagtctttt
gccacgcacagcaccgataaaaaagacgagaaaacatcggagaagacgtagtggcagttt
cactggcggagtctatcctcgaaagggtcaccgaaacaggagtcttcttggccatgcgat
accaccaccaaatgtacattcggctgattggagagacatgttggctatcactga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCGGCGTCGTTTTGAAAAGCTTCGA 198 291 15 Antisense
TTACAGATGCGAACGTTCCAGCCGA 621 681 127 Antisense
TTCCAGCCGAACGCATCGATTCGAG 207 701 142 Antisense
GAAAATGGATCGATGCCCAGTCTTT 149 353 169 Antisense
TTTGCCACGCACAGCACCGATAAAA 577 665 192 Antisense
GGCAGTTTCACTGGCGGAGTCTATC 506 535 247 Antisense
GAGTCTATCCTCGAAAGGGTCACCG 382 399 263 Antisense
GAAACAGGAGTCTTCTTGGCCATGC 80 357 287 Antisense
ATGCGATACCACCACCAAATGTACA 213 41 308 Antisense
GTACATTCGGCTGATTGGAGAGACA 632 459 328 Antisense
GGAGAGACATGTTGGCTATCACTGA 312 519 344 Antisense
Sequence Source Affymetrix Proprietary Database